CLOSICOMB SUSTAINED ACTION ORAL ANTHELMINTIC AND FLUKICIDE FOR SHEEP

Australia - English - APVMA (Australian Pesticides and Veterinary Medicines Authority)

Buy It Now

Active ingredient:
CLOSANTEL | OXFENDAZOLE
Available from:
VIRBAC (AUSTRALIA) PTY LTD
Class:
Veterinary Pesticide
Therapeutic group:
SHEEP | EWE | HOGGET | LAMB | OVINE | RAM | WEANER | WETHER
Therapeutic area:
PARASITICIDES
Therapeutic indications:
BARBER'S POLE WORM - HAEMONCHUS PLACEI | BARBER'S POLE WORM-HAEMONCHUS CONTORTUS | BLACK SCOUR WORM - TELADORSAGIA SPP. | LARGE BOWEL WORM - O. VENULOSUM | LARGE LUNGWORM - DICTYOCAULUS FILARIA | LARGE MOUTHED BOWEL WORM | LIVER FLUKE | NASAL BOT | NODULE WORM - O. COLUMBIANUM | SMALL BROWN STOMACH WORM-OSTERTAGIA SPP. | STOMACH HAIR WORM | TAPEWORM - MONIEZIA SPP. | THIN NECKED INTESTINAL WORM | SHEEP NASAL BOT FLY | TAPEWORM - HEADS/SEGMENTS | TELADORSAGIA
Authorization status:
Registered
Authorization number:
49934
Authorization date:
1998-05-04

December2006 Page1of3 Draft Label –Front Panel

_______________________________________________________________________________________________

POISON

KEEP OUT OF REACHOF CHILDREN

READ SAFETY DIRECTIONS BEFORE OPENING OR USING

FOR ANIMAL TREATMENT ONLY

Closicomb ®

Sustained action Oral Anthelmintic

and Flukicide for Sheep

ACTIVE CONSTITUENT:

37.5 g/L CLOSANTEL

22.6 g/L OXFENDAZOLE

For the control of susceptible mature andimmature

Gastro-intestinal Roundworms and Tapeworms, Lung Worms,

Liver Fluke (Fasciola hepatica) including 4 week oldimmature stages,

all stages of Nasal Bots (Oestrus ovis) and sustained control of

susceptible Barber’s Pole Worm (Haemonchus contortus) in sheep.

[ImageofSheep]

1 L

INTERNAL

PARASITES

APPROVED

LABEL

Info

pest

Verified

December 2006 Page1 of 3 DraftLabel– BackLabel

_______________________________________________________________________________________________

DIRECTIONSFOR USE:

Dosage and Administration:

SHAKEWELL BEFORE USE.

Closicomb®doserateis1mL/5kg bodyweight.

Closicomb®isready touseanddoesnot require mixing.

Closicomb®canbe usedatthe recommended dosesinsheepofallagesincluding

pregnant ewes.

DosageGuide:

Bodyweight

Kg Dose Volume

mL Sheep Treated

1 Litre

Up to15 3 333

16-204 250

21-255 200

26-306 166

31-357 142

36-408 125

41-459 111

46-5010 100

51-5511 90

56-6012 83

61-6513 76

66-7014 71

71-7515 66

Sheepinexcess of 75kgtobedosed at1mLper5kg.A representative sampleof

animals shouldbe weighedbeforetreatment. Dose themobtotheheaviest animalby

liveweightineachgroup (ewes,rams,lambs);donotunderdose. Wherethereisalarge

variation in sizewithin the group,doserateshouldbebasedonthelabel directions for

each weightrange.Drafting intotwo ormorelinesmay beappropriate,toavoid excessive

overdosing.Check accuracyofdrenching gun beforeand duringuse.Rinsedrenchinggun

afteruse.

Medicinalclaim:

Closicomb®containsClosantel,amemberofthe Salicylanilides familyof chemicalsand

Oxfendazole, amember ofthe Benzimidazole(“white”) groupof anthelmintics.

Closicomb®iseffectiveagainst sensitivestrains (matureandimmature) ofthefollowing

internal parasites ofsheep:

(Haemonchuscontortus)Barber’spoleworms : withsustained protectionagainstre-

infestation ofBarber’spole wormin sheepfor4weeks afterdosing;

(Fasciola hepatica) Liver fluke: from fourweekoldstages;

(Oestrus ovis)Nasal bots :all stages;

(Haemonchus placei)Barbers poleworm;

(Trichostrongylus axei)Stomachhairworm;

(Ostertagia/Teladorsagiaspp)Small brownstomachworm

(Trichostrongylusspp)Black scourworm

(Cooperiaspp) Smallintestinalworm;

(Nematodirusspp) Thinnecked intestinal worm;

(Oesophagostomumcolumbianum)Noduleworm;

APPROVED

LABEL

December 2006 Page2 of 3 DraftLabel– BackLabel

_______________________________________________________________________________________________

(Chabertiaovina) Large mouthedbowelworm;

(Dictyocaulus filaria) Lungworm

(Monieziaspp)Tapeworm.

