METHYLDOPA tablet film coated

United States - English - NLM (National Library of Medicine)

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METHYLDOPA- methyldopa tablet, film coated

Bryant Ranch Prepack


Methyldopa Tablets, USP

Rx only


Methyldopa is an antihypertensive and is the L-isomer of alpha-methyldopa. It is levo-3-(3,4-

dihydroxyphenyl)-2-methylalanine sesquihydrate. Methyldopa is supplied as tablets for oral

administration, containing 125 mg, 250 mg and 500 mg of methyldopa. The amount of methyldopa is

calculated on the anhydrous basis. Its molecular formula is C

1 1/2 H

, with a molecular

weight of 238.24, and its structural formula is:

Methyldopa is a white to yellowish white, odorless fine powder and is sparingly soluble in water.

The tablets contain the following inactive ingredients: pregelatinized starch, sodium starch glycolate,

povidone, microcrystalline cellulose, magnesium stearate, hypromellose, FD&C yellow #6 lake and

titanium dioxide. In addition 125 mg and 250 mg tablets contain corn starch.


Methyldopa is an aromatic-aminoacid decarboxylase inhibitor in animals and in man. Although the

mechanism of action has yet to be conclusively demonstrated, the antihypertensive effect of methyldopa

probably is due to its metabolism to alpha-methylnorepinephrine, which then lowers arterial pressure by

stimulation of central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction

of plasma renin activity. Methyldopa has been shown to cause a net reduction in the tissue concentration

of serotonin, dopamine, norepinephrine, and epinephrine.

Only methyldopa, the L-isomer of alpha-methyldopa, has the ability to inhibit dopa decarboxylase and to

deplete animal tissues of norepinephrine. In man, the antihypertensive activity appears to be due solely

to the L-isomer. About twice the dose of the racemate (DL-alpha-methyldopa) is required for equal

antihypertensive effect.

Methyldopa has no direct effect on cardiac function and usually does not reduce glomerular filtration

rate, renal blood flow, or filtration fraction. Cardiac output usually is maintained without cardiac

acceleration. In some patients the heart rate is slowed.

Normal or elevated plasma renin activity may decrease in the course of methyldopa therapy.

Methyldopa reduces both supine and standing blood pressure. It usually produces highly effective

lowering of the supine pressure with infrequent symptomatic postural hypotension. Exercise

hypotension and diurnal blood pressure variations rarely occur.

Pharmacokinetics and Metabolism

The maximum decrease in blood pressure occurs four to six hours after oral dosage. Once an effective

dosage level is attained, a smooth blood pressure response occurs in most patients in 12 to 24 hours.

After withdrawal, blood pressure usually returns to pretreatment levels within 24 to 48 hours.

Methyldopa is extensively metabolized. The known urinary metabolites are: α-methyldopa mono-0-

sulfate; 3-0-methyl-α-methyldopa; 3,4-dihydroxyphenylacetone; α-methyldopamine; 3-0-methyl-α-

methyldopamine and their conjugates.

Approximately 70 percent of the drug which is absorbed is excreted in the urine as methyldopa and its

mono-o-sulfate conjugate. The renal clearance is about 130 mL/min in normal subjects and is diminished

in renal insufficiency. The plasma half-life of methyldopa is 105 minutes. After oral doses, excretion is

essentially complete in 36 hours.

Methyldopa crosses the placental barrier, appears in cord blood, and appears in breast milk.




Methyldopa is contraindicated in patients:

- with active hepatic disease, such as acute hepatitis and active cirrhosis.

- with liver disorders previously associated with methyldopa therapy (see WARNINGS).

- with hypersensitivity to any component of this product.

- on therapy with monoamine oxidase (MAO) inhibitors.


It is important to recognize that a positive Coombs test, hemolytic anemia, and liver disorders

may occur with methyldopa therapy. The rare occurrences of hemolytic anemia or liver

disorders could lead to potentially fatal complications unless properly recognized and managed.

Read this section carefully to understand these reactions.

