BROWN SNAKE ANTIVENOM

Main information

  • Trade name:
  • BROWN SNAKE ANTIVENOM
  • Class:
  • Veterinary Medicine
  • Medicine domain:
  • Animals
  • Medicine type:
  • Allopathic drug

Documents

Localization

  • Available in:
  • BROWN SNAKE ANTIVENOM
    Australia
  • Language:
  • English

Therapeutic information

  • Therapeutic group:
  • CAT | DOG | HORSE | BITCH | CASTRATE | CAT - QUEEN | CAT - TOM | COLT | DONKEY | ENDURANCE HORSE | FILLY | FOAL | GELDING | HIGH
  • Therapeutic area:
  • IMMUNOTHERAPY
  • Therapeutic indications:
  • BROWN SNAKE BITE - PSEUDONAJA TEXTILIS

Other information

Status

  • Source:
  • Australian Pesticides and Veterinary Medicines Authority (APVMA)
  • Authorization status:
  • Registered
  • Authorization number:
  • 36588
  • Last update:
  • 09-08-2016

Patient Information leaflet: composition, indications, side effects, dosage, interactions, adverse reactions, pregnancy, lactation

PRODUCT NAME: Brown Snake Antivenom

PAGE: 1 OF 8

DESCRIPTION: Carton, Label, Leaflet

APVMA FILE NO:36588

PRODUCT CODES: C05592301, 05592300, 00629800

VERSIONS:H, G, F

NOTES: carton, label and leaflet

DATE:11/10/2004

Textcontained above this line does not appear on labelling

Carton

Info

pest

Main Panel: 9

Verified

FOR ANIMAL TREATMENT ONLY

Brown Snake Antivenom

Contains not more than 170 mg/mL equine plasma protein

(500 units brown snake antivenom)

500 Units 2.2 mg/mL Phenol added

For the treatment of brown snake (Pseudonaja textilis) bite in dogs, cats and

horses.

Pfizer

Side Panel 1:READ THE ENCLOSED LEAFLET BEFORE USING THIS PRODUCT

To be used by, or under the direct supervision of, a registered veterinary surgeon

DIRECTIONS FOR USE

Contents must be left in outer package until immediately before use

Dose: Read enclosed leaflet

Any portion of contents remaining should be discarded

WITHHOLDING PERIODS NIL

Side Panel 2:Disposal:Dispose of empty container bywrapping with paper and putting in

garbage. Discarded needles should immediately be placed in a designated and

appropriately labelled ’sharps‘ container.

Store between 2 o

C and 8 o

C (Refrigerate. Do not freeze). Protect from light.

(B)7559-

EXP.

mth/yr mL

(item numbers and version)

PRODUCT NAME: Brown Snake Antivenom

PAGE: 2 OF 8

DESCRIPTION: Carton, Label, Leaflet

APVMA FILE NO:36588

PRODUCT CODES: C05592301, 05592300, 00629800

VERSIONS:H, G, F

NOTES: carton, label and leaflet

DATE:11/10/2004

Textcontained above this line does not appear on labelling

Side Panel 3:Pfizer Animal Health

A division of Pfizer Australia Pty Ltd

38-42 Wharf Road

West Ryde NSW 2114

AUSTRALIA

Australian Technical Services Toll Free 1800 814 883

APVMA 36588/1004 Recycle Logo

Top Flap: Brown Snake Antivenom

500 units

Carton Base:Barcode

PRODUCT NAME: Brown Snake Antivenom

PAGE: 3 OF 8

DESCRIPTION: Carton, Label, Leaflet

APVMA FILE NO:36588

PRODUCT CODES: C05592301, 05592300, 00629800

VERSIONS:H, G, F

NOTES: carton, label and leaflet

DATE:11/10/2004

Textcontained above this line does not appear on labelling

stamped)

(B) 7559-

Label

FOR ANIMAL TREATMENT ONLY

500 units Brown Snake Antivenom

SEE ENCLOSED LEAFLET

WHPS NIL

Store at 2 o C to 8 o C (Refrigerate.

