CHEMMART ALLOPURINOL allopurinol 300mg tablet blister pack
Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
Patient Information leaflet
(PIL)
06-02-2017
Summary of Product characteristics
(SPC)
06-02-2017
Public Assessment Report
(PAR)
26-11-2017
Active ingredient:
Allopurinol
Available from:
Arrow Pharma Pty Ltd
INN (International Name):
Allopurinol
Patient Information leaflet
CHEMMART ALLOPURINOL
_contains the active ingredient, allopurinol (al-oe-PUR-in-ol)_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
ASK YOUR DOCTOR OR PHARMACIST IF
YOU DO NOT UNDERSTAND ANYTHING OR
ARE WORRIED ABOUT TAKING YOUR
MEDICINE.
This leaflet answers some common
questions about allopurinol.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. Some more recent
information on your medicine may
be available. Speak to your
pharmacist or doctor to obtain the
most up-to-date information.
All medicines have risks and
benefits. Your doctor or pharmacist
has weighed the risks of you taking
this medicine against the benefits
they expect it will have for you.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT ALLOPURINOL IS
USED FOR
The name of your medicine is
Chemmart Allopurinol. It contains
the active ingredient, allopurinol.
Allopurinol is used to treat:
• gouty arthritis or gout
• kidney stones
•
rare conditions where high levels
of uric acid occur in the blood
(for example, Lesch-Nyhan
syndrome).
Allopurinol is used to treat the
symptoms of these conditions, but it
will not cure them. Also, it will not
help treat the pain that occurs in an
acute attack of gout.
_HOW IT WORKS_
Allopurinol belongs to a group of
medicines called anti-uricaemic
agents. These medicines work by
reducing high levels of uric acid in
the body, which are usually due to
gout. Excess amounts of uric acid in
the blood may lead to uric acid
crystals being made and deposited in
the joints, thereby causing pain,
swelling and tenderness.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you.
Your doctor may have prescribed
allopurinol for another reason.
This medicine is available only with
a doctor's prescription.
There is no evidence that this
medicine is addi
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Summary of Product characteristics
1
CHEMMART ALLOPURINOL
NAME OF THE MEDICINE
Allopurinol.
Chemical Name: 1,5-dihydro-4H-pyrazolo[3,4-_d_]pyrimidin-4-one.
Chemical Structure:
Molecular Formula: C
5
H
4
N
4
O
Molecular Weight: 136.1
CAS Registry No: 315-30-0
DESCRIPTION
Allopurinol is a white or off-white, almost odourless powder. It is
very slightly soluble in water and in
alcohol, and is practically insoluble in chloroform and in ether. It
dissolves in dilute solutions of alkali
hydroxides.
Chemmart
Allopurinol
also
contains
the
following
excipients:
lactose
monohydrate,
magnesium
stearate, povidone and maize starch.
PHARMACOLOGY
Allopurinol inhibits xanthine oxidase, the enzyme which catalyses the
conversion of hypoxanthine to
xanthine, and of xanthine to urate/uric acid.
Allopurinol decreases urate formation in two ways: the inhibition of
xanthine oxidase reduces the amount
of hypoxanthine and xanthine converted to urate/uric acid; this action
makes more hypoxanthine and
xanthine available for re-utilisation in the purine metabolic cycle,
which in turn, by a feedback mechanism,
decreases overall _de novo _purine formation.
Since allopurinol decreases urate formation, it reduces urate/uric
acid concentrations in both body fluids
and urine. In contrast, the uricosuric agents which increase
urate/uric acid excretion via the kidney will
reduce the urate concentration in body fluids, but increase urate/uric
acid concentrations in urine.
Reduction of the urate concentrations in body fluids by allopurinol
permits mobilisation and dissolution of
urate deposits anywhere in the body, the commonest sites being those
in the skin, bones, joints and
kidney interstitial tissue.
Therapeutic effects therefore include: the resolution of skin tophi
and the healing of urate sinuses;
eventual reduction in the frequency of attacks of acute gouty
arthritis; improvement in joint mobility;
reduction of the urate load to be excreted via the kidney; prevention
and treatment of acute uric acid
nephropathy; and, in the long-term, reduced risk of renal impairment
by urate/
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