With prolonged methyldopa therapy, 10 to 20 percent of patients develop a positive direct Coombs test

which usually occurs between 6 and 12 months of methyldopa therapy. Lowest incidence is at daily

dosage of 1 g or less. This on rare occasions may be associated with hemolytic anemia, which could

lead to potentially fatal complications. One cannot predict which patients with a positive direct Coombs

test may develop hemolytic anemia.

Prior existence or development of a positive direct Coombs test is not in itself a contraindication to use

of methyldopa. If a positive Coombs test develops during methyldopa therapy, the physician should

determine whether hemolytic anemia exists and whether the positive Coombs test may be a problem. For

example, in addition to a positive direct Coombs test there is less often a positive indirect Coombs test

which may interfere with cross matching of blood.

Before treatment is started, it is desirable to do a blood count (hematocrit, hemoglobin, or red cell

count) for a baseline or to establish whether there is anemia. Periodic blood counts should be done

during therapy to detect hemolytic anemia. It may be useful to do a direct Coombs test before therapy

and at 6 and 12 months after the start of therapy.

If Coombs-positive hemolytic anemia occurs, the cause may be methyldopa and the drug should be

discontinued. Usually the anemia remits promptly. If not, corticosteroids may be given and other causes

of anemia should be considered. If the hemolytic anemia is related to methyldopa, the drug should not

be reinstituted.

When methyldopa causes Coombs positivity alone or with hemolytic anemia, the red cell is usually

coated with gamma globulin of the IgG (gamma G) class only. The positive Coombs test may not revert

to normal until weeks to months after methyldopa is stopped.

Should the need for transfusion arise in a patient receiving methyldopa, both a direct and an indirect

Coombs test should be performed. In the absence of hemolytic anemia, usually only the direct Coombs

test will be positive. A positive direct Coombs test alone will not interfere with typing or cross

matching. If the indirect Coombs test is also positive, problems may arise in the major cross match and

the assistance of a hematologist or transfusion expert will be needed.

Occasionally, fever has occurred within the first three weeks of methyldopa therapy, associated in

some cases with eosinophilia or abnormalities in one or more liver function tests, such as serum

alkaline phosphatase, serum transaminases (SGOT, SGPT), bilirubin, and prothrombin time. Jaundice,

with or without fever, may occur with onset usually within the first two to three months of therapy. In

some patients the findings are consistent with those of cholestasis. In others the findings are consistent

with hepatitis and hepatocellular injury.

Rarely, fatal hepatic necrosis has been reported after use of methyldopa. These hepatic changes may

represent hypersensitivity reactions. Periodic determinations of hepatic function should be done

particularly during the first 6 to 12 weeks of therapy or whenever an unexplained fever occurs. If fever,

abnormalities in liver function tests, or jaundice appear, stop therapy with methyldopa. If caused by

methyldopa, the temperature and abnormalities in liver function characteristically have reverted to

normal when the drug was discontinued. Methyldopa should not be reinstituted in such patients.

Rarely, a reversible reduction of the white blood cell count with a primary effect on the granulocytes

has been seen. The granulocyte count returned promptly to normal on discontinuance of the drug. Rare

cases of granulocytopenia have been reported. In each instance, upon stopping the drug, the white cell

count returned to normal. Reversible thrombocytopenia has occurred rarely.



Methyldopa should be used with caution in patients with a history of previous liver disease or

dysfunction (see WARNINGS).

Some patients taking methyldopa experience clinical edema or weight gain which may be controlled by

use of a diuretic. Methyldopa should not be continued if edema progresses or signs of heart failure


Hypertension has recurred occasionally after dialysis in patients given methyldopa because the drug is

removed by this procedure.

Rarely, involuntary choreoathetotic movements have been observed during therapy with methyldopa in

patients with severe bilateral cerebrovascular disease. Should these movements occur, stop therapy.

Laboratory Tests

Blood count, Coombs test and liver function tests are recommended before initiating therapy and at

periodic intervals (see WARNINGS).

Drug Interactions

When methyldopa is used with other antihypertensive drugs, potentiation of antihypertensive effect may

occur. Patients should be followed carefully to detect side reactions or unusual manifestations of drug


Patients may require reduced doses of anesthetics when on methyldopa. If hypotension does occur

during anesthesia, it usually can be controlled by vasopressors. The adrenergic receptors remain

sensitive during treatment with methyldopa.

