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Carboplatin Injection 50 mg/5 mL, 150 mg/15 mL and 450 mg/45 mL
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common
questions about Carboplatin Accord
Injection. It does not contain all the
available information. It does not take the
place of talking to your doctor or
All medicines have risks and benefits.
Your doctor has weighed the risks of you
being given carboplatin against the
benefits they expect it will have for you.
If you have any concerns about being
given this medicine, ask your doctor or
Keep this leaflet.
You may need to read it again.
What Carboplatin Accord
Injection is used for
This medicine is used to treat:
cancer of the testes
some types of lung cancer
cancer of the brain and/or spinal cord
cancer of the head and neck
neuroblastoma (a cancer of the
nerves and adrenal glands)
a type of cancer called sarcoma.
Carboplatin belongs to a group of
medicines called antineoplastic or
cytotoxic medicines. You may also hear
of these being called chemotherapy
medicines. This medicine is classified as
a platinum-complex cytotoxic.
It works by killing cancer cells and/or
stopping cancer cells from growing and
Carboplatin is often used in combination
with other medicines to treat cancer.
Ask your doctor if you have any
questions about why this medicine has
been prescribed for you.
Your doctor may have prescribed it for
This medicine is not addictive.
This medicine is available only with a
Before you are given
When you must not be given
You should not be given Carboplatin
Accord Injection if you have an allergy
any medicine containing carboplatin
compounds such as cisplatin or
Some of the symptoms of an allergic
reaction may include shortness of breath,
wheezing or difficulty breathing;
swelling of the face, lips, tongue or other
parts of the body; rash, itching or hives
on the skin; dizziness or light-
Females: tell your doctor or
pharmacist if you are pregnant or
intend to become pregnant.
Like most cytotoxic medicines
carboplatin is not recommended for use
during pregnancy. If there is any need to
consider carboplatin during your
pregnancy, your doctor or pharmacist
will discuss the benefits and risks of
Males: tell your doctor or pharmacist
if your partner intends to become
pregnant while you are being given
carboplatin, or shortly after you have
stopped treatment with Carboplatin
Carboplatin may cause birth defects if
either the male or female is using it at the
time of conception. It is recommended
that you use some kind of birth control
while you are using carboplatin and for at
least 12 weeks after you stop treatment.
A barrier method of birth control, such as
a condom, should be used while you are
being given carboplatin and for the first
week of this 12 week period. Your doctor
will discuss this with you.
Do not breast-feed if you are being
treated with this medicine.
It is not known whether carboplatin
passes into breast milk and there is a
possibility that the breast-fed baby may
You must not be given this medicine if
you have any of the following
very low numbers of white blood
cells, red blood cells or platelets
severe kidney problems (your dose
may be reduced with some milder
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Tell your doctor if you have an
infection or high temperature.
Your doctor may decide to delay your
treatment until the infection has gone. A
mild illness, such as a cold, is not usually
a reason to delay treatment.
If you are not sure whether you should
be given this medicine, talk to your
Before you are given it
Tell your doctor if you have allergies to
any other medicines, foods,
preservatives or dyes.
Tell your doctor if you have any of the
following medical conditions:
condition of the blood with a reduced
number of red blood cells, white
blood cells, or platelets
bleeding problems or problems with
neurological problems (problems
with the nervous system)
herpes zoster infections (also known
chicken pox (now or recently), or if
you have been in recent contact with
someone who has chicken pox.
Tell your doctor if you have had
previous treatment with cisplatin.
If you have not told your doctor about
any of the above, tell him/her before
you are given carboplatin.
Taking other medicines
Tell your doctor or pharmacist if you
are taking or using any other
medicines, including any that you get
without a prescription from your
pharmacy, supermarket or health food
Some medicines and carboplatin may
interfere with each other. These include:
other medicines used to treat cancer
(such as paclitaxel and
therapy or any other treatment which
weakens your immune system
some antibiotics used to treat serious
aminoglycosides (such as
gentamicin, tobramycin or amikacin)
some vaccines (ask your doctor).
These medicines may be affected by
carboplatin, or may affect how well it
works. You may need different amounts
of your medicines, or you may need to
take or use different medicines.
