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Soludox

Main information

  • Trade name:
  • Soludox 500 mg/g Powder for Use in Drinking Water for Pigs and Chickens
  • Available from:
  • Eurovet Animal Health B.V.
  • Pharmaceutical form:
  • Powder and solvent for oral solution
  • Prescription type:
  • POM-V - Prescription Only Medicine – Veterinarian
  • Medicine domain:
  • Animals
  • Medicine type:
  • Allopathic drug
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Documents

Localization

  • Available in:
  • Soludox 500 mg/g Powder for Use in Drinking Water for Pigs and Chickens
    United Kingdom
  • Language:
  • English

Therapeutic information

  • Therapeutic group:
  • Chickens, Pigs
  • Therapeutic area:
  • Antimicrobial

Other information

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Status

  • Source:
  • VMD - Veterinary Medicines Directorate
  • Authorization status:
  • Authorized
  • Authorization number:
  • 16849/4015
  • Authorization date:
  • 07-09-2011
  • Last update:
  • 21-12-2016

Summary of Product characteristics

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Revised: December 2015

AN: 01390/2014

SUMMARY OF PRODUCT CHARACTERISTICS

1. NAME OF THE VETERINARY MEDICINAL PRODUCT

Soludox 500 mg/g powder for use in drinking water for pigs and chickens

2. QUALITATIVE AND QUANTITATIVE COMPOSITION

1 g powder contains:

Active substance:

Doxycycline hyclate 500 mg, corresponding to 433 mg doxycycline

Excipients:

For the full list of excipients, see section 6.1.

3 PHARMACEUTICAL FORM

Powder for use in drinking water.

Yellow crystalline powder.

4 CLINICAL PARTICULARS

4.1 Target species

Pigs and chickens (broiler, pullet, breeder).

4.2 Indications for use, specifying the target species

Pigs: For the treatment of the clinical signs associated with porcine respiratory

disease caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, and

Mycoplasma hyopneumoniae susceptible to doxycycline.

Chickens: Where clinical disease is present in the flock, to reduce mortality,

morbidity, clinical signs and to reduce lesions due to Pasteurellosis caused by

Pasteurella multocida, or to reduce morbidity and lesions due to respiratory

infections caused by Ornithobacterium rhinotracheale (ORT).

4.3 Contra-indications

Do not use in cases of hypersensitivity to the active substance or to any of the

excipients.

Do not use in animals with an impaired liver function.

4.4 Special warning for each target species.

None.

Page 1 of 6

Revised: December 2015

AN: 01390/2014

4.5 Special precautions for use

Special precautions for use in animals

Due to likely variability (time, geographical) in susceptibility of bacteria to

doxycycline, especially susceptibility of A. pleuropneumoniae and O. rhinotracheale

which may differ from country to country and even farm to farm, bacteriological

sampling and susceptibility testing are recommended. Use of the product should be

based on the culture and sensitivity of micro-organisms from diseased cases on

farms. If this is not possible, therapy should be based on local (regional, farm level)

epidemiological information about susceptibility of the target bacteria.

As eradication of the target pathogens may not be achieved, medication should

therefore be combined with good management practices, e.g. good hygiene, proper

ventilation, no overstocking.

Special precautions to be taken by the person administering the veterinary medicinal

product to animals

If you know you are allergic to the tetracycline class of antibiotics, special care

should be taken when handling this product or the medicated solution.

During preparation and administration of the medicated drinking water, skin contact

with the product and inhalation of dust particles should be avoided. Wear

impermeable gloves (e.g. rubber or latex) and an appropriate dust mask (e.g.

disposable half-mask respirator conforming to European Standard EN149) when

applying the product.

In the event of eye or skin contact, rinse the affected area with large amounts of

clean water and if irritation occurs, seek medical attention. Wash hands and

contaminated skin immediately after handling the product.

If you develop symptoms following exposure such as skin rash, you should seek

medical advice and show this warning to the physician. Swelling of the face, lips or

eyes, or difficulty with breathing are more serious symptoms and require urgent

medical attention.

Do not smoke, eat or drink while handling the product.

Take measures to avoid producing dust when incorporating the product into water.

Avoid direct contact with skin and eyes when handling the product to prevent

sensitisation and contact dermatitis.

4.6 Adverse reactions (frequency and seriousness)

Tetracyclines may - in very rare cases - induce photosensitivity and allergic

reactions. If suspected adverse reactions occur, treatment should be discontinued.