When methyldopa and lithium are given concomitantly, the patient should be carefully monitored for

symptoms of lithium toxicity. Read the circular for lithium preparations.

Several studies demonstrate a decrease in the bioavailability of methyldopa when it is ingested with

ferrous sulfate or ferrous gluconate. This may adversely affect blood pressure control in patients

treated with methyldopa. Coadministration of methyldopa with ferrous sulfate or ferrous gluconate is

not recommended.

Monoamine oxidase (MAO) inhibitors: See CONTRAINDICATIONS.

Drug/Laboratory Test Interactions

Methyldopa may interfere with measurement of: urinary uric acid by the phosphotungstate method,

serum creatinine by the alkaline picrate method, and SGOT by colorimetric methods. Interference with

spectrophotometric methods for SGOT analysis has not been reported.

Since methyldopa causes fluorescence in urine samples at the same wave lengths as catecholamines,

falsely high levels of urinary catecholamines may be reported. This will interfere with the diagnosis of

pheochromocytoma. It is important to recognize this phenomenon before a patient with a possible

pheochromocytoma is subjected to surgery. Methyldopa does not interfere with measurement of VMA

(vanillylmandelic acid), a test for pheochromocytoma, by those methods which convert VMA to vanillin.

Methyldopa is not recommended for the treatment of patients with pheochromocytoma. Rarely, when

urine is exposed to air after voiding, it may darken because of breakdown of methyldopa or its


Carcinogenesis, Mutagenesis, Impairment of Fertility

No evidence of a tumorigenic effect was seen when methyldopa was given for two years to mice at

doses up to 1800 mg/kg/day or to rats at doses up to 240 mg/kg/day. (30 and 4 times the maximum

recommended human dose in mice and rats, respectively, when compared on the basis of body weight;

2.5 and 0.6 times the maximum recommended human dose in mice and rats, respectively, when compared

on the basis of body surface area; calculations assume a patient weight of 50 kg).

Methyldopa was not mutagenic in the Ames Test and did not increase chromosomal aberration or sister

chromatid exchanges in Chinese hamster ovary cells. These in vitro studies were carried out both with

and without exogenous metabolic activation.

Fertility was unaffected when methyldopa was given to male and female rats at 100 mg/kg/day (1.7 times

the maximum daily human dose when compared on the basis of body weight; 0.2 times the maximum

daily human dose when compared on the basis of body surface area). Methyldopa decreased sperm

count, sperm motility, the number of late spermatids and the male fertility index when given to male rats

at 200 and 400 mg/kg/day. (3.3 and 6.7 times the maximum daily human dose when compared on the basis

of body weight; 0.5 and 1 times the maximum daily human dose when compared on the basis of body

surface area).


Teratogenic Effects. Pregnancy Category B

Reproduction studies performed with methyldopa at oral doses up to 1000 mg/kg in mice, 200 mg/kg in

rabbits and 100 mg/kg in rats revealed no evidence of harm to the fetus. These doses are 16.6 times, 3.3

times and 1.7 times, respectively, the maximum daily human dose when compared on the basis of body

weight; 1.4 times, 1.1 times and 0.2 times, respectively, when compared on the basis of body surface

area; calculations assume a patient weight of 50 kg. There are, however, no adequate and well-

controlled studies in pregnant women in the first trimester of pregnancy. Because animal reproduction

studies are not always predictive of human response, methyldopa should be used during pregnancy only

if clearly needed.

Published reports of the use of methyldopa during all trimesters indicate that if this drug is used during

pregnancy the possibility of fetal harm appears remote. In five studies, three of which were controlled,

involving 332 pregnant hypertensive women, treatment with methyldopa was associated with an

improved fetal outcome. The majority of these women were in the third trimester when methyldopa

therapy was begun.

In one study, women who had begun methyldopa treatment between weeks 16 and 20 of pregnancy gave

birth to infants whose average head circumference was reduced by a small amount (34.2 ± 1.7 cm vs.

