EXETICK TICK AND FLEA SPOT-ON FOR DOGS AND PUPPIES

Australia - English - APVMA (Australian Pesticides and Veterinary Medicines Authority)

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Active ingredient:
PERMETHRIN (40:60::CIS:TRANS)
Available from:
Intervet Australia Pty Limited
INN (International Name):
permethrin 40:60(650g/L)
Pharmaceutical form:
TOPICAL SOLUTION/SUSPENSION
Composition:
PERMETHRIN (40:60::CIS:TRANS) PYRETHROID Active 650.0 g/L
Units in package:
#6x1mL; #tubes; $3x1mL; $tubes; %6x6x1mL; %tube; ^6x3x1mL; ^tubes
Class:
VP - Veterinary Pesticide
Manufactured by:
INTERVET AUSTRALIA
Therapeutic group:
DOG | DOG - PUPPY | BITCH | CASTRATE | PUPPY
Therapeutic area:
PARASITICIDES
Therapeutic indications:
BROWN DOG TICK | CAT FLEA | DOG FLEA | PARALYSIS TICK | AUSTRALIAN PARALYSIS TICK | DOG TICK | SCRUB TICK
Product summary:
Poison schedule: 6; Withholding period: WHP: N/A; Host/pest details: DOG: [BROWN DOG TICK, CAT FLEA, DOG FLEA, PARALYSIS TICK]; DOG - PUPPY: [BROWN DOG TICK, CAT FLEA, DOG FLEA, PARALYSIS TICK]; Poison schedule: 6; Withholding period: ; Host/pest details: DOG: [BROWN DOG TICK, CAT FLEA, DOG FLEA, PARALYSIS TICK]; DOG - PUPPY: [BROWN DOG TICK, CAT FLEA, DOG FLEA, PARALYSIS TICK]; Aids in the control of fleas on dogs for up to 4 weeks. Aids in the control of ticks on dogs for up to 2 weeks.DO NOT use on cats. This product is TOXIC TO CATS. Also see PRECAUTIONS on label.
Authorization status:
Registered
Authorization number:
52709
Authorization date:
2020-07-01

File Name: Exetick RLP Text Label V4–CC – 19

Dec 12

Prepared By:

L. Wirth

Preparation Date:

3/8/2011

Last Revised:

11/12/2012

Intervet/MSD Animal Health Label

& Printer Specifications:

PPC TBD

Version:

(19/12/2012)

Page 1 of 6

PRIMARY PACKS – CARTONS 3x1mL [6x1mL, 6x3x1mL, 6x6x1mL] TEXT

EXETICK SPOT-ON

MAIN PANEL

Text above line and in label footer not part of label text

POISON

KEEP OUT OF REACH OF CHILDREN

READ SAFETY DIRECTIONS BEFORE OPENING OR USING

FOR ANIMAL TREATMENT ONLY

DOG PICTURE

DOG PICTURE

DOG PICTURE

DOG PICTURE

EXETICK

®

Tick and flea spot-on

for dogs and puppies

ACTIVE CONSTITUENT:

650 g/L PERMETHRIN 40:60 (CIS:TRANS RATIO)

X

[CAT PICTURE]

TOXIC

TO CATS

[DOG PICTURE]

USE ON

DOGS

Aids in the control of fleas (Ctenocephalides canis,

Ctenocephalides felis) on dogs for up to 4 weeks.

Aids in the control of ticks (Rhipicephalus sanguineus, Ixodes

holocyclus) on dogs for up to 2 weeks.

3x1mL [6x1mL, 6x3x1mL, 6x6x1mL] Pipettes

COOPERS LOGO

RLP

APPROVED

File Name: Exetick RLP Text Label V4–CC – 19

Dec 12

Prepared By:

L. Wirth

Preparation Date:

3/8/2011

Last Revised:

11/12/2012

Intervet/MSD Animal Health Label

& Printer Specifications:

PPC TBD

Version:

(19/12/2012)

Page 2 of 6

PRIMARY PACKS – CARTONS 3x1mL [6x1mL, 6x3x1mL, 6x6x1mL] TEXT

EXETICK SPOT-ON

OTHER PANELS

Text above line and in label footer not part of label text

EXETICK

®

Tick and flea spot-on for dogs and puppies

THIS

PRODUCT

IS

PART

OF

A

TOTAL

FLEA

CONTROL

PROGRAMME:

Keeping your pet free from fleas means treating both the animal and its environment.

