DIETHYLPROPION HYDROCHLORIDE tablet

Land: Verenigde Staten

Taal: Engels

Bron: NLM (National Library of Medicine)

Werkstoffen:

DIETHYLPROPION HYDROCHLORIDE (UNII: 19V2PL39NG) (DIETHYLPROPION - UNII:Q94YYU22B8)

Beschikbaar vanaf:

Bryant Ranch Prepack

Toedieningsweg:

ORAL

Prescription-type:

PRESCRIPTION DRUG

therapeutische indicaties:

Diethylpropion hydrochloride tablets USP, 25 mg are indicated in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m2 or higher and who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone. Below is a chart of BMI based on various heights and weights. BMI is calculated by taking the patient's weight, in kilograms (kg), divided by the patient's height, in meters (m), squared. Metric conversions are as follows: pounds divided by 2.2 = kg; inches × 0.0254 = meters. The usefulness of agents of this class (See CLINICAL PHARMACOLOGY ) should be measured against possible risk factors inherent in their use such as those described below. Diethylpropion hydrochloride tablets USP, 25 mg are indicated for use as monotherapy only. Pulmonary hypertension, advanced arteriosclerosis, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sy

Product samenvatting:

NDC: 63629-8215-1: 30 Tablets in a BOTTLE NDC: 63629-8215-2: 90 Tablets in a BOTTLE

Autorisatie-status:

Abbreviated New Drug Application

Productkenmerken

DIETHYLPROPION HYDROCHLORIDE- DIETHYLPROPION HYDROCHLORIDE TABLET
BRYANT RANCH PREPACK
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DIETHYLPROPION HYDROCHLORIDE TABLETS USP, 25 MG
CIV
RX ONLY
DESCRIPTION
Diethylpropion Hydrochloride Tablets USP, 25 mg are available for oral
administration as
tablets containing 25 mg diethylpropion hydrochloride, USP. The
inactive ingredients in
each tablet are: microcrystalline cellulose, lactose monohydrate,
mannitol, tartaric acid,
povidone, talc, and zinc stearate.
Diethylpropion hydrochloride is a sympathomimetic agent. The chemical
name for
diethylpropion hydrochloride is 1-phenyl-2-diethyl-amino-1-propanone
hydrochloride.
Its chemical structure is:
CLINICAL PHARMACOLOGY
Diethylpropion hydrochloride is a sympathomimetic amine with some
pharmacologic
activity similar to that of the prototype drugs of this class used in
obesity, the
amphetamines. Actions include some central nervous system stimulation
and elevation
of blood pressure. Tolerance has been demonstrated with all drugs of
this class in which
these phenomena have been looked for.
Drugs of this class used in obesity are commonly known as "anorectics"
or
"anorexigenics". It has not been established, however, that the action
of such drugs in
treating obesity is primarily one of appetite suppression. For
example, other central
nervous system actions or metabolic effects may be involved.
Adult obese subjects instructed in dietary management and treated with
"anorectic"
drugs lose more weight on the average than those treated with placebo
and diet, as
determined in relatively short-term clinical trials.
The magnitude of increased weight loss of drug-treated patients over
placebo-treated
patients averages some fraction of a pound a week. However, individual
weight loss may
vary substantially from patient to patient. The rate of weight loss is
greatest in the first
weeks of therapy for both drug and placebo subjects and tends to
decrease in
succeeding weeks. The possible origins of the increased weight loss
due to the various
drug effects are not established