patrexin 250 mg capsule - search results

United States - English - NLM (National Library of Medicine)

neutrexin- trimetrexate glucuronate injection, powder, lyophilized, for solution

medimmune oncology, inc. - trimetrexate glucuronate (unii: l137u4a79k) (trimetrexate - unii:upn4iti8t4) - injection, powder, lyophilized, for solution - 200 mg in 16 ml - neutrexin (trimetrexate glucuronate for injection) with concurrent leucovorin administration (leucovorin protection) is indicated as an alternative therapy for the treatment of moderate-to-severe pneumocystis carinii pneumonia (pcp) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (aids), who are intolerant of, or are refractory to, trimethoprim-sulfamethoxazole therapy or for whom trimethoprim-sulfamethoxazole is contraindicated. this indication is based on the results of a randomized, controlled double-blind trial comparing neutrexin with concurrent leucovorin protection (tmtx/lv) to trimethoprim‑sulfamethoxazole (tmp/smx) in patients with moderate-to-severe pneumocystis carinii pneumonia, as well as results of a treatment ind. these studies are summarized below: this double-blind, randomized trial initiated by the aids clinical trials group (actg) in 1988 was designed to compare the safety and efficacy of tmtx/lv to that of tmp/smx for the treatment of histol