CONSUMER MEDICINE INFORMATION
What is in this leaflet
This leaflet answers some common
questions about PRABEZ tablets. It
does not contain all the available
information. It does not take the
place of talking to your doctor or
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking PRABEZ
against the benefits this medicine is
expected to have for you.
If you have any concerns about
using PRABEZ ask your doctor or
Keep this leaflet with your
You may need to read it again.
What PRABEZ is used
The name of your medicine is
PRABEZ. It contains the active
ingredient rabeprazole sodium.
PRABEZ is used to treat reflux
oesophagitis or reflux disease. This
can be caused by food and acid from
the stomach flowing the wrong way
(reflux) back up the food pipe, also
known as the oesophagus.
Reflux can cause a burning sensation
in the chest rising up to the throat,
also known as heartburn.
PRABEZ is also used to help stop
reflux oesophagitis from coming
back or relapsing.
PRABEZ is used to treat peptic
ulcers. Depending on the position of
the ulcer it is called a gastric or
duodenal ulcer. A gastric ulcer
occurs in the stomach. A duodenal
ulcer occurs in the duodenum which
is the tube leading out of the
These ulcers can be caused by too
much acid being made in the
Most people who have a peptic ulcer
also have a bacteria called
Helicobacter pylori in their stomach.
Your doctor may also prescribe a
course of antibiotics (clarithromycin
and amoxycillin) for you. When
PRABEZ is taken with antibiotics,
the combination therapy will kill the
Helicobacter pylori and let your ulcer
The presence of the bacteria
Helicobacter pylori may cause the
stomach to become inflamed,
resulting in pain, nausea and
When PRABEZ tablets are taken
with antibiotics, they will help kill
Helicobacter pylori and allow the
stomach to heal.
How PRABEZ works
PRABEZ belongs to a group of
medicines called proton pump
inhibitors (PPIs). PRABEZ works by
decreasing the amount of acid the
stomach makes, to give relief from
the symptoms and allow healing to
take place. Your food will still be
digested in the normal way.
Your doctor may have prescribed
PRABEZ for another reason. Ask
your doctor if you have any questions
about why PRABEZ has been
prescribed for you.
PRABEZ is only available with a
Before you take
When you must not take it
Do not take PRABEZ if you have
an allergy to:
any of the ingredients listed at the
end of this leaflet.
other proton pump inhibitors
Symptoms of an allergic reaction
rash, itching or hives on the skin
shortness of breath, wheezing or
swelling of the face, lips, tongue
or other parts of the body
Do not take PRABEZ if:
the packaging is torn or shows
signs of tampering.
the expiry date (month and year)
printed on the pack has passed. If
you take PRABEZ after the
expiry date it may not work.
Before you start to take it:
You must tell your doctor if:
you are pregnant or intend to
you are breast-feeding or intend
to breast-feed. It is not known if
PRABEZ passes into breast milk.
you have or have ever had liver
Taking other medicines:
Tell your doctor or pharmacist if
you are taking any other
medicines, including medicines you
can buy without a prescription
from a pharmacy, supermarket or
health food shop.
Do not take PRABEZ and tell your
doctor or pharmacist if you are
taking any of the following:
atazanavir, a medicine used
(with other antiretrovirals) to
treat HIV-1 infection
clopidogrel, an antiplatelet
You should not take PRABEZ
while taking these medicines.
Also tell your doctor or pharmacist
if you are taking any of the
cyclosporin, a medicine used to
treat several conditions including
prevention of graft rejection
following kidney, liver or heart
transplantation; severe, active
rheumatoid arthritis; severe skin
diseases; kidney disease where
other treatments have failed.
methotrexate, a medicine used to
treat some kinds of cancer. It is
also used to treat psoriasis (skin
disease) and rheumatoid arthritis.
digoxin, a medicine used to treat
ketoconazole, a medicine used to
treat fungal infections.
clarithromycin, a medicine used
to treat infections.
These medicines may be affected by
PRABEZ or may affect how well
PRABEZ works. Your doctor or
pharmacist can tell you what to do if
you are taking any other medicines.
If you have not told your doctor or
pharmacist about any of the above,
tell them before you start taking
Your doctor will advise you whether
or not to take
PRABEZ or if you need to have your
Follow the directions given to you
by your doctor and pharmacist.
How much to take:
The usual dose is one tablet at the
same time each day. For treating
Helicobacter pylori infections in
combination with antibiotics
(clarithromycin and amoxycillin), the
dose is one tablet twice each day,
morning and evening.
The dose of PRABEZ tablets is
usually 20 mg, but may vary from 10
mg to 40 mg per day depending on
what condition you are being treated
for and how severe it is.
PRABEZ should not be given to
How to take it:
PRABEZ should be swallowed
whole, with a glass of water or
DO NOT crush or chew the
tablets. They have a special
coating, which protects them
from the acid in your stomach. If
the coating is broken by chewing,
the tablets may not work.
It does not matter if you take
PRABEZ with food or on an
Ask your doctor or pharmacist for
help if you do not understand the
instructions provided with this
If you forget to take it:
If you forget to take your tablet take
it as soon as you remember, and then
continue to take it as you would
However, if it is almost time for your
next dose, skip the dose you missed
and take your next dose when you
are meant to.
