VIRBAC DUODIP TREATMENT FOR SHEEP BODY LICE

Australia - English - APVMA (Australian Pesticides and Veterinary Medicines Authority)

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Active ingredient:
DIFLUBENZURON
Available from:
VIRBAC (AUSTRALIA) PTY LTD
Class:
Veterinary Pesticide
Therapeutic group:
SHEEP | EWE | HOGGET | LAMB | OVINE | RAM | WEANER | WETHER
Therapeutic area:
PARASITICIDES
Therapeutic indications:
SHEEP BODY LOUSE | DAMALINIA OVIS (PREV. GENUS) | LICE - SYNTHETIC PYRETHROID RE | SHEEP BODY LICE
Authorization status:
Registered
Authorization number:
53113
Authorization date:
2000-07-25

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Duodip.Doc

Revision B MATERIAL SAFETY DATA SHEET

Product Name:

VirbacDuodip Treatment for Sheep BodyLice and Sheep Blowfly Page: 1 of 6

Date of Issue

21 June, 2007

Section 1 - Identification of Chemical Product and Company

Company: Virbac (Australia) Pty.Ltd

ABN 77 003 268871

Address 15 PritchardPlace, Peakhurst, NSW 2210, Australia

Locked Bag1000, Peakhurst Delivery Centre, Peakhurst, NSW 2210, Australia

Telephone: (02) 9533 2000 or 1800 242 100

Fax: (02) 9533 1522

Emergencyphone As above during business hours; answering machine after hours

Substance: Diflubenzuronis a benzoylurea derivative.

Trade Name: VirbacDuodip Treatment for Sheep BodyLice and Sheep Blowfly

Product Use: For the control and treatment of lice (Bovicola ovis) and control of blowfly(Lucilia

cuprina) strike on sheep, including lice resistant to synthetic pyrethroids and flies

resistant to organophosphates.

Creation Date: August, 2002

Revision Date: June, 2007

Section 2 - Hazards Identification

STATEMENTOF HAZARDOUS NATURE

This productis classifiedas:Hazardous accordingto the criteriaof ASCC Australia.

Not a Dangerous Good according to theAustralian DangerousGoods (ADG) Code.

Risk Phrases:R22, R36/37/38. Harmful if swallowed. Irritating to eyes, respiratory system and skin.

SafetyPhrases:S20, S38, S24/25, S36/37. Whenusing, do not eat ordrink.In caseof insufficient ventilation, wear

suitable respiratory equipment. Avoid contact with skinand eyes. Wearsuitableprotectiveclothing and gloves.

SUSDP Classification:S5

ADG Classification:None allocated.Not a Dangerous Good.

UN Number:None allocated

EmergencyOverview

Physical Description & colour: Beige to off-white suspension.

Odour:No data.

Major Health Hazards:No overtsigns of Diflubenzuron toxicity were observedin any of the acutestudies

conducted. The oral LD

in rats and mice is greaterthan 4640 mg/kg, and the dermal LD

is greaterthan10,000

mg/kg in ratsand greaterthan 4000 mg/kg in rabbits.It isnonirritating to skin and slightly irritating to eyes.

Potential Health Effects

See section 11 for Chronic exposure studies.

Inhalation

Short termexposure:Available data indicates that this product isnot harmful. However product is an inhalation

irritant. Symptoms may include headache, irritation of noseand throat and increasedsecretionof mucousinthe nose

and throat. Other symptomsmay also becomeevident, but they should disappear after exposure has ceased.

Skin Contact:

Short termexposure:Available data indicates that this product is not harmful. It should present no hazards in

normal use. However product is askin irritant. Symptomsmay include itchinessand reddening of contacted skin.

Othersymptoms may also become evident, but all should disappear once exposure has ceased.

Eye Contact:

Short termexposure:Available data shows that this product is notharmful. However product is aneye irritant.

Symptoms may include stinging and reddeningof eyesandwatering which may become copious. Other symptoms

may also become evident. If exposure isbrief, symptomsshould disappear onceexposure has ceased. However,

lengthy exposure or delayed treatment may cause permanent damage.

VIRBAC (AUSTRALIA) PTY. LTD.