Products are available to control fleas and the flea eggs on the animal, in pets’

bedding and in the house. Your veterinary surgeon can advise you on which

products best meet your needs.

DIRECTIONS FOR USE:

Restraints

DO NOT USE on cats. This product is TOXIC TO CATS.

X

[CAT PICTURE]

TOXIC

TO CATS

[DOG PICTURE]

USE ON

DOGS

Keep cats separated from recently treated dogs.

There are reports of toxic effects in cats which groom or contact dogs treated

48 hours earlier.

Toxic effects include behaviour changes, drooling, tremors and death.

Seek veterinary advice immediately if you suspect toxicity in a cat.

Precautions

Wetting by rain or swimming may reduce the effective protection period of

EXETICK.

EXETICK is an effective and easy to use product. EXETICK demonstrates greater

than 95% control within 3 days of application. EXETICK is not an organophosphate

and is not contraindicated for use with other drugs and pesticides. EXETICK has

been shown to have a wide margin of safety in dogs and may be used on any age or

breed of dog. EXETICK may be used during pregnancy and lactation. As with all

flea and tick control products, EXETICK should be used as part of a control

programme aimed at reducing flea and tick populations in the dog’s environment. All

dogs in the household should be treated with EXETICK at the same time. Cats

should also be treated with a flea control product (not EXETICK). Bedding should

washed

and treated

with

suitable product

regularly.

Areas

likely

to be

contaminated with flea eggs or larvae should be cleaned.

paralysis

tick

areas

daily

searching

removal

paralysis

ticks

(Ixodes

holocyclus) is recommended.

File Name: Exetick RLP Text Label V4–CC – 19

Dec 12

Prepared By:

L. Wirth

Preparation Date:

3/8/2011

Last Revised:

11/12/2012

Intervet/MSD Animal Health Label

& Printer Specifications:

PPC TBD

Version:

(19/12/2012)

Page 3 of 6

PRIMARY PACKS – CARTONS 3x1mL [6x1mL, 6x3x1mL, 6x6x1mL] TEXT

EXETICK SPOT-ON

OTHER PANELS (continued)

Text above line and in label footer not part of label text

DOSAGE AND ADMINISTRATION:

Dogs 15kg bodyweight and under: Apply the contents of one tube (1mL) of EXETICK on

the back of the dog between the shoulder blades.

Dogs greater than 15kg bodyweight: Use two tubes. Apply the contents of one tube

(1mL) on the back of the dog between the shoulder blades. The contents of the second tube

(1mL) should be applied to the back over the base of the tail.

Application

For spot-on use.

Open one sachet and remove the pipette.

Step 1: The dog should be standing for easy application. With

one hand, hold pipette in an upright position away from your

face and snap tip open by bending it and folding it back on

itself.

Step 2: Part the hair until the skin is visible and place pipette

tip against the skin between the shoulder blades.

Step 3 (small dogs): Squeeze pipette firmly applying the entire

contents directly to the skin.

Step 3 (larger dogs): Apply the entire contents of the pipette

evenly to two spots, both located at different application sites

along the backline from the shoulder to the base of the tail.

NOT TO BE USED FOR ANY PURPOSE OR IN ANY MANNER CONTRARY TO

THIS LABEL UNLESS AUTHORISED UNDER APPROPRIATE LEGISLATION.

SAFETY DIRECTIONS: Will irritate the eyes and skin. Avoid contact with eyes

and skin. Wash hands after use.

File Name: Exetick RLP Text Label V4–CC – 19

Dec 12

Prepared By:

L. Wirth

Preparation Date:

3/8/2011

Last Revised:

11/12/2012

Intervet/MSD Animal Health Label

& Printer Specifications:

PPC TBD

Version:

(19/12/2012)

Page 4 of 6

PRIMARY PACKS – CARTONS 3x1mL [6x1mL, 6x3x1mL, 6x6x1mL] TEXT

EXETICK SPOT-ON

OTHER PANELS (continued)

Text above line and in label footer not part of label text

FIRST AID: If poisoning occurs, contact a doctor or Poisons Information

Centre (Phone Australia 131126).

Additional information is in the Material Safety Data Sheet.

PROTECTION OF WILDLIFE, FISH, CRUSTACEA AND ENVIRONMENT: Harmful

to fish. Do not contaminate dams, waterways or drains with chemical or used

containers. Do not allow solution to contact food or food utensils.

DISPOSAL: Dispose of empty container by wrapping with paper and putting in

garbage.

