PHYSOSTIGMINE SALICYLATE injection

Land: USA

Språk: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv ingrediens:

PHYSOSTIGMINE SALICYLATE (UNII: 2046ZRO9VU) (PHYSOSTIGMINE - UNII:9U1VM840SP)

Tilgjengelig fra:

A-S Medication Solutions

Administreringsrute:

INTRAVENOUS

Resept typen:

PRESCRIPTION DRUG

Indikasjoner:

To reverse the effect upon the central nervous system, caused by clinical or toxic dosages of drugs capable of producing the anticholinergic syndrome. Physostigmine Salicylate Injection should not be used in the presence of asthma, gangrene, diabetes, cardiovascular disease, mechanical obstruction of the intestine or urogenital tract or any vagotonic state, and in patients receiving choline esters and depolarizing neuromuscular blocking agents (decamethonium, succinylcholine). For post-anesthesia, the concomitant use of atropine with physostigmine salicylate is not recommended, since the atropine antagonizes the action of physostigmine. 2.0 mg intramuscularly or INTRAVENOUSLY AT SLOW CONTROLLED RATE (SEE ABOVE). Dosage may be repeated if life threatening signs, such as arrhythmia, convulsions or coma occurs.

Produkt oppsummering:

Product: 50090-4406 NDC: 50090-4406-0 2 mL in a AMPULE / 1 in a BAG

Autorisasjon status:

unapproved drug other

Preparatomtale

PHYSOSTIGMINE SALICYLATE- PHYSOSTIGMINE SALICYLATE INJECTION
A-S MEDICATION SOLUTIONS
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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PHYSOSTIGMINE SALICYLATE INJECTION
RX ONLY
DESCRIPTION:
Physostigmine Salicylate Injection is a derivative of the Calabar
bean, and its active
moiety, physostigmine, is also known as eserine. Its chemical
structure is:
It is soluble in water and a 0.5% aqueous solution has a pH of 5.8.
Physostigmine Salicylate Injection is available in 2 mL ampules, each
mL containing 1 mg
of Physostigmine Salicylate in a vehicle composed of sodium
metabisulfite 0.1%, benzyl
alcohol 2.0% as a preservative in Water for Injection.
CLINICAL PHARMACOLOGY:
Physostigmine Salicylate Injection is a reversible anticholinesterase
which effectively
increases the concentration of acetylcholine at the sites of
cholinergic transmission. The
action of acetylcholine is normally very transient because of its
hydrolysis by the
enzyme, acetylcholinesterase. Physostigmine Salicylate Injection
inhibits the destructive
action of acetylcholinesterase and thereby prolongs and exaggerates
the effect of the
acetylcholine.
Physostigmine Salicylate Injection contains a tertiary amine and
easily penetrates the
blood brain barrier, while an anticholinesterase, such as neostigmine,
which has a
quaternary ammonium ion is not capable of crossing the barrier.
Physostigmine
Salicylate Injection can reverse both central and peripheral
anticholinergia. The
anticholinergic syndrome has both central and peripheral signs and
symptoms. Central
toxic effects include anxiety, delirium, disorientation,
hallucinations, hyperactivity and
seizures. Severe poisoning may produce coma, medullary paralysis and
death.
Peripheral toxicity is characterized by tachycardia, hyperpyrexia,
mydriasis, vasodilation,
urinary retention, diminution of gastrointestinal motility, decrease
of secretion in salivary