Promedyl DM Linctus

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

PSEUDOEPHEDRINE HYDROCHLORIDE; DEXTROMETHORPHAN HYDROBROMIDE; CHLORPHENIRAMINE MALEATE

Boleh didapati daripada:

Duopharma Marketing Sdn. Bhd.

INN (Nama Antarabangsa):

PSEUDOEPHEDRINE HYDROCHLORIDE; DEXTROMETHORPHAN HYDROBROMIDE; CHLORPHENIRAMINE MALEATE

Unit dalam pakej:

90 ml

Dikeluarkan oleh:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
1
PROMEDYL DM LINCTUS
Dextromethorphan hydrobromide/Chlorpheniramine maleate/Pseudoephedrine
hydrochloride (15mg/2mg/30mg per 5ml)
WHAT IS IN THIS LEAFLET
1.
What Promedyl DM Linctus is
used for
2.
How Promedyl DM Linctus
works
3.
Before you use Promedyl DM
Linctus
4.
How to use Promedyl DM
Linctus
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of
Promedyl DM Linctus
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT PROMEDYL DM LINCTUS IS
USED FOR
Promedyl DM Linctus is used for
the relief of dry irritating cough and
nasal (nose) congestion.
HOW PROMEDYL DM LINCTUS WORKS
Dextromethorphan hydrobromide is
a
cough
suppressant
used
for
the
relief
on
non-productive
cough.
It
has a central action on the cough
centre
in
the
brain).
Although
structurally
related
to
morphine,
dextromethorphan
has
no
classical
analgesic (pain relief) properties and
little sleep induce properties.
Chlorpheniramine
maleate
is
an
antihistamine
which
works
by
blocking a certain natural substance
(histamine)
that
your
body
makes
during an allergic reaction. It also
helps to dry up the nasal lining.
Pseudoephedrine
hydrochloride,
a
decongestant
which
works
by
reducing
the
swelling
of
blood
vessels inside your nose. This helps
to
open
up
your
nasal
airway,
making breathing easier.
BEFORE YOU USE PROMEDYL DM
LINCTUS
-
_When you must not use it _
_ _
Do not take Promedyl DM Linctus if
you:
•
are
allergic
to
any
medicine
containing
dextromethorphan,
chlorpheniramine
maleate,
pseudoephedrine
hydrochloride
or
any
ingredients
of
this
product.
•
have heart disease.
•
Have
severe
high
blood
pressure.
•
are
receiving
monoamine
oxidase
inhibitors
(MAOIs-
medicines
used
to
treat
depression) therapy
When Promedyl DM Linctus is used
for treatment of cough and cold, it is
not to be used in children less than 2
years of age. It is needed to be used
with
caution
and
doctor’s
or
pharmacist’s advice in children 2 to
6 years of age.
Dizzi

Ciri produk

Glue
Glue
Spine
Glue
Glue
Pg 1
Pg 2
Pg 3
Pg 4
Pg 5
Pg 6
Pg 7
Pg 8
Pg 9
Pg 10
Pg 11
Pg 12
SOOTHES DRY, IRRITATING COUGH
WITH NASAL DECONGESTION
DESCRIPTION
A flavoured, clear, colourless to straw coloured
syrup
COMPOSITION
Each 5ml contains
Pseudoephedrine HCL 30mg
Dextromethorphan HBr 15mg
Chlorpheniramine Maleate 2.0mg
Contains preservatives
0.21%
w/v
Methylparaben
&
0.031%
w/v
Propylparaben
PHARMACODYNAMICS
Pseudoephedrine
is
a
direct-
and
indirect- acting sympathomimetic. It is a
stereoisomer of ephedrine and has a
similar action, but has been stated to
have
less
pressor
activity
and
fewer
CNS effects. Pseudoephedrine salts are
given by mouth for symptomatic relief of
nasal congestion.
Dextromethorphan
hydrobromide
is
a
cough suppressant used for the relief of
non-productive cough; it has a central
action
on
the
cough
centre
in
the
medulla.
It
is
also
an
antagonist
of
N-methyl-D-aspartate
(NMDA)
receptors. Although structurally related
to
morphine,
dextrometho
r
phan
has
no
classical analgesic properties and
little sedative activity.
Chlorpheniramine
Maleate,
an
alkylamine
derivative,
is
a
sedating
antihistamine that causes a moderate
degree
of
sedation;
it
also
has
antimuscarinic activity.
PHARMACOKINETICS
Pseudoephedrine
is
readily
absorbed
from
the
gastrointestinal
tract.
It
is
largely excreted unchanged in the urine
together
with
small
amounts
of
its
hepatic metabolite. It has a half life of
about
5
to
8
hours,
elimination
is
enhanced
and
half
life
accordingly
shorter in acid urine. Small amounts are
distributed into breast milk.
Dextromethorphan is rapidly absorbed
from
the
gastrointestinal
tract.
It
is
metabolize in the liver and excreted in
the urine as unchanged dextrometho-
rphan
and
demethylated
metabolites
including dexthrophan which has some
cough suppressant activity.
Chlorpheniramine maleate is absorbed
relatively slowly from the gastrointesti-
nal
tract,
peak
plasma
concentration
occurring at about 2.6 to 6 hours after
administration by mouth. Bioavailability
is low, values of 25 to 50% having b