Ovitrelle
ﾐ｡ﾑびﾐｰﾐｽﾐｰ: ﾐ片ｲﾑﾐｾﾐｿﾐｵﾐｹﾑﾐｺﾐｸﾐｹ ﾑﾐｾﾑ社ｷ
ﾐｯﾐｷﾑ巾ｺ: ﾐｱﾐｾﾐｻﾐｳﾐｰﾑﾑﾐｺﾐｸﾐｹ
ﾐ佯ﾑひｾﾑﾐｽﾐｸﾐｺ: EMA (European Medicines Agency)
ﾑひｾﾐｽﾐｺﾐｰﾑ ﾐｱﾑﾐｾﾑ尉紗ﾐｰ
(PIL)
04-10-2023
ﾐ･ﾐｰﾑﾐｰﾐｺﾑひｵﾑﾐｸﾑﾑひｸﾐｺﾐｸ ﾐｿﾑﾐｾﾐｴﾑσｺﾑひｰ
(SPC)
04-10-2023
ﾐ｡ﾐｾﾐｾﾐｱﾑ禍ｸﾑび ﾐｾﾐｱﾑ禍ｵﾑﾑひｲﾐｵﾐｽﾐｽﾐｰﾑ ﾐｾﾑﾐｵﾐｽﾐｺﾐｰ
(PAR)
18-01-2021
ﾐ籍ｺﾑひｸﾐｲﾐｽﾑ巾ｹ ﾐｸﾐｽﾐｳﾑﾐｵﾐｴﾐｸﾐｵﾐｽﾑ:
ﾑﾐｾﾑﾐｸﾐｾﾐｳﾐｾﾐｽﾐｰﾐｴﾐｾﾑびﾐｾﾐｿﾐｸﾐｽ ﾐｰﾐｻﾑﾐｰ
ﾐ頒ｾﾑﾑびσｿﾐｽﾐｰ ﾑ:
Merck Europe B.V.
ﾐｺﾐｾﾐｴ ﾐ籍｢ﾐ｡:
G03GA08
ﾐ侑斷 (ﾐ慴ｵﾐｶﾐｴﾑσｽﾐｰﾑﾐｾﾐｴﾐｽﾐｰﾑ ﾐ侑ｼﾑ):
choriogonadotropin alfa
ﾐ｢ﾐｵﾑﾐｰﾐｿﾐｵﾐｲﾑひｸﾑﾐｵﾑﾐｺﾐｰﾑ ﾐｳﾑﾑσｿﾐｿﾐｰ:
ﾐ渙ｾﾐｻﾐｾﾐｲﾐｸ ﾑﾐｾﾑﾐｼﾐｾﾐｽﾐｸ ﾐｸ ﾑﾐｻﾐｸﾐｷﾐｰ ﾐｽﾐｰ ﾐｿﾐｾﾐｻﾐｾﾐｲﾐｰﾑひｰ ﾑﾐｸﾑﾑひｵﾐｼﾐｰ,
ﾐ｢ﾐｵﾑﾐｰﾐｿﾐｵﾐｲﾑひｸﾑﾐｵﾑﾐｺﾐｸﾐｵ ﾐｾﾐｱﾐｻﾐｰﾑﾑひｸ:
Anovulation; Reproductive Techniques, Assisted; Infertility, Female
