600 x 214 mm
I-DEPO-MEDRONE 40MG/ML V
30 Jan 2019
Read all of this leaflet carefully before
you start taking this medicine because
it contains important information for you
Depo-Medrone is a steroid medicine,
prescribed for many different conditions,
including serious illnesses.
You need to take it regularly to get the
Don’t stop taking this medicine without
talking to your doctor – you may need to reduce
the dose gradually.
Depo-Medrone can cause side effects in
some people (read section 4. Possible side
effects). Some problems such as mood changes
(feeling depressed, or “high”), or stomach
problems can happen straight away. If you feel
unwell in any way, keep taking Depo-Medrone,
but see your doctor straight away.
Some side effects only happen after
weeks or months. These include weakness
of arms and legs, or developing a round face
(read section 4. Possible side effects for more
If you take it for more than 3 weeks, you
will get a blue “steroid card”: always keep
it with you and show it to any doctor or nurse
Keep away from people who have
chickenpox or shingles, if you have never
had them. They could affect you severely. If
you do come into contact with chickenpox or
shingles, see your doctor straight away.
Now read the rest of this leaflet. It includes
other important information on the safe and
effective use of this medicine that might be
especially important for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your
doctor or nurse.
- If you get any side effects, talk to your doctor or
nurse. This includes any possible side effects not
listed in this leaflet. See section 4.
What is in this leaflet
1. What Depo-Medrone is and what it is used for
What you need to know before you take Depo-
3. How to take Depo-Medrone
4. Possible side effects
5. How to store Depo-Medrone
Contents of the pack and other information
1. What Depo-Medrone is
and what it is used for
Depo-Medrone contains methylprednisolone
Methylprednisolone belongs to a group of
medicines called steroids. Their full name is
corticosteroids. These corticosteroids occur
naturally in the body and help to maintain health
and well-being. Boosting your body with extra
corticosteroid, such as Depo-Medrone, is an
effective way to treat various illnesses involving
inflammation in the body. Depo-Medrone reduces
this inflammation, which could otherwise go on
making your condition worse. You must take this
medicine regularly to get maximum benefit from it.
Depo-Medrone can help when injected into
the body by a doctor or nurse, such as in or
near a joint, to treat local symptoms caused by
inflammatory or rheumatic conditions such as:
Bursitis: inflammation in the fluid containing
spaces around the shoulder, knee and/or elbow
joints. For this condition this medicine will be
injected directly into one or more of these spaces.
Osteoarthritis and rheumatoid arthritis:
inflammation located in between the joints. For
these conditions this medicine will be injected
directly into one or more joint spaces.
Skin problems: such as alopecia areata
(patchy baldness), keloids (scar tissue), lichen
planus or simplex (small, purplish raised patches
of skin or spots), discoid lupus (round-shaped
patches, often on the face) or granuloma
annulare (circular warty growths).
Epicondylitis and tenosynovitis: Tennis
elbow (epicondylitis) or a tendon’s covering
sheath (tenosynovitis). For these conditions this
medicine will be injected into the tendon or the
Alternatively this medicine may be injected into
a muscle to help treat more general (systemic)
problems affecting the whole body (e.g. symptoms
caused by a hypersensitivity to a medicine) or
allergic, inflammatory or rheumatic problems
brain e.g. meningitis caused by tuberculosis
bowel and gut e.g. Crohn’s disease
(inflammation of the gut) or ulcerative colitis
(inflammation of the lower bowel)
joints e.g. rheumatoid arthritis
lungs e.g. asthma, severe hay fever or
rhinitis, tuberculosis or inflammation caused
by breathing in (aspirating) vomit or stomach
skin e.g. Stevens-Johnson syndrome (an
autoimmune disorder in which an immune
system causes the skin to blister and peel)
or systemic lupus erythematosus (lupus), an
autoimmune disorder which causes a rash
with fever, arthritis, inflammation of the blood
vessels, kidney problems and problems affecting
Your doctor may use this medicine to treat
conditions other than those listed above. Ask your
doctor if you are unsure why you have been given
2. What you need to know
before you take
Do not take Depo-Medrone if:
You think you have ever suffered an allergic
reaction, or any other type of reaction after
being given Depo-Medrone, methylprednisolone
acetate, another corticosteroid, or any of the
ingredients in this medicine (Section 6 of this
leaflet contains a list of ingredients). An allergic
reaction may cause a skin rash or reddening,
swollen face or lips or shortness of breath.