Inform your veterinary surgeon if adverse reactions occur that are not stated.

4.7 Use during pregnancy, lactation or lay

Doxycycline has a low affinity for forming complexes with calcium and studies have

demonstrated that doxycycline scarcely affects skeleton formation. No negative

effects were observed in poultry after the administration of therapeutic doses of

doxycycline.

In the absence of specific studies the use of the product is not recommended during

pregnancy or lactation.

Page 2 of 6

Revised: December 2015

AN: 01390/2014

4.8 Interaction with other medicinal products and other forms of interaction

Do not combine with antibiotics that are bactericidal, e.g. penicillins or

cephalosporins.

Absorption of doxycycline can be decreased in the presence of high quantities of

calcium, iron, magnesium or aluminium in the diet. Do not administer together with

antacids, kaolin and iron preparations.

It is advised that the interval between the administration of other products containing

polyvalent cations should be 1-2 hours because they limit the absorption of

tetracyclines.

Doxycycline increases the action of anticoagulants.

The solubility of the product is pH dependent and it will precipitate if mixed in alkaline

solution.

Do not store the drinking water in metallic containers.

4.9 Amounts to be administered and administration route

Administration orally with the drinking water.

The recommended dose in pigs is:

12.5 mg doxycycline hyclate (25 mg product) per kg body weight per day for 4

consecutive days. If no improvement in clinical signs is seen within this time, the

diagnosis should be reviewed and treatment changed. In case of severe infections

the medication period may be prolonged for a maximum of 8 consecutive days as

determined by the attending veterinary surgeon.

The recommended dose in chickens is:

10 mg doxycycline hyclate (20 mg product) per kg body weight per day for 3-4

consecutive days in case of infections caused by P. multocida and

20 mg doxycycline hyclate (40 mg product) per kg body weight per day for 3-4

consecutive days in case of infections caused by O. rhinotracheale.

Based on the dose to be used, and the number and weight of the animals to be

treated, the daily amount of product required can be calculated. The following

formula can be used to calculate the concentration of the product required in drinking

water:

mg product / kg body

weight / day x Mean body weight (kg)

of animals to be treated = .... mg product per

l

drinking water Mean daily water consumption (l) per animal

To ensure a correct dosage body weight should be determined as accurately as

possible. The uptake of medicated drinking water depends on the clinical condition of

the pigs/chickens. In order to obtain the correct dosage the concentration of

doxycycline has to be adjusted accordingly. The use of suitably calibrated weighing

equipment is recommended if part packs are used. The daily amount of product

required is to be added to the drinking water such that all medication will be

consumed in 24 hours. Medicated drinking water should be refreshed or replaced

every 24 hours. It is recommended to prepare a concentrated pre-solution -

approximately 100 grams product per litre drinking water - and to dilute this further to

therapeutic concentrations if required. Alternatively, the concentrated solution can be

Page 3 of 6

Revised: December 2015

AN: 01390/2014

used in a proportional water medicator. Solubility of the product is pH dependent and

it may precipitate out if it is mixed in hard alkaline drinking water. Use at minimum

concentrations of 200 mg powder per litre drinking water in areas with hard alkaline

drinking water (hardness above 10.2 °d and pH more than 8.1). During the treatment

period animals should not have access to water sources other than the medicated

water.

4.10 Overdose (symptoms, emergency procedures, antidotes)

Overdoses up to 1.6 times the label recommended dose resulted in no clinical signs

that could be attributed to treatment. Poultry tolerate double overdoses of

doxycycline (40 mg/kg body weight) without any clinical effect.

4.11 Withdrawal periods

Pigs:

Meat and offal: 4 days.

Chickens:

Meat and offal: 3 days, following a dose rate of 10 mg/kg body weight for 4 days.

Meat and offal: 9 days, following a dose rate of 20 mg/kg body weight for 4 days.

Not authorised for use in birds producing eggs for human consumption.

Do not use within 4 weeks of onset of laying.

5. PHARMACOLOGICAL PROPERTIES

Pharmacotherapeutic group: Antibacterial - Tetracycline.

ATCvet code: QJ 01AA02

5.1 Pharmacodynamic properties

Doxycycline belongs to the group of the tetracycline antibiotics. These antibiotics

have a broad-spectrum of antimicrobial activity, sharing the same basic structure of

polycyclic naphthacenecarboxamide.