ﾐ｢ﾐｵﾑﾐｰﾐｿﾐｵﾐｲﾑひｸﾑﾐｵﾑﾐｺﾐｸﾐｵ ﾐｿﾐｾﾐｺﾐｰﾐｷﾐｰﾐｽﾐｸﾑ :
Ovitrelle ﾐｵ ﾐｿﾐｾﾐｺﾐｰﾐｷﾐｰﾐｽ ﾐｿﾑﾐｸ ﾐｻﾐｵﾑﾐｵﾐｽﾐｸﾐｵﾑひｾ ﾐｽﾐｰ:ﾐｶﾐｵﾐｽﾐｸﾑひｵ, ﾐｿﾐｾﾐｴﾐｻﾐｾﾐｶﾐｵﾐｽﾐｸ ﾐｽﾐｰ ﾑﾑσｿﾐｵﾑﾐｾﾐｲﾑσｻﾑ肖ﾐｸﾐｸ ﾐｴﾐｾ ﾐｰﾑﾐｸﾑﾑひｸﾑﾐｰﾐｽﾐｰ ﾑﾐｵﾐｿﾑﾐｾﾐｴﾑσｺﾑﾐｸﾑ ﾐｺﾐｰﾑひｾ ﾐｸﾐｽ ﾐｲﾐｸﾑびﾐｾ ﾐｾﾐｿﾐｻﾐｾﾐｶﾐｴﾐｰﾐｽﾐｵ (IVF): Ovitrelle ﾑﾐｵ ﾐｸﾐｽﾐｶﾐｵﾐｺﾑひｸﾑﾐｰ, ﾐｷﾐｰ ﾐｴﾐｰ ﾑﾐｵ ﾐｷﾐｰﾐｴﾐｵﾐｹﾑﾑひｲﾐｰ ﾐｾﾐｺﾐｾﾐｽﾑﾐｰﾑひｵﾐｻﾐｽﾐｾﾑひｾ ﾑﾑ諌ｷﾑﾑ紹ｲﾐｰﾐｽﾐｵ ﾐｽﾐｰ ﾑﾐｾﾐｻﾐｸﾐｺﾑσｻﾐｰ ﾐｸ luteinisation ﾑﾐｻﾐｵﾐｴ ﾑﾑひｸﾐｼﾑσｻﾐｰﾑﾐｸﾑ ﾐｽﾐｰ ﾑﾐｾﾐｻﾐｸﾐｺﾑσｻﾐｰﾑﾐｵﾐｽ ﾑﾐｰﾑﾑひｵﾐｶ;ﾐｾﾐｲﾑσｻﾐｰﾑﾐｸﾑ ﾐｸﾐｻﾐｸ ﾐｾﾐｻﾐｸﾐｳﾐｾ-ﾐｾﾐｲﾑσｻﾑ肖ひｾﾑﾐｽﾐｾﾐｹ ﾐｶﾐｵﾐｽﾐｸ: Ovitrelle ﾐｿﾑﾐｵﾐｴﾐｿﾐｸﾑﾐｲﾐｰﾑ ﾐｿﾑﾐｵﾐｴﾐｸﾐｷﾐｲﾐｸﾐｺﾐｰ ﾐｾﾐｲﾑσｻﾐｰﾑﾐｸﾑ ﾐｸ luteinisation ﾐｲ ﾐｾﾐｲﾑσｻﾐｰﾑﾐｸﾑ ﾐｸﾐｻﾐｸ ﾐｾﾐｻﾐｸﾐｳﾐｾ-ﾐｾﾐｲﾑσｻﾐｰﾑﾐｸﾑ ﾐｿﾑﾐｸ ﾐｿﾐｰﾑﾐｸﾐｵﾐｽﾑひｾﾐｺ ﾑﾐｻﾐｵﾐｴ ﾑﾑひｸﾐｼﾑσｻﾐｰﾑﾐｸﾑ ﾐｽﾐｰ ﾑﾐｾﾐｻﾐｸﾐｺﾑσｻﾐｰﾑﾐｵﾐｽ ﾑﾐｰﾑﾑひｵﾐｶ.
