MOXYPEN FORTE 500 MG capsules

Israel - English - Ministry of Health

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Active ingredient:
AMOXICILLIN TRIHYDRATE
Available from:
ABIC MARKETING LTD, ISRAEL
ATC code:
J01CA04
Pharmaceutical form:
CAPSULES
Composition:
AMOXICILLIN TRIHYDRATE 500 MG
Administration route:
PER OS
Prescription type:
Required
Manufactured by:
TEVA CANADA LIMITED
Therapeutic group:
AMOXICILLIN
Therapeutic area:
AMOXICILLIN
Therapeutic indications:
Infections caused by amoxycillin - susceptible organisms. Prevention of bacteremia in patients at risk of developing bacterial endocarditis.
Authorization number:
130 22 30823 00
Authorization date:
2014-01-31

Documents in other languages

Patient Information leaflet Patient Information leaflet - Hebrew

11-10-2018

361-33-668287200A Rev 02.indd 2

2018-09-06 9:03 AM

Moxypen Forte SPC KOD 08/2018 corrections

ע עבקנ הז ןולע טמרופ" ."רשואו קדבנ ונכותו תואירבה דרשמ י" :רשואמ ןולע

6/3/2014

“This leaflet format has been determined by the Ministry of Health and the content thereof has been

checked and approved.” Date of approval: 6/3/2014

MOXYPEN

FORTE 500 mg

CAPSULES

MOXYPEN

FORTE 250 mg

POWDER FOR THE PREPARATION OF SUSPENSION

Composition

Moxypen Forte 500 mg Capsules

Each capsule contains:

Active Ingredient

Amoxicillin 500 mg

Other Ingredients

Magnesium stearate, EEC erythrosine E 127, titanium dioxide ,FD&C Blue # 2, ,

gelatin.

Printed ink contains: titanium dioxide , dehydrated alcohol, isopropyl alcohol, shellac,

povidone , butyl alcohol, propylene glycol, sodium hydroxide .

Moxypen Forte 250mg Powder for the Preparation of Suspension

Each 5 ml of suspension contains:

Active Ingredient

Amoxicillin 250 mg

Other Ingredients

Sucrose, , sprayed dried mask flavor, silicon dioxide, sodium citrate anhydrous,

xanthan gum, sodium benzoate, FD&C Red # 40.

Distilled water added for reconstitution.

Moxypen Forte suspension contains about 3 g. sucrose (2,916.9 mg) per 5 ml.

Sodium content: 3.20 mg per 5 ml.

Mechanism of Action

Moxypen is a broad-spectrum semisynthetic penicillin. It is bactericidal against

sensitive organisms during the stage of active multiplication and acts by inhibiting the

biosynthesis of bacterial cell wall mucopeptides.

Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed from the

gastrointestinal tract following oral administration. Its absorption is unaffected by

food, and it may therefore be taken without regard to meals.

Amoxicillin diffuses readily into most body tissues and fluids but not into the brain

spinal

fluid,

except

when

meninges

inflamed.

achieves

good

penetration into bronchial secretions and also achieves high urinary concentrations

of the unchanged antibiotic.

The wide range of organisms sensitive to the bactericidal action of Moxypen

include:

Gram-Positive

Streptococcus

fecalis,

Streptococcus

pneumoniae,

Streptococcus

pyrogenes,

Streptococcus

viridans,

Staphylococus

aureus

(penicillin-sensitive),

Listeria

monocytogenes.

Moxypen Forte SPC KOD 08/2018 corrections

Gram-Negative

Hemophilus influenzae, Escherichia coli, Proteus mirabilis, Salmonella species,

Shigella

species,

Bordetella

pertussis,

Brucella

species,

Neisseria

gonorrhea,

Neisseria menigitidis.

Indications

Infections caused by amoxicillin-susceptible organisms including upper respiratory

tract

infections,

chest

infections,

urinary

tract

infections,

skin

soft

tissue

infections, and gonorrhea.

Moxypen

used

prevention

bacteremia

associated

with

procedures such as dental extraction in patients at risk of developing bacterial

endocarditis.

Contraindications

Known hypersensitivity to a penicillin-type drug, or to other

-lactam antibiotics,

e.g., cephalosporins.

This drug should not be administered to babies born to mothers with a history of

hypersensitivity to a penicillin-type drug.