You get a rash, or another symptom of
a generalized (systemic) infection that is not
being treated with antibiotics or anti-virals,
or if you have a widespread (systemic) fungal
You have recently had, or are about to have any
See your doctor immediately if any of the
above applies to you.
This medicine should not be injected:
into the Achilles tendon (which is located behind
the ankle joint)
directly into a vein (intravenous), the spinal cord
(intrathecal), the outer covering of the brain
(extradural), into the nostrils (intranasal), in the
eye (intraocular) or by the epidural route.
Warnings and precautions
Talk to your doctor or nurse before taking
Depo-Medrone if you have any of the following
conditions. Your doctor may also have to monitor
your treatment more closely, alter your dose or
give you another medicine.
Acute adrenal insufficiency (when your body
cannot produce enough corticosteroid due to
problems with your adrenal glands).
Acute pancreatitis (inflammation of the
Chickenpox, measles, shingles or a herpes
eye infection. If you think you have been in
contact with someone with chickenpox, measles
or shingles and you have not already had these
illnesses, or if you are unsure if you have had
If you have ever had a severe depression
or manic depression (bipolar disorder). This
includes having depression before while taking
steroid medicines like Depo-Medrone or if any
of your close family has had these illnesses.
Cushing’s syndrome (a hormone disorder
caused by high levels of cortisol in the blood)
Diabetes (or if there is a family history of
Epilepsy, fits or seizures.
Glaucoma (increased pressure in the eye) or if
there is a family history of glaucoma.
Contact your doctor if you experience blurred
vision or other visual disturbances.
You have recently suffered a heart attack.
Heart problems, including heart failure or
Hypertension (high blood pressure).
Hypotension (low blood pressure).
Hypothyroidism (an under-active thyroid).
Kaposi’s sarcoma (a type of skin cancer).
Kidney or liver disease.
Muscle problems (pain or weakness) have
happened while taking steroid medicines in the
Myasthenia gravis (a condition causing tired
and weak muscles).
Osteoporosis (brittle bones – bones that break
Pheochromocytoma (a rare tumour of adrenal
gland tissue. The adrenal glands are located
above the kidneys).
Scleroderma (also known as systemic
sclerosis, an autoimmune disorder), because the
risk of a serious complication called scleroderma
renal crisis may be increased.
Package leaflet: Information for
40 mg/ml Suspension for
The following information is intended for
healthcare professionals only.
40 mg/ml Suspension for Injection
FOR FURTHER INFORMATION PLEASE REFER TO THE
SUMMARY OF PRODUCT CHARACTERISTICS.
Posology and method of administration
Depo-Medrone may be used by any of the following
routes: intramuscular, intra-articular, intralesional,
intrarectal, intrabursal, periarticular, or into the tendon
sheath. It must not be used by the intrathecal, epidural
or intravenous routes.
Undesirable effects may be minimised by using the
lowest effective dose for the minimum period.
Depo-Medrone vials are intended for single dose use only.
The following may serve as a guide:
The usual dose is 20 to 120 mg daily or weekly, with
adjustment on the basis of the individual requirements
of the patient.
When used according to instructions, there is no
information to suggest that a change in dosage is
warranted in the elderly. Treatment of elderly patients,
however, particularly if long-term, should be planned
bearing in mind the more serious consequences of the
common side effects of corticosteroids in old age and
close clinical supervision is required.
Dosage depends principally on the condition and to
a lesser extent on body weight and age of the patient.
Intramuscular (for sustained systemic effect):
Allergic conditions (hay fever, asthma, rhinitis, drug
reactions), 80 - 120 mg (2 - 3 ml).
Dermatological conditions, 40 - 120 mg (1 - 3 ml).
