Verapress MR 240mg tablets

Main information

  • Trade name:
  • Verapress MR 240mg tablets
  • Dosage:
  • 240mg
  • Pharmaceutical form:
  • Modified-release tablet
  • Administration route:
  • Oral
  • Class:
  • No Controlled Drug Status
  • Prescription type:
  • Valid as a prescribable product
  • Medicine domain:
  • Humans
  • Medicine type:
  • Allopathic drug

Documents

Localization

  • Available in:
  • Verapress MR 240mg tablets
    United Kingdom
  • Language:
  • English

Therapeutic information

  • Product summary:
  • BNF: 02060200; GTIN: 5033847000211

Status

  • Source:
  • eMC
  • Authorization number:
  • PL 14017/0004
  • Last update:
  • 29-01-2019

Patient Information leaflet: composition, indications, side effects, dosage, interactions, adverse reactions, pregnancy, lactation

PACKAGE INFORMATION LEAFLET

Please read this leaflet carefully before you

start taking your tablets.

Keep this leaflet. You may need to read it again.

If you have any further questions ask your doctor

or pharmacist.

This medicine has been prescribed for you only.

Do not pass it on to others. It may harm them,

even if their signs of illness are the same as yours.

If you get any side effects talk to your doctor

or pharmacist. This includes any possible side

effects not listed in this leaflet.

In this leaflet:

1. What Verapress MR 240 Tablets are and what

they are used for

2. What you need to know before you take

Verapress MR 240 Tablets

3. How to take Verapress MR 240 Tablets

4. Possible side effects

5. How to store Verapress MR 240 Tablets

6. Contents of the pack and other information

1. WHAT VERAPRESS MR 240 TABLETS ARE

AND WHAT THEY ARE USED FOR

The name of your medicine is: Verapress MR 240

Tablets

Verapress MR 240 Tablets belong to a group of

medicines called calcium channel blockers. Calcium

channel blockers change the amount of calcium

getting into the muscle cells in your heart and blood

vessels. This can change the strength and speed

with which your heart beats. It also opens up the

blood vessels so blood can be pumped around

the body more easily. This helps more oxygen to

get to your heart muscle and can lower your blood

pressure.

Verapress MR 240 Tablets are indicated for the

treatment of mild to moderate hypertension (high

blood pressure) and the treatment and prevention

of angina pectoris (chest pain).

2. WHAT YOU NEED TO KNOW BEFORE YOU

TAKE VERAPRESS MR 240 TABLETS

If you are unsure if any of the lists applies to

you, ask your doctor before you start to take

your tablets.

Do not take Verapress MR 240 Tablets:

If you are allergic (hypersensitive) to Verapamil

Hydrochloride or to any of the other ingredients

of Verapress MR 240 Tablets (listed in section 6 -

Further information).

If you are having a cardiogenic shock (a sudden

and rapid fall in blood pressure).

If you are having or have recently had a heart

attack particularly if a slow heart beat, low blood

pressure or left ventricular failure of the heart are

involved.

If you have second or third degree atrioventricular

block or sino-atrial block (a disorder where parts

of the heart may beat at the wrong time causing

the heart not to pump blood around the body very

well).

If you have sick sinus syndrome (a heart beat

disorder).

If you have heart failure that is not currently being

treated.

If you have severe bradycardia (a condition where

the heart beats at less than 50 beats per minute).

If you have low blood pressure where the higher

blood pressure reading is below 90.

If you have Wolff-Parkinson-White syndrome (a

heart problem causing rapid heart rate sometimes

associated with symptoms such as dizziness or

faintness).

If you are already taking a medicine containing

ivabradine

treatment

certain

heart

diseases.

Warnings and Precautions

Consult your doctor or pharmacist before taking

Verapress MR 240 Tablets if:

You are pregnant or planning to become pregnant

or are breast feeding.

You suffer or you have ever suffered in the past

from low blood pressure, from a condition known

as "heart failure", an abnormally slow or irregular

heart beat, or any other cardiac problem.

You suffer or you have ever suffered in the past

from

kidney

liver

disorders.

These

above

mentioned medical conditions may mean that

your doctor will need to monitor you more closely.

You

planning

have

medical

dental

surgery. This medicine may affect the anaesthetics

or other treatments used.

You have a condition where the nerve to muscle

transmission is affected e.g. myasthenia gravis,

Lambert-Eaton syndrome, advanced Duchenne

muscular dystrophy.