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Date of Issue

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Ingestion:

Short termexposure:Available data shows that this product is harmful, but symptoms are not available. This

product is unlikely to causeany irritationproblems in the short or long term.

Carcinogen Status:

ASCC:No significant ingredient isclassified ascarcinogenic by ASCC.

NTP:No significant ingredient is classified as carcinogenic by NTP.

IARC:No significant ingredient isclassified ascarcinogenic by IARC.

Section 3 – Composition/Information on Ingredients

Ingredients CAS No Conc,% TWA (mg/m3) STEL (mg/m3)

Diflubenzuron 35367-38-5 25 not set not set

Other non hazardous ingredients secret to 100 not set not set

This isa commercial product whose exact ratio of components may vary slightly. Minor quantities of other non

hazardousingredients arealso possible.

The TWA exposure value is the average airborne concentrationof aparticular substance when calculatedover a normal 8 hourworking dayfor a 5

dayworkingweek. The STEL (Short Term Exposure Limit) isan exposure value thatshould notbe exceeded for morethan 15 minutes andshould

not be repeated for more than 4 times per day. There should be atleast 60 minutes between successive exposures atthe STEL. The term "peak "is

used when theTWA limit, because of the rapid action of the substance, should neverbe exceeded, even briefly.

Section 4 - First Aid Measures

General Information:

You should call The Poisons Information Centre if youfeel that you may have been poisoned, burned orirritated by

this product. The number is13 1126 fromanywhere inAustralia and is availableat all times. Have this MSDS with

you whenyou call.

Inhalation:If irritation occurs, contact a PoisonsInformation Centre, or call a doctor.Removesource of

contamination or move victim to fresh air. If breathingis difficult, oxygen may be beneficial if administered bytrained

personnel, preferably on adoctor's advice. In severecases, symptoms of pulmonary oedema can be delayedup to 48

hours after exposure.

Skin Contact:Quickly and gently, blotor brush away excess chemical.Washgently and thoroughly withwater (use

non-abrasive soap if necessary) for 20minutes oruntil chemical is removed. Under running water, remove

contaminatedclothing, shoes and leather goods (e.g. watchbands and belts). If irritation persists, repeat flushingand

obtain medical advice. Completely decontaminateclothing, shoes and leathergoods before reuse or discard.

Eye Contact:Quickly and gently blot or brush awayproduct.Immediately flush the contaminated eye(s) with

lukewarm, gently flowing water until the product isremovedor until a few minutes after irritation has ceased, while

holdingthe eyelid(s) open.Takecare not to rinse contaminatedwater into the unaffected eyeor onto the face.

Ingestion:If swallowed, doNOT induce vomiting. Wash mouth with water and contact a Poisons Information

Centre, or call a doctor.

Section 5 – Fire Fighting Measures

Fire and Explosion Hazards: Thereis no risk ofan explosionfrom this product under normal circumstances if it is

involved in a fire. Violent steam generation or eruptionmay occurupon application ofdirectwater stream onhot

liquids.

No fire decomposition productsare expected from thisproducts attemperaturesnormally achieved in a fire.

Extinguishing Media:Not Combustible. Use extinguishing media suited to burning materials.

Fire Fighting:

Flash point:No data

Upper FlammabilityLimit:No data.

Lower FlammabilityLimit:No data.

Autoignitiontemperature:No data.

Flammability Class:No data.

Section 6 – Accidental Release Measures

Accidental release:In the event of a majorspill, prevent spillage from entering drainsor water courses. Wear full

protective clothing includingface mask, face shield andgauntlets. All skin areas should be covered. See above under

Personal Protection regarding AustralianStandards relating to personal protectiveequipment. Suitable materials for

VIRBAC (AUSTRALIA) PTY. LTD.