Do not freeze). Protect from light.

Pfizer APVMA36588/1004

PRODUCT NAME: Brown Snake Antivenom

PAGE: 4 OF 8

DESCRIPTION: Carton, Label, Leaflet

APVMA FILE NO:36588

PRODUCT CODES: C05592301, 05592300, 00629800

VERSIONS:H, G, F

NOTES: carton, label and leaflet

DATE:11/10/2004

Textcontained above this line does not appear on labelling

Leaflet

FOR ANIMAL TREATMENT ONLY

VETERINARY SNAKE ANTIVENOMS

To be used by, or under the direct supervision of, a registered veterinary surgeon.

TIGER-BROWN SNAKE COMBINED ANTIVENOM

BROWN SNAKE ANTIVENOM

Snake Antivenoms are refined preparations of plasma from appropriately immunised horses. Each

antivenom contains not more than 170 mg/mL of equine plasma protein consisting of concentrated

globulins or their derivatives which specificallyneutralise toxic substancesin the venoms, i.e.Tiger-

Brown Snake Combined Antivenomneutralises the toxins of tiger snake (Notechis scutatus), and

brown snake (Pseudonaja textilis),Brown Snake Antivenom, neutralises the toxins of brown snake.

Antivenoms are standardisedso that each vial ofTiger-Brown Snake Combined Antivenom

contains 3000 units of tiger snake antivenom and1000 units of brown snake antivenom, which is

sufficient to neutralise 30 mg of tiger snake venomand 10 mg of brown snake venom. Each vial of

Brown Snake Antivenomcontains 500 units of brown snake antivenom, which is sufficient to

neutralise 5 mgof brown snake venom. The lethal dose of tiger snake venom for the dog and cat is

0.03 mg/kg and 0.1 mg/kg respectively and for brown snake venom is 0.08 mg/kg and 0.1 mg/kg

respectively.

The amountofantivenomrequired fortreatmentwill depend on the likely amount of venom injected by

the snake. This in turn depends on the size of the snake, the number of strikes, the effectiveness of

the strikes, and the fullness of the venom glands.

Tiger snake antivenom will also neutralise the venom of a number of other snakes e.g. black snake

(Pseudechis porphyriacus)and copperhead (Austrelapssuperbus)See table 2.

INDICATIONS FOR USE

Antivenom should be administered as soon as signsof envenomation are observed. In domestic

animals it is usual that signs have developed before presentation to the veterinarian.

DIAGNOSIS OF SNAKEBITE

Diagnosis is usually based on clinical signs orknown encounter with a snake. The snake may be

positively identified or, venom inplasma or urine may be identifiedby using a Snake Venom Detection

Kit.

SIGNS OF ENVENOMATION

Animals may present with a diversity of clinical signs. Onset is usually suddenwith collapse or vomiting

within minutes of being bitten. Recovery may occurwithin 30 minutes to be followed by a progressive

onset of clinical signs. Any or all of the followingsigns may be observed; weakness, ataxia or flaccid

paralysis, dilated pupils, respiratory distress, abdominal breathing, vomiting, agitation, trembling and

salivation. Blood may fail to clot and bleeding timebe extended. Haemolysis and haemoglobinuria or

myoglobinuria may be observed.

PRODUCT NAME: Brown Snake Antivenom

PAGE: 5 OF 8

DESCRIPTION: Carton, Label, Leaflet

APVMA FILE NO:36588

PRODUCT CODES: C05592301, 05592300, 00629800

VERSIONS:H, G, F

NOTES: carton, label and leaflet

DATE:11/10/2004

Textcontained above this line does not appear on labelling

Flaccid paralysis may progress torespiratory paralysis or coma.

Signs may vary depending on the species bitten and theidentity of the snake as shown. (Table1).

TABLE I Comparative Frequency of Commonly Observed signs of Snake Bite in Animals.