Rheumatic disorders, collagen disease, SLE,
40 - 120 mg (1 - 3 ml) per week.
Adrenogenital syndrome, 40 mg (1 ml) every two weeks.
On average the effect of a single 2 ml (80 mg) injection
may be expected to last approximately two weeks.
In the case of seasonal allergic rhinitis a single injection
is frequently sufficient. If necessary, however, a second
injection may be given after 2 to 3 weeks.
Rheumatoid arthritis, osteo-arthritis. The dose of
Depo-Medrone depends upon the size of the joint and
the severity of the condition. Repeated injections, if
needed, may be given at intervals of one to five or more
weeks depending upon the degree of relief obtained from
the initial injection. A suggested dosage guide is: large
joint (knee, ankle, shoulder), 20 - 80 mg (0.5 -2 ml);
medium joint (elbow, wrist), 10 - 40 mg (0.25 - 1 ml);
small joint (metacarpophalangeal, interphalangeal,
sternoclavicular, acromioclavicular), 4 -10 mg (0.1 -
Subdeltoid bursitis, prepatellar bursitis, olecranon
bursitis. For administration directly into bursae,
4 - 30 mg (0.1 - 0.75 ml). In most cases, repeat
injections are not needed.
Keloids, localized lichen planus and simplex,
granuloma annulare, alopecia areata, and discoid
lupus erythematosus. For administration directly into
the lesion for local effect in dermatological conditions,
20 - 60 mg (0.5 - 1.5 ml).
For large lesions, the dose may be distributed by
repeated local injections of 20 - 40 mg (0.5 - 1 ml).
One to four injections are usually employed. Care
should be taken to avoid injection of sufficient material
to cause blanching, since this may be followed by
a small slough.
Ulcerative colitis, 40 - 120 mg (1 - 3 ml). Administer in
retention enemas or by continuous drip in 30 - 300 ml
of water, three to seven times weekly for two or more
Epicondylitis. Infiltrate 4 - 30 mg (0.1 - 0.75 ml) into
the affected area.
Into the tendon sheath:
Tendonitis, tenosynovitis, epicondylitis. For
administration directly into the tendon sheath,
4 - 30 mg (0.1 - 0.75 ml). In recurrent or chronic
conditions, repeat injections may be necessary.
Special precautions should be observed when
administering Depo-Medrone. Intramuscular injections
should be made deeply into the gluteal muscles. The
usual technique of aspirating prior to injection should
be employed to avoid intravascular administration.
Doses recommended for intramuscular injection must
not be administered superficially or subcutaneously.
Intra-articular injections should be made using
precise, anatomical localisation into the synovial space
of the joint involved. The injection site for each joint
is determined by that location where the synovial
cavity is most superficial and most free of large
vessels and nerves. Suitable sites for intra-articular
injection are the knee, ankle, wrist, elbow, shoulder,
phalangeal and hip joints. The spinal joints, unstable
joints and those devoid of synovial space are not
suitable. Treatment failures are most frequently the
result of failure to enter the joint space. Intra-articular
injections should be made with care as follows,
ensure correct positioning of the needle into the
synovial space and aspirate a few drops of joint fluid.
The aspirating syringe should then be replaced by
Stomach ulcer, diverticulitis (inflammation
of the bowel wall) or other serious stomach or
Thrombophlebitis - vein problems due to
thrombosis (clots in the veins) resulting in
phlebitis (red, swollen and tender veins).
Traumatic brain injury.
Tuberculosis (TB) or if you have suffered
tuberculosis in the past.
You must tell your doctor before you take this medicine
if you have any of the conditions listed above.
Other medicines and Depo-Medrone
Tell your doctor or nurse if you are taking, have
recently taken or might take any other medicines.
You should tell your doctor if you are taking any of
the following medicines which can affect the way
Depo-Medrone or the other medicine works:
Acetazolamide - used to treat glaucoma and
Aminoglutethimide and cyclophosphamide
– used for treating cancer.
Antibacterials (such as isoniazid,
erythromycin, clarithromycin and
Anticoagulants - used to ‘thin’ the blood such
as acenocoumarol, phenindione and warfarin.
