AKNEMYCIN PLUS SOLUTION
Country: Singapore
Language: English
Source: HSA (Health Sciences Authority)
Patient Information leaflet
(PIL)
10-11-2009
Summary of Product characteristics
(SPC)
27-12-2019
Active ingredient:
ERYTHROMYCIN; TRETINOIN
Available from:
ZUELLIG PHARMA PTE. LTD.
ATC code:
D10AF52
Dosage:
4 g/100 g
Pharmaceutical form:
SOLUTION
Composition:
ERYTHROMYCIN 4 g/100 g; TRETINOIN 0.025 g/100 g
Administration route:
TOPICAL
Prescription type:
Prescription Only
Manufactured by:
ALMIRALL HERMAL GmbH
Authorization status:
ACTIVE
Authorization date:
2000-02-04
Patient Information leaflet
AKNEMYCIN® PLUS
SOLUTION
COMPOSITION
100g of solution contains erythromycin 4.0g and tretinoin 0.025g.
PHARMACOLOGY
Erythromycin has an antibacterial effect against Propionibacterium acnes, a skin bacterium
which is responsible in the pathogenesis of acne. Erythromycin penetrates the sebaceous gland
ducts following topical application, and has a bacteriostatic effect there.
Tretinoin (vitamin A acid) is a deep-acting keratolytic agent. It causes comedolysis and reduction
in size of the sebaceous glands.
INDICATIONS
All forms of acne, both non-inflammatory forms with comedones and inflammatory forms with
papules and pustules, particularly in the case of fat-rich skin.
DOSAGE AND ADMINISTRATION
Aknemycin Plus is applied directly to the skin from the special applicator bottle. Apply the
solution once or twice daily to the affected skin after washing, unless otherwise directed by
your doctor.
The duration of use depends on the condition of the skin and should not exceed 12 weeks.
CONTRAINDICATIONS
Aknemycin Plus should not be given to patients who are sensitive to erythromycin or tretinoin.
It should not be given to patients with acute eczema, rosacea, or acute skin inflammations,
particularly in the mouth region (perioral dermatitis).
It should not be given to patients with a family history of cutaneous epithelioma.
DRUG INTERACTIONS
The simultaneous administration of other skin preparations should be avoided, as this could
aggravate irritations to the skin.
Most significant incompatibilities with light, oxidising agents.
PRECAUTIONS / WARNINGS
Aknemycin Plus may not be applied in the immediate vicinity of the lips and nostrils.
Avoid contact with eyes.
UV rays (sunlight, sunray lamps, solarium), X-rays and bathing in chlorinated or salt water may
aggravate the skin
Read the complete document
Summary of Product characteristics
AKNEMYCIN® PLUS
SOLUTION
COMPOSITION
100g of solution contains erythromycin 4.0g and tretinoin 0.025g.
PHARMACOLOGY
Erythromycin has an antibacterial effect against Propionibacterium
acnes, a skin bacterium
which is responsible in the pathogenesis of acne. Erythromycin
penetrates the sebaceous gland
ducts following topical application, and has a bacteriostatic effect
there.
Tretinoin (vitamin A acid) is a deep-acting keratolytic agent. It
causes comedolysis and reduction
in size of the sebaceous glands.
INDICATIONS
All forms of acne, both non-inflammatory forms with comedones and
inflammatory forms with
papules and pustules, particularly in the case of fat-rich skin.
DOSAGE AND ADMINISTRATION
Aknemycin Plus is applied directly to the skin from the special
applicator bottle. Apply the
solution once or twice daily to the affected skin after washing,
unless otherwise directed by
your doctor.
The duration of use depends on the condition of the skin and should
not exceed 12 weeks.
CONTRAINDICATIONS
Aknemycin Plus should not be given to patients who are sensitive to
erythromycin or tretinoin.
It should not be given to patients with acute eczema, rosacea, or
acute skin inflammations,
particularly in the mouth region (perioral dermatitis).
It should not be given to patients with a family history of cutaneous
epithelioma.
Pregnancy and women planning a pregnancy.
DRUG INTERACTIONS
The simultaneous administration of other skin preparations should be
avoided, as this could
aggravate irritations to the skin.
Most significant incompatibilities with light, oxidising agents.
PRECAUTIONS / WARNINGS
Aknemycin Plus may not be applied in the immediate vicinity of the
lips and nostrils.
Avoid contact with eyes.
UV rays (sunlight, sunray lamps, solarium), X-rays and bathing in
chlorinated or salt water may
aggravate the skin irritations described under “Side effects”.
Sunburn should be allowed to heal
before applying Aknemycin Plus. Wind and rain may be unusually
irritating to patients under
treatment.
Use in pregnancy and lacta
Read the complete document