Snake specified - all animals

Animal specified - all snakes

Tiger

Brown

Black

Copper-

head

Dogs

Cats

Horses

Cattle

Sudden collapse soon

after bite, temporary

recovery then relapse

+

++

+

++

+

Neurological signs

weakness, ataxia,

flaccid paralysis

++++

++++

++++

++++

++++

++++

++++

++++

Excitement, trembling,

salivation, vomiting,

defecation, muscle

spasm

+++

+++

+++

+++

+++

++

+++

+

Pupils dilated, pupillary

light reflex slow or

absent

++++

+++

+++

+++

+++

++++

+++

+++

Local swelling

+

+

+++

++

++

++

+

Haemoglobinuria,

myoglobinuria or

jaundice

++

+

+

++

+

Non-clotting blood,

extended coagulation

time, continuous

haemorrhage from

wounds, haematemesis

and haematuria

++

++

++

++

++

++

++

Key: + = 1 to 10%, ++ = 11-30%, +++ = 31 to 75%, ++++ = 76 to 100% of cases reported

PRODUCT NAME: Brown Snake Antivenom

PAGE: 6 OF 8

DESCRIPTION: Carton, Label, Leaflet

APVMA FILE NO:36588

PRODUCT CODES: C05592301, 05592300, 00629800

VERSIONS:H, G, F

NOTES: carton, label and leaflet

DATE:11/10/2004

Textcontained above this line does not appear on labelling

DIRECTIONS FOR USE

ANTIVENOM CHOICE

Choice of the appropriate antivenom where the snake has been identified is given in Table 2.Tiger-

Brown Snake Combined Antivenommay be used wherever monovalent tiger snake antivenom or

monovalent brown snake antivenom are indicated. Where the identity of the snake is unknown the

recommended veterinary antivenom is listed in Table 3. Polyvalent Snake Antivenom is also

appropriate in all states where several venomous species are found.

Note: Brown Snake Antivenom contains 500 unitsof brown snake antivenom, sufficient to

neutralise 5 mg of brown snake venom. Additional antivenom maybe required if signs of

envenomation are not reversed following infusion of the recommended initial dose.

TABLE 2 Initial Antivenom Dosage when Snake has been Identified

SNAKE

APPROPRIATE ANTIVENOM AND INITIAL DOSE

Common Black Snake

Tiger Snake Antivenom or 3000 units

Black Snake Antivenom 6000 units

Common Brown Snake

Dugite

Gwardar

Brown Snake Antivenom 500 - 1000 units

Copperhead

Tiger Snake Antivenom 3000 units*

Death Adder

Death Adder Antivenom 6000 units

Mulga (King Brown Snake)

Black Snake Antivenom or 18000 units

Tiger Snake Antivenom 18000 units

Rough-Scaled (Clarence River) Snake

Tiger Snake Antivenom 3000 units

Small-eyed Snake

Tiger Snake Antivenom 3000 units

Whipsnake

Tiger Snake Antivenom 3000 units

Small-Scaled or Fierce Snake

Taipan Antivenom 12000 units

Taipan

Taipan Antivenom 12000 units

Tiger Snake

Tasmanian Tiger Snake

Chappell Island Black Tiger Snake

Tiger Snake Antivenom 3000 units

“ 6000 units

“ 12000 units

Australian Sea Snake

Sea Snake Antivenom 1000 units

* Tasmania 6000 units

PRODUCT NAME: Brown Snake Antivenom

PAGE: 7 OF 8

DESCRIPTION: Carton, Label, Leaflet

APVMA FILE NO:36588

PRODUCT CODES: C05592301, 05592300, 00629800

VERSIONS:H, G, F

NOTES: carton, label and leaflet

DATE:11/10/2004

Textcontained above this line does not appear on labelling

TABLE 3 Choice of Antivenom and Dosage whenthe Identity of the Snake is Uncertain

State

Recommended Antivenom for Veterinary Use

Initial Dose (Units)

Tasmania

Tiger Snake

6000

Victoria

Tiger-Brown Snake Combined Antivenom

Contents of one container

N.S.W.