Anticholinesterases - used to treat
myasthenia gravis (a muscle condition) such as
distigmine and neostigmine.
Antidiabetics – medicines used to treat high
Antiemetics (such as aprepitant and
Aspirin and non-steroidal anti-inflammatory
medicines (also called NSAIDs) such as
ibuprofen used to treat mild to moderate pain.
Barbiturates, carbamazepine, phenytoin
and primidone – used to treat epilepsy.
Carbenoxolone - used for heartburn.
Ciclosporin - used to treat conditions such as
severe rheumatoid arthritis, severe psoriasis or
following an organ or bone marrow transplant.
Digoxin - used for heart failure and/or an
irregular heart beat.
Diltiazem – used for heart problems or high
Ethinylestradiol and norethisterone – an
Pharmacokinetic enhancers (such as
cobicistat) used to treat HIV infections.
Indinavir and ritonavir – used to treat HIV
Ketoconazole or itraconazole – used to treat
Pancuronium and vecuronium – or other
medicines called neuromuscular blocking agents
which are used in some surgical procedures.
Potassium depleting agents – such
as diuretics (sometimes called water
tablets), amphotericin B, xanthenes or
beta2 agonists (e.g. medicines used to treat
Rifampicin and rifabutin – antibiotics used to
treat tuberculosis (TB).
Tacrolimus – used following an organ
transplant to prevent rejection of the organ.
Vaccines - tell your doctor or nurse if you
have recently had, or are about to have any
vaccination. You must not have ‘live’ vaccines
while using this medicine. Other vaccines may
be less effective.
If you are taking long term medication(s)
If you are being treated for diabetes, high blood
pressure or water retention (oedema) tell your
doctor as he/she may need to adjust the dose of
the medicines used to treat these conditions.
Before you have any operation tell your doctor,
dentist or anaesthetist that you are taking this
If you require a test to be carried out by your
doctor or in hospital it is important that you tell
the doctor or nurse that you are taking Depo-
Medrone. This medicine can affect the results of
Depo-Medrone with drink
Do not drink grapefruit juice while taking this
Pregnancy and breast-feeding
You must tell your doctor if you are pregnant,
think you might be pregnant, or are trying to
become pregnant as this medicine could slow the
baby’s growth. Depo-Medrone should be used
during pregnancy only if clearly needed.
Cataracts have been observed in infants born to
mothers treated with long-term corticosteroids
If you are breast-feeding, ask your doctor or
nurse for advice before taking this medicine, as
methylprednisolone is excreted into breast milk.
If you continue breast-feeding while you are having
treatment, your baby will need extra checks to
make sure he or she is not being affected by your
Ask your doctor or nurse for advice before taking
Driving and using machines
Undesirable effects, such as dizziness, a feeling of
spinning (vertigo), visual disturbances and fatigue
are possible after treatment with corticosteroids. If
you are affected do not drive or operate machinery.
Depo-Medrone contains sodium
This medicinal product contains less than
1 mmol sodium (23mg) per vial, i.e. essentially
3. How to take Depo-Medrone
Remember to always carry a Steroid
Treatment Card. Make sure your doctor
or nurse has filled out the details of your
medicine, including the dose and how long
you will require steroid treatment.
You should show your steroid card to anyone who
gives you treatment (such as a doctor, nurse or
dentist) while you are taking this medicine, and for
3 months after your last injection.
If you are admitted to hospital for any reason
always tell your doctor or nurse that you are taking
this medicine. You can also wear a medic-alert
bracelet or pendant to let medical staff know that
you are taking a steroid if you have an accident or
Your doctor will decide on the site of injection, how
much of the medicine and how many injections
you will receive depending on the condition being
treated and its severity. Your doctor will inject you
with the lowest dose for the shortest possible time
to get effective relief of your symptoms.
Your doctor or nurse will tell you how many
injections you will require for the condition you are
being treated for, and when you will get them.
