MURICIN- mupirocin ointment
Country: United States
Language: English
Source: NLM (National Library of Medicine)
Summary of Product characteristics
(SPC)
21-12-2022
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Active ingredient:
MUPIROCIN (UNII: D0GX863OA5) (MUPIROCIN - UNII:D0GX863OA5)
Available from:
Dechra Veterinary Products
INN (International Name):
MUPIROCIN
Composition:
MUPIROCIN 20 mg in 1 g
Administration route:
TOPICAL
Prescription type:
PRESCRIPTION
Therapeutic indications:
Muricin ointment is indicated for the topical treatment of canine bacterial infections of the skin, including superficial pyoderma, caused by susceptible strains of Staphylococcus aureus and Staphylococcus intermedius. This drug is contraindicated in animals with a history of sensitivity reactions to any of its components.
Product summary:
NDC 17033-420-15. Store between 15° and 30°C (59° and 86°F). Keep out of reach of children.
Authorization status:
Abbreviated New Animal Drug Application
Summary of Product characteristics
MURICIN- MUPIROCIN OINTMENT
DECHRA VETERINARY PRODUCTS
----------
MURICIN
(MUPIROCIN OINTMENT) 2%
For dermatologic use on dogs.
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed
veterinarian.
DESCRIPTION:
Each gram of Muricin ointment contains 20 mg of mupirocin in a bland,
water-washable
ointment base consisting of polyethylene glycol 400 and polyethylene
glycol 3350
(polyethylene glycol ointment, NF). Mupirocin is a
naturally-occurring, broadspectrum
antibiotic. The chemical name is
(_E_)-(2_S_,3_R_,4_R_,5_S_)-5-[(2_S_,3_S_,4_S_,5_S_)-2,3-Epoxy-5-
hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-β-methyl-2_H_-pyran-2-crotonic
acid,
ester with 9-hydroxynonanoic acid. The chemical structure is:
CLINICAL PHARMACOLOGY:
Mupirocin is a chemical entity produced by fermentation of the
organism _Pseudomonas_
_fluorescens._ Mupirocin inhibits bacterial protein synthesis by
reversibly and specifically
binding to bacterial isoleucyl transfer-RNA synthetase. Due to this
mode of action,
mupirocin shows no cross resistance with chloramphenicol,
erythromycin, gentamicin,
lincomycin, neomycin, novobiocin, penicillin, streptomycin, and
tetracycline. Mupirocin is
an antimicrobial agent that inhibits the growth of Gram-positive and
Gram-negative
bacteria. Bacteria susceptible to the action of mupirocin _in vitro_
include the aerobic
isolates of _Staphylococcus aureus_ (including methicillin-resistant
strains and β-
lactamase-producing strains), _Staphylococcus intermedius,
Staphylococcus epidermidis,_
other coagulase positive or negative Staphylococci, α-hemolytic
Streptococci, β group A
Streptococci (including _S. pyogenes_), other β Streptococci
(including _S. agalactiae_),
group D Streptococci (including _S. faecalis_ and _S. faecium_), group
Viridans Streptococci,
_Streptococcus pneumoniae, Corynebacterium hofmanii, Bacillus
subtilis, Escherichia coli,_
_Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris,
Enterobacter cloacae,_
_Enterobacter aerogenes, Citrobacter freundii, Hemophilus
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