STORAGE: Store below 30

C (Room Temperature) in a cool, dry, well-ventilated

area. Do not store for prolonged periods in direct sunlight. Store pipettes in the

unopened sachets until ready to use.

APVMA Approval No. 52709/54487

REFER TO BATCH AND EXPIRY ON SIDE [BOTTOM/TOP] PANEL.

For further information contact MSD Animal Health Customer Service on 1800

033 461.

Warranty

Intervet Australia Pty Ltd (IAPL), known as MSD Animal Health warrants that this

product is of merchantable quality and fit for its intended purpose. IAPL’s liability for

any loss, including consequential losses or injury caused by any act or omission,

including negligent acts or omissions, by IAPL or its agent, is limited to replacing or

repairing the product at the option of IAPL. If possible, a sample of any product

causing concern should be retained or delivered to IAPL within 30 days for a scientific

examination.

Intervet Australia Pty Limited

(MSD Animal Health)

91-105 Harpin Street, Bendigo East VIC 3550

® Registered Trademark © 2012

File Name: Exetick RLP Text Label V4–CC – 19

Dec 12

Prepared By:

L. Wirth

Preparation Date:

3/8/2011

Last Revised:

11/12/2012

Intervet/MSD Animal Health Label

& Printer Specifications:

PPC TBD

Version:

(19/12/2012)

Page 5 of 6

IMMEDIATE CONTAINER - FOIL SACHET TEXT

EXETICK SPOT-ON

Text above line and in label footer not part of label text

POISON

FOR ANIMAL TREATMENT ONLY

Exetick

Tick and flea spot-on

for dogs and puppies

650 g/L PERMETHRIN 40:60

TOXIC TO CATS

1mL

B. xxxxx Exp. xxxxx

File Name: Exetick RLP Text Label V4–CC – 19

Dec 12

Prepared By:

L. Wirth

Preparation Date:

3/8/2011

Last Revised:

11/12/2012

Intervet/MSD Animal Health Label

& Printer Specifications:

PPC TBD

Version:

(19/12/2012)

Page 6 of 6

IMMEDIATE CONTAINER – PIPETTE TEXT

EXETICK SPOT-ON

Text above line and in label footer not part of label text

650 g/L PERMETHRIN 40:60

TOXIC TO CATS 1mL

B. xxxxx Exp. xxxxx

POISON FOR ANIMAL TREATMENT ONLY

Exetick

Tick and flea spot-on

for dogs and puppies

Product Name: Exetick Tick and Flea Spot-on for Dogs and

Puppies

MATERIAL SAFETY DATA SHEET

This revision issued: May, 2011

Page: 1 of 7

MATERIAL SAFETY DATA SHEET

Issued by: Intervet Australia Pty Limited Phone: 1 800 033 461 (Business Hours)

Poisons Information Centre: 13 11 26 from anywhere in Australia, (0800 764 766 in New Zealand)

Chemical nature:

Permethrin in a suitable solvent.

Trade Name:

Exetick Tick and Flea Spot-on for Dogs and Puppies

Recommended Use:

Aids in the control of fleas and ticks on dogs as advised on registered label.

APVMA No:

52709

Creation Date:

May, 2011

This version issued:

May, 2011

and is valid for 5 years from this date.

Statement of Hazardous Nature:

This product is classified as:

Xn, Harmful. Xi, Irritating. N, Dangerous to the environment. F, Flammable.

Hazardous according to the criteria of SWA.

Dangerous according to the Australian Dangerous Goods (ADG) Code.

Risk Phrases:

R10, R22, R43, R36/38, R51/53. Flammable. Harmful if swallowed. May cause sensitisation by skin

contact. Irritating to eyes and skin. Toxic to aquatic organisms, may cause long-term adverse effects to the aquatic

environment.

Safety Phrases:

S16, S20, S28, S36, S61, S24/25. Keep away from sources of ignition - No smoking. When using,

do not eat or drink. After contact with skin, wash immediately with plenty of soap and water. Wear suitable protective

clothing. Avoid release to the environment. Refer to special instructions/Safety Data Sheets. Avoid contact with skin and

eyes.

SUSMP Classification:

ADG Classification:

Class 3: Flammable liquids.

UN Number:

1993, FLAMMABLE LIQUID, N.O.S.

Physical Description & Colour:

Dark amber coloured liquid.

Odour:

Strong "chemical" odour.

