DUOGARD LINE-ON FOR VERY LARGE DOGS 5 WEEK INTEGRATED FLEA AND TICK CONTROL

Australia - English - APVMA (Australian Pesticides and Veterinary Medicines Authority)

Buy It Now

Active ingredient:
pyriproxyfen(3g/L)+permethrin 40:60(400g/L)
Available from:
VIRBAC
INN (International Name):
pyriproxyfen(3g/L)+permethrin 40:60(400g/L)
Pharmaceutical form:
TOPICAL SOLUTION/SUSPENSION
Units in package:
4 x 8mL pipettes
Class:
Veterinary Pesticide
Therapeutic group:
DOG | BITCH | CASTRATE | PUPPY
Therapeutic area:
insecticide
Therapeutic indications:
BROWN DOG TICK | CAT FLEA | FLEA - EGG | FLEA - LARVAE (CTENOCEPHALIDES SPP.) | CTENOCEPHALIDES SPP. | DOG TICK
Product summary:
For the treatment & control of Fleas (C. felis) & Brown Dog Ticks in dogs. Protection against flea & tick infestation for up to 5 weeks and Prevention of development of flea eggs & larvae for up to 5 weeks.TOXIC TO CATS - See Restraints on label regarding cats. Do not use on puppies under 3 months of age. Do not use on sick or convalescing dogs or on nursing bitches. Do not exceed recommended dose. Not for the treatment or control of Paralysis Tick.
Authorization status:
Registered and available
Authorization number:
51342/51377
Authorization date:
2010-11-04

RECEIVED

ByE-Labels

JWebb

9:10am

06, 2010

Product:

Duogard

line

ty Large Dogs

5

Week

Integrated Flea And Tick Control

APVMA

51342

FINAL

Date:

1"

October

201 0

1 P2018-2

Text

above

header line, below

footer line

italics

between

parallel lines

does

appea

label

Pipette

Label

POISON

KEEP OUT

REACH OF CHILDREN

READ SAFETY DIRECTIONS

ANIMAL

TREATMENT

ONLY

Duogard@

LINE-ON

FOR

VERY

.LARGE DOGS

Wee]{

Integ

ted Flea and Tick Control

ACTIVE CONSTITUENTS:

11"1

3.0g/L

OXYFE

400g/L

40:60

11"1

TOXIC TO CATS

<

BEFORE USING THIS PRODUCT,

READ

DIRECTIONS ON OUTER

PACK

<

<'l

STORAGE:

Store

below

30°C

temperatu r

VIRBAC

(AUSTRALIA) PTY LIMITED

VIRBAC

New Zealand

Virbac Corporate Logo

Approved

Info

pest

Verified

Product:

Du~ard

Very

Large

Dogs 5 Week Integrated Flea And

Tick

Control

APVMA

No: 51342

FINAL

Date: 1" October

1 P6S06

Text

above

header

line,

below

footer

fine

and in italics

between

parallel

fines

does

appear

label.

CARTON LABEL

Front Panel

POISON

KEEP.

REACH OF

ILDREN

READ SAFETY DIRECTIONS BEFORE OPENING OR USING

FOR AN

TREATMENT

ONLY

Duogard@)

LINE-ON

FOR

VERY

LARGE

DOGS

5 Week Integrated Flea and Tick Control

ACTIVE CONSTITUENTS: 3.0g/L PYRIPROXYFEN; 400g/L PERMETHR

40:60

V!RBAC

LOGO

RECEIVED

Prevents development

Flea Eggs and Larvae

to 5 weeks

Kills Fleas and Ticks

(not

paralysis tick)

5 weeks

1 [2, 3, 4

pipettes

Approved

ByE-Labels

JWebb

11am

06, 2010

Product:

Duo~ard

Line-On

Very

Large

Dogs

5

Week Integrated Flea And Tick Control

APVMA

No: 51342

FINAL

Date:

1"

Ocrober 2010

1 P6506

Text

above

header line, below

footer line

italics

between

parallel lines does not appear

label.

