Aflibercept (rch) (a-flib-er-cept)
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common
questions about Lidaveg.
It does not contain all the available
information. It does not take the
place of talking to your doctor.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Lidaveg
against the benefits they expect it
will have for you.
If you have any concerns about
taking this medicine, ask your
Keep this leaflet as you may need to
read it again.
What Lidaveg is used
Lidaveg is used to treat advanced
large bowel cancer (that is, cancer in
the colon or rectum) in combination
with chemotherapy agents.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you.
Lidaveg contains the active
Lidaveg is an anti-cancer medicine
that blocks the growth of blood
vessels that provide nutrients and
oxygen to cancer cells. This prevents
the growth of the cancer cells.
Your doctor may have prescribed
Lidaveg for another purpose.
This medicine is only available with
a doctor's prescription.
Lidaveg is not addictive.
Before you are given
Do not receive Lidaveg if you are
allergic to Lidaveg or any of the
ingredients listed at the end of this
Some symptoms of an allergic
reaction include: skin rash, hives,
itching or redness of the skin;
shortness of breath, wheezing or
difficulty breathing; or swelling of
the face, lips, tongue or other parts of
Lidaveg should not be used in your
eye, since it may severely damage
Do not receive Lidaveg:
after the expiry date (EXP)
printed on the vial.
if the packaging is damaged or
shows signs of tampering.
Tell your doctor if you are
pregnant or are planning on
having a baby.
Do not use Lidaveg if you are
pregnant unless otherwise advised by
your doctor. Lidaveg may harm your
Your doctor will advise you about
using effective contraception during
treatment with Lidaveg and for at
least six months after your last dose
Tell your doctor if you plan to start
a family in the future.
Lidaveg may affect your ability to
become pregnant. Your doctor will
advise you of your options prior to
Tell your doctor if you are breast-
feeding or plan to breast-feed.
You should not breast-feed while
using Lidaveg and for at least six
months after the last dose of Lidaveg.
Lidaveg may affect the growth and
development of your baby.
Lidaveg should not be given to a
child or adolescent.
Talk to your doctor if you have any
other health problems, especially
you or anyone if your family have
a history of bleeding problems
you have any bleeding problems
or if you notice any bleeding after
treatment or if you feel extreme
tiredness, weakness, dizziness or
have changes in the colour of
your stool. If the bleeding is
severe, your doctor will stop your
treatment with Lidaveg. This is
because Lidaveg may increase the
risk of bleeding
you have a history of blood clots
or stroke, or you are taking
medicines to thin the blood to
prevent blood clots (e.g.
warfarin). The signs of a blood
clot may vary depending on
where it appears (e.g. lungs, leg,
heart or brain) but may include
symptoms such as chest pain,
coughing, being short of breath or
having difficulty breathing. Other
signs may include swelling in one
or both legs, pain or tenderness in
one or both legs, discolouration
and warmth of the skin on the
affected leg or visible veins. It
may also present itself as a
sudden numb or weak feeling in
the face, arms or legs.
you have high blood pressure.
Lidaveg may increase blood
pressure and your doctor will
need to monitor your blood
pressure and may adjust your
blood pressure medicines or dose
you have had heart or circulation
problems, such as stroke
you have conditions causing
inflammation or bleeding or the
bowel. Symptoms may include
fever, vomiting, diarrhoea and
you have stomach ulcers
you have kidney problems
(protein in the urine)
you have ever had any allergies
or are allergic to any other
medicines, foods, dyes, or
you have had seizures, or cancer
which has spread to your brain or
you are 65 years of age or older
and experience diarrhoea,
dizziness, weakness, weight loss
or severe loss of body fluids
(called dehydration). Your doctor
should monitor you carefully
Tell your doctor if you are going to
have an operation or you have had
a dental procedure or any other
surgery within the last 4 weeks.
Tell your doctor if you have a
surgical wound that has not healed.
Tell your doctor if you have recently
received, or are receiving,
If you have not already told your
doctor about any of the above, tell
them before you are given Lidaveg.
Taking other medicines
Tell your doctor if you are taking any
other medicines including herbal
supplements and vitamins and those
that you buy without a prescription
from your pharmacy, supermarket or
health food store.
This is because some medicines can
affect the way Lidaveg works or
Lidaveg can affect how other
How Lidaveg is given
Lidaveg will be given by a drip
(infusion) into one of your veins
(intravenous use) in hospital by a
doctor or nurse for about an hour.
Lidaveg will be administered to you
in combination with other
Lidaveg should not be used if you
notice the solution is cloudy and/or
visible particles are present in the
vial or in the infusion bag.