Joints - the normal dose for an injection into
a joint will depend on the size of the joint. Large
joints (e.g. knee, ankle and shoulder) may require
20 - 80 mg (0.5 – 2 ml), medium sized joints
(e.g. elbow or wrist) 10 - 40 mg (0.25 – 1 ml) and
small joints (e.g. finger or toe joints) may require
a 4 - 10 mg (0.1 -0.25 ml) dose.
Joint injections may be given weekly over a period
of several weeks, depending on how quickly you
respond to treatment.
Bursitis, epicondylitis (tennis elbow) and
tendonitis – the usual dose is between 4-30 mg
(0.1 - 0.75 ml). In most cases repeat injections
will not be needed for bursitis and epicondylitis.
Repeat injections may be necessary to treat long
Skin conditions – the usual dose is between
20 – 60mg (0.5 – 1.5ml) injected into the affected
part or parts of the skin.
For other more general conditions 40 – 120 mg
(1 – 3ml) of this medicine may be injected into
a large muscle.
Treatment will normally be the same as for
younger adults. However, your doctor may want
to see you more regularly to check how you are
getting on with this medicine.
600 x 214 mm
I-DEPO-MEDRONE 40MG/ML V
30 Jan 2019
Blood, heart and circulation
High blood pressure, symptoms of which
are headaches, or generally feeling unwell.
Problems with the pumping of your heart
(heart failure) symptoms of which are swollen
ankles, difficulty in breathing and palpitations
(awareness of heart beat) or irregular beating
of the heart, irregular or very fast or slow
Low blood pressure, symptoms may
include dizziness, fainting, lightheadedness,
blurred vision, a rapid or irregular heartbeat
Increase of white blood cells (leukocytosis).
Body water and salts
Swelling and high blood pressure, caused by
increased levels of water and salt content.
Cramps and spasms, due to the loss of
potassium from your body. In rare cases this can
lead to congestive heart failure (when the heart
cannot pump properly).
Nausea (feeling sick) or vomiting (being sick).
Thrush in the gullet (discomfort on swallowing).
Persistent hiccups, especially when high doses
A feeling of dizziness or spinning (vertigo).
Cataracts (indicated by failing eyesight).
Glaucoma (raised pressure within the eye,
causing pain in the eyes and headaches).
Swollen optic nerve (causing a condition called
papilloedema, and which may cause sight
Increased intra-ocular pressure, with possible
damage to the optic nerve or cataracts
(indicated by failing eyesight).
Thinning of the clear part at the front of the
eye (cornea) or of the white part of the eye
Worsening of viral or fungal eye infections.
Protruding of the eyeballs (exophthalmos).
Disease of the retina and choroid
membrane, symptoms of which are blurred
or distorted vision (due to a disease called
Poor wound healing.
Irritability in children.
Feeling tired or unwell.
Skin reactions at the site of injection.
Irritability in adults.
Methylprednisolone can damage your liver,
hepatitis and increase of liver enzymes have
Hormones and metabolic system
Slowing of normal growth in infants, children
and adolescents which may be permanent.
Round or moon-shaped face (Cushingoid facies).
Diabetes or worsening of existing diabetes.
Irregular or no periods in women.
Abnormal localized or tumour-like accumulations
of fat in the tissues.
Increased appetite and weight gain.
Prolonged therapy can lead to lower levels of
some hormones which in turn can cause low
blood pressure and dizziness. This effect may
persist for months.
The amount of certain chemicals (enzymes)
called alanine transaminase, aspartate
transaminase and alkaline phosphatase that help
the body digest drugs and other substances in
your body may be raised after treatment with
a corticosteroid. The change is usually small and
the enzyme levels return to normal after your
medicine has cleared naturally from your system.
You will not notice any symptoms if this happens,
but it will show up if you have a blood test.
Increased susceptibility to infections which can
hide or change normal reactions to skin tests,
such as that for tuberculosis.
Metabolism and nutrition disorders
Accumulation of fat tissue on localized parts of
Muscles, bones and joints
Brittle bones (bones that break easily).
Broken bones or fractures.
Breakdown of bone due to poor circulation of
blood, this causes pain in the hip.
Torn muscle tendons causing pain and/or
Muscle cramps or spasms.
