Min-I-Jet adrenaline (epinephrine) 1:10000 1mg/10mL injection pre-filled syringe
Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
Patient Information leaflet
(PIL)
24-08-2020
Summary of Product characteristics
(SPC)
24-08-2020
Public Assessment Report
(PAR)
26-11-2017
Active ingredient:
adrenaline (epinephrine)
Available from:
BPPR Consulting
INN (International Name):
adrenaline (epinephrine)
Authorization status:
Registered
Patient Information leaflet
ADRENALINE 1:10,000 INJECTION MINIJET®
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ADRENALINE 1:10,000
INJECTION MINIJET®
CONSUMER MEDICINE INFORMATION
You may have been given this product in an emergency situation by a
non-medical health professional.
WHAT IS IN THIS
LEAFLET?
This leaflet contains information
about Adrenaline 1:10,000
Injection MINIJET. Please read
it carefully and keep it for future
reference. The information in
this leaflet is only a summary
and is not intended to replace
advice from your doctor.
Please consult your doctor or
pharmacist if you have any
comments or questions.
WHAT IS
ADRENALINE?
Adrenaline is a chemical which
is produced naturally by our
bodies. It helps to regulate
most of the important functions
such as heart rate, blood
pressure and breathing. When
we have a fright or have to fight
or run, extra adrenaline is
released into our blood. As this
adrenaline circulates round the
body it makes our heart beat
faster, helps us to get more air
into our lungs and increases the
blood supply to the muscles.
This helps us to cope with
emergencies and is why we
often get palpitations when we
are frightened. Adrenaline
injections are used to treat
some emergency situations
which can occur in the heart and
lungs. It can only be given by
injection and it acts very quickly.
WHEN IS ADRENALINE
USED?
Adrenaline injections are only
used in medical emergencies.
They are not used as regular
treatment.
Adrenaline 1:10,000 is used in
people whose hearts have
suddenly stopped (cardiac
arrest). The adrenaline can
help to restart the heart and
stimulates it to beat strongly.
As adrenaline is only used in
medical emergencies, the
injection may be given by
paramedical personnel such as
ambulance or nursing staff.
WHO SHOULD NOT
HAVE ADRENALINE
INJECTIONS?
As adrenaline is an emergency
life-saving product it should not
be withheld from anyone who
needs it.
However it should be given
cautiously to elderly people, to
those with high blood pressure,
thyroid problems and some
people with high pressure in the
eye.
Care must also be taken when
giving
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Summary of Product characteristics
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ADRENALINE HYDROCHLORIDE INJECTION
ADRENALINE 1:10 000
PRODUCT INFORMATION
NAME OF MEDICINE
Adrenaline Hydrochloride
CHEMICAL STRUCTURE:
Molecular formula: C
9
H
13
NO
3
Chemical Name: (R)-1-(3,4-dihydroxyphenyl)-2-methylaminoethanol
CAS number: 51-43-4
DESCRIPTION
Adrenaline is a white odourless crystalline powder, soluble in
solutions of mineral acids and alkalis. Adrenaline
1:10,000 is a sterile solution of adrenaline hydrochloride in water
containing adrenaline hydrochloride 0.1
mg/mL and not more than 0.2% sulfur dioxide from an equivalent amount
of sodium metabisulfite as an
antioxidant. The solution also contains sodium chloride, sodium
citrate, citric acid monohydrate and
hydrochloric acid. The solution contains no antimicrobial
preservatives.
PHARMACOLOGY
Adrenaline is a direct-acting sympathomimetic agent exerting its
effect on alpha and beta adrenoreceptors.
Major effects are increased systolic blood pressure, reduced diastolic
pressure, tachycardia, hyperglycaemia
and hypokalaemia. It is a powerful cardiac stimulant. It has
vasopressor properties, an antihistaminic action
and is a bronchodilator. Its action is rapid in onset and of short
duration.
Adrenaline is rapidly distributed to the heart, spleen, several
glandular tissues and adrenergic nerves. It
crosses the placenta and is excreted in breast milk. It is
approximately 50% bound to plasma proteins. The
onset of action is rapid and after intravenous infusion the half life
is approximately 5-10 minutes.
Adrenaline is rapidly metabolised in the liver and tissues. Up to 90%
of the IV dose is excreted as metabolites
in the urine.
INDICATIONS
Adjunctive use in the management of cardiac arrest.
CONTRAINDICATIONS
Contraindications are relative as this product is intended for use in
life-threatening emergencies.
The following contraindications should be considered: hyperthyroidism,
hypertension, ischaemic heart disease,
diabetes mellitus, narrow angle glaucoma and known sensitivity to
sympathomimetic amines.
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Adrenaline should not be used in the prese
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