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Date of Issue

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protective clothing includerubber, PVC. Stop leak if safe todo so, and containspill. Absorb onto sand, vermiculite or

other suitable absorbent material. If spill istoo large or if absorbent material isnot available, try to create adike to

stop materialspreading orgoing into drains orwaterways.Sweep upand shovelor collect recoverable product into

labelledcontainers for recycling orsalvage, and dispose ofpromptly. After spills, wash area preventingrunoff from

entering drains. If a significant quantity of material entersdrains, advise emergency services. Full details regarding

disposal of used containers, spillageandunused material may be found on the label. If there is any conflict between

this MSDS and the label, instructionsonthe label prevail. Ensure legality of disposal by consulting regulations prior to

disposal. Thoroughly launder protectiveclothingbefore storage orre-use. Adviselaundry of nature of contamination

when sending contaminated clothing tolaundry.

Section 7 – Handling and Storage

Handling:Keep exposureto this product to a minimum, and minimise the quantities kept in work areas. Check

Section 8 of this MSDS for details of personal protectivemeasures,and make sure that those measures arefollowed.

The measuresdetailed below under "Storage" shouldbe followed during handling in order tominimise risks to

personsusing the productin the workplace. Also, avoidcontact or contamination of productwith incompatible

materials listed in Section 10.

Storage:This product is aScheduled Poison. Observe all relevantregulationsregardingsale, transport and storage

of this class ofpoison. Make sure that containers of thisproduct arekept tightly closed. Makesure that the product

does not comeinto contactwith substanceslisted under "Materials toavoid" in Section 10. Someliquid preparations

settle orseparate onstanding and may require stirringbefore use.Check packaging - theremay be further storage

instructionsonthe label.

Section 8 Exposure Controlsand Personal Protection

The followingAustralian Standards will provide general advice regarding safety clothing and equipment:

Respiratory equipment:AS/NZS 1715, Protective Gloves:AS 2161, Industrial Clothing:AS2919, Industrial Eye

Protection:AS1336andAS/NZS 1337, Occupational ProtectiveFootwear:AS/NZS2210.

Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 )

Exposure limits have not been established by ASCC for any of the significant ingredients in thisproduct.

The ADI for Diflubenzuron isset at 0.02mg/kg/day. Thecorresponding NOEL is set at 2mg/kg/day. ADI means

AcceptableDaily Intake and NOEL means No-observable-effect-level. Valuestaken from Australian ADI List,

December 2006.

Ventilation:No special ventilation requirements arenormally necessary for thisproduct. Howevermake sure that

the work environment remainsclean and that dusts are minimised.

Eye Protection:Protective glasses or gogglesshould be wornwhenthis product is beingused. Failure to protect

your eyes may cause themharm. Emergency eye wash facilities arealso recommended in an area close to where

this product is beingused.

Skin Protection:Preventskincontact by wearing impervious gloves,clothesand, preferably, apron. Make sure that

all skin areasare covered. See belowfor suitable material types.

Protective Material Types:We suggest that protective clothingbemade from the following materials:rubber,

PVC.

Respirator:Usually, no respiratoris necessary whenusing this product. However, if you have any doubts consult

the AustralianStandard mentioned above.

Eyebaths oreyewashstations and safety deluge showersshould be provided near to where this product is being

used.

Section 9 - Physical and Chemical Properties:

Physical Description & colour:Beige to off-white suspension.

Odour:No data.

Boiling Point:Not available.

Freezing/Melting Point: No specific data. Liquid at normal temperatures.

Volatiles: No specific data. Expectedto be low at 100°C.

Vapour Pressure:No data.

Vapour Density:No data.

Specific Gravity:1.08-1.12

Water Solubility:Soluble.

pH:3.0-4.0

VIRBAC (AUSTRALIA) PTY. LTD.

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Volatility:No data.

Odour Threshold:No data.

Evaporation Rate:No data.

Coeff Oil/water distribution: No data

Section 10 – Stabilityand Reactivity

Reactivity:This product isunlikely to react ordecompose undernormal storage conditions. However, if you have

any doubts, contact the supplier for advice onshelf life properties.

Conditions to Avoid:This product should bekept in a cool place, preferably below30°C.

Incompatibilities:strongoxidising agents.

Fire Decomposition:No significant quantities of decompositionproducts areexpected at temperaturesnormally

achieved in afire.

Polymerisation:This product is unlikely to undergopolymerisation processes.