Resistancemay develop to anydrench. Askyourlocal veterinarypractitioner or animal

healthadviserforrecommended parasitemanagementpractices foryourareatoreduce

development of resistance.It isadvisable that a drench resistancetest beconducted

before anydrench isused.

WITHHOLDING PERIOD:

MEAT:DONOT USElessthan28daysbeforeslaughter for human consumption.

TRADEADVICE: Export SlaughterInterval (ESI):

DO NOTUSE less than60daysbeforeslaughter for export. The ESI on this label

wascorrectatthe timeoflabelapproval. Before using thisproduct confirm the

currentESIfrom either thereseller or theAPVMAwebsite

www.apvma.gov.au/residues/ESI.shtml

SAFETYDIRECTIONS:

Willirritatethe eyesand skin.Avoid contactwitheyes andskin.Whenusingthe

productwear rubber gloves. Washhands after use. After eachday'suse wash

gloves.

FIRST AID:

If poisoning occurs, contact adoctor orPoisonsInformation Centre.Phone

Australia 131 126.

Additional information islistedin the MaterialSafetyDataSheet.

VIRBAC(AUSTRALIA)PTY.LIMITED

15PritchardPlace,PeakhurstNSW2210

Freecall CustomerServiceLine:1800 009 847

www.virbac.com.au

DISPOSAL:

Disposeof emptycontainer bywrappingwithpaperandputtingingarbage.

STORAGE:

Store below 30 °C(Room Temperature). Storeinoriginalcontainer. Resealafteruse.

®RegisteredTrademark ofVirbac.

[B]: CODE:

EXP: APVMA:49934/1L/1006

MadeinAustralia Logo Barcode

APPROVED

LABEL

PDF Proof

JOB DES: Closicomb 5L

DIMENSIONS: TICK 102 x 41, FRONT 150 x 230, BACK 215 x 250

DATE: 04/12/06

INKS: 4 COLOUR PROCESS

93 Rookwood Road Yagoona

New South Wales 2199

Phone 9796 3000 Fax 9790 4885 OK TOPROCEED

TO PROOF OK TOPROCEED

TO PRINT ALTERATIONS

4 Colour Process

Dieline

POISON

KEEP OUT OF REACH OF CHILDREN

READ SAFETY DIRECTIONS BEFORE OPENING OR USING

FOR ANIMAL TREATMENT ONLY

For the control of susceptible mature and immature

Gastro-intestinal Roundworms and Tapeworms, Lung

Worms, Liver Fluke (Fasciola hepatica) including 4 week

old immature stages, all stages of Nasal Bots (Oestrus

ovis) and sustained control of susceptible Barber’s

ACTIVE CONSTITUENTS:

37.5 g/L CLOSANTEL

DIRECTIONS FOR USE:

Dosage andAdministration:

SHAKEWELL BEFORE USE. Closicomb ® dose rate is 1 mL /5 kg

bodyweight.Closicomb ® is ready to use and does not require mixing.

Closicomb ® can be used at the recommended doses in sheep of all ages

including pregnant ewes.

Dosage Guide:

Sheep in excess of 75 kg

to be dosed at 1 mL per

5 kg.A representative

sample of animals should

be weighed before

treatment. Dose the mob

according to the heaviest

animal by liveweight in

each group (ewes, rams,

lambs); do not underdose.

Where there is a large

variation in size within the

group, dose rate should be

based on the label

directions for each weight

range. Drafting into two or

more lines may be

appropriate, to avoid excessive overdosing. Check accuracy of drenching gun

before and during use. Rinse drenching gun after use.

Medicinal Claim

Closicomb ® contains Closantel, a member of the Salicylanilides family of

chemicals and Oxfendazole, a member of the Benzimidazole (“white”) group of

anthelmintics.Closicomb ® is effective against sensitive strains (mature and

immature) of the following internal parasites of sheep:

(Haemonchus contortus) Barber’s pole worms: with sustained protection against

reinfestation of Barber’s pole worm in sheep for 4 weeks after dosing;

(Fasciola hepatica) Liver fluke: from four week old stages;

(Oestrus ovis) Nasal bots: all stages;

(Haemonchus placei) Barber’s Pole worm;

(Trichostrongylus axei) Stomach hair worm;

(Ostertagia/Teladorsagiaspp) Small brown stomach worm;

(Trichostrongylusspp) Black scour worm;

(Cooperiaspp) Small intestinal worm;

(Nematodirusspp)Thin necked intestinal worm;

(Oesophagostomum columbianum) Nodule worm;

(Oesophagostomum venulosum) Large bowel worm;

(Chabertia ovina) Large mouthed bowel worm;

(Dictyocaulus filaria) Lungworm;

(Monieziaspp) Tapeworm.

Resistance may develop to any drench.Ask your local veterinary practitioner or

animal health adviser for recommended parasite management practices for your

area to reduce development of resistance. It is advisable that a drench resistance

WITHHOLDING PERIOD:

MEAT: DO NOT USE less than 28 days before slaughter

for human consumption.