Warnings

Serious and occasionally even fatal hypersensitivity reactions due to penicillin

therapy

have

been

reported.

Although

anaphylaxis

more

frequent

following

parenteral

therapy,

occurred

patients

receiving

oral

penicillins.

Such

reactions are more likely to occur in individuals with a history of hypersensitivity to

penicillins and/or a history of sensitivity to multiple allergens. There have also been

reports of individuals with a history of penicillin hypersensitivity experiencing severe

reactions when treated with cephalosporins.

Therefore before initiating therapy with this drug, careful inquiry should be made

concerning previous hypersensitivity reactions to penicillins, cephalosporins, or other

allergens, because of the risk of anaphylactoid reactions.

If an allergic reaction occurs, the drug should be discontinued and appropriate

therapy instituted.

Serious

anaphylactoid

reactions

require

immediate

emergency

treatment

with

adrenaline.

Oxygen,

intravenous

steroids

airway

management

including

intubation, should also be administered as indicated.

Amoxicillin should be avoided if infectious mononucleosis is suspected since the

occurrence of a morbilliform rash has been associated with this condition following

the use of amoxicillin.

Prolonged use may occasionally result in overgrowth of non-susceptible organisms

Pseudomembranous colitis has been reported with nearly all antibacterial agents,

including

amoxicillin,

range

severity

from

mild

life-threatening.

Therefore, it is important to consider this diagnosis in patients who present with

diarrhea subsequent to the administration of antibacterial agents.

Treatment with antibacterial agents alters the normal flora of the colon and may

permit overgrowth of clostridia. Clostridium difficile associated diarrhea (CDAD) has

been reported with use of nearly all antibacterial agents, including amoxicillin, and

may range in severity from mild diarrhea to fatal colitis.

C.difficile produces toxins A and B which contribute to the development of CDAD.

Hypertoxin producing strains of C.difficile cause increased morbidity and mortality, as

these

infections

refractory

antimicrobial

therapy

require

colectomy. CDAD must be considered in all patients who present with diarrhea

following antibiotic use. Careful medical history is necessary since CDAD has been

reported to occur over two months after the administration of antibacterial agents.

Moxypen Forte SPC KOD 08/2018 corrections

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against

C.difficile

need

discontinued.

Appropriate

fluid

electrolyte

management, protein supplementation, antibiotic treatment of C.difficile, and surgical

evaluation should be instituted as clinically indicated.

After

diagnosis

pseudomembranous

colitis

been

established,

appropriate

therapeutic

measures

should

initiated.

Mild

cases

pseudomembranous

colitis

usually

respond

drug

discontinuation

alone.

moderate to severe cases, consideration should be given to management with fluids

and electrolytes, protein supplementation, and treatment with an antibacterial drug

clinically effective against Clostridium difficile colitis.

Prolongation of prothrombin time has been reported rarely in patients receiving

amoxicillin. Appropriate monitoring should be undertaken when anticoagulants are

prescribed concurrently.

In patients with reduced urine output crystalluria has been observed very rarely,

predominantly with parenteral therapy. During the administration of high doses of

amoxicillin, it is advisable to maintain adequate fluid intake and urinary output in

order to reduce the possibility of amoxicillin crystalluria .

Erythematous (morbilliform) rashes have been associated with glandular fever in

patients receiving amoxicillin.

Use during Pregnancy

Reproduction studies have been performed in mice and rats at doses up to ten

(10) times the human dose and have revealed no evidence of impaired fertility or

harm to the fetus due to amoxicillin. There are, however, no adequate and well-

controlled studies in pregnant women. Because animal reproduction studies are not

always predictive of human response, this drug should be used during pregnancy

only if clearly needed.

Use during Labor and Delivery

Oral ampicillin-class antibiotics are poorly absorbed during labor. Studies in guinea

pigs showed that intravenous administration of ampicillin slightly decreased the

uterine tone and frequency of contractions but moderately increased the height and

duration of contractions. However, it is not known whether use of amoxicillin in

humans during labor or delivery has immediate or delayed adverse effects on the

fetus, prolongs the duration of labor, or increases the likelihood that forceps delivery

or other obstetrical intervention or resuscitation of the newborn will be necessary.

Use in Breastfeeding

Since penicillins are excreted in breast milk, administration of this drug to nursing

mothers may lead to sensitization of their infants. Therefore, having taken into

account the importance of the drug to the mother, either discontinue nursing or

discontinue the drug.