Do not have any vaccinations
(immunisations) without your doctor’s
approval while you are being treated
Carboplatin Accord Injection
for up to 12 months after you stop
treatment with it.
Carboplatin may lower your body’s
resistance to infection and there is a
chance that you may get the infection the
immunisation is meant to prevent.
In addition, other people living in your
household should not take oral polio
vaccine (Sabin) since there is a chance
they could pass the polio virus on to you.
Your doctor and pharmacist have more
information on medicines to be careful
with or avoid while you are being given
How Carboplatin Accord
Injection is given
How much is given
Your doctor will decide what dose you
will receive. This depends on your
condition and other factors, such as your
weight, height, kidney function, blood
counts and other chemotherapy
medicines you are being given.
Carboplatin may be given alone or in
combination with other drugs.
Several courses of carboplatin therapy
may be needed depending on your
response to treatment.
Additional treatment may not be
repeated until your blood cell numbers
return to acceptable levels and any
unwanted effects have been controlled.
Ask your doctor if you want to know
more about the dose of carboplatin you
How it is given
Carboplatin Accord Injection is diluted in
a fluid bag and then given as an infusion
(drip) into your veins, over 15 to 60
minutes. It must only be given by a
doctor or nurse.
How long it is given
Carboplatin is usually given as a single
infusion on one day. This is called one
‘cycle’ of chemotherapy. A cycle is
usually repeated 4 weeks after the
previous cycle. Your doctor will decide
how many of these cycles you need.
If you receive too much
As carboplatin is given to you under
the supervision of your doctor, it is
very unlikely that you will receive an
overdose. However, if you experience
any side effects after being given
Carboplatin Accord injection tell your
doctor immediately or go to Accident
and Emergency at the nearest hospital
In case of overdose, immediately contact
the poisons information center for advice
(phone 13 11 26 in Australia or 0800 764
766 in New Zealand).
Symptoms of an overdose may include
the side effects listed below in the ‘Side
Effects’ section, but are usually of a more
Ask your doctor, nurse or pharmacist
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if you have any concerns.
While you are being
Things you must do
If you are about to be started on any
new medicine, remind your doctor and
pharmacist that you are being given
Tell any other doctors, dentists, and
pharmacists who treat you that you are
being given this medicine.
If you are going to have surgery, tell
the surgeon or anaesthetist you are
being given this medicine.
If you become pregnant while you are
being treated with this medicine, tell
your doctor immediately.
Keep all of your doctor’s appointments
so that your progress can be checked.
Your doctor may want to check your
blood pressure and do some blood,
hearing and other tests from time to time
to check on your progress and detect any
unwanted side effects.
Keep follow up appointments with
It is important to have your follow-up
cycles of carboplatin at the appropriate
times to get the best effects from your
Carboplatin can lower the number of
white blood cells and platelets in your
blood. This means that you have an
increased chance of getting an infection
or bleeding. The following precautions
should be taken to reduce your risk of
infection or bleeding:
avoid people with infections. Check
with your doctor immediately if you
think you are getting an infection, or
if you get a fever or chills, cough or
hoarseness, lower back or side pain,
or find it painful or difficult to
check with your doctor immediately
if you notice any unusual bleeding or
bruising, black stools, blood in urine
or stools or pinpoint red spots on
be careful when using a regular
toothbrush, dental floss or toothpick.
Your doctor or nurse may
recommend other ways to clean your
teeth and gums. Check with your
doctor before having any dental
be careful not to cut yourself when
you are using sharp objects such as a
safety razor or nail cutters;
avoid contact sports or other
situations where you may get bruised
Carboplatin and its breakdown products
may be excreted in body fluids and
waste, including blood, urine, faeces,
vomitus and semen. In general,
precautions to protect other people should
be taken while you are receiving
chemotherapy and for one week after the
Flush the toilet twice to dispose of
any body fluids and waste
Wear gloves to clean any spill of
body fluid or waste. Use paper
towels or old rags, a strong solution
of non-bleaching detergent and large
amounts of water to mop up the spill.
