Dipeptiven

Ország: Új-Zéland

Nyelv: angol

Forrás: Medsafe (Medicines Safety Authority)

Aktív összetevők:

Alanylglutamine 200 mg/mL;  ;  

Beszerezhető a:

Fresenius Kabi New Zealand Limited

INN (nemzetközi neve):

Alanylglutamine 200 mg/mL

Adagolás:

200 mg/mL

Gyógyszerészeti forma:

Concentrate for infusion

Összetétel:

Active: Alanylglutamine 200 mg/mL     Excipient: Nitrogen Water for injection

db csomag:

Bottle, glass, 50 mL

Osztály:

General sale

Recept típusa:

General sale

Gyártó:

Ajinomoto North America Inc

Terápiás javallatok:

Dipeptiven® is indicated as part of a clinical nutrition regimen in patients in hypercatabolic and/or hypermetabolic states. It should be given together with parenteral or enteral nutrition or a combination of both.

Termék összefoglaló:

Package - Contents - Shelf Life: Bottle, glass, - 50 mL - 24 months from date of manufacture stored at or below 25°C - Bottle, glass, - 100 mL - 24 months from date of manufacture stored at or below 25°C - Bottle, glass, - 250 mL - 24 months from date of manufacture stored at or below 25°C

Engedély dátuma:

2004-07-19

Betegtájékoztató

March, 2012
CMI FOR DIPEPTIVEN
Filename:
DipCMI10312-clean
Page 1 of 2
Changes: indication
DIPEPTIVEN
®
Alanylglutamine
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This
leaflet
answers
some
common
question
about
Dipeptiven. It does not contain
all the available information. It
does not take the place of talking
to your doctor or pharmacist.
All
medicines
have
risks
and
benefits.
Your
doctor
has
weighed the risks of you being
given
Dipeptiven
against
the
benefits this medicine is expected
to have for you.
If you have any concerns about
this medicine, ask your doctor or
pharmacist.
Keep this leaflet. You may need
to read it again.
WHAT
IS
DIPEPTIVEN
USED
FOR
AND
HOW
DOES IT WORK
Dipeptiven
is
an
amino
acid/dipeptide
infusion
solution,
which
is
given
as
part
of
parenteral
and/or
enteral
nutritional
therapy.
When
the
intake of nutrients or food into the
mouth or directly into the gut is
not possible or it is not enough to
supply
the
body’s
needs
then
nutrients or foods can be given
intravenously
or
through
the
gastrointestinal
tract
or
a
combination
of
both.
This
is
especially
important
for
people
whose bodies are under physical
stress
from
illness
or
recent
surgery. During illness or after
surgery
the
body
requires
nutrition or food. Amino acids are
the building blocks used by the
body
to
make
proteins.
Dipeptiven is usually given as a
supplement
to
amino
acid
solutions
or
an
amino
acid
containing infusion regimen as
part
of
complete
nutritional
support.
Your
doctor
may
have
prescribed
Dipeptiven
for
another
reason.
Ask
your
doctor
if
you
have
any
questions
about
why
Dipeptiven
has
been
prescribed for you.
BEFORE
YOU
ARE
GIVEN DIPEPTIVEN
When
should
you
NOT
be
given Dipeptiven ?
_You _
_should _
_NOT _
_be _
_given _
_Dipeptiven if: _

You
have
an
allergy
to
Dipeptiven or any of the
ingredients
listed
at
the
end of this leaflet.

You
have
severe
liver
failure.

You
have
severe
kidney
failure (if dialysis facilities
are not available).

You have too much acid in
your
blood,
also
called
metabo

Termékjellemzők

  
Filename: DipDS0312-clean 
Page 1 of 5 

DATA SHEET 

NAME OF MEDICINE 
DIPEPTIVEN
®
 (N(2)-l-alanyl-l-glutamine 200 mg/mL) 
Concentrate for Solution for Infusion 

PRESENTATION 
Dipeptiven is a clear, colourless concentrate for solution for
infusion. 

Content 
100 mL contains: 
20 g N(2)-L-alanyl-L-glutamine (= 8.20 g L-alanine, 13.46 g L-glutamine) 
Water for Injections 

Theoretical osmolarity 
921 mosmol/L  
Titration acidity 

90 
– 105 mmol NaOH/L 
pH value 

5.4 - 6.0 

USES

ACTIONS

The  dipeptide  N(2)-L-alanyl-L-glutamine  is  endogenously  split  into  the  amino  acids 
glutamine and alanine hereby supplying glutamine with infusion solutions for parenteral 
nutrition.   The released amino acids  flow as nutrients  into their respective body pools 
and  are  metabolised  according  to  the  needs  of  the  organism.    Many  disease 
conditions,  in  which  parenteral nutrition is indicated,  are accompanied by a glutamine 
depletion, which glutamine containing infusion regimens
counteract. 

PHARMACOKINETICS 
N(2)-L-alanyl-L-glutamine  is  rapidly  split  into  alanine  and  glutamine  after  infusion.    In 
man,  half-lives  of  between  2.4  and  3.8  (in  terminal  renal  insufficiency  4.2  min)  and  a 
plasma clearance of between 1.6 and 2.7 L/min were determined.  The disappearance 
of the dipeptide was accompanied by an equimolar increase of the corresponding  free 
amino  acids.    Hydrolysis  probably  takes  place  exclusively  in  the  extracellular  space.  
Renal elimination of N(2)-L-alanyl-glutamine under constant infusion is below 5 % and 
thus the same as that of infused amino acids. 

INDICATIONS

Dipeptiven  is  indicated  as  part  of  a  clinical  nutritio