Use in Pediatrics

Penicillins are excreted largely unchanged by the kidney. Because renal function is

incompletely developed in infants, the rate of elimination of the drug tends to be

slow. Penicillin-type drugs should therefore be administered with caution, particularly

in neonates, and organ system function (renal, hepatic, and hematological) should

be evaluated frequently.

Use in Patient with Impairment of Renal Function

In patients with renal impairment, the rate of excretion of amoxicillin will be reduced

depending on the degree of impairment and it may be necessary to reduce the total

daily unit amoxicillin dosage accordingly

Moxypen Forte SPC KOD 08/2018 corrections

Use in Geriatrics

This drug is known to be substantially excreted by the kidney, and the risk of toxic

reactions to this drug may be greater in patients with impaired renal function.

Because elderly patients are more likely to have decreased renal function, care

should be taken in dose selection and it may be useful to monitor renal function.

Adverse Reactions

The following convention has been utilised for the classification of undesirable

effects:-

Very common (>1/10), common (>1/100, <1/10), uncommon (>1/1000,<1/100), rare

(>1/10,000, <1/1000), very rare (<1/10,000)

The majorities of side effects listed below are not unique to amoxicillin and may

occur when using other pencillins.

Unless otherwise stated, the frequency of adverse events has been derived from

more than 30 years of post-marketing reports.

Infections and infestations

Very Rare:

Mucocutaneous candidiasis

Blood and lymphatic system disorders

Very rare:

Reversible leucopenia (including severe neutropenia or

agranulocytosis), reversible thrombocytopenia and

haemolytic anaemia.

Prolongation of bleeding time and prothrombin.

Immune system disorders

Very rare:

As with other antibiotics, severe allergic reactions,

including angioneurotic oedema, anaphylaxis, serum

sickness and hypersensitivity vasculitis.

If a hypersensitivity reaction is reported, the treatment

must be discontinued. (See also Skin and

subcutaneous tissue disorders)

Nervous system disorders

Very rare:

Hyperkinesia, dizziness and convulsions. Convulsions

may occur in patients with impaired renal function or in

those receiving high doses.

Gastrointestinal disorders

Clinical Trial Data

*

Common :

Diarrhoea and nausea.

*

Uncommon :

Vomiting.

Moxypen Forte SPC KOD 08/2018 corrections

Post-marketing Data

Very rare:

Antibiotic associated colitis (including

pseudomembraneous colitis and haemorrhagic colitis).

Black hairy tongue

Superficial tooth discolouration has been reported in

children. Good oral hygiene may help to prevent tooth

discolouration as it can usually be removed by

brushing.

Hepato-biliary disorders

Very rare:

Hepatitis and cholestatic jaundice. A moderate rise in

AST and/or ALT.

The significance of a rise in AST and/or ALT is unclear.

Skin and subcutaneous tissue disorders

Clinical Trial Data

*Common :

Skin rash

*Uncommon :

Urticaria and pruritus

Post-marketing Data

Very rare :

Skin reactions such as erythema multiforme, Stevens

Johnson syndrome, toxic epidermal necrolysis, bullous

and exfoliative dermatitis and acute generalised

exanthematous pustulosis (AGEP)

(See also Immune system disorders).

Renal and urinary tract disorders

Very rare :

Interstitial nephritis, crystalluria .

*

The incidence of these AEs was derived from clinical studies involving a total of

approximately 6,000 adult and paediatric patients taking amoxicillin.

Precautions

In the treatment of group A

-hemolytic streptococcal infections, therapy with this

drug should be continued for at least 10 days to help prevent the occurrence of acute

rheumatic fever or glomerulonephritis. Following completion of treatment, cultures

should be taken to determine whether streptococci have been eradicated.

As with any potent drug, periodic assessment of renal, hepatic and hematopoietic

functions should be made during prolonged therapy.

All patients with gonorrhea should have a serologic test for syphilis at the time of

diagnosis. Patients with amoxicillin should have a follow-up serologic test for syphilis

after 3 months.

Moxypen Forte SPC KOD 08/2018 corrections

The possibility of superinfection with mycotic or bacterial pathogens should be kept

in mind during therapy. If superinfection occurs, appropriate therapy should be

instituted.

