ESTROPLAN FLEXI

País: Australia

Idioma: inglés

Fuente: APVMA (Australian Pesticides and Veterinary Medicines Authority)

Ingredientes activos:

CLOPROSTENOL AS SODIUM

Disponible desde:

PARNELL TECHNOLOGIES PTY LTD

Designación común internacional (DCI):

cloprostenol as Na salt(250ug/mL)

formulario farmacéutico:

PARENTERAL LIQUID/SOLUTION/SUSPENSION

Composición:

CLOPROSTENOL AS SODIUM PROSTAGLANDIN Active 250.0 ug/ml

Unidades en paquete:

100mL

clase:

VM - Veterinary Medicine

Fabricado por:

PARNELL TECHNOLOGIES

Grupo terapéutico:

COW | BOVINE | FEMALE CATTLE

Área terapéutica:

ENDOCRINE SYSTEM

indicaciones terapéuticas:

CYSTIC OVARIES | INDUCE ABORTION | INDUCTION OF PARTURITION | PYOMETRA | SUB OESTRUS | SYNCHRONISATION OF OESTRUS | INDUCTION OF CALVING | SILENT HEAT

Resumen del producto:

Poison schedule: 4; Withholding period: WHP:MEAT:DO NOT use less than 1 day be fore slaughter for human consumption. M ILK:NIL; Host/pest details: COW: [CYSTIC OVARIES, INDUCE ABORTION, INDUCTION OF PARTURITION, PYOMETRA, SUB OESTRUS, SYNCHRONISATION OF OESTRUS]; Poison schedule: 4; Withholding period: ; Host/pest details: COW: [CYSTIC OVARIES, INDUCE ABORTION, INDUCTION OF PARTURITION, PYOMETRA, SUB OESTRUS, SYNCHRONISATION OF OESTRUS]; For luteolysis of functional corpora lutea in cows.Do not use in pregnant animals when abortion or induced parturition is not the objective. Do not administer intravenously.

Estado de Autorización:

Registered

Fecha de autorización:

2023-07-01

Información para el usuario

APPROVED
LABEL
APPROVED
LABEL
Info
PEST


Verified
APPROVED
LABEL
Company:
PARNELL Laboratories (Aust) Pty Ltd
File Name:
49746_47366_Leaflet_MPL_V01.pdf
Dimensions:
450mm x 95mm
Scale:
90% (if printed on A3 sheet)
Date:
20/05/2009
Colours:
BLACK
50247b-01
PRESCRIPTION ANIMAL REMEDY
KEEP OUT OF REACH OF CHILDREN
FOR ANIMAL TREATMENT ONLY
ACTIVE CONSTITUENT
CLOPROSTENOL (as the sodium salt) 250
μ
g/mL
FOR LUTEOLYSIS OF FUNCTIONAL CORPORA LUTEA IN COWS.
PHARMACOLOGY
Prostaglandins (PGs) are 20-carbon unsaturated fatty
acids which consist of a cyclopentane ring with two
aliphatic side chains. They are synthesised from free
arachidonic acid in most major tissues in the body and
serve as local hormones, acting on tissues near their
site of synthesis.
PGs are structurally classified into nine major groups,
A to I, each containing subgroups denoted by
the
subscripts 1, 2 and 3. In domestic animals the most
important PG appears to be PGF2
α
. Cloprostenol is a
functional synthetic analogue of the naturally occurring
PGF2
α
dinoprost.
ACTIONS
In
the
reproductive
system
PGs
play
a
role
in
ovulation, luteolysis, gamete transport, uterine motility,
expulsion of foetal membranes, and sperm transport in
both the male and female tracts.
PGs
are
employed
in
reproductive
therapeutics
primarily
for
their
potent
luteolytic
effects.
PGF2
α
causes rapid regression of functional corpora lutea,
with
resultant
rapid
decline
in
progesterone
production. Luteolysis is usually followed by ovarian
follicular development and a return to oestrus with
normal ovulation. In cattle oestrus occurs 2 - 4 days
after luteolysis. The early corpus luteum is insensitive
to the effects of PG; this refractory period spans the first
4 - 5 days post ovulation in cows.
The precise mechanism of PG-induced luteolysis is
uncertain but may relate to blood flow changes in the
uteroovarian vessels, inhibition of the normal
ovarian
response to circulating gonadotrophin, or stimulation
of
catalytic
enzymes.
PGF2
α
also
has
a
direct
stimulatory effect on uterine

Ficha técnica

PAGE 1 OF 2
MATERIAL SAFETY DATA SHEET:
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE
COMPANY/UNDERTAKING
PRODUCT NAME : Estroplan flexi
OTHER NAMES : Estroplan, Cloprostenol Injection
RECOMMENDED USE: FOR ANIMAL TREATMENT ONLY. Luteolysis of functional
corpora lutea in cows.
MANUFACTURER COMPANY DETAILS:
LICENSEE (NEW ZEALAND) DETAILS:
Parnell Manufacturing Pty Ltd
Parnell NZ Co
ADDRESS
ADDRESS
Unit 4, Century Estate
PO Box 73160
476 Gardeners Road
Auckland International Airport
Alexandria, NSW 2015
Manukau 2150
Australia
New Zealand
TELEPHONE NUMBER
TELEPHONE NUMBER
61 (0)2-9667 4411
0800 446 282 (Toll free within NZ)
EMERGENCY TELEPHONE NUMBER
EMERGENCY TELEPHONE NUMBER
61 (0)2-9667 4411 (Business Hours)
0800 446 282 (Business Hours)
FACSIMILE NUMBER
FACSIMILE NUMBER
61 (0)2-9667 4139
0800 727 533 (Toll free within NZ)
2. HAZARDS IDENTIFICATION
Hazardous substance according to criteria of Worksafe Australia.
3. COMPOSITION/INFORMATION ON INGREDIENTS
CHEMICAL ENTITY
CAS NUMBER
PROPORTION
Buffering Agents
<1% w/v
Cloprostenol (as sodium)
55028-72-3
0.025% w/v
Preservative
<1% w/v
Water
7732-18-5
to 100%
4. FIRST AID MEASURES
Wash off any _Estroplan _contacting skin immediately using soap and
water. Seek medical assistance if required.
SWALLOWED: Seek medical assistance if required.
EYE: If in eyes, hold eyes open, flood with water for at least 15
minutes. Seek medical assistance if required.
SKIN: If skin contact occurs remove contaminated clothing and wash
skin thoroughly with soap and water. Seek
medical assistance if required.
INHALED: Seek medical assistance if required.
FIRST AID FACILITIES: No specific first aid facilities required.
ADVICE TO DOCTOR: Treat symptomatically as required.
5. FIRE-FIGHTING MEASURES
This material is not considered a fire hazard. Use standard fire
fighting techniques to extinguish fires involving
this material. Use water spray, dry chemical, carbon dioxide or foam.
6. ACCIDENTAL RELEASE MEASURES
Clear immediate area of unprotected personnel. Clean up spilled
material