TRADE ADVICE: Export Slaughter Interval (ESI):

DONOTUSE less than 60 days before slaughter for export.The ESIon this

label was correct at the time of label approval. Before using this product

confirm the current ESIfrom either the reseller or theAPVMA website

www.apvma.gov.au/residues/ESI.shtml.

SAFETY DIRECTIONS:

Will irritate the eyes and skin.Avoid contact with eyes and skin.When using the

product, wear rubber gloves.Wash hands after use.After each days use, wash

gloves.

FIRST AID:

If poisoning occurs, contact a doctor or Poisons Information Centre. Phone

Australia 131 126.

Additional information is listed in the Material Safety Data Sheet.

VIRBAC (AUSTRALIA) PTY. LIMITED

15 Pritchard Place, Peakhurst NSW 2210

Freecall Customer Service Line: 1800 009 847

www.virbac.com.au

DISPOSAL:

Triple or pressure rinse container including exterior and cap. Dispose of rinsate

and any undiluted chemical according to State legislative requirements.

Container may be recycled at a drumMUSTER collection site if it is clean, dry

and the drumMUSTER logo is visible. Provide cap separately.

STORAGE:

Store below 30ºC (Room temperature). Store in original container. Reseal after

use.

® RegisteredTrademark ofVirbac

[B]: CODE: 1P0270-3

C o ntro l s

r o undw o rms

C o mb i n ation

d ren c h

Cont

r o l s

li verflu

ke

U se

to

r o tate

dr enc

he

s

Closicomb

Sustained ActionOral Anthelmintic

Closicomb

Sustained ActionOral Anthelmintic

and Flukicide for Sheep ®

Bodyweight Dose VolumeAnimals treated

(kg) (mL) 5L

up to 15 3 1666

16-20 4 1250

21-25 5 1000

26-30 6 833

31-35 7 714

36-40 8 625

41-45 9 555

46-50 10 500

51-55 11 454

55-60 12 416

61-65 13 384

66-70 14 657

71-75 15 333

312214220305

5 L IN TE RN ALPARAS

49934_NA_5L_LABEL_MPL_V1

53% on A4

75.2% on A4

APPROVED

LABEL

PDF Proof

JOB DES: Closicomb 20L

DIMENSIONS: 60 x 150, 430 x 270

DATE: 04/12/06

INKS: 4 COLOUR PROCESS

93 Rookwood Road Yagoona

New South Wales 2199

Phone 9796 3000 Fax 9790 4885 OK TOPROCEED

TO PROOF OK TOPROCEED

TO PRINT ALTERATIONS

4 Colour Process

Dieline

Controls

roundworms

Use to rotate

Controls

DIRECTIONS FOR USE:

Dosage andAdministration:

SHAKEWELL BEFORE USE.

Closicomb ® dose rate is 1 mL /5 kg bodyweight.

Closicomb ® is ready to use and does not require mixing.

Closicomb ® can be used at the recommended doses in

sheep of all ages including pregnant ewes.

Dosage Guide:

Sheep in excess of 75 kg to be dosed at 1 mL per 5 kg.A

representative sample of animals should be weighed before

treatment. Dose the mob according to the heaviest animal

by liveweight in each group (ewes, rams, lambs); do not

underdose.Where there is a large variation in size within

the group, dose rate should be based on the label

directions for each weight range. Drafting into two or more

lines may be appropriate, to avoid excessive overdosing.

Check accuracy of drenching gun before and during use.

Rinse drenching gun after use.

Medicinal Claim:

Closicomb ® contains Closantel, a member of the

Salicylanilides family of chemicals and Oxfendazole, a

member of the Benzimidazole (“white”) group of

anthelmintics.Closicomb ® is effective against sensitive

strains (mature and immature) of the following internal

parasites of sheep:

(Haemonchus contortus) Barber’s pole worms: with

sustained protection against re-infestation of Barber’s pole

worm in sheep for 4 weeks after dosing;

(Fasciola hepatica) Liver fluke: from four week old stages;

(Oestrus ovis) Nasal bots: all stages;

(Haemonchus placei) Barber’s Pole worm;

(Trichostrongylus axei) Stomach hair worm;

(Ostertagia/Teladorsagiaspp) Small brown stomach worm;

(Trichostrongylusspp) Black scour worm;

(Cooperiaspp) Small intestinal worm;

(Nematodirusspp)Thin necked intestinal worm;

(Oesophagostomum columbianum) Nodule worm;

(Oesophagostomum venulosum) Large bowel worm;

(Dictyocaulus filaria) Lungworm;

(Monieziaspp) Tapeworm.

Resistance may develop to any drench.Ask your local

veterinary practitioner or animal health adviser for

recommended parasite management practices for your area

to reduce development of resistance. It is advisable that a

drench resistance test be conducted before any drench is

used.

WITHHOLDING PERIOD:

MEAT: DO NOT USE less than 28 days before slaughter for

human consumption.