Carton Label

Back Panel

Indi

cations:

the treatment and control of Fleas

(Ctenocephalides

felis)

and Ticks

(Rhipicephalus

sanguineus)

in dogs.

Protection against

and tick infestations for up to 5 weeks and prevention

of development of flea eggs and larvae f

to 5 weeks. Not for the treatment

control

Paralysis Tick

(Ixodes

holocyclus).

DIRECTIONS FOR USE:

RESTRAINTS

DO NOT USE ON CATS.

r-K_e

_e_p_c-

at_s

s_e_p_a-ra-te

- d--f

r_e-ce_n_

d_d_o

--------------

-...~..

"'6

There are reports of toxic effects in cats which groom or contact dogs

treated 48 hours earlier.

,

Toxic effects include behaviour changes, droo

ng, tremors and death.

Seek Veterinary advice immediately

you· suspect toxicity in a cat.

CONTRAINDICATIONS

DO NOT USE on

puppi

er 3 mo

nths

age.

DO NOT USE on

onvalescing

s or

nursin

g bitches.

DO NOT exceed reco

ende

d dose.

sage

Admin

trati

For external application to the

dog's skin,

single topical

administra~ion

0.25ml

bodyweight.

Dogs weighi

over 30kg apply 2 pipettes of 8m

Hold the pipette upright. Unscrew the cap and cut off the sealing plug

twisting the closure. Apply

the total contents of the pipette onto the skin distributed between the base of the tail

the neck

of the dog. DO NOT wash

shampoo dog after treatment.

is necessary to shampoo the dog

during the protec

period

is recommended to renew the application

this product afterwards

in order to maintain protection against flea and tick reinfestations otherwise, retreatment may be

repeated at 4 week intervals.

NOT TO BE USED FOR ANY PURPOSE OR

ANY MANNER CONTRARY

THIS LABEL

UNLESS AUTHORISED UNDER APPROPRIATE LEGISLATION.

IMPORTANT THAT TREATMENT

CONTINUED THROUGHOUT THE YEAR.

GENERAL INSTRUCTIONS:

To ensure the best results from this product

is very important that your dog's environment is also

treated to help prevent flea reinfestations.

To ensure maximum flea control remember

Treat other

ts in the househol

Where insecticide use is not recommended

(e.g

young

puppies and nursing

tches), fleas can

removed

careful use of a flea comb.

Treat the dog's surroundings (such as bedding, carpet, furniture, yard, etc) wi

insecticide

and vacuum regularly.

SAFETY DIRECTIONS:

Will

irritat

skin

. Avoid

cont

with

eyes and ski

Wash hands

FIRST AID:

isoning

cont

act a

or Po

n Ce

Phone Aus

tral

126.

Product: Duogard Line-On

Large

Dogs 5 Week Integrated

a And

Tick

Control

APVMA

51342

FINA

Date: 1" October 2010

1 P6506

Text above

header line,

ter line and

tween parallel

lines

does

not appear

abel.

Carton Label

Bacl( Panel cont.

PROTECTION OF WILDLIFE, FISH, CRUSTACEANS AND ENVIRONMENT:

Dangerous to fish and crustaceans.

NOT contaminate fish ponds, drains, rivers and streams with

the pesticide or the used container.

STORAGE:

Store below 30°C (Room temperature): Protect from light.

DISPOSAL:

Dispose of empty container by wrapping with paper and putting

garbage.

VIRBAC (AUSTRALIA) PTY. LIMITED

Horsley Road, Milperra NSW 2214

eecall Customer Servi

Line: 1800 009

virbac.com.au

®Registered

Trademark of Virbac (Australia) Pty Limited.