As with any potent drug, periodic assessment of renal, hepatic and haematopoietic

function should be made during prolonged therapy. The possibility of superinfections

with mycotic or bacterial pathogens should be kept in mind during therapy. If

superinfections occur (usually involving Aerobacter, Pseudomonas or Candida), the

drug should be discontinued and/or appropriate therapy instituted.

In patients with reduced urine output, crystalluria has been observed very rarely,

predominantly with parenteral therapy.

During

administration

high

doses

amoxicillin,

crystalluria

been

observed

very

rarely,

predominantly

with

parenteral

therapy.

During

administration of high doses of amoxicillin adequate fluid intake and urinary output

must

maintained

patients

receiving

high

doses

amoxicillin

(see

also

Warnings).

Moxypen Forte 250mg Suspension contains about 3 g sucrose per 5 ml, therefore

caution should be exercised when administered to diabetics.

Drug Interactions

Penicillins/Chloramphenicol/Erythromycin/Tetracyclines/Sulfonamides

: Since

bacteriostatic drugs may interfere with the bactericidal effect of penicillins in the

treatment of meningitis or other conditions where a rapid bactericidial effect is

necessary, it is best to avoid concurrent therapy.

Amoxicillin/Probenecid

: Probenecid

decrease

renal

tubular

secretion

penicillin-type drugs including amoxicillin, resulting in increased blood levels pf

amoxicillin.

Amoxicillin/Oral Contraceptives

: In common with other antibiotics, amoxicillin may

affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of

combined oral contraceptives.

Amoxicillin/Allopurinol:

Concurrent administration of allopurinol during treatment

with amoxicillin can increase the likelihood of allergic skin reactions. It is not known

whether

this

potentiation

ampicillin

rashes

allopurinol

hyperuricemia present in these patients. Similar reactions can be expected with

amoxicillin.

Amoxicillin/Anticoagulants:

Prolongation of prothrombin time has been reported

rarely in patients receiving amoxicillin. Appropriate monitoring should be undertaken

when anticoagulants are prescribed concurrently.

Effects on ability to drive and use machines

Adverse effects on the ability to drive or operate machinery have not been observed

Diagnostic Interference

Treatment with penicillins may result in false positive reactions when testing for the

presence of glucose in urine using Clinitest, Benedict's Solution or Fehling's Solution.

Tests based on enzymatic glucose oxidase reactions such as Clinistix or Test-Tape

are not affected.

A transient decrease in plasma concentration of total conjugated estriol, estriol-

glucuronide,

conjugated

estrone,

estradiol

been

noted

following

administration to pregnant women.

Information for Patients:

Patients should be counseled that antibacterial drugs, including amoxicillin, should

only be used to treat bacterial infections. They do not treat viral infections (e.g., the

common cold).When amoxicillin is prescribed to treat a bacterial infection, patients

should be told that although it is common to feel better early in the course of therapy,

medication

should

taken

exactly

directed.

Skipping

doses

Moxypen Forte SPC KOD 08/2018 corrections

completing the full course of therapy may:(1) decrease the effectiveness of the

immediate

treatment

increase

likelihood

that

bacteria

will

develop

resistance and will not be treatable by amoxicillin or other antibacterial drugs in the

future.

Diarrhea is a common problem caused by antibiotics which usually ends when the

antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients

can develop watery and bloody stools (with or without stomach cramps and fever)

even as late as 2 or more months after having taken the last dose of the antibiotic. If

this occurs, patients should contact their physician as soon as possible.

Dosage and Administration

Moxypen is not affected by food and may therefore be administered without regard

to meals.

With the exception of gonorrhea, treatment with Moxypen should be continued for

minimum

48-72 hours

beyond

time

which

patient

becomes

asymptomatic or evidence of bacterial eradication has been obtained.

In the treatment of group A

-hemolytic streptococcal infections, therapy with this

drug should be continued for at least 10 days to help prevent the occurrence of acute

rheumatic fever or glomerulonephritis.

Upper Respiratory Tract and Chest Infections

Adults and Children over 10 Years of Age

The recommended dosage is 250-500 mg 3 times daily, every 8 hours.

Infants and Children under 10 Years of Age

In infants under 2 years of age, the dosage is 62.5 mg 3 times daily, every 8 hours.