Discard the towels or rags into a
separate waste bag and dispose of
fluids in the toilet.
Wash linen or clothing that is heavily
contaminated by body fluids or
waste separately from other items.
Use a strong solution of non-
bleaching detergent and large
amounts of water.
Place soiled disposable nappies and
other pads in a plastic bag, seal and
dispose into the garbage.
For sexual intercourse, use a barrier
method such as a condom.
While you are being given carboplatin
your doctor should order regular tests to
check the number of blood cells in your
blood. The results of these tests will be
used to determine the amount of
carboplatin you will be given for your
Things to be careful of
Be careful driving or operating
machinery until you know how
carboplatin affects you.
This medicine may cause dizziness, light-
headedness, tiredness and drowsiness in
some people. If you have any of these
symptoms, do not drive, operate
machinery, or do anything else that could
Be careful when drinking alcohol while
you are taking this medicine.
If you drink alcohol, dizziness or light-
headedness may be worse.
Tell your doctor, pharmacist or nurse
as soon as possible if you do not feel
well while you are being treated with
Like other medicines, carboplatin may
have unwanted side effects, some of
which may be serious. You may need
medical attention if you get some of the
If you are over 65 years of age you may
have an increased chance of getting side
Ask your doctor or pharmacist to
answer any questions you may have.
Tell your doctor, pharmacist or nurse
if you notice any of the following and
they worry you:
mild nausea or vomiting
diarrhoea or constipation
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weakness, tiredness or fatigue
sore muscles or joints
pain or irritation at the injection site
The above list includes the more common
side effects of this medicine. They are
usually mild and short-lived. Temporary
loss of hair, particularly that on the scalp
is a less common but upsetting side effect
of carboplatin and occurs in a small
number of patients (about 2 patients per
100 treated). The severity of hair loss will
depend on the dose of carboplatin given.
It is more common when other anticancer
medicines are used together with
Tell your doctor or nurse as soon as
possible if you notice any of the
muscle irritability or cramps
blurred vision or other visual
tingling in the fingers or toes
flaking or peeling of the skin, rash or
The above list includes serious side
effects which may require medical
If any of the following happen, tell
your doctor or nurse immediately or
go to Accident and Emergency at your
signs of an allergic reaction (such as
shortness of breath, wheezing or
difficulty breathing; swelling of the
face, lips, tongue or other parts of the
body; rash, itching or hives on the
skin; dizziness or light-headedness)
signs of infection, such as fever,
chills, sore throat or mouth ulcers
shortness of breath
unusual bleeding or bruising
problems with urination e.g. pain or
yellowing of the skin or eyeballs
severe nausea and vomiting
a feeling of tightness, pressure or
heaviness in the chest.
The above list includes very serious side
effects. You may need urgent medical
attention or hospitalisation.
Tell your doctor, nurse or pharmacist
if you notice anything that is making
you feel unwell.
Other side effects not listed above may
also occur in some people. Some of these
side effects can only be found when your
doctor does tests from time to time to
check your progress.
The benefits and side effects of
carboplatin may take some time to occur.
Therefore, even after you have finished
receiving your carboplatin treatment you
should tell your doctor immediately if
you notice any of the side effects listed
Carboplatin Injection will be stored in the
pharmacy or on the ward. The injection is
kept in a cool dry place, protected from
light, where the temperature stays below
What it looks like
Carboplatin Accord Injection is a clear
colourless solution which will be diluted
in a fluid bag and given as an infusion
(‘drip’). It is available in 3 presentations;
50 mg/5 mL, 150 mg/15 mL and
450 mg/45 mL in single packs.
Carboplatin Accord Injection contains
carboplatin as the active ingredient. It
also contains water for injections.
This medicine does not contain lactose,
sucrose, gluten, tartrazine or any other
Name and Address of the
Accord Healthcare Pty Ltd
Level 24, 570 Bourke Street
Melbourne, VIC, 3000
Australian Registration Numbers
50 mg/5 mL: AUST R 215852
150 mg/15 mL: AUST R 215853
450 mg/45 mL: AUST R 215854
Date of Preparation
This leaflet was prepared on 27 January