(8]:

EXP:

APVMA: 51342/51377

[BARCODE]

CODE: 1 P6506-4

Product:

Duo9;ard

Line

-On For

Very

Large

Do?;s

5 Week Integrated

Flea

Tick Control

APVMA

No: 51342

FINAL

·Date: 1" October 2010

1 P6506

Text above I

header

line,

below

ter l

in italics

between

parallel

does

t appear

labe

Carton

Label

Top,

Bottom

Side

Panels

Duogard@

LINE-ON

FOR ·

vERY

LARGE

DOGS

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Duogard Line-On

Products.Doc

Revision E

SAFETY DATA SHEET

Product Name:

Duogard Line-On for Small Dogs, Medium Dogs, Large Dogs and Extra

Large Dogs (4 products)

Page: 1 of 6

Date of Issue

20 July, 2015

Emergency: Virbac: 02 9772 9772 or 1800 242 100 (Business hours only)

Poisons Information Centre: 13 1126 from anywhere in Australia, (0800 764 766 in New Zealand)

Section 1 - Identification of The Material and Supplier

Company:

Virbac (Australia) Pty. Ltd

ABN 77 003 268 871

Address

361 Horsley Rd, Milperra, NSW 2214, Australia

Locked Bag 6000, Milperra Business Centre, NSW 1891, Australia

Telephone:

(02) 9772 9772 or 1800 242 100

Fax:

(02) 9772 9773

Emergency phone

As above during business hours; answering machine after hours

Chemical nature:

Permethrin is a pyrethroid derived pesticide.

Trade Name:

Duogard Line-On for Small Dogs, Medium Dogs, Large Dogs and Extra Large Dogs

(4 products)

Product Code:

DUOLINSD24 (SM. DOG 24s); DUOLINSD04 (SM. DOG 4s)

DUOLINMD24 (MED. DOG 24s); DUOLINMD04 (MED. DOG 4s)

DUOLINLD24 (LGE. DOG 24s); DUOLINLD04 (LGE. DOG 4s)

DUOLINXL24 (XL. DOG 24s); DUOLINXL04 (XL. DOG 4s)

Product Use:

Insecticidal preparation for the treatment and prevention of fleas and ticks in dogs.

Creation Date:

September, 2002

This version issued:

July, 2015

and is valid for 5 years from this date.

Section 2 - Hazards Identification

STATEMENT OF HAZARDOUS NATURE

This product is classified as:

Hazardous according to the criteria of SWA Australia.

Not a Dangerous Good according to Australian Dangerous Goods (ADG) Code, IATA and IMDG/IMSBC criteria.

Risk Phrases:

R22, R36/38. Harmful if swallowed. Irritating to eyes and skin.

Safety Phrases:

S20, S24/25. When using, do not eat or drink. Avoid contact with skin and eyes.

SUSMP Classification:

S5 (Small & Medium Dogs) S6 (Large & Extra Large dogs)

ADG Classification:

None allocated. Not a Dangerous Good.

UN Number:

None allocated

GHS Signal word: DANGER.

Flammability class: C1 (combustible liquid)

HAZARD STATEMENT:

H227: Combustible liquid.

H302: Harmful if swallowed.

H315: Causes skin irritation.

H320: Causes eye irritation.

H335: May cause respiratory irritation.

PREVENTION

P102: Keep out of reach of children.

P262: Do not get in eyes, on skin, or on clothing.

P264: Wash contacted areas thoroughly after handling.

P270: Do not eat, drink or smoke when using this product.

P281: Use personal protective equipment as required.

RESPONSE

P362: Take off contaminated clothing and wash before reuse.

P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor if you feel unwell.

P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353: IF ON SKIN (or hair): Remove immediately all contaminated clothing. Rinse skin with water.

P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if

present and easy to do. Continue rinsing.

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Duogard Line-On

Products.Doc

Revision E

SAFETY DATA SHEET

Product Name:

Duogard Line-On for Small Dogs, Medium Dogs, Large Dogs and Extra

Large Dogs (4 products)

Page: 2 of 6

Date of Issue

20 July, 2015

Emergency: Virbac: 02 9772 9772 or 1800 242 100 (Business hours only)

Poisons Information Centre: 13 1126 from anywhere in Australia, (0800 764 766 in New Zealand)

P309+P311 If exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.

