Israel - English - Ministry of Health
drugs for the treatment of migraines of the ergot group (in large
Side effects: In addition to the desired effect of the medicine, adverse
reactions may occur during the course of taking this medicine, for
example: nausea/vomiting, headache (see below), dizziness - especially
when rising from a lying to a standing position (see "Warnings"), fast
heartbeat, flushing of face and neck, weakness. These side effects
usually disappear within a short time following the period of adaptation
to the medicine. However, if they persist and/or are bothersome,
consult your doctor.
Side effects that require special attention:
Skin rash or irritation,
dryness of the mouth, persistent headache (see below), blurred vision
(rare): stop the treatment and refer to the doctor.
Side effects resulting from overdosage: Bluish-coloured lips, fingernails
or palms of the hands, pressure in head.
In the event that you experience side effects not mentioned in this
leaflet, or if there is a change in your general health, consult your
Dosage: According to doctor's instructions only.
Do not exceed the recommended dosage.
This medicine is not usually intended for children and infants.
Directions for use: Do not chew! Swallow the medicine with a large
amount of water after meals. The tablets can be halved but not
How can you contribute to the success of the treatment?
Complete the full course of treatment as instructed by the doctor.
Even if there is an improvement in your health, do not discontinue
use of this medicine before consulting your doctor; and even then
this should be done gradually.
During treatment with this medicine, especially at the beginning, you
may suffer from headaches which accompany the action of this
medicine; this may be overcome by taking aspirin or similar pain
reliever. You should try to continue treatment in spite of the pain. If
the pain persists or worsens, consult your doctor about continuation
Avoid poisoning! This medicine and all other medicines, must be
stored in a safe place out of the reach of children and/or infants, to
avoid poisoning. If you have taken an overdose, or if a child has
accidentally swallowed the medicine, proceed immediately to a hospital
emergency room and bring the package of the medicine with you.
Do not induce vomiting unless explicitly instructed to do so by a
doctor! This medicine has been prescribed for the treatment of your
ailment; in another patient it may cause harm.
Do not give this
medicine to your relatives, neighbours or acquaintances.
Do not take medicines in the dark! Check the label and the dose each
time you take your medicine. Wear glasses if you need them.
Storage: In a cool and dry place, below 25
Even if kept in their original container and stored as recommended,
medicines may be kept for a limited period only. Please note the
expiry date of the medicine! In case of doubt, consult the pharmacist
who dispensed the medicine to you.
Do not store different medications in the same package.
License number: 6931.25325, 5138.25326
Manufacturer: Perrigo Israel Pharmaceuticals Ltd., Yeruham.
PATIENT PACKAGE INSERT IN ACCORDANCE WITH
THE PHARMACISTS' REGULATIONS (PREPARATIONS) - 1986
The dispensing of this medicine requires a doctor's prescription
Read this package insert carefully in its entirety
before using this medicine
The format of this leaflet was determined by the Ministry of Health
and its content was checked and approved by it in January 2006
Each tablet contains:
Each tablet contains:
Isosorbide 5 mononitrate 20 mg
Isosorbide 5 mononitrate 40 mg
Each tablet also contains:
Each tablet also contains:
Lactose 151.7 mg
Lactose 303.4 mg
Lactose monohydrate, talcum, colloidal silicon
dioxide, potato starch, microcrystalline cellulose, aluminium stearate.
Therapeutic group: Nitrates.
Therapeutic activity: Prophylactic treatment of angina pectoris and
treatment of cardiac failure.
When should the preparation not be used?
Do not use this medicine if you are sensitive to any of its ingredients
or to other medications of the nitrates group.
Do not use this medicine in cases of myocardial infarction, severe
hypotension, anaemia or cerebral accident.
This preparation is not intended for the relief of an acute attack of
Do not use concomitantly with medicines of the PDE5 inhibitor
group (medicines for the treatment of erectile dysfunction) such as
Viagra, Cialis and Levitra in light of the severe side effects that may
occur (such as fainting, myocardial infarction). If you have taken
Viagra, you must not take Mononit within the next 48 hours. If you
are in doubt, contact your family physician or cardiologist.
Do not take this medicine without consulting a doctor before
starting treatment in the following cases:
If you are pregnant or if you are breastfeeding.
If you are suffering, or have suffered in the past, from impaired function
of the eyes (e.g. glaucoma), the liver, the kidney/urinary tract, the
digestive system (e.g. ulcer), the thyroid gland, from orthostatic
hypotension, cerebral hemorrhage or damage, low body temperature.
If you are sensitive to lactose.
How will this medicine affect your daily life?
Do not drink wine or
alcoholic beverages while under treatment with this medicine.
Warnings: Avoid sudden changes from a lying/sitting position to a
standing position, in order to avoid dizziness and in extreme cases
fainting. It is also recommended to avoid standing for many hours,
over-exertion or exposure to the sun.
Drug interactions: If you are taking another drug concomitantly or
if you have just finished treatment with another medicine, inform the
attending doctor in order to prevent hazards or lack of efficacy arising
from drug interactions. This is especially important for medicines
belonging to the following groups: cough and cold preparations,
antiasthmatic preparations, antihypertensives and heart medications,