ﾐ榧ｱﾐｷﾐｾﾑ ﾐｿﾑﾐｾﾐｴﾑσｺﾑひｾﾐｲ:
Revision: 22
ﾐ｡ﾑひｰﾑびτ ﾐ籍ｲﾑひｾﾑﾐｸﾐｷﾐｰﾑﾐｸﾑ:
ﾑσｿﾑ諌ｻﾐｽﾐｾﾐｼﾐｾﾑ禍ｵﾐｽ
ﾐ頒ｰﾑひｰ ﾐ籍ｲﾑひｾﾑﾐｸﾐｷﾐｰﾑﾐｸﾑ:
2001-02-02
ﾑひｾﾐｽﾐｺﾐｰﾑ ﾐｱﾑﾐｾﾑ尉紗ﾐｰ
28
ﾐ. ﾐ嶢侑｡ﾐ｢ﾐ榧漬墟
29
ﾐ嶢侑｡ﾐ｢ﾐ榧漬墟: ﾐ侑斷､ﾐ榧ﾐ慴籍ｦﾐ侑ｯ ﾐ厘 ﾐ渙榧｢ﾐﾐ片岱侑｢ﾐ片嶢ｯ
OVITRELLE
250 ﾐ慴侑墟ﾐ榧寅ﾐ籍慴/0.5 ML ﾐ侑斷孟片墟ｦﾐ侑榧斷片 ﾐﾐ籍厘｢ﾐ漬榧
ﾐ ﾐ渙ﾐ片頒漬籍ﾐ侑｢ﾐ片嶢斷 ﾐ斷籍渙ｪﾐ嶢斷片斷
ﾐ｡ﾐ渙ﾐ侑斷ｦﾐ榧漬墟
xﾐｾﾑﾐｸﾐｾﾐｳﾐｾﾐｽﾐｰﾐｴﾐｾﾑびﾐｾﾐｿﾐｸﾐｽ ﾐｰﾐｻﾑﾐｰ (choriogonadotropin alfa)
ﾐ渙ﾐ榧ｧﾐ片｢ﾐ片｢ﾐ ﾐ漬斷侑慴籍｢ﾐ片嶢斷 ﾐｦﾐｯﾐ嶢籍｢ﾐ ﾐ嶢侑｡ﾐ｢ﾐ榧漬墟,
ﾐ渙ﾐ片頒 ﾐ頒 ﾐ厘籍渙榧ｧﾐ斷片｢ﾐ ﾐ頒 ﾐ侑厘渙榧嶢厘漬籍｢ﾐ ﾐ｢ﾐ榧漬
ﾐ嶢片墟籍ﾐ｡ﾐ｢ﾐ漬, ﾐ｢ﾐｪﾐ ﾐ墟籍｢ﾐ ﾐ｢ﾐｯ ﾐ｡ﾐｪﾐ頒ｪﾐﾐ孟 ﾐ漬籍孟斷
ﾐ厘 ﾐ漬籍｡ ﾐ侑斷､ﾐ榧ﾐ慴籍ｦﾐ侑ｯ.
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ﾐ厘ｰﾐｿﾐｰﾐｷﾐｵﾑひｵ ﾑひｰﾐｷﾐｸ ﾐｻﾐｸﾑﾑひｾﾐｲﾐｺﾐｰ. ﾐ慴ｾﾐｶﾐｵ ﾐｴﾐｰ ﾑﾐｵ
ﾐｽﾐｰﾐｻﾐｾﾐｶﾐｸ ﾐｴﾐｰ ﾑ ﾐｿﾑﾐｾﾑﾐｵﾑひｵﾑひｵ ﾐｾﾑひｽﾐｾﾐｲﾐｾ.
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ﾐ籍ｺﾐｾ ﾐｸﾐｼﾐｰﾑひｵ ﾐｽﾑ紹ｺﾐｰﾐｺﾐｲﾐｸ ﾐｴﾐｾﾐｿﾑ諌ｻﾐｽﾐｸﾑひｵﾐｻﾐｽﾐｸ
ﾐｲﾑ諌ｿﾑﾐｾﾑﾐｸ, ﾐｿﾐｾﾐｿﾐｸﾑひｰﾐｹﾑひｵ ﾐ漬ｰﾑ威ｸﾑ ﾐｻﾐｵﾐｺﾐｰﾑ ﾐｸﾐｻﾐｸ
ﾑﾐｰﾑﾐｼﾐｰﾑﾐｵﾐｲﾑ.
