ROBENXIN 66GKG POWDER

Land: Malaysia

Språk: engelsk

Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiv ingrediens:

ROBENIDINE HYDROCHLORIDE

Tilgjengelig fra:

RANGE PHARMA SDN. BHD.

INN (International Name):

ROBENIDINE HYDROCHLORIDE

Enheter i pakken:

25 kg; 10 kg

Produsert av:

RANGE PHARMA SDN. BHD.

Preparatomtale

ROBENXIN 66G/KG POWDER
DESCRIPTION AND COMPOSITION
ROBENXIN 66G/KG POWDER is an off white to yellowish powder. Each kg
contains 66g of Robenidine
Hydrochloride as its active ingredient.
PHARMACODYNAMICS
Antiprotozoal containing robenidine hydrochloride is used for
anticoccidial treatment in broiler production.
Shows anticoccidial activities against: _Eimeria acervulina_, _E.
maxima_, _E. tenella_, _E. necatrix_, _E. brunetti_
and _E. mivati_.
Acting robenidine hydrochloride is the result of dual action which is
shown at different stages of the
parasite's development in the intestinal mucosal part of broiler
chickens. The first mechanism of action is
reflected like this: robenidine hydrochloride inhibits the development
of the first generation schizont, and
the other is reflected by killing another generation schizont and
possibly merozoite.
Also, robenidine hydrochloride acts on gametogenesis parasites. Dual
mechanism of action is particularly
advantageous for anticoccidial drugs, because the risk of relapse is
reduced in case of bird's stress and
following feed termination. Combination of coccidiocides and
coccidiostatic effects is also important factor
in minimizing the possibility of clinical manifestation of coccidiosis
after the discontinuation of robenidine
hydrochloride.
By using histochemical techniques, it has been confirmed that
robenidine hydrochloride has a negative
effect on the development of the first generation of schizont, first
generation of merozoite and the second
generation of schizont. It was also confirmed that robenidine
hydrochloride gives effect in preventing
anticoccidial protein synthesis.
PHARMACOKINETICS
Reabsorption
After oral application, robenidine is partially absorbed from the
gastrointestinal tract (20 to 40%) and
rapidly excreted, mainly it is not metabolized.
Distribution
After a single dose (5 to 8 times higher than the recommended dose),
robenidine distribution in tissues
and the medicine reaches the highest concentration for 8 hours in the
muscles, liver, kidneys and blood