P333+P313: If skin irritation or rash occurs: Get medical advice.

P337+P313: If eye irritation persists: Get medical advice.

P370+P378: In case of fire, use carbon dioxide, dry chemical, foam, water fog.

STORAGE

P410: Protect from sunlight.

P402+P404: Store in a dry place. Store in a closed container.

P403+P235: Store in a well-ventilated place. Keep cool.

DISPOSAL

P501: Dispose of contents and containers as specified on the registered label.

Emergency Overview

Physical Description & colour

: Clear liquid, presented in 2, 4 and 8mL flexible pipettes.

Odour:

No date.

Major Health Hazards:

Permethrin is harmful to non-harmful via the oral route, with a reported LD

for technical

Permethrin in rats of 430 to 4000 mg/kg. Via the dermal route, it is not harmful, with a reported dermal LD

in rats of

over 4000 mg/kg, and in rabbits of greater 2000 mg/kg. No major health hazards are known.

Potential Health Effects

See section 11 for Chronic exposure studies.

Inhalation

Short term exposure:

Available data indicates that this product is not harmful. However product may be mildly

irritating, although unlikely to cause anything more than mild transient discomfort.

Skin Contact:

Short term exposure:

Available data indicates that this product is not harmful. It should present no hazards in

normal use. However product is a skin irritant. Symptoms may include itchiness and reddening of contacted skin.

Other symptoms may also become evident, but all should disappear once exposure has ceased.

Eye Contact:

Short term exposure

: Available data shows that this product is not harmful. However product is an eye irritant.

Symptoms may include stinging and reddening of eyes and watering which may become copious. Other symptoms

may also become evident. If exposure is brief, symptoms should disappear once exposure has ceased. However,

lengthy exposure or delayed treatment may cause permanent damage.

Ingestion:

Short term exposure

: Available data shows that this product is harmful, but symptoms are not available. However,

this product may be irritating to mucous membranes but is unlikely to cause anything more than transient discomfort.

Carcinogen Status:

SWA:

No significant ingredient is classified as carcinogenic by SWA.

NTP:

No significant ingredient is classified as carcinogenic by NTP.

IARC:

Permethrin is Class 3 - unclassifiable as to carcinogenicity to humans.

Section 3 – Composition/Information on Ingredients

Ingredients

CAS No

Conc,%

TWA (mg/m3)

STEL (mg/m3)

Permethrin

52645-53-1

34.1

not set

not set

Pyriproxyfen

95737-68-1

not set

not set

Glycol ether (solvent)

secret

to 100

not set

not set

This is a commercial product whose exact ratio of components may vary slightly. Minor quantities of other non

hazardous ingredients are also possible.

The TWA exposure value is the average airborne concentration of a particular substance when calculated over a normal 8 hour working day for a 5

day working week. The STEL (Short Term Exposure Limit) is an exposure value that should not be exceeded for more than 15 minutes and should

not be repeated for more than 4 times per day. There should be at least 60 minutes between successive exposures at the STEL. The term "peak "is

used when the TWA limit, because of the rapid action of the substance, should never be exceeded, even briefly.

Section 4 - First Aid Measures

General Information:

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Duogard Line-On

Products.Doc

Revision E

SAFETY DATA SHEET

Product Name:

Duogard Line-On for Small Dogs, Medium Dogs, Large Dogs and Extra

Large Dogs (4 products)

Page: 3 of 6

Date of Issue

20 July, 2015

Emergency: Virbac: 02 9772 9772 or 1800 242 100 (Business hours only)

Poisons Information Centre: 13 1126 from anywhere in Australia, (0800 764 766 in New Zealand)

You should call The Poisons Information Centre if you feel that you may have been poisoned, burned or irritated by

this product. The number is 13 1126 from anywhere in Australia and is available at all times. Have this SDS with you

when you call.

Inhalation:

No first aid measures normally required. However, if inhalation has occurred, and irritation has

developed, remove to fresh air and observe until recovered. If irritation becomes painful or persists more than about

30 minutes, seek medical advice.

