Страна: Малайзия
Язык: английский
Источник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
FENOFIBRATE
UNIMED SDN BHD
FENOFIBRATE
3x10'stablet Tablets
Troikaa Pharmaceuticals Ltd
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ FENO-TG 160 MG TABLET Fenofibrate 160 mg WHAT IS IN THIS LEAFLET 1. What Feno-TG is used for 2. How Feno-TG works 3. Before you use Feno-TG 4. How to use Feno-TG 5. While you are using it 6. Side effects 7. Storage and Disposal of Feno-TG 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT FENO-TG IS USED FOR FENO-TG is used to lower the level of fats (lipids) in the blood. For example the fats known as triglycerides. It is used, alongside a low fat diet and other nonmedical treatments such as exercise and weight loss, to lower levels of fats in the blood. HOW WORKS FENO-TG works through the activation of a cell nuclear receptor called peroxisome proliferator-activated receptor alpha, which reduces the amount of triglycerides and bad cholesterol made in the body and increases the good cholesterol. BEFORE YOU USE FENO-TG - _When you must not use it _ _ _ Do not take Feno-TG if: • You have an allergy to FENO-TG or any ingredients of it and Gemfibrozil - _Before you start use it _ Tell your doctor if: • You have any allergies to any other medicines or any other substances, such as food, preservatives or dyes. • You are pregnant or intend to become pregnant and breast-feeding or intend to breast-feed. • You have or have had any other medical conditions, including: Kidney problems and muscular aching, tenderness or weakness not caused by exercise. PREGNANCY AND LACTATION Ask your doctor or pharmacist for advice before taking this medicine if you are pregnant or breast-feeding. - _Taking other medicines _ Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. In particular please let your doctor know if you already take: • Anti-coagulants to thin your blood , other drugs used to control lipid (fat) levels in the blood and Ciclosporin (an immunosuppressant) HOW TO USE FENO-TG - _How much to use _ _ _ Always take FENO-TG 160 mg exactl Прочитать полный документ
FRONT DESCRIPTION : FENO-TG 160 mg Tablets (Fenofibrate Tablets), is a lipid regulating agent available as tablets for oral administration. Elevated levels of total cholesterol (total-C), low density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apo B), an LDL membrane complex, are associated with human atherosclerosis. Similarly, decreased levels of high density lipoprotein cholesterol (HDL-C) and its transport complex, apolipoprotein A (apo AI and apo AII) are associated with the development of atherosclerosis. COMPOSITION : Fenofibrate BP 160 mg. The effects of fenofibric acid have been explained by the activation of peroxisome proliferator activated receptor α (PPAR α ). Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles (which are thought to be atherogenic due to their susceptibility to oxidation), to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. Activation of PPAR α also induces an increase in the synthesis of apoproteins A-I, A-II and HDL-cholesterol. Absorption : Fenofibrate is well absorbed from the gastrointestinal tract. Following oral administration, approximately 60% of a single dose of radiolabelled fenofibrate appeared in urine, primarily as fenofibric acid Each film coated tablet contains : Orange coloured, round shape, biconvex film coated tablets. Fenofibric acid, the active metabolite of fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL). In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII. Fenofibrate also reduces serum uric Прочитать полный документ