Major Health Hazards:

Permethrin is harmful to non-harmful via the oral route, with a reported LD

for technical

Permethrin in rats of 430 to 4000 mg/kg. Via the dermal route, it is not harmful, with a reported dermal LD

in rats of over

4000 mg/kg, and in rabbits of greater 2000 mg/kg. irritating to eyes and skin, harmful if swallowed, possible skin

sensitiser.

Persons sensitised to permethrin should avoid contact with this product.

Inhalation:

Short Term Exposure:

Available data indicates that this product is not harmful. In addition product is unlikely to

cause any discomfort or irritation.

Long Term Exposure:

No data for health effects associated with long term inhalation.

Section 1 - Identification of The Material and Supplier

Potential Health Effects

Emergency Overview

Section 2 - Hazards Identification

Intervet Australia Pty Limited

91-105 Harpin Street

Tel: 1 800 033 461

Bendigo East, Vic 3550, AUSTRALIA

Fax: 1 800 817 414

Company ABN: 79 008 467 034

Product Name: Exetick Tick and Flea Spot-on for Dogs and

Puppies

MATERIAL SAFETY DATA SHEET

This revision issued: May, 2011

Page: 2 of 7

MATERIAL SAFETY DATA SHEET

Issued by: Intervet Australia Pty Limited Phone: 1 800 033 461 (Business Hours)

Poisons Information Centre: 13 11 26 from anywhere in Australia, (0800 764 766 in New Zealand)

Skin Contact:

Short Term Exposure:

Classified as a potential sensitiser by skin contact. Exposure to a skin sensitiser, once

sensitisation has occurred, may manifest itself as skin rash or inflammation, and in some individuals this reaction can be

severe. In addition product is a skin irritant. Symptoms may include itchiness and reddening of contacted skin. Other

symptoms may also become evident, but all should disappear once exposure has ceased.

Long Term Exposure:

No data for health effects associated with long term skin exposure.

Eye Contact:

Short Term Exposure

: This product is an eye irritant. Symptoms may include stinging and reddening of eyes and

watering which may become copious. Other symptoms may also become evident. If exposure is brief, symptoms should

disappear once exposure has ceased. However, lengthy exposure or delayed treatment may cause permanent damage.

Long Term Exposure

: No data for health effects associated with long term eye exposure.

Ingestion:

Short Term Exposure

: Significant oral exposure is considered to be unlikely. Available data shows that this product

is harmful, but symptoms are not available. However, this product is an oral irritant. Symptoms may include burning

sensation and reddening of skin in mouth and throat. Other symptoms may also become evident, but all should disappear

once exposure has ceased.

Long Term Exposure

: No data for health effects associated with long term ingestion.

Carcinogen Status:

SWA:

No significant ingredient is classified as carcinogenic by SWA.

NTP:

No significant ingredient is classified as carcinogenic by NTP.

IARC:

Permethrin is Class 3 - unclassifiable as to carcinogenicity to humans.

See the IARC website for further details. A web address has not been provided as addresses frequently change.

Ingredients

CAS No

Conc,%

TWA (mg/m

3

)

STEL (mg/m

3

)

permethrin

52645-53-1

650g/L

not set

not set

Propylene glycol monomethyl ether

107-98-2

350g/L

This is a commercial product whose exact ratio of components may vary slightly. Minor quantities of other non hazardous

ingredients are also possible.

The SWA TWA exposure value is the average airborne concentration of a particular substance when calculated over a normal 8 hour working day for a

5 day working week. The STEL (Short Term Exposure Limit) is an exposure value that may be equalled (but should not be exceeded) for no longer than

15 minutes and should not be repeated more than 4 times per day. There should be at least 60 minutes between successive exposures at the STEL.

The term "peak "is used when the TWA limit, because of the rapid action of the substance, should never be exceeded, even briefly.

General Information:

You should call The Poisons Information Centre if you feel that you may have been poisoned, burned or irritated

by this product. The number is 13 11 26 from anywhere in Australia (0800 764 766 in New Zealand) and is

available at all times. Have this MSDS with you when you call.

Inhalation:

First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor.

Skin Contact:

Gently blot away excess liquid. Wash gently and thoroughly with warm water (use non-abrasive soap if

necessary) for 10-20 minutes or until product is removed. Under running water, remove contaminated clothing, shoes and

leather goods (e.g. watchbands and belts) and completely decontaminate them before reuse or discard. If irritation

persists, repeat flushing and seek medical attention.