Skin Contact:

Quickly and gently, blot or brush away excess chemical. Wash gently and thoroughly with water (use

non-abrasive soap if necessary) for 20 minutes or until chemical is removed. Under running water, remove

contaminated clothing, shoes and leather goods (e.g. watchbands and belts). If irritation persists, repeat flushing and

obtain medical advice. Completely decontaminate clothing, shoes and leather goods before reuse or discard.

Eye Contact:

Quickly and gently blot or brush away product. Immediately flush the contaminated eye(s) with

lukewarm, gently flowing water until the product is removed or until a few minutes after irritation has ceased, while

holding the eyelid(s) open. Take care not to rinse contaminated water into the unaffected eye or onto the face.

Ingestion:

If swallowed, do NOT induce vomiting. Wash mouth with water and contact a Poisons Information

Centre, or call a doctor.

Section 5 – Fire Fighting Measures

Fire and Explosion Hazards

: There is a slight risk of an explosion from this product if commercial quantities are

involved in a fire. Violent steam generation or eruption may occur upon application of direct water stream on hot

liquids. Vapours from this product are heavier than air and may accumulate in sumps, pits and other low-lying spaces,

forming potentially explosive mixtures. They may also flash back considerable distances.

Fire decomposition products from this product may be toxic if inhaled. Take appropriate protective measures.

Extinguishing Media

: Preferred extinguishing media are carbon dioxide, dry chemical, foam, water fog.

Fire Fighting

: If a significant quantity of this product is involved in a fire, call the fire brigade.

Flash point

:

No data

Upper Flammability Limit:

22.7%

Lower Flammability Limit:

1.4% (based on figures for solvent)

Autoignition temperature:

No data.

Flammability Class:

Section 6 – Accidental Release Measures

Accidental release

: In the event of a major spill, prevent spillage from entering drains or water courses. Wear full

protective clothing including face mask, face shield and gauntlets. All skin areas should be covered. See above under

Personal Protection regarding Australian Standards relating to personal protective equipment. Suitable materials for

protective clothing include rubber, PVC. Stop leak if safe to do so, and contain spill. Absorb onto sand, vermiculite or

other suitable absorbent material. If spill is too large or if absorbent material is not available, try to create a dike to

stop material spreading or going into drains or waterways. Sweep up and shovel or collect recoverable product into

labelled containers for recycling or salvage, and dispose of promptly. Recycle containers wherever possible after

careful cleaning. After spills, wash area preventing runoff from entering drains. If a significant quantity of material

enters drains, advise emergency services. This material may be suitable for approved landfill. Ensure legality of

disposal by consulting regulations prior to disposal. Thoroughly launder protective clothing before storage or re-use.

Advise laundry of nature of contamination when sending contaminated clothing to laundry.

Section 7 – Handling and Storage

Handling

: Keep exposure to this product to a minimum, and minimise the quantities kept in work areas. Check

Section 8 of this SDS for details of personal protective measures, and make sure that those measures are followed.

The measures detailed below under "Storage" should be followed during handling in order to minimise risks to

persons using the product in the workplace. Also, avoid contact or contamination of product with incompatible

materials listed in Section 10.

Storage

: This product is a Scheduled Poison. Observe all relevant regulations regarding sale, transport and storage

of this class of poison. Make sure that containers of this product are kept tightly closed. Make sure that the product

does not come into contact with substances listed under "Materials to avoid" in Section 10. Store below 30°C. Some

liquid preparations settle or separate on standing and may require stirring before use. Check packaging - there may

be further storage instructions on the label.

