Adrenaline Injection BP 1 in 1000
Country: New Zealand
Language: English
Source: Medsafe (Medicines Safety Authority)
Summary of Product characteristics
(SPC)
05-09-2017
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Active ingredient:
Adrenaline acid tartrate 1.8 mg/mL equivalent to 1 mg/ml adrenaline;
Available from:
Max Health Limited
INN (International Name):
Adrenaline acid tartrate 1.8 mg/mL (= 1 mg/ml adrenaline)
Dosage:
1 mg/mL
Pharmaceutical form:
Solution for injection
Composition:
Active: Adrenaline acid tartrate 1.8 mg/mL equivalent to 1 mg/ml adrenaline Excipient: Hydrochloric acid Sodium chloride Sodium hydroxide Sodium metabisulfite Water for injection
Units in package:
Ampoule, glass, 5 x 1ml, 5 dose units
Class:
Restricted
Prescription type:
Restricted
Manufactured by:
Halewood Chemicals Ltd
Product summary:
Package - Contents - Shelf Life: Ampoule, glass, 5 x 1ml - 5 dose units - 18 months from date of manufacture stored at or below 25°C protect from light - Ampoule, glass, 50 x 1ml - 50 dose units - 18 months from date of manufacture stored at or below 25°C protect from light
Authorization date:
1989-02-09
Summary of Product characteristics
ADRENALINE ACID TARTRATE INJECTION
1:1 000 (1 mg/mL)
PRESENTATION
Adrenaline injection contains no antimicrobial agent. It should be
used only once and any
residue discarded. It is a clear, colourless solution and should not
be used if it is coloured.
ADRENALINE 1:1000
Adrenaline acid tartrate equivalent to adrenaline 1:1000 (1 mg/1 mL)
with sodium metabisulfite
and sodium chloride in Water for Injections BP; Sodium hydroxide or
hydrochloric acid is used
for pH adjustment, pH 2.8 to 3.6.
USES
ACTIONS
Adrenaline acts on both alpha and beta adrenergic receptors of tissues
innervated by
sympathetic nerves, except the sweat glands and arteries of the face.
It is the most potent
alpha receptor activator. Adrenaline stimulates the heart to increased
output; raises the
systolic
blood pressure;
lowers
diastolic
blood
pressure;
relaxes bronchial
spasm and
mobilises liver glycogen, resulting in hyperglycaemia and possibly
glycosuria.
PHARMACOKINETICS
Parentally administered adrenaline has a rapid onset and short
duration of action. The
circulating drug is metabolised by the liver and other tissues. The
majority is taken up and
metabolised by sympathetic nerve endings. Adrenaline is excreted in
the urine, mainly in the
form of metabolites.
Adrenaline crosses the placenta but not the blood-brain barrier. It is
also distributed into breast
milk (see USE IN PREGNANCY and USE IN LACTATION).
INDICATIONS
ADRENALINE 1:10,000 is used as an adjunct in the management of cardiac
arrest.
ADRENALINE 1:1,000 is the drug of choice in the emergency treatment of
acute severe
anaphylactic reactions due to insect bites, drugs and other allergens.
It may also be used for
the symptomatic relief of respiratory distress due to bronchospasm.
DOSAGE AND ADMINISTRATION
The 1:1,000 (1 mg/1 mL) injection is preferably administered
subcutaneously. It may also be
administered intramuscularly but not in the buttocks.
In emergency situations, adrenaline may be injected very slowly
intravenously but ONLY as the
dilute solution 1:10,000.
Adrenaline injectio
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