Eye Contact:

Quickly and gently blot material from eyes. Immediately flush the contaminated eye(s) with lukewarm,

gently flowing water for 20 minutes or until the product is removed, while holding the eyelid(s) open. Take care not to

Section 3 - Composition/Information on Ingredients

Section 4 - First Aid Measures

Product Name: Exetick Tick and Flea Spot-on for Dogs and

Puppies

MATERIAL SAFETY DATA SHEET

This revision issued: May, 2011

Page: 3 of 7

MATERIAL SAFETY DATA SHEET

Issued by: Intervet Australia Pty Limited Phone: 1 800 033 461 (Business Hours)

Poisons Information Centre: 13 11 26 from anywhere in Australia, (0800 764 766 in New Zealand)

rinse contaminated water into the unaffected eye or onto the face. Obtain medical attention immediately. Take special

care if exposed person is wearing contact lenses.

Ingestion:

If swallowed, do NOT induce vomiting. Wash mouth with water and contact a Poisons Information Centre,

or call a doctor.

Fire and Explosion Hazards:

The major hazard in fires is usually inhalation of heated and toxic or oxygen

deficient (or both), fire gases. This product is classified as flammable. There is a moderate risk of an explosion from this

product if commercial quantities are involved in a fire. Firefighters should take care and appropriate precautions. Any

explosion will likely spread the fire to surrounding materials. Water spray may be used to cool drums involved in a fire,

reducing the chances of an explosion. Violent steam generation or eruption may occur upon application of direct water

stream on hot liquids. Vapours from this product are heavier than air and may accumulate in sumps, pits and other low-

lying spaces, forming potentially explosive mixtures. They may also flash back considerable distances.

Fire decomposition products from this product may be toxic if inhaled. Take appropriate protective measures.

Extinguishing Media

: Suitable extinguishing media are carbon dioxide, dry chemical, foam, water fog. Alcohol

resistant foam is the preferred firefighting medium but, if it is not available, normal foam can be used. Try to contain spills,

minimise spillage entering drains or water courses.

Fire Fighting

: If a significant quantity of this product is involved in a fire, call the fire brigade. There is a danger of a

violent reaction or explosion if significant quantities of this product are involved in a fire. Recommended personal

protective equipment is full fire kit and breathing apparatus.

Flash point

:

38-40°C

Upper Flammability Limit:

6.1%

Lower Flammability Limit:

2.3%

Autoignition temperature:

270°C

Flammability Class:

Flammable

Accidental release

: This product is sold in small packages, and the accidental release from one of these is not

usually a cause for concern. For minor spills, clean up, rinsing to sewer and put empty container in garbage. Although no

special protective clothing is normally necessary because of occasional minor contact with this product, it is good practice

to wear impermeable gloves when handling chemical products. In the event of a major spill, prevent spillage from entering

drains or water courses and call emergency services.

Handling

: Keep exposure to this product to a minimum, and minimise the quantities kept in work areas. Check Section

8 of this MSDS for details of personal protective measures, and make sure that those measures are followed. The

measures detailed below under "Storage" should be followed during handling in order to minimise risks to persons using

the product in the workplace. Also, avoid contact or contamination of product with incompatible materials listed in Section

10.

Storage

: This product is a Scheduled Poison. Observe all relevant regulations regarding sale, transport and storage of

this schedule of poison. Store in a cool, well ventilated area, and make sure that surrounding electrical devices and

switches are suitable. Check containers periodically for leaks. Containers should be kept closed in order to minimise

contamination and possible evaporation. Make sure that the product does not come into contact with substances listed

under "Incompatibilities" in Section 10. If you keep more than 10000kg or L of Dangerous Goods of Packaging Group III,

you may be required to license the premises or notify your Dangerous Goods authority. If you have any doubts, we

suggest you contact your Dangerous Goods authority in order to clarify your obligations. Check packaging - there may be

further storage instructions on the label.

Section 7 - Handling and Storage

Section 5 - Fire Fighting Measures

Section 6 - Accidental Release Measures

Product Name: Exetick Tick and Flea Spot-on for Dogs and

Puppies

MATERIAL SAFETY DATA SHEET

This revision issued: May, 2011

Page: 4 of 7

MATERIAL SAFETY DATA SHEET

Issued by: Intervet Australia Pty Limited Phone: 1 800 033 461 (Business Hours)

Poisons Information Centre: 13 11 26 from anywhere in Australia, (0800 764 766 in New Zealand)

The following Australian Standards will provide general advice regarding safety clothing and equipment:

Respiratory equipment: AS/NZS 1715, Protective Gloves: AS 2161, Occupational Protective Clothing: AS/NZS 4501 set

2008, Industrial Eye Protection: AS1336 and AS/NZS 1337, Occupational Protective Footwear: AS/NZS2210.