Doxycycline is primarily a bacteriostatic drug. It exerts its action by inhibiting the

protein synthesis of the bacterial cell. Inhibition of bacterial protein synthesis results

in disturbance of all functions necessary for the life of bacteria. Cell-division and the

formation of the cell wall in particular are impaired.

Doxycycline is a broad-spectrum antibiotic, active against a large number of Gram-

positive and Gram-negative, aerobe and anaerobe micro-organisms, Mycoplasmata,

Chlamydiae and Rickettsiae.

For Ornithobacterium rhinotracheale, results demonstrate a great variation from high

to low susceptibility, depending on the geographical region where isolates came

from.

In pig pathogens resistance to doxycycline may also vary; in particular, susceptibility

figures of A. pleuropneumoniae may differ from country to country and even farm to

farm.

Four resistance mechanisms acquired by micro-organisms against tetracyclines in

general have been reported: decreased accumulation of tetracyclines (decreased

Page 4 of 6

Revised: December 2015

AN: 01390/2014

permeability of the bacterial cell wall and active efflux), protein protection of the

bacterial ribosome, enzymatic inactivation of the antibiotic and rRNA mutations

(preventing the tetracycline binding to ribosome). Tetracycline resistance is usually

acquired by means of plasmids or other mobile elements (e.g. conjugative

transposons). Cross-resistance between tetracyclines has also been described. Due

to the greater liposolubility and greater facility to pass through cell membranes (in

comparison to tetracycline), doxycycline retains a certain degree of efficacy against

micro-organisms with acquired resistance to tetracyclines.

5.2 Pharmacokinetic particulars

Doxycycline is absorbed in the stomach and the first part of the duodenum.

Compared to the older tetracyclines, the absorption of doxycycline is less affected by

the presence of bivalent cations in food. Bioavailability in non-fasted pigs is

approximately 21%.

Following oral administration at a dose of 12.8 mg/kg body weight, steady state

concentrations during medication range between a C

min of 0.40 µg/ml in the early

morning to a C

max of 0.87 µg/ml in the late afternoon in pigs.

Following administration of doxycycline hyclate at an actual dose of 21 mg/kg body

weight to chickens, mean plasma concentrations above 1 µg/ml were reached within

6 hours and lasted for 6 hours after cessation of medication. From 24 hours up to 96

hours after start of treatment, the doxycycline plasma concentrations exceeded 2

µg/ml. Following administration of doxycycline hyclate at an actual dose of 10 mg/kg

body weight, steady state plasma concentrations ranged from 0.75 to 0.93 µg/g

between 12 and 96 hours after start of medication.

Because doxycycline is highly lipid soluble, it has a good tissue penetration.

Respiratory tract tissue: plasma ratios of 1.3 (healthy lungs), 1.9 (pneumonic lungs)

and 2.3 (nasal mucosa) have been reported for doxycycline. Plasma protein binding

is high (over 90%).

Doxycycline is scarcely metabolised. Doxycycline is primarily excreted with the

faeces.

6. PHARMACEUTICAL PARTICULARS

6.1 List of excipients

Tartaric acid

6.2 Incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be

mixed with other veterinary medicinal products.

6.3 Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf life after first opening the immediate packaging: 9 months.

Shelf life after dilution or reconstitution according to directions: 24 hours.

Page 5 of 6

Revised: December 2015

AN: 01390/2014

6.4 Special precautions for storage

Keep the bag tightly closed after first opening in order to protect from moisture.

6.5 Nature and composition of immediate packaging

The packs consists of one of the following laminates:

Polyester / polyethylene / aluminium / polyethylene and an inner

layer of polyethylene.

Polyester / polyethylene / aluminium and an inner layer of ionomer

(surlyn).

Polyethylene terephtalic acid / aluminium / polyamide and an inner

layer of polyethylene.

Pack sizes of 100 g, 250 g, 500 g, 1 kg and 10x100 g in a carton box.

Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal

product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such

veterinary medicinal product should be disposed of in accordance with local

requirements.

7. MARKETING AUTHORISATION HOLDER

Eurovet Animal Health B.V.

Handelsweg 25

5531 AE Bladel

The Netherlands

8. MARKETING AUTHORISATION NUMBER

Vm 16849/4015

9. DATE OF FIRST AUTHORISATION

7 September 2011

10. DATE OF REVISION OF THE TEXT

December 2015

Approved: 09 December 2015

Page 6 of 6

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