TRADE ADVICE: Export Slaughter Interval (ESI):

DONOTUSE less than 60 days before slaughter for

export.The ESI on this label was correct at the time of

label approval. Before using this product confirm the

current ESI from either the reseller or theAPVMA website

www.apvma.gov.au/residues/ESI.shtml

SAFETY DIRECTIONS:

Will irritate the eyes and skin.Avoid contact with eyes and

skin.When using the product, wear rubber gloves.Wash

hands after use.After each days use, wash gloves.

FIRST AID:

If poisoning occurs, contact a doctor or Poisons

Information Centre. PhoneAustralia 131 126.

Additional information is listed in the Material Safety Data

Sheet.

VIRBAC (AUSTRALIA) PTY. LIMITED

15 Pritchard Place, Peakhurst NSW 2210

Freecall Customer Service Line: 1800 009 847

www.virbac.com.au

DISPOSAL:

Triple or pressure rinse container including exterior and

cap. Dispose of rinsate and any undiluted chemical

according to State legislative requirements. Container may

be recycled at a drumMUSTER collection site if it is clean,

dry and the drumMUSTER logo is visible. Provide cap

separately.

STORAGE:

Store below 30ºC (Room temperature). Store in original

container. Reseal after use.

® RegisteredTrademark ofVirbac

[B]: CODE: 1P0269-3

EXP: APVMA: 49934/20L/1006

Combination

drench

Bodyweight Dose Volume Sheep Treated

Kg mL 20 Litre

Up to 15 3 6666

16 – 20 4 5000

21 – 25 5 4000

26 – 30 6 3333

31 – 35 7 2857

36 – 40 8 2500

41 – 45 9 2222

46 – 50 10 2000

51 – 55 11 1818

56 – 60 12 1666

61 – 65 13 1538

66 – 70 14 1428

71 – 75 15 1333

For the control of

susceptible mature and

immature Gastro-intestinal

Roundworms and

Tapeworms, LungWorms,

Liver Fluke (Fasciola

hepatica) including 4 week

old immature stages, all

stages of Nasal Bots

(Oestrus ovis) and

sustained control of

susceptible Barber’s Pole

Worm (Haemonchus

ACTIVE CONSTITUENTS:

37.5 g/L CLOSANTEL

POISON

KEEP OUT OF REACH OF CHILDREN

READ SAFETY DIRECTIONS BEFORE OPENING OR USING

FOR ANIMAL TREATMENT ONLY

CYAN MAGENTA YELLOW BLACK IN TE RN ALPARAS

Closicomb

Sustained ActionOral Anthelmintic

Closicomb

Sustained ActionOral Anthelmintic

and Flukicide for Sheep ®

Closicomb

Sustained ActionOral Anthelmintic

49934_NA_20L_LABEL_MPL_V1

52.4% on A4

74.3% on A3

APPROVED

LABEL

December2006 Page1of5 Draft Label –Front Panel

_______________________________________________________________________________________________

POISON

KEEP OUT OF REACHOF CHILDREN

READ SAFETY DIRECTIONS BEFORE OPENING OR USING

FOR ANIMAL TREATMENT ONLY

Closicomb ®

Sustained action Oral Anthelmintic

and Flukicide for Sheep

ACTIVE CONSTITUENT:

37.5 g/L CLOSANTEL

22.6 g/L OXFENDAZOLE

For the control of susceptible mature andimmature

Gastro-intestinal Roundworms and Tapeworms, Lung Worms,

Liver Fluke (Fasciola hepatica) including 4 week oldimmature stages,

all stages of Nasal Bots (Oestrus ovis) and sustained control of

susceptible Barber’s Pole Worm (Haemonchus contortus) in sheep.

[ImageofSheep]

25 L

INTERNAL

PARASITES

APPROVED

LABEL

December 2006 Page1 of 5 DraftLabel– BackLabel

_______________________________________________________________________________________________

Closicomb ®

Sustained ActionOralAnthelmintic

and Flukicide for Sheep

DIRECTIONSFOR USE:

Dosage and Administration:

SHAKEWELL BEFORE USE.

Closicomb®doserateis1mL/5kg bodyweight.

Closicomb®isready touseanddoesnot require mixing.

Closicomb®canbe usedatthe recommended dosesinsheepofallagesincluding

pregnant ewes.

DosageGuide:

Bodyweight

Kg Dose Volume

mL Sheep Treated

25Litre

Up to15 3 8,333

16-20 46,250

21-25 55,000

26-30 64,166

31-35 73,571

36-40 83,125

41-45 92,777

46-50 102,500

51-55 112,272

56-60 122,083

61-65 131,923

66-70 141,785

71-75 151,666

Sheepinexcess of 75kgtobedosed at1mLper5kg.A representative sampleof

animals shouldbe weighedbeforetreatment. Dose themobtotheheaviest animalby

liveweightineachgroup (ewes,rams,lambs);donotunderdose. Wherethereisalarge

variation in sizewithin the group,doserateshouldbebasedon thelabel directions for

each weightrange.Drafting intotwo ormorelinesmay beappropriate,toavoid excessive

overdosing.Check accuracyofdrenching gun beforeand duringuse.Rinsedrenchinggun

afteruse.