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ﾐ｢ﾐｾﾐｲﾐｰ ﾐｻﾐｵﾐｺﾐｰﾑﾑﾑひｲﾐｾ ﾐｵ ﾐｿﾑﾐｵﾐｴﾐｿﾐｸﾑﾐｰﾐｽﾐｾ ﾐｻﾐｸﾑﾐｽﾐｾ ﾐｽﾐｰ
ﾐ漬ｰﾑ. ﾐ斷ｵ ﾐｳﾐｾ ﾐｿﾑﾐｵﾐｾﾑびﾑび諌ｿﾐｲﾐｰﾐｹﾑひｵ ﾐｽﾐｰ ﾐｴﾑﾑσｳﾐｸ
ﾑﾐｾﾑﾐｰ. ﾐ｢ﾐｾ ﾐｼﾐｾﾐｶﾐｵ
ﾐｴﾐｰ ﾐｸﾐｼ ﾐｽﾐｰﾐｲﾑﾐｵﾐｴﾐｸ, ﾐｽﾐｵﾐｷﾐｰﾐｲﾐｸﾑﾐｸﾐｼﾐｾ ﾑﾐｵ
ﾐｿﾑﾐｸﾐｷﾐｽﾐｰﾑﾐｸﾑひｵ ﾐｽﾐｰ ﾑび肖ﾐｽﾐｾﾑひｾ ﾐｷﾐｰﾐｱﾐｾﾐｻﾑ紹ｲﾐｰﾐｽﾐｵ ﾑﾐｰ
ﾑﾑ貫禍ｸﾑひｵ ﾐｺﾐｰﾑひｾ ﾐ漬ｰﾑ威ｸﾑひｵ.
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ﾐ籍ｺﾐｾ ﾐｿﾐｾﾐｻﾑτﾐｸﾑひｵ ﾐｽﾑ紹ｺﾐｰﾐｺﾐｲﾐｸ ﾐｽﾐｵﾐｶﾐｵﾐｻﾐｰﾐｽﾐｸ
ﾑﾐｵﾐｰﾐｺﾑﾐｸﾐｸ, ﾑσｲﾐｵﾐｴﾐｾﾐｼﾐｵﾑひｵ ﾐ漬ｰﾑ威ｸﾑ ﾐｻﾐｵﾐｺﾐｰﾑ ﾐｸﾐｻﾐｸ
ﾑﾐｰﾑﾐｼﾐｰﾑﾐｵﾐｲﾑ. ﾐ｢ﾐｾﾐｲﾐｰ
ﾐｲﾐｺﾐｻﾑ紗ﾐｲﾐｰ ﾐｸ ﾐｲﾑﾐｸﾑﾐｺﾐｸ ﾐｲﾑ諌ｷﾐｼﾐｾﾐｶﾐｽﾐｸ ﾐｽﾐｵﾐｶﾐｵﾐｻﾐｰﾐｽﾐｸ
ﾑﾐｵﾐｰﾐｺﾑﾐｸﾐｸ, ﾐｽﾐｵﾐｾﾐｿﾐｸﾑﾐｰﾐｽﾐｸ ﾐｲ ﾑひｰﾐｷﾐｸ ﾐｻﾐｸﾑﾑひｾﾐｲﾐｺﾐｰ.
ﾐ漬ｸﾐｶﾑひｵ
ﾑひｾﾑﾐｺﾐｰ 4.
ﾐ墟籍墟漬 ﾐ｡ﾐｪﾐ頒ｪﾐﾐ孟 ﾐ｢ﾐ籍厘 ﾐ嶢侑｡ﾐ｢ﾐ榧漬墟
1.
ﾐ墟ｰﾐｺﾐｲﾐｾ ﾐｿﾑﾐｵﾐｴﾑﾑひｰﾐｲﾐｻﾑ紹ｲﾐｰ Ovitrelle ﾐｸ ﾐｷﾐｰ ﾐｺﾐｰﾐｺﾐｲﾐｾ ﾑﾐｵ
ﾐｸﾐｷﾐｿﾐｾﾐｻﾐｷﾐｲﾐｰ
2.
ﾐ墟ｰﾐｺﾐｲﾐｾ ﾑびﾑ紹ｱﾐｲﾐｰ ﾐｴﾐｰ ﾐｷﾐｽﾐｰﾐｵﾑひｵ, ﾐｿﾑﾐｵﾐｴﾐｸ ﾐｴﾐｰ
ﾐｸﾐｷﾐｿﾐｾﾐｻﾐｷﾐｲﾐｰﾑひｵ Ovitrelle
3.
ﾐ墟ｰﾐｺ ﾐｴﾐｰ ﾐｸﾐｷﾐｿﾐｾﾐｻﾐｷﾐｲﾐｰﾑひｵ Ovitrelle
4.