In children 2-10 years of age, the dosage is 125 mg 3 times daily, every 8 hours.

For more severe infections, the dosage may be increased to 250 mg 3 times daily.

The recommended dosage according to body weight is 20 mg/kg per day in

divided doses every 8 hours. For more severe infections, the dosage may be

increased to 40 mg/kg body weight per day every 8 hours.

Skin and Soft-tissue Infections

Treat as for upper respiratory tract and chest infections.

Uncomplicated Lower Urinary Tract Infections

Adults

A single dose of 3 g may be administered.

Children

A single dose of 100 mg/kg body weight may be administered.

Gonorrhea

A single dose of 3 g may be administered.

Prophylaxis of Bacterial Endocarditis (in dental procedures)

Adults and Children over 10 Years of Age

A single dose of 3 g about 1 hour prior to the procedure, to prevent bacteremia.

Children under 10 Years of Age

Half the adult dose.

Overdosage

Overdosage

penicillin

drugs

cause

neuromuscular

hyperirritability

convulsive seizures.

Interstitial nephritis resulting in oliguric renal failure has been reported in a small

number of patients after overdosage with amoxicillin. Renal impairment appears to

be reversible with cessation of drug administration. High blood levels may occur

Moxypen Forte SPC KOD 08/2018 corrections

more readily in patients with impaired renal function because of decreased renal

clearance of amoxicillin.

Discontinue medication, treat symptomatically, and institute supportive measures

as required. In patients with renal function impairment, the antibiotic may be removed

from the circulation by hemodialysis, not by peritoneal dialysis.

Pharmaceutical Precautions

Moxypen Forte 250mg Suspension

Following reconstitution Moxypen Forte Suspension is stable for 14 days when

kept at room temperature or in a refrigerator. Any unused portion of the suspension

must be discarded thereafter.

Moxypen Capsules 500 mg

Store in a dry place below 25

Registration Numbers:

Moxypen Forte 500 mg Capsules:130 22 30823 00.

Moxypen Forte 250 mg/5 ml Suspension: 132 01 31050 00.

Manufacturer

Teva Canada Ltd.,

Toronto, Ontario,

Canada M1B 2K9.

Importer

Abic Marketing Ltd.

POB 8077, Nethanya, Israel

העדוה העדוה

לע לע

הרמחה הרמחה

(

(

עדימ עדימ

)תוחיטב )תוחיטב

ןכדועמ( ןכדועמ(

05.2013

05.2013

ךיראת

_____

December 25, 2013

____

םש

רישכת

תילגנאב

רפסמו

םושירה

__

MOXYPEN Capsules 250 mg: 130 87 30824 00; 500 mg: 130 22 30823 00,

Forte, powder for the preparation of suspension 250 mg/5ml: 132 01 31050 00

םש

לעב

םושירה

ןיול ,ןומולס

ןייטשלאו

:.ד.ת ,_מ"עב

3696

חתפ , הווקת

_

ןולעב ןולעב

ל

ל

אפור אפור

ספוט

הז

דעוימ

טורפל

תורמחהה

דבלב

תורמחהה

תושקובמה קרפ

ןולעב טסקט

יחכונ טסקט

שדח

Indication

contraindications

Posology, dosage & administration

Special Warnings and Special

Precautions for Use

Use in Pediatrics

Penicillins are excreted largely

unchanged by the kidney. Because

renal

function

incompletely

developed in infants, the rate of

elimination of the drug tends to be

slow.

Penicillin-type

drugs

should

therefore

administered

with

caution, particularly in neonates, and

organ

system

function

should

evaluated frequently.

adequate fluid intake and urinary

output must be maintained in patients

receiving high doses of amoxicillin

Prolonged use may occasionally result in overgrowth of

non-susceptible organisms

Erythematous

(morbilliform)

rashes

have

been

associated with glandular fever in patients receiving

amoxicillin.

Use in Pediatrics

Penicillins are excreted largely unchanged by the

kidney.

Because

renal

function

incompletely

developed in infants, the rate of elimination of the drug

tends to be slow. Penicillin-type drugs should therefore

be administered with caution, particularly in neonates,

organ

system

function

(renal,

hepatic,

hematological)

should be evaluated frequently.

