देश: संयुक्त राज्य
भाषा: अंग्रेज़ी
स्रोत: NLM (National Library of Medicine)
DETOMIDINE HYDROCHLORIDE (UNII: 95K4LKB6QE) (DETOMIDINE - UNII:7N8K34P2XH)
Zoetis Inc.
detomidine hydrochloride
detomidine 10 mg in 1 mL
INTRAMUSCULAR
PRESCRIPTION
Dormosedan® is indicated for use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings. It has been used successfully for the following: to calm fractious horses, to provide relief from abdominal pain, to facilitate bronchoscopy, bronchoalveolar lavage, nasogastric intubation, nonreproductive rectal palpations, suturing of skin lacerations, and castrations. Additionally, an approved, local infiltration anesthetic is indicated for castration. Dormosedan® should not be used in horses with pre-existing AV or SA block, with severe coronary insufficiency, cerebrovascular disease, respiratory disease, or chronic renal failure. Intravenous potentiated sulfonamides should not be used in anesthetized or sedated horses as potentially fatal dysrhythmias may occur. Information on the possible effects of detomidine hydrochloride in breeding horses is limited to uncontrolled clinical reports; therefore, this drug is not recommended for use in breeding animals.
Dormosedan® is supplied in 5- and 20-mL multidose vials.
New Animal Drug Application
DORMOSEDAN STERILE- DETOMIDINE HYDROCHLORIDE SOLUTION ZOETIS INC. ---------- DORMOSEDAN (DETOMIDINE HYDROCHLORIDE) _Sedative and Analgesic For Use in Horses Only_ _Sterile Solution_ _10mg/mL_ CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Dormosedan® is a synthetic alpha-2 adrenoreceptor agonist with sedative and analgesic properties. The chemical name is 1H imidazole, 4-[(2,3-dimethylphenyl) methyl]- hydrochloride and the generic name is detomidine hydrochloride. It is a white, crystalline, water-soluble substance having a molecular weight of 222.7. The molecular formula is C H N ∙HCl. CHEMICAL STRUCTURE: Each mL of Dormosedan® contains 10.0 mg detomidine hydrochloride, 1.0 mg methyl paraben, 5.9 mg sodium chloride, and water for injection, q.s. CLINICAL PHARMACOLOGY Dormosedan®, a non-narcotic sedative and analgesic, is a potent α -adrenoreceptor agonist which produces sedation and superficial and visceral analgesia which is dose dependent in its depth and duration. Profound lethargy and a characteristic lowering of the head with reduced sensitivity to environmental stimuli (sounds, etc.) are seen with detomidine. A short period of incoordination is characteristically followed by immobility and a firm stance with front legs well spread. The analgesic effect is most readily seen as ® 12 14 2 2 an increase in the pain threshold at the body surface. Sensitivity to touch is little affected and in some cases may actually be enhanced. With detomidine administration, heart rate is markedly decreased, blood pressure is initially elevated, and then a steady decline to normal is seen. A transient change in the conductivity of the cardiac muscle may occur, as evidenced by partial atrioventricular (AV) and sinoauricular (SA) blocks. This change in the conductivity of the cardiac muscle may be prevented by IV administration of atropine at 0.02 mg/kg of body weight. No effect on blood clotting time or other hematological parameters was encountered at dosages o पूरा दस्तावेज़ पढ़ें