ﾐ柘諌ｷﾐｼﾐｾﾐｶﾐｽﾐｸ ﾐｽﾐｵﾐｶﾐｵﾐｻﾐｰﾐｽﾐｸ ﾑﾐｵﾐｰﾐｺﾑﾐｸﾐｸ
5.
ﾐ墟ｰﾐｺ ﾐｴﾐｰ ﾑﾑ貫ﾑﾐｰﾐｽﾑ紹ｲﾐｰﾑひｵ Ovitrelle
6.
ﾐ｡ﾑ諌ｴﾑ貫ﾐｶﾐｰﾐｽﾐｸﾐｵ ﾐｽﾐｰ ﾐｾﾐｿﾐｰﾐｺﾐｾﾐｲﾐｺﾐｰﾑひｰ ﾐｸ
ﾐｴﾐｾﾐｿﾑ諌ｻﾐｽﾐｸﾑひｵﾐｻﾐｽﾐｰ ﾐｸﾐｽﾑﾐｾﾑﾐｼﾐｰﾑﾐｸﾑ
1.
ﾐ墟籍墟漬 ﾐ渙ﾐ片頒｡ﾐ｢ﾐ籍漬嶢ｯﾐ漬 OVITRELLE ﾐ ﾐ厘 ﾐ墟籍墟漬 ﾐ｡ﾐ
ﾐ侑厘渙榧嶢厘漬
ﾐ墟籍墟漬 ﾐ渙ﾐ片頒｡ﾐ｢ﾐ籍漬嶢ｯﾐ漬 OVITRE
ﾐ湲ﾐｾﾑﾐｸﾑひｰﾑび ﾐｿﾐｾﾐｻﾐｽﾑ巾ｹ ﾐｴﾐｾﾐｺﾑσｼﾐｵﾐｽﾑ
ﾐ･ﾐｰﾑﾐｰﾐｺﾑひｵﾑﾐｸﾑﾑひｸﾐｺﾐｸ ﾐｿﾑﾐｾﾐｴﾑσｺﾑひｰ
1
ﾐ渙ﾐ侑嶢榧孟片斷侑 I
ﾐ墟ﾐ籍｢ﾐ墟 ﾐ･ﾐ籍ﾐ籍墟｢ﾐ片ﾐ侑｡ﾐ｢ﾐ侑墟 ﾐ斷 ﾐ渙ﾐ榧頒｣ﾐ墟｢ﾐ
2
1.
ﾐ侑慴 ﾐ斷 ﾐ嶢片墟籍ﾐ｡ﾐ｢ﾐ漬片斷侑ｯ ﾐ渙ﾐ榧頒｣ﾐ墟｢
Ovitrelle 250 ﾐｼﾐｸﾐｺﾑﾐｾﾐｳﾑﾐｰﾐｼﾐｰ/0,5 ml ﾐｸﾐｽﾐｶﾐｵﾐｺﾑﾐｸﾐｾﾐｽﾐｵﾐｽ
ﾑﾐｰﾐｷﾑひｲﾐｾﾑ ﾐｲ ﾐｿﾑﾐｵﾐｴﾐｲﾐｰﾑﾐｸﾑひｵﾐｻﾐｽﾐｾ ﾐｽﾐｰﾐｿﾑ諌ｻﾐｽﾐｵﾐｽﾐｰ
ﾑﾐｿﾑﾐｸﾐｽﾑﾐｾﾐｲﾐｺﾐｰ
2.