Section 8 Exposure Controls and Personal Protection

The following Australian Standards will provide general advice regarding safety clothing and equipment:

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Duogard Line-On

Products.Doc

Revision E

SAFETY DATA SHEET

Product Name:

Duogard Line-On for Small Dogs, Medium Dogs, Large Dogs and Extra

Large Dogs (4 products)

Page: 4 of 6

Date of Issue

20 July, 2015

Emergency: Virbac: 02 9772 9772 or 1800 242 100 (Business hours only)

Poisons Information Centre: 13 1126 from anywhere in Australia, (0800 764 766 in New Zealand)

Respiratory equipment: AS/NZS 1715, Protective Gloves: AS 2161, Occupational Protective Clothing: AS/NZS 4501

set 2008, Industrial Eye Protection: AS1336 and AS/NZS 1337, Occupational Protective Footwear: AS/NZS2210.

SWA Exposure Limits

TWA (mg/m

3

)

STEL (mg/m

3

)

Exposure limits have not been established by SWA for any of the significant ingredients in this product.

The ADI for Permethrin is set at 0.05mg/kg/day. The corresponding NOEL is set at 5mg/kg/day.

The ADI for Pyriproxyfen is set at 0.07mg/kg/day. The corresponding NOEL is set at 7mg/kg/day. ADI means

Acceptable Daily Intake and NOEL means No-observable-effect-level. Values taken from Australian ADI List, June

2013.

Ventilation:

No special ventilation requirements are normally necessary for this product. However make sure that

the work environment remains clean and that dusts are minimised.

Eye Protection:

Protective glasses or goggles should be worn when this product is being used. Failure to protect

your eyes may cause them harm. Emergency eye wash facilities are also recommended in an area close to where

this product is being used.

Skin Protection:

Prevent skin contact by wearing impervious gloves, clothes and, preferably, apron. Make sure that

all skin areas are covered. See below for suitable material types.

Protective Material Types:

We suggest that protective clothing be made from the following materials: rubber,

PVC.

Respirator:

Usually, no respirator is necessary when using this product. However, if you have any doubts consult

the Australian Standard mentioned above. Otherwise, not normally necessary.

Eyebaths or eyewash stations and safety deluge showers should be provided near to where this product is being

used.

Section 9 - Physical and Chemical Properties:

Physical Description & colour

Clear liquid, presented in 2, 4 and 8mL flexible pipettes.

Odour:

No date.

Boiling Point:

Not available.

Freezing/Melting Point:

No specific data. Liquid at normal temperatures.

Volatiles:

No specific data. Expected to be low at 100°C.

Vapour Pressure:

No data.

Vapour Density:

No data.

Specific Gravity:

1.07-1.11

Water Solubility:

Miscible.

pH:

No data.

Volatility:

No data.

Section 10 – Stability and Reactivity

Reactivity:

This product is unlikely to react or decompose under normal storage conditions. However, if you have

any doubts, contact the supplier for advice on shelf life properties.

Conditions to Avoid:

This product should be kept in a cool place, preferably below 30°C.

Incompatibilities:

strong acids, strong bases, strong oxidising agents.

Fire Decomposition:

Carbon dioxide, and if combustion is incomplete, carbon monoxide and smoke. Water.

Carbon monoxide poisoning produces headache, weakness, nausea, dizziness, confusion, dimness of vision,

disturbance of judgment, and unconsciousness followed by coma and death.

Polymerisation:

This product is unlikely to undergo polymerisation processes.

Section 11 – Toxicological Information

Toxicity:

Acute toxicity: Permethrin is harmful to non-harmful via the oral route, with a reported LD

for technical

Permethrin in rats of 430 to 4000 mg/kg. Via the dermal route, it is not harmful, with a reported dermal LD

in rats of

over 4000 mg/kg, and in rabbits of greater 2000 mg/kg. Permethrin caused mild irritation of both the intact and

abraded skin of rabbits. It also caused conjunctivitis when it was applied to the eyes. The 4-hour inhalation LC

rats was greater than 23.5 mg/L, indicating practically no inhalation toxicity. The toxicity of Permethrin is dependent

on the ratio of the isomers present; the cis-isomer being more toxic.

Chronic toxicity: No adverse effects were observed in dogs fed Permethrin at doses of 5 mg/kg/day for 90 days.