Swollen or painful joints due to infection.
Nerves and mood issues
Steroids, including Depo-Medrone, can cause
serious mental health problems.
Feeling depressed, including thinking about
Feeling high (euphoria) or moods that go up and
Feeling anxious, having problems sleeping,
difficulty in thinking or being confused.
Feeling, seeing or hearing things which do not
exist. Having strange and frightening thoughts,
changing how you act or having feelings of being
If you notice any of these problems talk to
a doctor straight away.
Other nervous system side effects may include
convulsions (seizures), amnesia (loss of memory),
cognitive disorder (mental changes), dizziness and
Back pain or weakness (due to Epidural
Lipomatosis, a rare disorder in which an
abnormal amount of fat is deposited on or
outside the lining of the spine).
Poor wound healing.
Abscess, especially near injection sites.
Thinning of skin, stretch marks.
Small purple/red patches on the skin.
Pale or darker patches on your skin, or raised
patches which are an unusual colour.
Increased hair on the body and face
Rash, itching, hives.
Increased clotting of the blood.
If you get any side effects, talk to your doctor or
pharmacist. This includes any possible side effects
not listed in this leaflet.
Reporting of side effects
If you get any side effects, talk to your doctor or
nurse. This includes any possible side effects
not listed in this leaflet. You can also report side
effects directly via HPRA Pharmacovigilence,
Earlsfort Terrace, IRL - Dublin 2; Tel:
+353 1 6764971; Fax: +353 1 6762517.
Website: www.hpra.ie; e-mail:
firstname.lastname@example.org. By reporting side effects, you
can help provide more information on the safety of
5. How to store Depo-Medrone
Keep this medicine out of the sight and reach of
Do not use this medicine after the expiry date
which is stated on the label and carton after
EXP. The expiry date refers to the last day of that
Do not store this medicine above 25°C. Do not
Keep the vial in the outer carton.
6. Contents of the pack and
What Depo-Medrone contains
The active substance is methylprednisolone
acetate. Each millilitre contains 40 mg of
The other ingredients are sodium chloride,
macrogol 3350, miripirium chloride, sodium
hydroxide, hydrochloric acid and water for
What Depo-Medrone looks like and
contents of the pack
Depo-Medrone is a sterile, white suspension
(liquid) for injection contained in a glass vial fitted
with a rubber cap and metal seal.
Depo-Medrone is available in packs containing
1 or 10 vials, containing 1 ml, 2 ml or 3ml of
Not all pack sizes may be marketed.
Marketing Authorisation Holder
Pfizer Healthcare Ireland
National Digital Park
Citywest Business Campus
Pfizer Manufacturing Belgium NV
Company contact address:
For further information on your medicine contact
Medical Information at the following address:
Pfizer Healthcare Ireland
National Digital Park
Citywest Business Campus
Telephone: 1800 633 363.
This leaflet was last revised in: MM/YYYY
Ref: DM 21_0 IE
another containing Depo-Medrone. To ensure position
of the needle, synovial fluid should be aspirated and the
injection made. After injection the joint is moved slightly
to aid mixing of the synovial fluid and the suspension.
Subsequent to therapy care should be taken for the
patient not to overuse the joint in which benefit has
been obtained. Negligence in this matter may permit an
increase in joint deterioration that will more than offset
the beneficial effects of the steroid.
Intrabursal injections should be made as follows: the
area around the injection site is prepared in a sterile way
and a wheal at the site made with 1 percent procaine
hydrochloride solution. A 20 to 24 gauge needle
attached to a dry syringe is inserted into the bursa and
the fluid aspirated. The needle is left in place and the
aspirating syringe changed for a small syringe containing
the desired dose. After injection, the needle is withdrawn
and a small dressing applied.
In the treatment of tenosynovitis and tendinitis care
should be taken to inject Depo-Medrone into the tendon
sheath rather than into the substance of the tendon.
Due to the absence of a true tendon sheath, the Achilles
tendon should not be injected with Depo-Medrone.