ﾐ墟籍ｧﾐ片｡ﾐ｢ﾐ漬片 ﾐ ﾐ墟榧嶢侑ｧﾐ片｡ﾐ｢ﾐ漬片 ﾐ｡ﾐｪﾐ｡ﾐ｢ﾐ籍
ﾐ柘ﾑ紹ｺﾐｰ ﾐｿﾑﾐｵﾐｴﾐｲﾐｰﾑﾐｸﾑひｵﾐｻﾐｽﾐｾ ﾐｽﾐｰﾐｿﾑ諌ｻﾐｽﾐｵﾐｽﾐｰ
ﾑﾐｿﾑﾐｸﾐｽﾑﾐｾﾐｲﾐｺﾐｰ ﾑﾑ諌ｴﾑ貫ﾐｶﾐｰ 250 ﾐｼﾐｸﾐｺﾑﾐｾﾐｳﾑﾐｰﾐｼﾐｰ
ﾑﾐｾﾑﾐｸﾐｾﾐｳﾐｾﾐｽﾐｰﾐｴﾐｾﾑびﾐｾﾐｿﾐｸﾐｽ
ﾐｰﾐｻﾑﾐｰ* (choriogonadotropin alfa) (ﾐｵﾐｺﾐｲﾐｸﾐｲﾐｰﾐｻﾐｵﾐｽﾑひｽﾐｸ ﾐｽﾐｰ
ﾐｿﾑﾐｸﾐｱﾐｻﾐｸﾐｷﾐｸﾑひｵﾐｻﾐｽﾐｾ 6 500 IU) ﾐｲ 0,5 ml ﾑﾐｰﾐｷﾑひｲﾐｾﾑ.
*ﾑﾐｵﾐｺﾐｾﾐｼﾐｱﾐｸﾐｽﾐｰﾐｽﾑひｵﾐｽ ﾑﾐｾﾐｲﾐｵﾑ威ｺﾐｸ
ﾑﾐｾﾑﾐｸﾐｾﾐｳﾐｾﾐｽﾐｰﾐｴﾐｾﾑびﾐｾﾐｿﾐｸﾐｽ, r-hCG, ﾐｿﾑﾐｾﾐｸﾐｷﾐｲﾐｵﾐｴﾐｵﾐｽ ﾐｲ
ﾐｾﾐｲﾐｰﾑﾐｸﾐｰﾐｻﾐｽﾐｸ ﾐｺﾐｻﾐｵﾑひｺﾐｸ ﾐｽﾐｰ
ﾐｺﾐｸﾑひｰﾐｹﾑﾐｺﾐｸ ﾑﾐｰﾐｼﾑﾑひｵﾑ (ﾐ｡ﾐ斷) ﾑﾑﾐｵﾐｷ
ﾑﾐｵﾐｺﾐｾﾐｼﾐｱﾐｸﾐｽﾐｰﾐｽﾑひｽﾐｰ ﾐ頒斷 ﾑひｵﾑﾐｽﾐｾﾐｻﾐｾﾐｳﾐｸﾑ
ﾐ厘ｰ ﾐｿﾑ諌ｻﾐｽﾐｸﾑ ﾑﾐｿﾐｸﾑﾑ諌ｺ ﾐｽﾐｰ ﾐｿﾐｾﾐｼﾐｾﾑ禍ｽﾐｸﾑひｵ
ﾐｲﾐｵﾑ禍ｵﾑﾑひｲﾐｰ ﾐｲﾐｸﾐｶﾑひｵ ﾑひｾﾑﾐｺﾐｰ 6.1.
3.
ﾐ嶢片墟籍ﾐ｡ﾐ｢ﾐ漬片斷 ﾐ､ﾐ榧ﾐ慴
ﾐ侑ｽﾐｶﾐｵﾐｺﾑﾐｸﾐｾﾐｽﾐｵﾐｽ ﾑﾐｰﾐｷﾑひｲﾐｾﾑ ﾐｲ ﾐｿﾑﾐｵﾐｴﾐｲﾐｰﾑﾐｸﾑひｵﾐｻﾐｽﾐｾ
ﾐｽﾐｰﾐｿﾑ諌ｻﾐｽﾐｵﾐｽﾐｰ ﾑﾐｿﾑﾐｸﾐｽﾑﾐｾﾐｲﾐｺﾐｰ
ﾐ岱ｸﾑﾑび貫, ﾐｱﾐｵﾐｷﾑﾐｲﾐｵﾑひｵﾐｽ ﾐｴﾐｾ ﾐｱﾐｻﾐｵﾐｴﾐｾﾐｶﾑ諌ｻﾑ
ﾑﾐｰﾐｷﾑひｲﾐｾﾑ
pH ﾐｽﾐｰ ﾑﾐｰﾐｷﾑひｲﾐｾﾑﾐｰ ﾐｵ 7,0 ﾂｱ 0,3, ﾐｾﾑﾐｼﾐｾﾐｻﾐｰﾐｻﾐｸﾑひｵﾑび貫
ﾐｼﾑ ﾐｵ 250-400 mOsm/kg.