SWA Exposure Limits

TWA (mg/m

3

)

STEL (mg/m

3

)

Propylene glycol monomethyl ether

No special equipment is usually needed when occasionally handling small quantities. The following instructions are for

bulk handling or where regular exposure in an occupational setting occurs without proper containment systems.

Ventilation:

No special ventilation requirements are normally necessary for this product. However make sure that the

work environment remains clean and that vapours and mists are minimised.

Eye Protection:

Protective glasses or goggles should be worn when this product is being used. Failure to protect your

eyes may cause them harm.

Skin Protection:

If you believe you may have a sensitisation to this product or any of its declared ingredients, you

should prevent skin contact by wearing impervious gloves, clothes and, preferably, apron. Make sure that all skin areas

are covered. See below for suitable material types.

Protective Material Types:

There is no specific recommendation for any particular protective material type.

Respirator:

Usually, no respirator is necessary when using this product. However, if you have any doubts consult the

Australian Standard mentioned above.

Physical Description & Colour

Dark amber coloured liquid.

Odour:

Strong "chemical" odour.

Boiling Point:

120°C at 100kPa

Freezing/Melting Point:

No specific data. Liquid at normal temperatures.

Volatiles:

Slowly volatile at 100°C, but 35% volatile at higher temperatures.

Vapour Pressure:

1.2 kPa at 20°C

Vapour Density:

No data.

Specific Gravity:

1.05-1.20 at 20°C

Water Solubility:

Insoluble.

pH:

No data.

Volatility:

No data.

Odour Threshold:

No data.

Evaporation Rate:

No data.

Coeff Oil/water Distribution

No data

Autoignition temp:

270°C

Reactivity:

This product is unlikely to react or decompose under normal storage conditions. However, if you have any

doubts, contact the supplier for advice on shelf life properties.

Conditions to Avoid:

Protect this product from light. Store in the closed original container in a dry, cool, well-

ventilated area out of direct sunlight.

Incompatibilities:

oxidising agents.

Fire Decomposition:

Combustion forms carbon dioxide, and if incomplete, carbon monoxide and smoke. Water is

also formed. May form hydrogen chloride gas, other compounds of chlorine. Carbon monoxide poisoning produces

Section 9 - Physical and Chemical Properties

Section 8 - Exposure Controls and Personal Protection

Section 10 - Stability and Reactivity

Product Name: Exetick Tick and Flea Spot-on for Dogs and

Puppies

MATERIAL SAFETY DATA SHEET

This revision issued: May, 2011

Page: 5 of 7

MATERIAL SAFETY DATA SHEET

Issued by: Intervet Australia Pty Limited Phone: 1 800 033 461 (Business Hours)

Poisons Information Centre: 13 11 26 from anywhere in Australia, (0800 764 766 in New Zealand)

headache, weakness, nausea, dizziness, confusion, dimness of vision, disturbance of judgment, and unconsciousness

followed by coma and death.

Polymerisation:

This product will not undergo polymerisation reactions.

Toxicity:

Acute toxicity: Permethrin is harmful to non-harmful via the oral route, with a reported LD

for technical

Permethrin in rats of 430 to 4000 mg/kg. Via the dermal route, it is not harmful, with a reported dermal LD

in rats of over

4000 mg/kg, and in rabbits of greater 2000 mg/kg. Permethrin caused mild irritation of both the intact and abraded skin of

rabbits. It also caused conjunctivitis when it was applied to the eyes. The 4-hour inhalation LC

for rats was greater than

23.5 mg/L, indicating practically no inhalation toxicity. The toxicity of Permethrin is dependent on the ratio of the isomers

present; the cis-isomer being more toxic.

Chronic toxicity: No adverse effects were observed in dogs fed Permethrin at doses of 5 mg/kg/day for 90 days. Rats

fed 150 mg/kg/day for 6 months showed a slight increase in liver weights. Very low levels of Permethrin in the diet of

chickens (0.1 ppm for 3 to 6 weeks after hatching) have been reported to suppress immune system activity.