The usual sterile precautions should be observed, with
In the absence of compatibility studies, this medicinal
product must not be mixed with other medicinal
Special precautions for storage
Do not store above 25
Do not freeze.
Keep the vial in the outer carton.
Special precautions for disposal and other
Depo-Medrone should not be mixed with any other
fluid. Parenteral drug products should be inspected
visually for particulate matter and discoloration prior
to administration whenever suspension and container
permit. Shake well before use.
Discard any remaining suspension after use.
HCP leaflet was last revised in: 07/2018.
Ref: DM 20_1 IE
In certain medical conditions medicines
like Depo-Medrone (steroids) should not be
stopped abruptly. If you suffer from any of
the following symptoms seek immediate
attention. Your doctor will then decide
whether you should continue taking your
Allergic reactions such as skin rash, swelling
of the face or wheezing and difficulty breathing.
This type of side effect is rare, but can be
Pancreatitis, stomach pain spreading to your
back, possibly accompanied by vomiting, shock
and loss of consciousness.
Ulcers or bleeding ulcers, symptoms
of which are severe stomach pain which
may go through to the back and could be
associated with bleeding from the back
passage, black or bloodstained stools and/or
Infections, this medicine can hide or change
the signs and symptoms of some infections, or
reduce your resistance to the infection, so that
they are hard to diagnose at an early stage.
Symptoms might include a raised temperature
and feeling unwell. Symptoms of a flare up
of a previous TB infection could be coughing
blood or pain in the chest. This medicine may
also make you more likely to develop a severe
Peritonitis, an inflammation (irritation) of the
peritoneum, the thin tissue that lines the inner
wall of the abdomen and covers most of the
abdominal organs. Symptoms are, the stomach
(abdomen) being very painful or tender, the
pain may become worse when the stomach is
touched or when you move.
Pulmonary embolus (blood clot in the lung)
symptoms include sudden sharp chest pain,
breathlessness and coughing up blood.
Raised pressure within the skull of children
(pseudotumour cerebri) symptoms of which are
headaches with vomiting, lack of energy and
drowsiness. This side effect usually occurs after
treatment is stopped.
Thrombophlebitis (blood clots or
thrombosis in a leg vein), symptoms of which
include painful swollen, red and tender
If you experience any of the following side
effects, or if you notice any other unusual
effects not listed in this leaflet, tell your
The following side effects may occur with
certain frequencies, which are defined as
not known: frequency cannot be estimated from
the available data.
Corticosteroids can affect growth in children so
your doctor will prescribe the lowest dose that will
be effective for your child.
If you take more Depo-Medrone than you
If you think you have been given too many
injections of this medicine please speak to your
Stopping/reducing the dose of your
Your medicine must not be stopped suddenly.
Your doctor will decide when it is time to stop your
You will need to come off this treatment slowly if
have been given Depo-Medrone for a long time
have been given high doses of Depo-Medrone,
or have already had a course of corticosteroid
tablets or injections in the last year
already have problems with your adrenal glands
(adrenocortical insufficiency) before you started
You will need to come off this medicine slowly to
avoid withdrawal symptoms. These symptoms
may include itchy skin, fever, muscle and joint
pains, runny nose, sticky eyes, sweating and
If your symptoms seem to return or get worse as
your dose of this medicine is reduced tell your
Mental problems while taking Depo-Medrone
Mental health problems can happen while taking
steroids like Depo-Medrone (see also Section 4,
Possible Side Effects).
These illnesses can be serious.
Usually they start within a few days or weeks of
starting the medicine.
They are more likely to happen at high doses.
Most of these problems go away if the dose is
lowered or the medicine is stopped. However, if the
problems do happen they might need treatment.
Talk to a doctor if you (or someone taking this
medicine) show any signs of mental problems. This
is particularly important if you are depressed, or
might be thinking about suicide. In a few cases
mental problems have happened when doses are
being lowered or stopped.
If you have any further questions on the use of this
medicine, ask your doctor or nurse.
4. Possible side effects
Like all medicines, this medicine can cause
side effects, although not everybody gets them.
Your doctor will have given you this medicine for
a condition which if not treated properly could