País: Nova Zelândia
Língua: inglês
Origem: Medsafe (Medicines Safety Authority)
Ipratropium bromide monohydrate 21ug; Salbutamol sulfate 120ug
Boehringer Ingelheim (NZ) Ltd
Ipratropium bromide monohydrate 21 µg
120µg/21µg per dose
Aerosol inhaler, metered dose
Active: Ipratropium bromide monohydrate 21ug Salbutamol sulfate 120ug Excipient: Dichlorodifluoromethane Lecithin Trichlorofluoromethane
Inhaler, metered, 200 dose units
Prescription
Prescription
Boehringer Ingelheim Pharma GmbH & Co KG
Package - Contents - Shelf Life: Inhaler, metered, - 200 dose units - 36 months from date of manufacture stored at or below 30°C
1993-07-30
NEW ZEALAND DATASHEET NAME OF MEDICINE COMBIVENT ® Salbutamol / Ipratropium bromide PRESENTATION Inhaler: 100 mcg / 20 mcg per inhalation. COMBIVENT metered dose inhaler has an opaque shaft with a grey mouthpiece and cap. The canister contains a creamy-white homogenous suspension of micronised substances in a chlorofluorohydrocarbon propellant mixture filled in an aluminium canister with a metering valve. Each metered dose contains salbutamol 100 mcg (equivalent to 120 mcg salbutamol sulphate), and ipratropium bromide mcg (equivalent to 21 mcg of ipratropium bromide monohydrate). USES ACTIONS COMBIVENT contains two active bronchodilating substances, salbutamol sulphate and ipratropium bromide. Salbutamol sulphate is a beta 2 -adrenergic agent which acts on airway smooth muscle resulting in relaxation. Salbutamol relaxes all smooth muscle from the trachea to the terminal bronchioles and protects against all bronchoconstrictor challenges. Ipratropium bromide is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. In preclinical studies, it appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase of intracellular concentration of Ca ++ which is caused by interaction of acetylcholine with muscarinic receptors on bronchial smooth muscle. Ca ++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol). The bronchodilation following inhalation of ipratropium bromide is primarily local and site specific to Leia o documento completo