Rats fed 150 mg/kg/day for 6 months showed a slight increase in liver weights. Very low levels of Permethrin in the

diet of chickens (0.1 ppm for 3 to 6 weeks after hatching) have been reported to suppress immune system activity.

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Duogard Line-On

Products.Doc

Revision E

SAFETY DATA SHEET

Product Name:

Duogard Line-On for Small Dogs, Medium Dogs, Large Dogs and Extra

Large Dogs (4 products)

Page: 5 of 6

Date of Issue

20 July, 2015

Emergency: Virbac: 02 9772 9772 or 1800 242 100 (Business hours only)

Poisons Information Centre: 13 1126 from anywhere in Australia, (0800 764 766 in New Zealand)

Reproductive effects: The fertility of female rats was affected when they received very high oral doses of 250

mg/kg/day of Permethrin during the 6th to 15th day of pregnancy. It is not likely that reproductive effects will be seen

in humans under normal circumstances.

Teratogenic effects: Permethrin is reported to show no teratogenic activity.

Mutagenic effects: Permethrin is reported to show no mutagenic activity.

Carcinogenic effects: The evidence regarding the carcinogenicity of Permethrin is inconclusive.

Organ toxicity: Permethrin is suspected of causing liver enlargement of the liver and nerve damage. Effects on the

immune system have been noted in animal studies.

Fate in humans and animals: Permethrin is efficiently metabolized by mammalian livers. Breakdown products, or

"metabolites," of Permethrin are quickly excreted and do not persist significantly in body tissues. When Permethrin is

administered orally to rats, it is rapidly metabolized and almost completely eliminated from the body in a few days.

Only 3 to 6% of the original dose was excreted unchanged in the faeces of experimental animals. Permethrin may

persist in fatty tissues, with half-lives of 4 to 5 days in brain and body fat. Permethrin does not block, or inhibit,

cholinesterase enzymes.

Section 12 – Ecological Information

Effects on birds: Permethrin is practically non-toxic to birds. The oral LD

for a Permethrin formulation is greater

than 9900 mg/kg in mallard ducks, greater than 13,500 mg/kg in pheasants, and greater than 15,500 mg/kg in

Japanese quail.

Effects on aquatic organisms: Aquatic ecosystems are particularly vulnerable to the impact of Permethrin. A fragile

balance exists between the quality and quantity of insects and other invertebrates that serve as fish food. The 48-hour

for rainbow trout is 0.0125 mg/L for 24 hours, and 0.0054 mg/L for 48 hours. The 48-hour LC

in bluegill sunfish

and salmon is 0.0018 mg/L. As a group, synthetic pyrethroids were toxic to all estuarine species tested. They had a

96-hour LC

of less than or equal to 0.0078 mg/L for these species. The bioconcentration factor for Permethrin in

bluefish is 715 times the concentrations in water and is 703 in catfish. This indicates that the compound has a low to

moderate potential to accumulate in these organisms.

Effects on other organisms: Permethrin is extremely toxic to bees. Severe losses may be expected if bees are

present at treatment time, or within a day thereafter. Permethrin is also toxic to wildlife. It should not be applied, or

allowed to drift, to crops or weeds in which active foraging takes place.

Environmental Fate:

Breakdown in soil and groundwater: Permethrin is of low to moderate persistence in the soil environment, with

reported half-lives of 30 to 38 days. Permethrin is readily broken down, or degraded, in most soils except organic

types. Soil microorganisms play a large role in the degradation of Permethrin in the soil. The addition of nutrients to

soil may increase the degradation of Permethrin. It has been observed that the availability of sodium and

phosphorous decreases when Permethrin is added to the soil. Permethrin is tightly bound by soils, especially by

organic matter. Very little leaching of Permethrin has been reported. It is not very mobile in a wide range of soil types.

Because Permethrin binds very strongly to soil particles and is nearly insoluble in water, it is not expected to leach or

to contaminate groundwater.

Breakdown in water: The results of one study near estuarine areas showed that Permethrin had a half-life of less

than 2.5 days. When exposed to sunlight, the half-life was 4.6 days. Permethrin degrades rapidly in water, although it

can persist in sediments. There was a gradual loss of toxicity after Permethrin aged for 48 hours in sunlight at 0.05

mg/L in water.