Do not take a double dose to make up
for the dose you missed.
If you are not sure what to do, check
with your doctor or pharmacist.
If you have trouble remembering
when to take your medicine, ask your
pharmacist for some hints.
If you have taken too much
Immediately telephone your doctor
or the Poisons Information Centre for
advice, or go to Accident and
Emergency at your nearest hospital.
Do this even if there are no signs of
discomfort or poisoning. You may
need urgent medical attention.
Poisons Information Centre
Australia: 13 11 26
While you are using
Things you must do
Use PRABEZ exactly as your
doctor has prescribed.
Always swallow PRABEZ tablets
Tell your doctor if you become
pregnant while you are taking
Tell your doctor or pharmacist
that you are taking PRABEZ if you
are about to start taking a new
Things you must not do
Do not use PRABEZ to treat
any other complaint unless
your doctor says to.
Do not give this medicine to
anyone else, even if they have
the same symptoms as you.
Do not crush or chew the
Do not give PRABEZ to
Things that may help your
Some self help measures suggested
below may help your condition. Talk
to your doctor or pharmacist for more
information about these measures.
Alcohol - your doctor may advise
you to limit your alcohol intake.
Aspirin and many other
medicines used to treat arthritis/
period pain/headaches - these
medicines may irritate the
stomach and may make your
condition worse. Your doctor or
pharmacist may suggest other
medicines you can take.
Caffeine - your doctor may advise
you to limit the number of drinks
which contain caffeine, such as
coffee, tea, cocoa and cola drinks,
because they contain ingredients
that may irritate your stomach.
Eating habits - eat smaller, more
frequent meals. Eat slowly and
chew your food carefully. Try not
to rush at meal times.
Smoking - your doctor may
advise you to stop smoking or at
least cut down.
Weight - your doctor may suggest
losing some weight to help your
PRABEZ is usually well tolerated
but tell your doctor or pharmacist as
soon as possible if you do not feel
well while you are taking PRABEZ.
PRABEZ helps most people with
peptic ulcers or reflux disease, but it
may have unwanted side effects in a
All medicines can have side effects.
Sometimes they are serious, most of
the time they are not. You may need
medical treatment if you get some
Do not be alarmed by this list of
possible side effects. You may not
experience any of them.
Ask your doctor or pharmacist to
answer any questions you may have.
Tell your doctor if you experience
any of the following and they
runny or blocked nose
sore throat and discomfort when
breast enlargement in men
itchy rash accompanied by skin
These side effects are usually mild.
People who take proton pump
inhibitor (PPI) medicines at high
doses for a long period of time (1
year or longer) may have an
increased risk of fractures of the hip,
wrist, or spine.
Tell your doctor immediately if
you notice any of the following:
bleeding or bruising more easily
signs of frequent infections such
as fever, severe chills, sore throat
or mouth ulcers.
These are serious side effects. You
may need urgent medical attention.
Serious side effects are rare.
Tell your doctor immediately and
do not take your next dose of
PRABEZ if you experience:
signs of allergy such as skin rash,
reddening, blisters or itching,
swelling of the face, lips or other
parts of the body, shortness of
breath or wheezing.
Other side effects not listed above
may also occur in some people. Tell
your doctor if you notice anything
making you feel unwell when you are
taking, or soon after you have
finished taking PRABEZ.
Other problems are more likely to
arise from the ulcer itself rather than
For this reason contact your doctor
immediately if you notice any of
pain or indigestion
you begin to vomit blood or food
you pass black (blood-stained)
Ask your doctor or pharmacist if
you do not understand anything in
After using PRABEZ
Do not take PRABEZ tablets out of
the blister pack until it is time to
take them. If you take them out of
the blister they may not keep well.
Keep PRABEZ tablets in a cool
dry place where the temperature is
below 25°C. Do not keep PRABEZ
in the refrigerator.
Do not store PRABEZ, or any
other medicine, in the bathroom or
near a sink. Do not leave medicines
in the car or on window sills. Heat
and dampness can destroy some
Keep your medicines where
children cannot reach them. A
locked cupboard at least one-and-
a-half metres (1.5 m) above the
ground is a good place to store
If your doctor tells you to stop
taking PRABEZ tablets, or the
tablets have passed their expiry
date, ask your pharmacist what to
do with any tablets that are left
What it looks like
PRABEZ 10 mg tablets are pink,
round, biconvex coated tablets and
plain on both sides.
This is available in a blister pack of
PRABEZ 20 mg tablets are light
yellow, round, biconvex coated
tablets and plain on both sides.
This is available in a blister pack of
Each PRABEZ tablet contains 10 mg
or 20 mg of rabeprazole sodium as
the active ingredient.
Each tablet also contains the
following other ingredients:
mannitol, light magnesium oxide,
purified talc, titanium dioxide and
The 20 mg tablets also contain
iron oxide yellow
The 10 mg tablets contain iron
The tablets do not contain lactose
Alphapharm Pty Limited
(ABN 93 002 359 739)
Level 1, 30 The Bond
30-34 Hickson Road
Millers Point NSW 2000
Phone: (02) 9298 3999
Australian registration numbers:
AUST R 196564
AUST R 196572
This leaflet was prepared on
15 June 2016.