Medicinalclaim:

Closicomb®containsClosantel,amemberofthe Salicylanilides familyof chemicalsand

Oxfendazole,amemberoftheBenzimidazole(“white”)group ofanthelmintics.

Closicomb®iseffectiveagainst sensitivestrains (matureandimmature) ofthefollowing

internal parasites ofsheep:

(Haemonchuscontortus)Barber’spoleworms : withsustained protectionagainstre-

infestation ofBarber’spole wormin sheepfor4weeks afterdosing;

(Fasciola hepatica) Liver fluke: from fourweekoldstages;

(Oestrus ovis)Nasal bots :all stages;

(Haemonchus placei)Barbers poleworm;

(Trichostrongylus axei)Stomachhairworm;

APPROVED

LABEL

December 2006 Page2 of 5 DraftLabel– BackLabel

_______________________________________________________________________________________________

(Trichostrongylusspp)Black scourworm

(Cooperiaspp) Smallintestinalworm;

(Nematodirusspp) Thinnecked intestinal worm;

(Oesophagostomumcolumbianum)Noduleworm;

(Oesophagostomumvenulosum)Largebowel worm;

(Chabertiaovina) Large mouthedbowelworm;

(Dictyocaulus filaria) Lungworm

(Monieziaspp)Tapeworm.

Resistancemay develop to anydrench. Askyourlocal veterinarypractitioner or animal

healthadviserforrecommended parasitemanagementpractices foryourareatoreduce

development of resistance.It isadvisable that a drench resistancetest beconducted

before anydrench isused.

WITHHOLDING PERIOD:

MEAT:DONOT USElessthan28daysbeforeslaughter for human consumption.

TRADE ADVICE:ExportSlaughter Interval (ESI):

DO NOTUSE less than60daysbeforeslaughter for export. The ESI on this label

wascorrectatthe timeoflabelapproval.Before using thisproduct confirm the

currentESIfrom either thereseller or theAPVMAwebsite

www.apvma.gov.au/residues/ESI.shtml

SAFETYDIRECTIONS:

Willirritatethe eyesand skin.Avoid contactwitheyes andskin.Whenusingthe

productwear rubbergloves. Washhands after use. After eachday's usewash

gloves.

FIRST AID:

If poisoning occurs, contact adoctor orPoisonsInformation Centre.Phone

Australia 131 126.

Additional information islistedin the MaterialSafetyDataSheet.

VIRBAC(AUSTRALIA)PTY.LIMITED

15PritchardPlace,PeakhurstNSW2210

Freecall CustomerServiceLine:1800 009 847

www.virbac.com.au

DISPOSAL:

Tripleor pressure rinse container including exterior or cap.Disposeofrinsateandany

undiluted chemical accordingtoStatelegislative requirements.Containermay be recycledat

a drumMUSTER collectionsite ifit is clean,dry and thedrumMUSTERlogoisvisible.

Provide cap separately.

STORAGE:

Store below 30 °C(Room Temperature). Storeinoriginalcontainer. Resealafteruse.

®RegisteredTrademark ofVirbac.

[B]: CODE:

APPROVED

LABEL

December 2006 Page3 of 5 DraftLabel– BackLabel

_______________________________________________________________________________________________

drumMUSTER – eligible containerLogo MadeinAustralia Logo Barcode

APPROVED

LABEL

December 2006 Page1 of 5 Draft Label– TickBoxSticker

_______________________________________________________________________________________________

Closicomb

®

Sustained Action Oral Anthelmintic

and Flukicide for Sheep

9Controlsroundworms

9Controls liver fluke

9Combinationdrench

9Use torotatedrenches

APPROVED

LABEL

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Closicomb

Sustained Action

Oral.Doc

Revision D SAFETY DATA SHEET

Product Name:

Closicomb Sustained Action Oral Anthelmintic and Flukicide for Sheep Page: 1 of 5

Date of Issue

8 April, 2013

Emergency:Virbac: 02 9772 9772 or1800 242 100(Business hours only)

Section 1 - Identification ofThe Material and Supplier

Company: Virbac (Australia) Pty. Ltd

ABN 77 003 268871

Address 361 Horsley Rd, Milperra, NSW 2214, Australia

Locked Bag6000, Milperra BusinessCentre, NSW 1891, Australia

Telephone: (02) 9772 9772 or 1800 242 100

Fax: (02) 9772 9773

Emergencyphone As above during business hours; answering machine after hours

Chemical nature: Closantel isabenzamide derivative.

Trade Name: Closicomb Sustained Action Oral Anthelmintic and Flukicide for Sheep

Product Code:CLCOM020; CLCOM005

Product Use: For the control of certain endoparisites insheep.

Creation Date: July,2002

This version issued: April, 2013and is valid for 5 years fromthis date.

Section 2 - Hazards Identification

STATEMENTOF HAZARDOUS NATURE

This productis classifiedas:Hazardous accordingto the criteriaof SWA Australia.