In patients with reduced urine output, crystalluria has

been

observed

very

rarely,

predominantly

with

parenteral therapy

During the administration of high doses of amoxicillin,

crystalluria

been

observed

very

rarely,

predominantly with parenteral therapy. During the

administration of high doses of amoxicillin

adequate

fluid intake and urinary output must be maintained in

patients receiving high doses of amoxicillin (see also

Warnings).

Interaction with Other

Medicaments and Other Forms of

Interaction

Fertility, pregnancy and

Lactation

Adverse events

ןולעב ןולעב

ןכרצל ןכרצל העדוה העדוה

לע לע

הרמחה הרמחה

עדימ ( עדימ (

ןולעב )תוחיטב ןולעב )תוחיטב

ןכרצל ןכרצל

ןכדועמ( ןכדועמ(

05.2013

05.2013

ךיראת

:

29.12.2013

Moxypen 250 mg & Moxypen Forte 500 mg

םש

רישכת

תילגנאב

Moxypen Forte 250 mg

רפסמ

םושיר

:רישכתה ןפיסקומ

250

ג"מ

:

130

87

30824

00

ןפיסקומ

הטרופ

500

ג"מ

:

130.22

.

30823

.

00

ןפיסקומ

הטרופ

250

ג"מ

:

132.01.31050.00

םש

לעב

םושירה

:

ןיול ,ןומולס

ןייטשלו

מ"עב

ספוט

הז

דעוימ

טורפל

תורמחהה

דבלב

תורמחהה

תושקובמה

קרפ

ןולעב טסקט

יחכונ טסקט

שדח המדקה יתמ

ןיא שמתשהל רישכתב

?

ןיא

שמתשהל

הפורתב

וז

םא

העודי תושיגר

דחאל

היביכרממ

וא תופורתל

תורחא

תצובקמ םינירופסולפצה

וא

.םיניליצינפה

תושיגר העודי םא ןיליציסקומאל

דחאל וא .הפורתה יביכרממ

תצובקמ תורחא תופורתל תושיגר העודי םא .םיניליצינפה וא םינירופסולפצה

( הקישנה תלחממ לבוס ךניה םא

mononucleosis

תורהזא תודחוימ תועגונה שומישב הפורתב

:

םא

ךניה

ה/שיגר

ןוזמל

והשלכ

וא הפורתל

ךילע ,יהשלכ

עידוהל

לע ךכ

אפורל

ינפל

תליטנ

שי.הפורתה חוודל

אפורל

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ךניה

ת/לבוס הלחממ

תיגרלא

.יהשלכ ךלהמב

לופיט

ךשוממ

שי

עצבל תוקידב

תויתפוקת

לש

דוקפית הילכה

דבכה

םדו

הפורתל וא והשלכ ןוזמל שיגר ךניה םא ינפל אפורל ךכ לע עידוהל ךילע ,יהשלכ .הפורתה תליטנ

הלחממ לבוס ךניה םא אפורל חוודל שי .יהשלכ תיגרלא

תוקידב עצבל שי ךשוממ לופיט ךלהמב .םדו דבכה ,הילכה דוקפית לש תויתפוקת

אפורל עידוהל שי ,וז הפורת לטונ ךניה םא וא םדב זוקולגה תמר לש הקידב ינפל ןתשב

ינפל

לופיטה רפס

אפורל םא

:

םא

ךניה

ןוירהב

וא

.הקינמ םא

ךניה

ת/לבוס

וא

תלבס

רבעב יוקילמ

דוקפיתב

,דבכה תכרעמ/הילכה

תכרעמ ,ןתשה

הקינמ וא ןוירהב ךניה םא

יוקילמ רבעב תלבס וא לבוס ךניה םא :דוקפיתב

.ןתשה תכרעמ/הילכה

דבכה לוכיעה

ןוגכ(

תקלד

וא )םייעמ תכרעמ

םדה

ןוגכ(

השירק

,)'וכו םא

תלבס

רבעב

הבוגתמ

תיגרלא הקיטויביטנאל

םא ,יהשלכ

ךניה לבוס

תלחמממ

mononucleosis

םוח(

לע

עקר

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הלוכי רתוי תרחואמ תיגרלא הבוגת שחרתהל

7-12

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םומיד םע ףירח לושלש

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הריהב האוצ וא ההכ ןתש

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לופיטה ןמזב שחרתהל תולולע ולא תועפות .לופיטה םות רחאל תועובש רפסמ וא

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