Children and Adolescents

There are no data on the use of verapamil prolonged

release tablets in children and adolescents.

Taking other medicines:

Please inform your doctor or pharmacist if you are

taking or have recently taken any of the following

medicines, even those not prescribed:

Digoxin and digitoxin (used to treat certain heart

conditions, such as heart failure)

Beta-blockers

(e.g.

atenolol,

metoprolol

propranolol)

other

treatment

heart

diseases and high blood pressure

Prazosin, terazosin (alpha blockers used to treat

high blood pressure and heart conditions)

Anti-arrhythmic agents used to steady an irregular

heart beat (e.g. flecainide, quinidine)

Carbamazepine, phenytoin, phenobarbital

(usually used in epilepsy)

Ciclosporin,

sirolimus,

everolimus,

tacrolimus

(normally used following organ transplants to help

prevent rejection)

Theophylline (used for breathing difficulties e.g.

asthma)

Rifampicin (antibiotic action for treatment of

various infections such as tuberculosis (TB))

Lithium (used for psychiatric conditions)

Cimetidine

(used

stomach

disorders

e.g.

ulcers and indigestion)

Aspirin, a non-steroidal anti-inflammatory

painkiller (NSAID) used to relieve pain and

reduce fever

Glibenclamide (used to treat certain types of

diabetes)

Diuretics (water tablets)

Erythromycin, clarithromycin and telithromycin

(used to treat types of infection)

Doxorubicin (an anti-cancer medicine)

Imipramine,

John’s

Wort

(used

treat

depression)

Buspirone (used to treat anxiety)

Colchicine, sulfinpyrazone (used to treat gout)

Ritonavir (used to treat HIV)

Medicines

known

‘statins’

used

lower

cholesterol

levels

(e.g.

atorvastatin,

lovastatin,

simvastatin)

Medicines used to relax muscles (used for

anesthesia during surgical procedures)

Almotriptan (used to treat migraine)

Midazolam (used as a sedative or anaesthetic)

Dabigatran (medicine to prevent the formation of

blood clots)

Medicines containing ivabradine for the treatment

of certain heart diseases

Drinking alcohol

Verapress MR 240 Tablets will increase the time

your body takes to get rid of alcohol. This means

that you may not have to drink as much for your

blood alcohol level to be above the legal limit to

drive. It will also take you longer to sober up.

VERAPRESS

®

MR 240 Tablets

VERAPAMIL HYDROCHLORIDE

Other important information

Do not drink grapefruit juice whilst taking your

tablets as it can affect the absorption of this

medicine.

Pregnancy and breast-feeding:

Consult

your

doctor

pharmacist

pregnant, trying to become pregnant, or breast-

feeding.

Driving and using machines:

Verapress MR 240 Tablets can make some people

feel dizzy especially when first starting to take the

tablets. Do not drive, operate machinery or do

anything that requires you to be alert, until you

know how the tablets affect you.

Important

information

about

some

of

the

ingredients of Verapress MR 240 Tablets:

This medicinal product contains 32 mg sodium per

dose. To be taken into consideration by patients on

a controlled sodium diet.

3. HOW TO TAKE VERAPRESS MR 240 TABLETS

Always take Verapress MR 240 Tablets exactly as

your doctor has told you. Check with your doctor if

you are not sure.

The tablets should not be chewed or crushed.

They should be swallowed whole with a glass of

water. It does not matter if you have not eaten.

ADULTS:

For treatment of hypertension (high blood

pressure):

recommended

dose

Verapress MR 240 tablet a day. Some patients

may need to take two tablets per day (one in the

morning and one in the evening with about 12 hours

between doses). Do not take more than two tablets

per day.

For the treatment and prevention of angina

pectoris (chest pain): The usual starting dose for

angina is one Verapress MR 240 tablet taken twice

a day. You should take one tablet in the morning and

one in the evening, with a gap of about 12 hours in

between them. Your doctor may prescribe a lower

dose according to your symptoms.

CHILDREN

Verapress MR 240 Tablets is NOT recommended

for children under 12 years of age.

Elderly

The dose will be the same as that for adults. If you

have kidney or liver problem, your doctor may lower

your dose.

If you take more Verapress MR 240 Tablets than

you should

case

overdose,

contact

your

nearest

hospital casualty department or tell your doctor

IMMEDIATELY taking your tablets with you.