Not a Dangerous Good according to theAustralian DangerousGoods (ADG) Code.

Risk Phrases:R36. Irritating to eyes.

SafetyPhrases:S25. Avoid contact with eyes.

SUSMP Classification:S6

ADG Classification:None allocated.Not a Dangerous Good.

UN Number:Noneallocated

GHS Signal word: WARNING.

HAZARD STATEMENT:

H320: Causeseye irritation.

PREVENTION

P264: Washcontacted areas thoroughly after handling.

P280: Wearprotective gloves, protectiveclothing andeye or face protection.

P281: Use personal protective equipmentas required.

RESPONSE

P337: If eye irritation persists: seek medical attention.

P353: Rinseskin orshowerwith water.

P301+P330+P331: IF SWALLOWED: Rinsemouth.Do NOT induce vomiting.

P305+P351+P338: IF IN EYES: Rinse cautiously with water forseveral minutes. Remove contactlenses,if

present and easy to do. Continue rinsing.

P337+P313: If eye irritationpersists: Get medical advice.

P370+P378: In case of fire:Not Combustible. Useextinguishing media suitedto burning materials.

STORAGE

P402+P404:Store in a dryplace.Store ina closedcontainer.

P403+P235:Store in a well-ventilated place. Keepcool.

DISPOSAL

P501: Dispose of contentsand containers to landfill.

EmergencyOverview

Physical Description & colour: Cream to beigecolouredliquid.

Odour:No data.

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Closicomb

Sustained Action

Oral.Doc

Revision D SAFETY DATA SHEET

Product Name:

Closicomb Sustained Action Oral Anthelmintic and Flukicide for Sheep Page: 2 of 5

Date of Issue

8 April, 2013

Emergency:Virbac: 02 9772 9772 or1800 242 100(Business hours only)

Major HealthHazards:No major health hazardsare known.

Potential Health Effects

Inhalation

Short termexposure:Available data indicates that this product isnot harmful. However, this product may be

irritating, but isunlikely to cause anything more thanmild transientdiscomfort.

Long Term exposure:No data for health effectsassociatedwith long term inhalation.

Skin Contact:

Short termexposure:Available data indicates that this product is not harmful. It should present no hazards in

normal use. In addition, thisproduct may be irritating,butis unlikely to cause anything more than mild transient

discomfort.

Long Term exposure:No data for health effectsassociatedwith long term skin exposure.

Eye Contact:

Short termexposure:Available data shows that this product is notharmful. In addition, this product is an eye

irritant. Symptoms may include stingingand reddeningofeyes andwateringwhich may become copious. Other

symptomsmay also become evident. If exposure isbrief,symptoms should disappear onceexposure has ceased.

However, lengthy exposure or delayedtreatment may cause permanent damage.

Long Term exposure:No data for health effectsassociatedwith long term eye exposure.

Ingestion:

Short termexposure:Available data shows that this product is not harmful. Thisproduct isunlikely to cause any

irritation problems in theshort or longterm.

Long Term exposure:No data for health effectsassociatedwith long term ingestion.

Carcinogen Status:

SWA:No significant ingredient is classified as carcinogenic by SWA.

NTP:No significant ingredient is classified as carcinogenic by NTP.

IARC:No significant ingredient isclassified ascarcinogenic by IARC.

Section 3 – Composition/Information on Ingredients

Ingredients CAS No Conc,% TWA (mg/m3) STEL (mg/m3)

Closantel 57808-65-8 3.58 not set not set

Oxfendazole 53716-50-0 2.12 not set not set

Non hazardous aliphatic glycol secret 30-60 not set not set

Other non hazardous ingredients secret <10 not set not set

Water 7732-18-5 to 100 not set not set

This isa commercial product whose exact ratio of components may vary slightly. Minor quantities of other non

hazardousingredients arealso possible.

The TWA exposure value is the average airborne concentrationof aparticular substance when calculated over a normal 8 hourworking dayfor a 5

dayworkingweek. The STEL (Short Term Exposure Limit)is an exposure value thatshouldnot be exceeded for morethan 15 minutes andshould

not be repeated for more than 4 times per day. There should beat least 60 minutes between successive exposures atthe STEL. The term "peak "is

used when theTWA limit, because of the rapid action of thesubstance, should never beexceeded, even briefly.

Section 4 - First Aid Measures

General Information:

You should call The Poisons Information Centre if youfeel that you may have been poisoned, burned orirritated by

this product. The number is13 1126 fromanywhere inAustralia and is availableat all times. Have this MSDS with

you whenyou call.

Inhalation:No first aid measuresnormally required.However,if inhalation hasoccurred, andirritation has

developed, remove to freshair and observe until recovered.If irritation becomespainful or persistsmore than about

30 minutes, seek medical advice.

Skin Contact:Irritation isunlikely. However, if irritation does occur, flushwith lukewarm, gently flowing water for 5

minutes oruntil chemical is removed.