Lidaveg must not be injected into the
eye, since it may severely damage it.
How much is given
The recommended dose of Lidaveg is
4 mg per kilogram of your body
How often is Lidaveg given
You will usually have an infusion
once every 2 weeks. Each 2 week
period is called one cycle of
chemotherapy. Your doctor will
decide how many of these cycles you
Your doctor will decide how often
you will receive Lidaveg and if you
need adjustment in the dose.
If you have any further questions on
the use of this medicine, ask your
doctor, pharmacist or nurse.
If you take too much
As Lidaveg is given to you under the
supervision of your doctor, it is very
unlikely that you will receive too
much. However, if you experience
any unexpected or worrying side
effects after being given Lidaveg
immediately telephone your doctor,
or the Poisons Information Centre
(telephone 13 11 26) or go to
Accident and Emergency at your
While you are using it
Things you must do
Tell all the doctors, dentists and
pharmacists who are treating you that
you are taking Lidaveg.
If you are about to be started on any
new medicine, tell your doctor and
pharmacist that you are taking
Men and women of childbearing
potential should use effective
contraception during treatment with
Lidaveg and up to 6 months after the
last dose of treatment.
Continue using Lidaveg until your
doctor tells you to stop. If your
condition gets worse, you must tell
Things you must not do
Do not take any other medicines
whether they require a prescription or
not without first telling your doctor
or consulting a pharmacist.
Things to be careful of
Be careful driving or operating
machinery until you know how
Lidaveg affects you. Lidaveg has not
been shown to affect your ability to
drive or operate machinery.
Lidaveg helps most people with
advanced large bowel cancer (that is,
cancer of the colon or rectum) but
like all medicines it can cause side
effects, although not everybody gets
Sometimes they are serious, but most
of the time they are not. Your doctor
has weighed the risks of using this
medicine against the benefits they
expect it will have for you.
The side effects listed below were
seen when Lidaveg was given
together with chemotherapy.
Do not be alarmed by the list of
possible list effects. You may not
experience any of them.
If any of the following happen
while you are being given Lidaveg
in the hospital/clinic, tell your
doctor or nurse immediately:
redness of skin
shortness of breath, wheezing or
difficulty breathing or swelling of
the face, lips tongue or other parts
of the body.
If you are outside of the
hospital/clinic go to Accident and
Emergency at your nearest
These are very serious side effects
although they are uncommon.
If you have them, you may have had
a serious allergic reaction to Lidaveg
and you may need urgent medical
attention or hospitalisation.
Tell your doctor immediately if
you notice any of the serious side
Stomach cramps or pains
Severe or bloody diarrhoea
Bleeding from the stomach or
bowel which may look like coffee
grounds or black, sticky bowel
Vomiting blood or material that
looks like coffee grounds
Coughing or spitting blood
Blocking of the arteries or veins
by a blood clot
Problems with your wounds
healing after surgery
Headache, vision changes,
confusion and/or seizures
Other side effects are described
Very common (may affect more
than 1 in 10 people)
Decrease in the number of white
Decrease in the number of cells in
the blood that help the blood to
Decrease in appetite
Difficulty in speaking or
Difficulty in breathing
Painful sores in the mouth
Swelling and numbness of the
hands and feet that occurs with
Feeling tired or weak
Loss of weight
Changes in liver or kidney
High blood pressure
Common (may affect up to 1 in 10
Urinary tract infection
Inflammation of the nasal
Pain in the mouth and/or throat
Haemorrhoids, rectal bleeding,
pain at the anus or in the rectum
Inflammation of the mouth
Changes in the colour of skin
Other side effects not listed above
may occur in some patients.
Ask your doctor or pharmacist to
answer any questions you may have.
After taking it
If you have any queries about any
aspect of your medicine, or any
questions regarding the information
in this leaflet, discuss them with your
doctor, nurse or pharmacist.
Store at 2°C to 8°C (Refrigerate. Do
not freeze). Protect from light.
What Lidaveg looks like
Lidaveg is a clear, colourless to pale
Lidaveg is available as 4mL and 8mL
sodium citrate (dihydrate)
citric acid monohydrate
sodium phosphate dibasic
sodium phosphate monobasic
hydrochloric acid and
water for injections.
Lidaveg is made in Germany.
Lidaveg is supplied in Australia by:
sanofi-aventis australia pty ltd
12-24 Talavera Road
Macquarie Park NSW 2113
This leaflet was prepared in June
Australian Register Number(s):
Lidaveg 100mg/4mL AUST R
Lidaveg 200mg/8mL AUST R