4.
ﾐ墟嶢侑斷侑ｧﾐ斷 ﾐ頒籍斷斷
4.1
ﾐ｢ﾐ片ﾐ籍渙片漬｢ﾐ侑ｧﾐ斷 ﾐ渙榧墟籍厘籍斷侑ｯ
Ovitrelle ﾐｵ ﾐｿﾐｾﾐｺﾐｰﾐｷﾐｰﾐｽ ﾐｷﾐｰ ﾑσｿﾐｾﾑびﾐｵﾐｱﾐｰ ﾐｿﾑﾐｸ
ﾐｻﾐｵﾑﾐｵﾐｽﾐｸﾐｵ ﾐｽﾐｰ:
窶｢
ﾐ柘諌ｷﾑﾐｰﾑﾑひｽﾐｸ ﾐｶﾐｵﾐｽﾐｸ, ﾐｿﾐｾﾐｴﾐｻﾐｾﾐｶﾐｵﾐｽﾐｸ ﾐｽﾐｰ
ﾑﾑσｿﾐｵﾑﾐｾﾐｲﾑσｻﾐｰﾑﾐｸﾑ ﾐｿﾑﾐｵﾐｴﾐｸ ﾐｿﾑﾐｸﾐｻﾐｰﾐｳﾐｰﾐｽﾐｵ ﾐｽﾐｰ
ﾐｰﾑﾐｸﾑﾑひｸﾑﾐｰﾐｽﾐｸ
ﾑﾐｵﾐｿﾑﾐｾﾐｴﾑσｺﾑひｸﾐｲﾐｽﾐｸ ﾑひｵﾑﾐｽﾐｾﾐｻﾐｾﾐｳﾐｸﾐｸ (ﾐ籍ﾐ｢), ﾐｺﾐｰﾑひｾ
_in vitro_
ﾑﾐｵﾑﾑひｸﾐｻﾐｸﾐｷﾐｰﾑﾐｸﾑ (ﾐ侑漬､). Ovitrelle ﾑﾐｵ ﾐｿﾑﾐｸﾐｻﾐｰﾐｳﾐｰ,
ﾐｷﾐｰ ﾐｴﾐｰ ﾐｿﾑﾐｵﾐｴﾐｸﾐｷﾐｲﾐｸﾐｺﾐｰ ﾐｺﾑﾐｰﾐｹﾐｽﾐｰ ﾑﾐｾﾐｻﾐｸﾐｺﾑσｻﾐｽﾐｰ
ﾐｼﾐｰﾑびτﾐｰﾑﾐｸﾑ ﾐｸ ﾐｻﾑτひｵﾐｸﾐｽﾐｸﾐｷﾐｰﾑﾐｸﾑ, ﾑﾐｻﾐｵﾐｴ
ﾑﾑひｸﾐｼﾑσｻﾐｰﾑﾐｸﾑ ﾐｽﾐｰ
ﾑﾐｾﾐｻﾐｸﾐｺﾑσｻﾐｽﾐｸﾑ ﾑﾐｰﾑﾑひｵﾐｶ.
窶｢
ﾐ籍ｽﾐｾﾐｲﾑσｻﾐｰﾑひｾﾑﾐｽﾐｸ ﾐｸﾐｻﾐｸ ﾐｾﾐｻﾐｸﾐｳﾐｾ-ﾐｾﾐｲﾑσｻﾐｰﾑひｾﾑﾐｽﾐｸ
ﾐｲﾑ諌ｷﾑﾐｰﾑﾑひｽﾐｸ ﾐｶﾐｵﾐｽﾐｸ: Ovitrelle ﾑﾐｵ ﾐｿﾑﾐｸﾐｻﾐｰﾐｳﾐｰ
ﾐ湲ﾐｾﾑﾐｸﾑひｰﾑび ﾐｿﾐｾﾐｻﾐｽﾑ巾ｹ ﾐｴﾐｾﾐｺﾑσｼﾐｵﾐｽﾑ