Reproductive effects: The fertility of female rats was affected when they received very high oral doses of 250 mg/kg/day

of Permethrin during the 6th to 15th day of pregnancy. It is not likely that reproductive effects will be seen in humans

under normal circumstances.

Teratogenic effects: Permethrin is reported to show no teratogenic activity.

Mutagenic effects: Permethrin is reported to show no mutagenic activity.

Carcinogenic effects: The evidence regarding the carcinogenicity of Permethrin is inconclusive.

Organ toxicity: Permethrin is suspected of causing liver enlargement of the liver and nerve damage. Effects on the

immune system have been noted in animal studies.

Fate in humans and animals: Permethrin is efficiently metabolized by mammalian livers. Breakdown products, or

"metabolites," of Permethrin are quickly excreted and do not persist significantly in body tissues. When Permethrin is

administered orally to rats, it is rapidly metabolized and almost completely eliminated from the body in a few days. Only 3

to 6% of the original dose was excreted unchanged in the faeces of experimental animals. Permethrin may persist in fatty

tissues, with half-lives of 4 to 5 days in brain and body fat. Permethrin does not block, or inhibit, cholinesterase enzymes.

Permethrin is Classed by SWA as a potential sensitiser by skin contact.

Ingredient

Risk Phrases

Permethrin

Conc>=25%: Xn; R22; R43

Toxic to aquatic organisms, may cause long-term adverse effects to the aquatic environment. This product is

biodegradable.

Effects on birds: Permethrin is practically non-toxic to birds. The oral LD

for a Permethrin formulation is greater than

9900 mg/kg in mallard ducks, greater than 13,500 mg/kg in pheasants, and greater than 15,500 mg/kg in Japanese quail.

Effects on aquatic organisms: Aquatic ecosystems are particularly vulnerable to the impact of Permethrin. A fragile

balance exists between the quality and quantity of insects and other invertebrates that serve as fish food. The 48-hour

for rainbow trout is 0.0125 mg/L for 24 hours, and 0.0054 mg/L for 48 hours. The 48-hour LC

in bluegill sunfish and

salmon is 0.0018 mg/L. As a group, synthetic pyrethroids were toxic to all estuarine species tested. They had a 96-hour

of less than or equal to 0.0078 mg/L for these species. The bioconcentration factor for Permethrin in bluefish is 715

times the concentrations in water and is 703 in catfish. This indicates that the compound has a low to moderate potential

to accumulate in these organisms.

Effects on other organisms: Permethrin is extremely toxic to bees. Severe losses may be expected if bees are present

at treatment time, or within a day thereafter. Permethrin is also toxic to wildlife. It should not be applied, or allowed to drift,

to crops or weeds in which active foraging takes place.

Classification of Hazardous Ingredients

Section 11 - Toxicological Information

Section 12 - Ecological Information

Product Name: Exetick Tick and Flea Spot-on for Dogs and

Puppies

MATERIAL SAFETY DATA SHEET

This revision issued: May, 2011

Page: 6 of 7

MATERIAL SAFETY DATA SHEET

Issued by: Intervet Australia Pty Limited Phone: 1 800 033 461 (Business Hours)

Poisons Information Centre: 13 11 26 from anywhere in Australia, (0800 764 766 in New Zealand)

Environmental Fate:

Breakdown in soil and groundwater: Permethrin is of low to moderate persistence in the soil environment, with

reported half-lives of 30 to 38 days. Permethrin is readily broken down, or degraded, in most soils except organic types.

Soil microorganisms play a large role in the degradation of Permethrin in the soil. The addition of nutrients to soil may

increase the degradation of Permethrin. It has been observed that the availability of sodium and phosphorous decreases

when Permethrin is added to the soil. Permethrin is tightly bound by soils, especially by organic matter. Very little leaching

of Permethrin has been reported. It is not very mobile in a wide range of soil types. Because Permethrin binds very

strongly to soil particles and is nearly insoluble in water, it is not expected to leach or to contaminate groundwater.

Breakdown in water: The results of one study near estuarine areas showed that Permethrin had a half-life of less than

2.5 days. When exposed to sunlight, the half-life was 4.6 days. Permethrin degrades rapidly in water, although it can

persist in sediments. There was a gradual loss of toxicity after Permethrin aged for 48 hours in sunlight at 0.05 mg/L in

water.