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Closicomb

Sustained Action

Oral.Doc

Revision D SAFETY DATA SHEET

Product Name:

Closicomb Sustained Action Oral Anthelmintic and Flukicide for Sheep Page: 3 of 5

Date of Issue

8 April, 2013

Emergency:Virbac: 02 9772 9772 or1800 242 100(Business hours only)

Eye Contact:Quickly and gently blot or brush awayproduct.Immediately flush the contaminated eye(s) with

lukewarm, gently flowing water until the product isremovedor until a few minutesafter irritation hasceased, while

holdingthe eyelid(s) open.Takecare not to rinse contaminatedwater into the unaffected eyeor onto the face.

Ingestion:First aid isnot generally required. If in doubt, contact a Poisons Information Centre or a doctor.

Section 5 – Fire Fighting Measures

Fire and Explosion Hazards: Thereis no risk ofan explosionfrom this product under normal circumstances if it is

involved in a fire.

Fire decomposition products from this product may be toxic if inhaled. Take appropriate protective measures.

This product islikely to decompose onlyafter heating todryness, followedby further strongheating.

Extinguishing Media:Not Combustible. Use extinguishing media suited to burning materials.

Fire Fighting:If a significant quantity of this productis involved ina fire, call thefire brigade.

Flash point: Doesnot burn.

Upper FlammabilityLimit: Doesnot burn.

Lower FlammabilityLimit: Doesnot burn.

Autoignitiontemperature: Doesnot burn.

Flammability Class: Doesnot burn.

Section 6 – Accidental Release Measures

Accidental release:Thisproduct is sold in smallpackages, andthe accidental release fromone of these is not

usually a cause forconcern. For minor spills, clean up, rinsing to sewer and put empty container in garbage. Although

no special protective clothing is normallynecessary becauseof occasional minor contactwith this product, it is good

practice to wear impermeable gloveswhen handlingchemicalproducts. In the event of a major spill, prevent spillage

from enteringdrainsorwater courses and call emergency services.

Section 7 – Handling and Storage

Handling:Keep exposureto this product to a minimum, and minimise the quantities kept in work areas. Check

Section 8 of this MSDS for details of personal protectivemeasures,and make sure that those measures arefollowed.

The measuresdetailed below under "Storage" shouldbe followed during handling in order tominimise risks to

personsusing the productin the workplace. Also, avoidcontact or contamination of productwith incompatible

materials listed in Section 10.

Storage:This product is aScheduled Poison. Observe all relevantregulations regardingsale, transport and storage

of this class ofpoison. Make sure that containers of thisproduct arekept tightly closed. Makesure that the product

does not comeinto contactwith substanceslisted under "Materials toavoid" in Section 10. Someliquid preparations

settle orseparate onstanding and may require stirringbefore use.Check packaging - theremay be further storage

instructionsonthe label.

Section 8 Exposure Controlsand PersonalProtection

The followingAustralian Standards will provide general advice regarding safety clothing and equipment:

Respiratory equipment:AS/NZS 1715, Protective Gloves:AS 2161, OccupationalProtective Clothing: AS/NZS 4501

set 2008, Industrial Eye Protection:AS1336andAS/NZS 1337, Occupational Protective Footwear:AS/NZS2210.

SWA Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 )

Exposure limits have not been established by SWA for anyof the significant ingredients in this product.

The ADI for Closantel is set at 0.025mg/kg/day.The correspondingNOEL issetat 2.5mg/kg/day.

The ADI forOxfendazole isset at 0.005mg/kg/day. Thecorresponding NOEL is set at0.5mg/kg/day. ADI means

AcceptableDaily Intake and NOEL means No-observable-effect-level. Valuestaken from Australian ADI List, Sept

2011.

Ventilation:No special ventilation requirements arenormally necessary for thisproduct. Howevermake sure that

the work environment remainsclean and that dusts are minimised.

Eye Protection:Protective glasses or gogglesshould be wornwhenthis product is beingused. Failure to protect

your eyes may cause themharm. Emergency eye wash facilities are also recommended in an area close to where

this product is beingused.

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Closicomb

Sustained Action

Oral.Doc

Revision D SAFETY DATA SHEET

Product Name:

Closicomb Sustained Action Oral Anthelmintic and Flukicide for Sheep Page: 4 of 5

Date of Issue

8 April, 2013

Emergency:Virbac: 02 9772 9772 or1800 242 100(Business hours only)

Skin Protection:You should avoidcontact even withmild skin irritants. Therefore you should wearsuitable

impervious elbow-length gloves and facial protectionwhenhandling this product. See below for suitable material

types.

Protective Material Types:We suggest that protective clothingbemade from the following materials:rubber,

PVC.

Respirator:Usually, no respiratoris necessary whenusing this product. However, if you have any doubts consult

the AustralianStandard mentioned above.Otherwise,not normallynecessary.

Section 9 - Physical and Chemical Properties:

Physical Description & colour:Cream to beige coloured liquid.

Odour:No data.

Boiling Point: Approximately 100°C at 100kPa.

Freezing/Melting Point:Approximately 0°C.

Volatiles: Water component.