S.A.

W.A.

N.T.

Tiger-Brown Snake Combined Antivenom

+

Death Adder

Contents of one container

6000

Qld. - Sth of Rockhampton

Tiger-Brown Snake Combined Antivenom

+

Death Adder

Contents of one container

6000

Qld. - Nth of Rockhampton

Brown Snake

+

Death Adder

500 - 1000

6000

ADMINISTRATION OF ANTIVENOM

Route of Injection

Antivenom should, whenever possible, be diluted 1 in 10 in an appropriate infusion fluid, (e.g.

Hartmann’s Solution) and infused slowly by the intravenous route (See Precautions in Administration

ofAntivenom).Absorption fromthe subcutaneous or intramuscular routes is too slow as it may take 12

hours for 30-40% of the antivenom toreach the circulation and 24 hours for 50% to be absorbed. If

signs ofenvenomation further develop, or persist, additional antivenom should be given intravenously.

PRECAUTIONS IN ADMINISTRATION OF ANTIVENOM

Antivenoms may bind complement and produce an anaphylactic-like reaction. This reaction can be

reduced by dilution of antivenom 1 to 10in Hartmann’s Solution prior to use.

Antivenom, appropriately diluted,should be administered by slowintravenous infusion over a 30

minute period. Syringes loaded with adrenaline (1:1000 or 1:10000, depending on animal species),

antihistamine and steroids should be at hand.

Before infusion the patient should receive anappropriate dose of parenteral, non-sedative

antihistamine. A small prophylactic dose ofadrenaline subcutaneously is also advisable.

Administration of antivenom should cease if urticaria,cough or a decrease in pulse pressure develop.

Adrenaline, antihistamine and steroid should be administered. Administration of antivenom should

recommence when signs have reversed.

WITHHOLDING PERIODS NIL

FIRST AID

If poisoning occurs, contact a doctor or PoisonsInformation Centre. Phone Australia 131126.

STORAGE OF ANTIVENOMS

Store between 2 o

C and 8 o

C (Refrigerate. Do not freeze). Protect from light.

PRODUCT NAME: Brown Snake Antivenom

PAGE: 8 OF 8

DESCRIPTION: Carton, Label, Leaflet

APVMA FILE NO:36588

PRODUCT CODES: C05592301, 05592300, 00629800

VERSIONS:H, G, F

NOTES: carton, label and leaflet

DATE:11/10/2004

Textcontained above this line does not appear on labelling

DISPOSAL

Dispose of empty containers,outer packaging or expired product by wrapping with paper and

putting in garbage.

RECORD OF CASES

Veterinary Practitioners can assist our effortsto improve recommended procedures for treatment

of snakebite by reporting any cases of snakebite treated by them, including the results or

treatment, to Pfizer Animal Health.

REFERENCES

Gallichio HA and Lewis PF. Immunisation of thedog with the toxoids of Australian Tiger Snake

(Notechis scutatus) and Brown Snake (Pseudonaja textilis) venoms 1979. Unpublished papers.

Lewis PF, Snakebite in Animals in Australia. InUniversity of Sydney Post Graduate Committee in

Veterinary Science (Proceedings No. 36) Fauna 1978:287-309.

Sutherland SK Australian Venoms. In Universityof Sydney Post Graduate Committee in Veterinary

Science (Proceedings No. 103) Veterinary Clinical toxicology 1987:227-251.

Australian Technical Services Toll Free 1800 814 883

www.pfizeranimalhealth.com.au

Tiger-Brown Snake Combined AntivenomAPVMA 46282/1004

Brown Snake Antivenom APVMA 36588/1004

(Item numbers and version) (Recycle logo) October 2004

Pfizer Animal Health ABN 50 008 422 348

A division of Pfizer Australia Pty Ltd

38-42 Wharf Road West Ryde NSW 2114 AUSTRALIA

Document Outline

There are no safety alerts related to this product.

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