ACYCLOVIR 200 STADA

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ACYCLOVIR

Boleh didapati daripada:

DKSH MALAYSIA SDN BHD

INN (Nama Antarabangsa):

ACYCLOVIR

Unit dalam pakej:

25Tablet Tablets

Dikeluarkan oleh:

STADA Arzneimittel AG

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
ACYCLOVIR 200 STADA
Acyclovir 200 mg
1
WHAT IS IN THIS LEAFLET
1.
What Acyclovir 200 STADA is used
for
2.
How Acyclovir 200 STADA works
3.
Before
you
take
Acyclovir
200
STADA
4.
How to take Acyclovir 200 STADA
5.
While you are using Acyclovir 200
STADA
6.
Side effects
7.
Storage and Disposal of Acyclovir
200 STADA
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT ACYCLOVIR 200 STADA IS USED
FOR
Acyclovir 200 STADA is a medicine for
the treatment of viral infections (antiviral
agent).
Acyclovir
is
used
for
Herpes
simplex virus infections, genital herpes
of the skin and mucous in particular
(primary and frequently recurring genital
herpes).
Recurrence
prevention
is
indicated
for
adults
with
very
severe
forms
of
very
frequently
recurring
genital herpes simplex virus infection.
HOW ACYCLOVIR 200 STADA WORKS
Acyclovir is an antiviral medicine, which
acts on infected cells by stopping the
virus growing.
BEFORE YOU USE ACYCLOVIR 200 STADA
_When you must not take it _
-
If
you
are
allergic
(hypersensitive)
to
medications
containing
acyclovir
or
valacyclovir, or any of the other
ingredients
of
Acyclovir
200
STADA.
-
If
your
kidney
function
is
impaired or your urinary output is
reduced
to
less
than
100ml
of
urine per 24 hours, you should not
use Acyclovir 200 STADA for
prevention because no data are
available on the use of Acyclovir
200 STADA in these conditions.
-
Acyclovir has been detected in
breast
milk
following
administration
of
acyclovir
products.
Breast-feeding
is
therefore
discouraged
while
taking Acyclovir 200 Stada.
_Before you start to take it _
-
Please discuss with your doctor
or
pharmacist
before
taking
Acyclovir 200 Stada.
_Taking other medicine _
-
Please
tell
your
doctor
or
pharmacist if you are taking or
have
recently
taken
any
other
medicines,
including
medicines
obtained
without
a
prescription.
Probenecid
(uricosuric
drug
for
gout) reduces acyclovir excretion
via
the
kidneys,
which
may
increase acyclovir pe

Ciri produk

Prescribing Information
STADA Arzneimittel AG, D-61118 Bad Vilbel, Germany
Dear patient,
Please be sure to carefully read this Insert because it contains
important information on how to use this medication
effectively and safely. If you have any questions or concerns, please
do not hesitate to ask your doctor or pharmacist.
Acyclovir 200 Stada
®
Product Description
Round, White, biconvex tablets, Imprint: VSI
Composition
Each tablet contains:
Pharmacologically active ingredient:
Acyclovir, 200mg
Other ingredients:
Microcrystalline cellulose, copolyvidon, magnesium stearate, sodium
starch glycolate, colloidal anhydrous silica
Presentation and contents
Original package of 25 tablets and 100 tablets. Not all sizes are
available in certain countries.
Acyclovir 200 Stada
®
is an antiviral drug
Pharmacodynamics
Mode of Action
Acyclovir is a guanine derivative whose activity is essentially
confined to viral thymidine kinase-producing human
pathogenic herpes viruses, i.e. herpes simplex virus types 1 and 2
(HSV-1 and HSV-2), and varicella-zoster virus
(VSV). Acyclovir is not pharmacologically active until it has been
converted by viral thymidine kinase inside virally
infected cells along the following pathway:
Phosphorylation of acyclovir (the substrate) to acyclovir
monophosphate is faster by viral thymidine kinase than by
host cell thymidine kinase. This relative selectivity minimizes the
toxicity of acyclovir to host cells. Normal cellular
nucleotidyl phosphotransferases then catalyse the sequential
conversion of acyclovir monophosphate to acyclovir
triphosphate.
Acyclovir triphosphate (the active form of the drug) selectively
inhibits viral DNA polymerase and is incorporated
into viral DNA. Acyclovir triphosphate competitively displaces
deoxyguanosine triphosphate nom DNA
polymerases. Acyclovir triphosphate has higher affinity for
HSV-encoded DNA polymerase than cellular DNA
polymerase (10 to 20 times greater). It acts as a substrate for
HSV-encoded DNA polymerase and, cleaving off
diphosphate is incorporated into