If you forget to take Verapress MR 240 Tablets

If you forget to take a dose, take it as soon as you

remember, unless it is almost time for your next

dose. Do not take a double dose to make up for a

forgotten dose.

have

trouble

remembering

take

your

tablets, tell your doctor or your pharmacist. If you

take too many tablets by mistake, any side effects

(see below) may be worse than usual; in this case

see your doctor.

If you stop taking Verapress MR 240 Tablets

It is important that you continue taking the tablets

until your doctor tells you to stop. Do NOT stop

because you feel better. If you stop taking the

tablets too soon your condition may get worse.

If you have any further questions on the use of this

product, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS

Like all medicines, Verapress MR 240 Tablets can

cause side effects, although not everybody gets them.

If you experience the following side effects you

should tell your doctor immediately:

If you have any unexpected wheezing or difficulty

breathing,

have

Quincke's

oedema

(swelling of the face with itching), swelling of the

mouth, lips, or tongue, or if you develop a skin

rash, pruritus (itching), or severe skin rash with

blistering and peeling of the skin. These are signs

you are having an allergic reaction.

If you develop yellowing of the skin or eyes, a

fever or tenderness around the middle. These are

signs that your liver may not be functioning as well

as usual.

If

have

bradycardia

(slow

heart

beats),

arrhythmia

(irregular

heart

beat),

palpitations

(awareness of an irregular or rapid heart beat),

heart

failure,

reversible

impairment

liver

function, chest pains for the first time or chest

pains

that

become

more

frequent,

dizziness,

weakness or confusion, swollen ankles, feeling

faint or breathless or a burning sensation in the

feet, which may become hot and throbbing.

Swelling of the limbs.

Hypotension (abnormally low blood pressure).

Do not stop taking the tablets, but tell your

doctor if you get any of the following:

Constipation

(the

most

common

side

effect),

flushing of the face or neck, headaches, feeling or

being sick, abdominal pain or discomfort, a feeling

of dizziness or spinning, tinnitus (ringing or buzzing

in the ears), tiredness, tremor, movement disorders,

muscle weakness, aches and pains in the joints

and/or muscles, skin rash or itching, a tingling or

prickling feeling on the skin, numbness and hair

loss. Impotence may occur rarely.

Other side effects might occur if Verapress MR

240 is used for a long time. Tell your doctor if you

develop swollen gums which start to spread over

your teeth, or if your breasts swell (males) or start

to produce milk (males and females). These effects

are rare and are resolved upon stopping taking the

tablets.

If any of the side effects gets serious, or if you

notice any side effects not listed in this leaflet,

please tell your doctor or pharmacist.

Reporting of side effects

If you get any side effects, talk to your doctor,

pharmacist or nurse. This includes any possible

side effects not listed in this leaflet. You can also

report side effects directly via the Yellow Card

Scheme at www.mhra.gov.uk/yellowcard.

By reporting side effects you can help provide more

information on the safety of this medicine.

5. HOW TO STORE VERAPRESS MR 240 TABLETS

Keep out of the sight and reach of children.

Do not use Verapress MR 240 Tablets after the

expiry date on the label and carton.

Do not store above 25°C.

Do not use Verapress MR 240 Tablets if you notice

any visible signs of deterioration.

Medicines should not be disposed of via wastewater

or household waste. Ask your pharmacist how to

dispose of medicines no longer required. These

measures will help to protect the environment.

6. CONTENTS OF THE PACK AND OTHER

INFORMATION

What Verapress MR 240 Tablets contain:

The active substance is: Verapamil Hydrochloride

240mg.

The other ingredients are: Core: Sodium alginate,

Microcrystalline cellulose, Povidone, Hypromellose,

Colloidal anhydrous silica, Magnesium stearate.

Coating: Hypromellose, Titanium dioxide, Macrogol,

Yellow Lake E-104, Blue Lake E-132 and Carnauba

wax.

What Verapress MR 240 Tablets look like and

content of the pack:

This

medicine

identified

modified

release, light-green film-coated, capsule-shaped,

scored tablets.

Verapress MR 240 Tablets are supplied in packs of

28 tablets.

The Manufacturer/Holder of Marketing

Authorisation is:

Dexcel

- Pharma Ltd, 7 Sopwith Way, Drayton

Fields, Daventry, Northamptonshire, NN11 8PB, UK.

This leaflet was last revised in January 2017