Section 11 – Toxicological Information

Toxicity: Acute toxicity:No overt signsof toxicity were observed inany of the acutestudies conducted.The oral

in rats and mice isgreater than 4640 mg/kg, and the dermal LD

is greaterthan 10,000mg/kg in ratsand

greaterthan4000 mg/kg inrabbits. It is nonirritating to skin andslightly irritatingto eyes.

Chronic toxicity:Rats given moderateamounts of Diflubenzuron for2 years had enlargedspleens, whilemice in a

similar studyhad liver and spleen enlargementat slightly lower levels of exposure. In a study with catsfed over a

wide range of dosesfor 21days, all of the females haddose related bloodchemistry changes at low dosesand the

males exhibited changes atdose levelsthat were slightly higher. The changeswere reversible. The chemistry

changes were associatedwith the formation of methaemoglobin,a form of hemoglobin that is unable to carry oxygen.

Reproductiveeffects:Day-old ducks and turkeys fed moderate amounts ofDiflubenzuron intheir diets for 90 days

had decreased testosteronelevels after42 days, but this did not occur inchickensand pheasants in the same study.

Combs and wattles, which reflect hormoneactivity, showedsome abnormalities. Some were underdevelopedand

others more developed compared to controls. A short-term decrease in testosterone levelswas shown in the sexually

immaturerats but no clear cut change was shown in young bull calves. A three-generation study on rats at low doses

showedno effect on matingperformance. It does not appear that Diflubenzuronhas asignificant effect on

reproduction .

Teratogenic effects:Diflubenzuron doesnot appear to be teratogenic. Newbornrats and rabbits did not develop any

birth defectsafter their motherswere exposed to low levelsof Diflubenzuron (1 to 4 mg/kg/day) on days 6 to18 of

gestation .

Mutagenic effects:Extensive testing onmammaliancells and onbacterial cells shows that Diflubenzuron isnot

mutagenic .

Carcinogenic effects:Rats fed diets containinglowto moderate amounts of Diflubenzurondaily for 2 years had no

increase in the number of new orabnormal tissue growthsor lesions. Mice fed low doses for80 weeks showed no

significant tumor development. Other studies onboth species at higher levelswere also negative for malignant

tumors. Diflubenzuron doesnot appear tobe carcinogenic.

Organ toxicity:Animal studieshave shown the liver and spleento be target organs.

Fate in humans and animals:Intestinal absorption in mammalsdecreaseswithincreasingdose levels.For example,

in rats, the total excretion in urine and bile decreasedfrom about 50% of the dose at 4 mg/kg to only 4% at900

mg/kg.Mice showed similar results.Acow given 10 mg/kgorally, eliminated almost all of the product overa 4-day

period. Therewere only minute amounts of the pesticide inthe milk. The chemical is not degraded in the digestive

tract, but that which is absorbed by the gut is completelybroken down before excretion. Rabbits' skin absorbed only

very small amounts, all ofwhich was recovered in the urine.Chickens excretedalmost all of an oral dose in 13 days.

Their eggshad low levelsofpesticideresidues (0.3 to0.6 mg/kg) from day 9 to theend of the9-weekstudy. Body

tissues(non-fatty) do not retain Diflubenzuron.

Section 12 – Ecological Information

Effects on birds:Diflubenzuron is practically nontoxicto wild birds. Bobwhite quail and mallard ducks bothhave an

8-day dietary LC

of greater than 4640ppm.

VIRBAC (AUSTRALIA) PTY. LTD.

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Effects on aquatic organisms:Diflubenzuron ispractically nontoxic to fish andaquatic invertebrates. TheLC

values (96-hour) for Diflubenzuron in various fish are:bluegillsunfish, 660 mg/L; rainbow trout, 240 mg/L; saltwater

minnow, 255mg/L; and channelcatfish,180 mg/L. In oyster larvaeand juvenilesEC

valueswere 130 and250

mg/L, respectively. Arthropods are most susceptible inthepre-molting stage. For instance, fiddler crabs, exposed for

as little as 1weekat levelsup to 0.05mg/L exhibited limbregeneration effects.Fish tissuecan showsome tracesof

the metabolites whenwater is contaminated with Diflubenzuron; however, tissue concentrations decline steadily with

time in cleanwater.