34.6 ± 1.3 cm [mean ± 1 S.D.]). Long-term follow-up of 195 (97.5%) of the children born to

methyldopa-treated pregnant women (including those who began treatment between weeks 16 and 20)

failed to uncover any significant adverse effect on the children. At four years of age, the developmental

delay commonly seen in children born to hypertensive mothers was less evident in those whose mothers

were treated with methyldopa during pregnancy than those whose mothers were untreated. The children

of the treated group scored consistently higher than the children of the untreated group on five major

indices of intellectual and motor development. At age 7 and one-half developmental scores and

intelligence indices showed no significant differences in children of treated or untreated hypertensive


Nursing Mothers

Methyldopa appears in breast milk. Therefore, caution should be exercised when methyldopa is given

to a nursing woman.

Pediatric Use

There are no well-controlled clinical trials in pediatric patients. Information on dosing in pediatric

patients is supported by evidence from published literature regarding the treatment of hypertension in

pediatric patients. (See DOSAGE AND ADMINISTRATION.)

Geriatric Use

Of the total number of subjects (1685) in clinical studies of methyldopa, 223 patients were 65 years of

age and over while 33 patients were 75 years of age and over. No overall differences in safety or

effectiveness were observed between these subjects and younger subjects, and other reported clinical

experience has not identified differences in responses between the elderly and younger patients, but

greater sensitivity of some older individuals cannot be ruled out. (See DOSAGE AND


This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug

may be greater in patients with impaired renal function. Because elderly patients are more likely to have

decreased renal function, care should be taken in dose selection and it may be useful to monitor renal



Sedation, usually transient, may occur during the initial period of therapy or whenever the dose is

increased. Headache, asthenia, or weakness may be noted as early and transient symptoms. However,

significant adverse effects due to methyldopa have been infrequent and this agent usually is well


The following adverse reactions have been reported and, within each category, are listed in order of

decreasing severity.

Cardiovascular: Aggravation of angina pectoris, congestive heart failure, prolonged carotid sinus

hypersensitivity, orthostatic hypotension (decrease daily dosage), edema or weight gain, bradycardia.

Digestive: Pancreatitis, colitis, vomiting, diarrhea, sialadenitis, sore or "black" tongue, nausea,

constipation, distension, flatus, dryness of mouth.

Endocrine: Hyperprolactinemia.

Hematologic: Bone marrow depression, leukopenia, granulocytopenia, thrombocytopenia, hemolytic

anemia; positive tests for antinuclear antibody, LE cells, and rheumatoid factor, positive Coombs test.

Hepatic: Liver disorders including hepatitis, jaundice, abnormal liver function tests (see WARNINGS).

Hypersensitivity: Myocarditis, pericarditis, vasculitis, lupus-like syndrome, drug-related fever,


Nervous System/Psychiatric: Parkinsonism, Bell’s palsy, decreased mental acuity, involuntary

choreoathetotic movements, symptoms of cerebrovascular insufficiency, psychic disturbances

including nightmares and reversible mild psychoses or depression, headache, sedation, asthenia or

weakness, dizziness, light-headedness, paresthesias.

Metabolic: Rise in BUN.

Musculoskeletal: Arthralgia, with or without joint swelling; myalgia.

Respiratory: Nasal stuffiness.

Skin: Toxic epidermal necrolysis, rash.

Urogenital: Amenorrhea, breast enlargement, gynecomastia, lactation, impotence, decreased libido.


Acute overdosage may produce acute hypotension with other responses attributable to brain and

gastrointestinal malfunction (excessive sedation, weakness, bradycardia, dizziness, light-headedness,

constipation, distention, flatus, diarrhea, nausea, vomiting).

In the event of overdosage, symptomatic and supportive measures should be employed. When ingestion

is recent, gastric lavage or emesis may reduce absorption. When ingestion has been earlier, infusions

may be helpful to promote urinary excretion. Otherwise, management includes special attention to

cardiac rate and output, blood volume, electrolyte balance, paralytic ileus, urinary function and cerebral


Sympathomimetic drugs [e.g., levarterenol, epinephrine, ARAMINE

(Metaraminol Bitartrate)] may be

indicated. Methyldopa is dialyzable.

