Maa: Malesia
Kieli: englanti
Lähde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
METFORMIN HYDROCHLORIDE
HOVID BERHAD
METFORMIN HYDROCHLORIDE
100tablet Tablets
HOVID BERHAD
DIABETMIN TABLET VIDIA17-var4 (MY) 595 DESCRIPTION DIABETMIN 500MG TABLET: Round, white film-coated tablet, bevel-edged and shallow convex faces with deep score line on one side. DIABETMIN RETARD TABLET: Round, white uncoated tablet with convex faces. DIABETMIN 850MG TABLET: Round, white film-coated tablet with deep convex faces and 'hovid' embossed on one face. DIABETMIN 1000MG TABLET: Oblong, white film-coated tablet, deep convex faces, deep scored and "HD" embossed on one face and scored on the other face. COMPOSITION DIABETMIN 500MG TABLET: Metformin Hydrochloride 500mg per tablet. DIABETMIN RETARD TABLET: Metformin Hydrochloride 850mg per tablet (Extended-release). DIABETMIN 850MG TABLET: Metformin Hydrochloride 850mg per tablet. DIABETMIN 1000MG TABLET: Metformin Hydrochloride 1000mg per tablet. ACTIONS AND PHARMACOLOGY Metformin is an oral biguanide antidiabetic agent. Its mode of action is thought to be multifactorial and includes delayed uptake of glucose from the gastro-intestinal tract; increased peripheral glucose utilization mediated by increased insulin sensitivity; and inhibition of increased hepatic and renal gluconeogenesis. PHARMACOKINETICS Metformin Hydrochloride is slowly and incompletely absorbed from the gastrointestinal tract. The absolute bioavailability of a single 500mg dose is reported to be about 50 to 60%, although this is reduced somewhat if taken with food. Plasma protein binding is negligible. It is excreted unchanged in the urine. The plasma elimination half-life is reported to range from about 2 to 6 hours after oral administration. INDICATIONS Metformin is used in the treatment of non-insulin-dependent diabetes mellitus (type 2) in adults, not responding to exercise and dietary modification. Diabetmin may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin. CONTRAINDICATIONS This medication is contraindicated in patients with the following medical problems: • Hypersensitivity to metformin. • Any condition needing close blood glucose Lue koko asiakirja