Effects on other organisms:Thecompound is nontoxic to bees.

Environmental Fate:

Breakdown in soil and groundwater:Diflubenzuronhas a low persistence insoil. The rate of degradation in soil is

strongly dependent on theparticle size ofthe Diflubenzuron. It is rapidly degraded by microbial processes. The half-

life in soil is 3to 4 days. Under fieldconditions, Diflubenzuronhas very low mobility.

Breakdown inwater:In sterilized water (no microbes), there appearsto be little degradationunder neutralor acidic

conditions. However, under field conditions, it is degradedrapidly. Residuescould not be detected in field water 72

hours after anapplicationof 110 g/hectare. Other studiessuggesta half-life of 1 to 3 weeks.

Breakdown invegetation:Very little Diflubenzuron isabsorbed,metabolized,or translocatedin plants. Residueson

cropssuch asapples have a half-life of 5 to 10 weeks.The half-life in oak leaf litter is 6 to 9 months.

Section 13 – Disposal Considerations

Disposal:Instructionsconcerning the disposal of this product andits containers are given onthe productlabel.

These shouldbe carefully followed.

Section 14 – Transport Information

ADG Code:This productis not classified as aDangerousGood. No special transport conditions are necessary

unless required by other regulations.

Section 15 – RegulatoryInformation

AICS:All of the significant ingredients inthis formulation are to be found in the public AICS Database.

Section 16 – Other Information

Much of the Information in this MSDS came from Extoxnet, a Pesticide Information Project of Cooperative Extension

Offices of Cornell University, Oregon StateUniversity, the Universityof Idaho, andthe University of California at Davis

and the Institute for Environmental Toxicology, Michigan State University.

This MSDS contains onlysafety-related information. For other data see product literature.

Contact point: Technical Manager, QA Manager or R&D Director

Telephone (02) 9533 2000 or 1800 242 100

Fax (02) 9533 1522

Acronyms:

ADG Code Australian Code for the Transport of Dangerous Goods by Road and Rail

AICS Australian Inventory of Chemical Substances

CAS number Chemical Abstracts Service Registry Number

HazchemNumber Emergency action code ofnumbers andletters that provide information to

emergency servicesespecially firefighters

IARC International Agency forResearch onCancer

ASCC Office of the Australian Safety and CompensationCouncil

NOS Not otherwisespecified

NTP National Toxicology Program (USA)

R-PhraseRisk Phrase

SUSDP Standard for the Uniform Scheduling ofDrugs & Poisons

UN NumberUnited Nations Number

VIRBAC (AUSTRALIA) PTY. LTD.

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Date of Issue

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THIS MSDS SUMMARISES OUR BEST KNOWLEDGEOFTHEHEALTHAND SAFETYHAZARD INFORMATIONOFTHE PRODUCT AND

HOW TOSAFELYHANDLE ANDUSE THE PRODUCT INTHE WORKPLACE.EACH USER MUSTREVIEW THIS MSDS IN THECONTEXTOF

HOW THE PRODUCT WILLBE HANDLEDANDUSED IN THE WORKPLACE.

IF CLARIFICATIONORFURTHER INFORMATION IS NEEDEDTOENSURETHATAN APPROPRIATE RISK ASSESSMENT CANBE MADE,

THE USER SHOULD CONTACTTHIS COMPANY SOWE CAN ATTEMPT TOOBTAIN ADDITIONAL INFORMATION FROMOUR SUPPLIERS

OURRESPONSIBILITYFOR PRODUCTS SOLDIS SUBJECT TO OURSTANDARD TERMS ANDCONDITIONS, ACOPYOFWHICH IS SENT

TOOUR CUSTOMERS AND IS ALSOAVAILABLEONREQUEST.

Please read all labels carefully before using product.

This MSDS isprepared in accord with the ASCCdocument “National Code of Practice for the Preparation

of Material Safety DataSheets” 2nd Edition [NOHSC:2011(2003)]

Copyright ©Kilford & Kilford Pty Ltd, June, 2007.

http://www.kilford.com.au/ Phone (02) 9251 4532

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