Country: Bandaríkin
Tungumál: enska
Heimild: NLM (National Library of Medicine)
POTASSIUM ACETATE (UNII: M911911U02) (POTASSIUM CATION - UNII:295O53K152)
Hospira, Inc.
POTASSIUM ACETATE
POTASSIUM ACETATE 3.93 g in 20 mL
INTRAVENOUS
PRESCRIPTION DRUG
Potassium Acetate Injection, USP, 40 mEq is indicated as a source of potassium, for the addition to large volume intravenous fluids, to prevent or correct hypokalemia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. Potassium administration is contraindicated in patients with severe renal insufficiency or adrenal insufficiency and in diseases where high potassium levels may be encountered.
Potassium Acetate Injection, USP is supplied as follows: Each container is partially filled to provide air space for complete vacuum withdrawal of the contents into the intravenous container. Store at 20 to 25ºC (68 to 77ºF). [See USP Controlled Room Temperature.] Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Novaplus is a registered trademark of Vizient, Inc. LAB-0902-4.0 Revised: 11/2020
New Drug Application
POTASSIUM ACETATE- POTASSIUM ACETATE INJECTION, SOLUTION, CONCENTRATE HOSPIRA, INC. ---------- POTASSIUM ACETATE INJECTION USP POTASSIUM ACETATE INJECTION, USP 40 MEQ/20 ML (2 MEQ/ML) _FOR ADDITIVE USE ONLY AFTER_ _DILUTION IN INTRAVENOUS FLUIDS_ PLASTIC VIAL RX ONLY DESCRIPTION Potassium Acetate Injection, USP, 40 mEq (2 mEq/mL) is a sterile, nonpyrogenic, _concentrated solution_ of potassium acetate in water for injection. The solution is administered after dilution by the intravenous route as an electrolyte replenisher. _It must_ _not be administered undiluted._ Each 20 mL vial contains 3.93 g of potassium acetate which provides 40 mEq each of potassium (K ) and acetate (CH COO ). It contains no bacteriostat, antimicrobial agent or added buffer. May contain acetic acid for pH adjustment. pH 6.2 (5.5 to 8.0). The osmolar concentration is 4 mOsmol/mL (calc.). The solution is intended as an alternative to potassium chloride to provide potassium ion (K ) for addition to large volume infusion fluids for intravenous use. Potassium acetate, USP is chemically designated CH COOK, colorless crystals or white crystalline powder very soluble in water. The semi-rigid vial is fabricated from a specially formulated polyolefin. It is a copolymer of ethylene and propylene. The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. The container requires no vapor barrier to maintain the proper drug concentration. CLINICAL PHARMACOLOGY As the principal cation of the intracellular fluid, potassium plays an important role in fluid and electrolyte balance. The normal potassium concentration in the intracellular fluid compartment is about 160 mEq/liter. The normal serum potassium range is 3.5 to 5.0 mEq/liter. The kidney normally regulates potassium balance but does not conserve potassium as well or as promptly as it conserves sodium. The daily turnover of potassium in the normal adult averages 50 to 150 mEq (milliequivalents) and represents 1.5 to 5% of the total p Lestu allt skjalið