The oral LD

of methyldopa is greater than 1.5 g/kg in both the mouse and the rat.


is a registered trademark of Merck.



Initiation of Therapy

The usual starting dosage of methyldopa tablet is 250 mg two to three times a day in the first 48 hours.

The daily dosage then may be increased or decreased, preferably at intervals of not less than two days,

until an adequate response is achieved. To minimize the sedation, start dosage increases in the evening.

By adjustment of dosage, morning hypotension may be prevented without sacrificing control of

afternoon blood pressure.

When methyldopa is given to patients on other antihypertensives, the dose of these agents may need to

be adjusted to effect a smooth transition. When methyldopa is given with anti-hypertensives other than

thiazides, the initial dosage of methyldopa should be limited to 500 mg daily in divided doses; when

methyldopa is added to a thiazide, the dosage of thiazide need not be changed.

Maintenance of Therapy

The usual daily dosage of methyldopa is 500 mg to 2 g in two to four doses. Although occasional

patients have responded to higher doses, the maximum recommended daily dosage is 3 g. Once an

effective dosage range is attained, a smooth blood pressure response occurs in most patients in 12 to 24

hours. Since methyldopa has a relatively short duration of action, withdrawal is followed by return of

hypertension usually within 48 hours. This is not complicated by an overshoot of blood pressure.

Occasionally tolerance may occur, usually between the second and third month of therapy. Adding a

diuretic or increasing the dosage of methyldopa frequently will restore effective control of blood

pressure. A thiazide may be added at any time during methyldopa therapy and is recommended if therapy

has not been started with a thiazide or if effective control of blood pressure cannot be maintained on 2 g

of methyldopa daily.

Methyldopa is largely excreted by the kidney and patients with impaired renal function may respond to

smaller doses. Syncope in older patients may be related to an increased sensitivity and advanced

arteriosclerotic vascular disease. This may be avoided by lower doses.

Pediatric Patients

Initial dosage is based on 10 mg/kg of body weight daily in two to four doses. The daily dosage then is

increased or decreased until an adequate response is achieved. The maximum dosage is 65 mg/kg or 3 g

daily, whichever is less (see PRECAUTIONS: Pediatric Use.)


Product: 63629-6804

NDC: 63629-6804-1 30 TABLET, FILM COATED in a BOTTLE

NDC: 63629-6804-2 90 TABLET, FILM COATED in a BOTTLE

Methyldopa 500mg Tablet


methyldopa tablet, film coated

Product Information

Product T ype


Ite m Code (Source )

NDC:6 36 29 -6 8 0 4(NDC:16 729 -0 31)

Route of Administration


Active Ingredient/Active Moiety

Ingredient Name

Basis of Strength

Stre ng th



50 0 mg

Inactive Ingredients

Ingredient Name

Stre ng th






FD&C YELLO W NO . 6 (UNII: H77VEI9 3A8 )


Product Characteristics


o range (peach)

S core

no sco re

S hap e


S iz e



Imprint Code



Packag ing


Item Code

Package Description

Marketing Start Date

Marketing End Date


NDC:6 36 29 -6 8 0 4-1

30 in 1 BOTTLE; Type 0 : No t a Co mbinatio n Pro duct

0 9 /30 /20 15


NDC:6 36 29 -6 8 0 4-2

9 0 in 1 BOTTLE; Type 0 : No t a Co mbinatio n Pro duct

0 9 /30 /20 15

Marketing Information

Marke ting Cate gory

Application Numbe r or Monograph Citation

Marke ting Start Date

Marke ting End Date


ANDA0 70 0 8 5

0 7/24/20 12

Labeler -

Bryant Ranch Prepack (171714327)



Ad d re s s


Busine ss Ope rations

Bryant Ranch Prepack

Bryant Ranch Prepack


REPACK(6 36 29 -6 8 0 4) , RELABEL(6 36 29 -6 8 0 4)

Revised: 5/2017

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