Vapour Pressure: 2.37 kPa at 20°C(watervapour pressure).

Vapour Density:No data.

Specific Gravity:1.06-1.10

Water Solubility: Completely soluble inwater.

pH:7.5-8.5 approx

Volatility:No data.

Odour Threshold:No data.

Evaporation Rate:No data.

Coeff Oil/water distribution: No data

Section 10 – Stabilityand Reactivity

Reactivity:This product isunlikely to react ordecompose undernormal storage conditions. However, if you have

any doubts, contact the supplier for advice onshelf life properties.

Conditions to Avoid:This product should bekept in a cool place, preferably below30°C.

Incompatibilities:No particular incompatibilities.

Fire Decomposition:Carbondioxide,and if combustion isincomplete, carbonmonoxide and smoke. Nitrogen and

its compounds, and undersomecircumstances, oxides ofnitrogen. Occasionallyhydrogencyanide gas. Hydrogen

chloride gas,other compounds of chlorine. Water.iodine compounds. Carbon monoxide poisoning produces

headache, weakness, nausea, dizziness, confusion, dimness of vision, disturbance of judgment, and

unconsciousness followedby coma and death. Hydrogen cyanidepoisoningsigns and symptoms are weakness,

dizziness, headache, nausea, vomiting, coma,convulsions, and death. Death results from respiratory arrest.

Hydrogencyanide gas actsvery rapidly; symptoms and deathcanboth occur quickly.

Polymerisation:This product is unlikely to undergopolymerisation processes.

Section 11 – Toxicological Information

Target Organs: There is no data to hand indicatingany particulartarget organs.

Classificationof Hazardous Ingredients

IngredientRisk Phrases

No hazardousingredientspresent in hazardous concentrations.

Section 12 – Ecological Information

This product isbiodegradable. It will notaccumulatein the soil orwater orcause long term problems.

Section 13 – Disposal Considerations

Disposal:Dispose of small quantities and empty containers bywrapping withpaper and putting in garbage. For

largerquantities, if recycling or reclaimingis notpossible, use acommercial waste disposalservice.

Section 14 – Transport Information

ADG Code:This productis not classified as aDangerousGood. No special transport conditions are necessary

unless required by other regulations.

VIRBAC (AUSTRALIA) PTY. LTD.

Document No:

Closicomb

Sustained Action

Oral.Doc

Revision D SAFETY DATA SHEET

Product Name:

Closicomb Sustained Action Oral Anthelmintic and Flukicide for Sheep Page: 5 of 5

Date of Issue

8 April, 2013

Emergency:Virbac: 02 9772 9772 or1800 242 100(Business hours only)

Section 15 – RegulatoryInformation

AICS:All of the significant ingredients inthis productare compliantwith NICNAS regulations.

Section 16 – Other Information

This MSDS contains onlysafety-related information. For other data see product literature.

Contact point: Technical Manager, QA Manager or R&D Director

Telephone (02) 9772 9772 or 1800 242 100

Fax (02) 9772 9773

Acronyms:

ADG Code Australian Code for the Transport of Dangerous Goods by Roadand Rail, 7th Edition

AICS Australian Inventory of Chemical Substances

CAS number Chemical Abstracts Service Registry Number

HazchemNumber Emergency action code ofnumbers andlettersthat provide information to emergency

servicesespecially firefighters

IARC International Agency forResearch onCancer

SWA Safe WorkAustralia, formerlyASCC and NOHSC

NOS Not otherwisespecified

NTP National Toxicology Program (USA)

R-PhraseRisk Phrase

SUSMP Standard for the Uniform Scheduling ofMedicines & Poisons

UN NumberUnited Nations Number

THIS MSDS SUMMARISES OUR BEST KNOWLEDGEOFTHEHEALTHAND SAFETYHAZARD INFORMATION OFTHEPRODUCTAND

HOW TOSAFELYHANDLE ANDUSE THE PRODUCT INTHE WORKPLACE.EACH USER MUSTREVIEW THIS MSDS IN THECONTEXTOF

HOW THE PRODUCT WILLBE HANDLEDANDUSED IN THE WORKPLACE.

IF CLARIFICATIONORFURTHER INFORMATION IS NEEDED TOENSURETHATAN APPROPRIATE RISK ASSESSMENT CANBE MADE,

THE USER SHOULD CONTACTTHIS COMPANY SOWE CAN ATTEMPT TOOBTAIN ADDITIONALINFORMATION FROMOUR SUPPLIERS

OURRESPONSIBILITYFOR PRODUCTS SOLDISSUBJECT TO OUR STANDARDTERMS ANDCONDITIONS, ACOPYOF WHICH IS SENT

TOOUR CUSTOMERS AND IS ALSOAVAILABLEONREQUEST.

Please read all labels carefully before using product.

This MSDS isprepared in accord withthe SWA document “Preparation of Safety Data Sheets for

HazardousChemicals - Code of Practice” (December 2011)

Copyright ©Kilford & Kilford Pty Ltd, April, 2013.

http://www.kilford.com.au/ Phone (02)9251 4532

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