Breakdown in vegetation: Permethrin is not phytotoxic, or poisonous, to most plants when it is used as directed. Some

injury has occurred on certain ornamental plants. No incompatibility has been observed with Permethrin on cultivated

plants. Treated apples, grapes, and cereal grains contain less than one mg/kg of Permethrin at harvest time.

Disposal: Dispose of small quantities and empty containers by wrapping with paper and putting in garbage. For larger

quantities, if recycling or reclaiming is not possible, use a commercial waste disposal service.

ADG Code:

1993, FLAMMABLE LIQUID, N.O.S.

Hazchem Code:

3Y

Special Provisions:

223, 274

Limited quantities:

ADG 7 specifies a Limited Quantity value of 5 L for this class of product.

Dangerous Goods Class:

Class 3: Flammable liquids.

Packaging Group:

Packaging Method:

P001, IBC03, LP01

Class 3 Flammable Liquids shall not be loaded in the same vehicle or packed in the same freight container with Classes 1

(Explosives), 2.1 (Flammable Gases where flammable liquids and flammable gases are both in bulk), 2.3 (Toxic Gases),

4.2 (Spontaneously Combustible Substances), 5.1 (Oxidising Agents), 5.2 (Organic Peroxides), 6 (Toxic Substances,

except Flammable Liquid is nitromethane), and 7 (Radioactive Substances). They may however be loaded in the same

vehicle or packed in the same freight container with Classes 2.1 (Flammable Gases except where the Flammable Liquids

and Flammable Gases are in bulk), 2.2 (Non-Flammable Non-Toxic Gases), 4.1 (Flammable Solids), 4.3 (Dangerous

When Wet Substances), 6 (Toxic Substances, where Flammable Liquid is nitromethane), 8 (Corrosive Substances), 9

(Miscellaneous Dangerous Goods), Foodstuffs or foodstuff empties.

AICS:

All of the significant ingredients in this formulation are compliant with NICNAS regulations.

The following ingredient: permethrin, is mentioned in the SUSMP.

This MSDS contains only safety-related information. For other data see product literature.

Acronyms:

ADG Code

Australian Code for the Transport of Dangerous Goods by Road and Rail (7

edition)

AICS

Australian Inventory of Chemical Substances

SWA

Safe Work Australia, formerly ASCC and NOHSC

CAS number

Chemical Abstracts Service Registry Number

Section 13 - Disposal Considerations

Section 14 - Transport Information

Section 15 - Regulatory Information

Section 16 - Other Information

Product Name: Exetick Tick and Flea Spot-on for Dogs and

Puppies

MATERIAL SAFETY DATA SHEET

This revision issued: May, 2011

Page: 7 of 7

MATERIAL SAFETY DATA SHEET

Issued by: Intervet Australia Pty Limited Phone: 1 800 033 461 (Business Hours)

Poisons Information Centre: 13 11 26 from anywhere in Australia, (0800 764 766 in New Zealand)

Hazchem Code

Emergency action code of numbers and letters that provide information to emergency

services especially firefighters

IARC

International Agency for Research on Cancer

NOS

Not otherwise specified

NTP

National Toxicology Program (USA)

R-Phrase

Risk Phrase

SUSMP

Standard for the Uniform Scheduling of Medicines & Poisons

UN Number

United Nations Number

THIS MSDS SUMMARISES OUR BEST KNOWLEDGE OF THE HEALTH AND SAFETY HAZARD INFORMATION OF THE PRODUCT AND HOW TO

SAFELY HANDLE AND USE THE PRODUCT IN THE WORKPLACE. EACH USER MUST REVIEW THIS MSDS IN THE CONTEXT OF HOW THE

PRODUCT WILL BE HANDLED AND USED IN THE WORKPLACE.

IF CLARIFICATION OR FURTHER INFORMATION IS NEEDED TO ENSURE THAT AN APPROPRIATE RISK ASSESSMENT CAN BE MADE, THE

USER SHOULD CONTACT THIS COMPANY SO WE CAN ATTEMPT TO OBTAIN ADDITIONAL INFORMATION FROM OUR SUPPLIERS

OUR RESPONSIBILITY FOR PRODUCTS SOLD IS SUBJECT TO OUR STANDARD TERMS AND CONDITIONS, A COPY OF WHICH IS SENT TO

OUR CUSTOMERS AND IS ALSO AVAILABLE ON REQUEST.

Please read all labels carefully before using product.

This MSDS is prepared in accord with the SWA document “National Code of Practice for the

Preparation of Material Safety Data Sheets” 2nd Edition [NOHSC:2001(2003)]

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