ACYCLOVIR 800 STADA

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ACYCLOVIR

Boleh didapati daripada:

DKSH MALAYSIA SDN BHD

INN (Nama Antarabangsa):

ACYCLOVIR

Unit dalam pakej:

35Tablet Tablets

Dikeluarkan oleh:

STADA Arzneimittel AG

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
ACYCLOVIR 800 STADA
Acyclovir 800 mg
1
WHAT IS IN THIS LEAFLET
1.
What Acyclovir 800 STADA is used
for
2.
How Acyclovir 800 STADA works
3.
Before
you
take
Acyclovir
800
STADA
4.
How to take Acyclovir 800 STADA
5.
While you are using it
6.
Possible side effects
7.
Storage and Disposal of Acyclovir
800 STADA
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT ACYCLOVIR 800 STADA IS USED
FOR
Acyclovir 800 STADA is a medicine for
the treatment of viral infections (antiviral
agent). Acyclovir is used for Shingles
(herpes zoster).
HOW ACYCLOVIR 800 STADA WORKS
Acyclovir is an antiviral medicine, which
acts on infected cells by stopping the
virus growing.
BEFORE YOU USE ACYCLOVIR 800 STADA
_When you must not take it _
-
If
you
are
allergic
(hypersensitive)
to
medications
containing
acyclovir
or
valacyclovir, or any of the other
ingredients
of
Acyclovir
800
STADA.
_Before you start to take it _
-
Please discuss with your doctor
or
pharmacist
before
taking
Acyclovir 800 Stada.
_Taking other medicine _
-
Please
tell
your
doctor
or
pharmacist if you are taking or
have
recently
taken
any
other
medicines,
including
medicines
obtained
without
a
prescription.
Probenecid
(uricosuric
drug
for
gout) reduces acyclovir excretion
via
the
kidneys,
which
may
increase acyclovir persistence in
the body.
HOW TO TAKE ACYCLOVIR 800 STADA
_How much to take _
-
The instructions given below apply
unless your doctor has prescribed
Acyclovir 800 Stada otherwise for
you.
-
Adults:
Shingles
(herpes
zoster):
Take
1
tablet (800mg) of acyclovir 5 times
daily every 4 hours during the day.
Patients
with
kidney
function
impairment,
which
is
particularly
prevalent in elderly patients, may
need a lower acyclovir dose than
indicated above. If you should have
kidney problems, your doctor will
adjust your dosage to reflect your
kidney function.
_When to take it _
-
Swallow the tablets whole with a
sufficient amount of liquid (eg. A
glass
of
water)
after
meals.
An
a

Ciri produk

Prescribing Information
STADA Arzneimittel AG, D-61118 Bad Vilbel, Germany
Dear patient,
Please be sure to carefully read this Insert because it contains
important information on how to use this medication
effectively and safely. If you have any questions or concerns, please
do not hesitate to ask your doctor or pharmacist.
Acyclovir 800 Stada
®
Product Description
Oblong, White tablet with breaking notch on both sides. Imprint: VS3
Composition
Each tablet contains:
Pharmacologically active ingredient: Acyclovir, 800mg
_Other ingredients:_
Microcrystalline cellulose, copolyvidon, magnesium stearate, sodium
starch glycolate, colloidal anhydrous silica
Presentation and contents
Original package of 35 tablets (7 blisters x 5 tablets)
Acyclovir 800 Stada
®
is an antiviral drug
Pharmacodynamics
Mode of Action
Acyclovir is a guanine derivative whose activity is essentially
confined to viral thymidine kinase-producing human
pathogenic herpes viruses, i.e. herpes simplex virus types 1 and 2
(HSV-1 and HSV-2), and varicella-zoster virus (VSV).
Acyclovir is not pharmacologically active until it has been converted
by viral thymidine kinase inside virally infected cells
along the following pathway:
Phosphorylation of acyclovir (the substrate) to acyclovir
monophosphate is faster by viral thymidine kinase than by host
cell thymidine kinase. This relative selectivity minimizes the
toxicity of acyclovir to host cells. Normal cellular nucleotidyl
phosphotransferases then catalyse the sequential conversion of
acyclovir monophosphate to acyclovir triphosphate.
Acyclovir triphosphate (the active form of the drug) selectively
inhibits viral DNA polymerase and is incorporated into viral
DNA. Acyclovir triphosphate competitively displaces deoxyguanosine
triphosphate nom DNA polymerases. Acyclovir
triphosphate has higher affinity for HSV-encoded DNA polymerase than
cellular DNA polymerase (10 to 20 times
greater). It acts as a substrate for HSV-encoded DNA polymerase and,
cleaving off diphosphate is incorporated into viral
DNA. Howev