Breakdown in vegetation: Permethrin is not phytotoxic, or poisonous, to most plants when it is used as directed.

Some injury has occurred on certain ornamental plants. No incompatibility has been observed with Permethrin on

cultivated plants. Treated apples, grapes, and cereal grains contain less than one mg/kg of Permethrin at harvest

time.

Section 13 – Disposal Considerations

Disposal:

Dispose of small quantities and empty containers by wrapping with paper and putting in garbage. For

larger quantities, if recycling or reclaiming is not possible, use a commercial waste disposal service. Refer to product

label for details.

Section 14 – Transport Information

UN Number:

This product is not classified as a Dangerous Good by ADG, IATA or IMDG/IMSBC criteria. No special

transport conditions are necessary unless required by other regulations.

Section 15 – Regulatory Information

AICS:

All of the significant ingredients in this product are compliant with NICNAS regulations.

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Duogard Line-On

Products.Doc

Revision E

SAFETY DATA SHEET

Product Name:

Duogard Line-On for Small Dogs, Medium Dogs, Large Dogs and Extra

Large Dogs (4 products)

Page: 6 of 6

Date of Issue

20 July, 2015

Emergency: Virbac: 02 9772 9772 or 1800 242 100 (Business hours only)

Poisons Information Centre: 13 1126 from anywhere in Australia, (0800 764 766 in New Zealand)

Section 16 – Other Information

Much of the Information in this SDS came from Extoxnet, a Pesticide Information Project of Cooperative Extension

Offices of Cornell University, Oregon State University, the University of Idaho, and the University of California at Davis

and the Institute for Environmental Toxicology, Michigan State University.

This SDS contains only safety-related information. For other data see product literature.

Contact point:

Technical Manager, QA Manager or R&D Director

Telephone

(02) 9772 9772 or 1800 242 100

Fax

(02) 9772 9773

Acronyms:

ADG Code

Australian Code for the Transport of Dangerous Goods by Road and Rail, 7th Edition

AICS

Australian Inventory of Chemical Substances

CAS number

Chemical Abstracts Service Registry Number

IARC

International Agency for Research on Cancer

SWA

Safe Work Australia, formerly ASCC and NOHSC

NOS

Not otherwise specified

NTP

National Toxicology Program (USA)

R-Phrase

Risk Phrase

SUSMP

Standard for the Uniform Scheduling of Medicines & Poisons

UN Number

United Nations Number

THIS SDS SUMMARISES OUR BEST KNOWLEDGE OF THE HEALTH AND SAFETY HAZARD INFORMATION OF THE PRODUCT AND HOW

TO SAFELY HANDLE AND USE THE PRODUCT IN THE WORKPLACE. EACH USER MUST REVIEW THIS SDS IN THE CONTEXT OF HOW

THE PRODUCT WILL BE HANDLED AND USED IN THE WORKPLACE.

IF CLARIFICATION OR FURTHER INFORMATION IS NEEDED TO ENSURE THAT AN APPROPRIATE RISK ASSESSMENT CAN BE MADE,

THE USER SHOULD CONTACT THIS COMPANY SO WE CAN ATTEMPT TO OBTAIN ADDITIONAL INFORMATION FROM OUR SUPPLIERS

OUR RESPONSIBILITY FOR PRODUCTS SOLD IS SUBJECT TO OUR STANDARD TERMS AND CONDITIONS, A COPY OF WHICH IS SENT

TO OUR CUSTOMERS AND IS ALSO AVAILABLE ON REQUEST.

Please read all labels carefully before using product.

This SDS is prepared in accord with the SWA document “Preparation of Safety Data Sheets for Hazardous

Chemicals - Code of Practice” (December 2011)

Copyright © Kilford & Kilford Pty Ltd, July, 2015.

http://www.kilford.com.au/

Phone (02)9251 4532

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