Country: Малезија
Језик: Енглески
Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMOXICILLIN TRIHYDRATE; Gentamicin sulfate
Vemedim Sdn Bhd
AMOXICILLIN TRIHYDRATE; Gentamicin sulfate
100 ml
VEMEDIM VETERINARY DRUGS AND PROBIOTICS CO., LTD (VEMEDIM ANIMAL HEALTH)
Manufactured by: VEMEDIM VETERINARY DRUGS AND PROBIOTICS CO., LTD (Vemedim Animal Health) Song Hau Industrial Zone, Chau Thanh District, Hau Giang Province, Vietnam Product Registration Holder: VEMEDIM SDN. BHD. 15, Jalan USJ 1/31, 47600 Subang Jaya Selangor, Darul Ehsan, Malaysia COMPOSITION: Each ml contains: Amoxicillin trihydrate ……………..…… 150 mg Gentamicin Sulfate …...…....…….… 40,000 IU Benzyl alcohol (as preservative) …..… 0.03 ml DESCRIPTION The finished product is ivory cream suspension. PHARMACODYNAMICS Amoxicillin is a bactericidal antibiotic that belongs to the penicillin group. It inhibits the synthesis of the mucopeptide, one of the components of the bacterial rigid cell wall that gives the bacteria mechanical stability, destroying the bacteria in its growth phase. Gentamicin is an aminoglycoside antibiotic that acts directly on the ribosome, where it inhibits protein biosynthesis and decreases the fidelity of interpretation of the genetic code. The penetration of gentamicin in the cell is increased when the permeability of the bacterial cell wall is altered by amoxicillin. This fact allows the use of smaller amounts of the aminoglycoside. The bound amoxicillin and gentamicin have a broad antibacterial spectrum that includes Gram positive bacteria (_corinebacteria_) and Gram negative bacteria (_E. coli, Pasteurella_ _spp_, and _ Salmonella_ _ spp_). Their association improves the therapeutic properties of each of these antibiotics administered alone. PHARMACOKINETICS Amoxicillin is well absorbed after parenteral administration. 17-20% of the active substance binds to plasma proteins. It is excreted mainly by unaltered urine and to a lesser extent by milk and bile. Gentamicin is poorly absorbed from the gastrointestinal tract, however, it is well absorbed after parenteral administration. It is rapidly distributed reaching the kidney, liver, lung, endometrium and breast parenchyma. Its elimination takes place in a biphasic manner, a first rapid phase corresponding to the di Прочитајте комплетан документ