Metacox 15 mg ad us. vet.

Hauptinformation

  • Handelsname:
  • Metacox® 15 mg ad us. vet., orale Suspension
  • Darreichungsform:
  • orale Suspension
  • Verwenden für:
  • Tiere
  • Art der Medizin:
  • allopathic Droge

Dokumenten

  • Information für medizinisches Fachpersonal:
  • Das Informationsblatt für dieses Produkt ist derzeit nicht verfügbar, können Sie eine Anfrage an unseren Kundendienst zu senden und wir werden Sie benachrichtigen, sobald wir in der Lage, um es zu erhalten.


    Fordern Sie die Packungsbeilage für medizinisches Fachpersonal.

Lokalisierung

  • Erhältlich in:
  • Metacox® 15 mg ad us. vet., orale Suspension
    Schweiz
  • Sprache:
  • Deutsch

Therapeutische Informationen

  • Therapiegruppe:
  • Nichtsteroidales Antiphlogistikum für Pferde

Weitere Informationen

Status

  • Quelle:
  • Institut für Veterinärpharmakologie
  • Zulassungsnummer:
  • 65142
  • Letzte Änderung:
  • 02-09-2017

Packungsbeilage

Metacox

15 mg ad us. vet., orale Suspension

Dr. E. Graeub AG

Nichtsteroidales Antiphlogistikum für Pferde

ATCvet: QM01AC06

Zusammensetzung

1 ml Suspension enthält:

Meloxicam 15 mg

Aromatica: Saccharinum natricum et alia, Conserv.: Natrii benzoas E211

Excip. ad susp.

Fachinformationen Wirkstoffe (CliniPharm)

Meloxicam

Eigenschaften / Wirkungen

Meloxicam ist ein nichtsteroidales Antiphlogistikum (NSAID) der Oxicam-Gruppe, das die

Prostaglandinsynthese hemmt und antiinflammatorisch, analgetisch, antiexsudativ und

antipyretisch wirkt. Es reduziert die Leukozyteninfiltration in das entzündete Gewebe.

Ausserdem besteht eine schwache Hemmung der kollageninduzierten

Thrombozytenaggregation. Meloxicam verfügt ebenfalls über antiendotoxische

Eigenschaften. Es konnte gezeigt werden, dass die Thromboxan B2 Produktion bei

Kälbern und Schweinen nach intravenöser E. coli-Endotoxin Verabreichung durch

Meloxicam gehemmt wird.

Pharmakokinetik

Absorption:

Wird das Tierarzneimittel entsprechend der Dosierungsanleitung verabreicht, beträgt die

orale Bioverfügbarkeit ungefähr 98%. Maximale Plasmakonzen-trationen werden nach

ungefähr 2 - 3 Stunden erreicht. Der Kumulationsfaktor von 1.08 weist darauf hin, dass

sich Meloxicam bei 1 × täglicher Verabreichung nicht anreichert.

Verteilung:

Meloxicam ist zu ungefähr 98% an Plasmaproteine gebunden. Das Verteilungsvolumen

beträgt 0.12 l/kg.

Metabolismus:

Der Metabolismus bei Ratten, Minipigs, Menschen, Rindern und Schweinen ist qualitativ

ähnlich, unterscheidet sich jedoch quantitativ. Die in allen Spezies gefundenen

Hauptmetaboliten sind 5-Hydroxy- und 5-Carboxy-Metaboliten sowie Oxalyl-Metaboliten.

Der Metabolismus bei Pferden wurde nicht untersucht. Alle Hauptmetaboliten haben sich

als pharmakologisch inaktiv erwiesen.

Elimination:

Meloxicam wird mit einer Eliminationshalbwertszeit von 7.7 Stunden ausgeschieden.

Indikationen

Linderung von Entzündungen und Schmerzen bei akuten und chronischen Erkrankungen

des Bewegungsapparates.

Metacox orale Suspension ist einmal täglich in einer Dosis von 0.6 mg Meloxicam pro kg

Körpergewicht (entspr. 1 ml pro 25 kg Körpergewicht) mit dem Futter vermischt oder direkt

in das Maul zu verabreichen (während maximal 14 Tagen).

Bei Verabreichung mit dem Futter sollte das Präparat mit wenig Futter vermischt vor der

eigentlichen Fütterung verabreicht werden.

Die Suspension sollte mit Hilfe der beiliegenden Metacox Dosierspritze verabreicht

werden. Die Spritze passt auf die Flasche und weist eine Skala in kg Körpergewicht

Graduierungsschritten auf.

Vor Gebrauch gut schütteln. Verunreinigungen während der Entnahme vermeiden.

Im Falle einer Überdosierung soll eine symptomatische Behandlung eingeleitet werden.

Anwendungseinschränkungen

Kontraindikationen

Nicht anwenden bei trächtigen oder säugenden Stuten.

Nicht anwenden bei Pferden mit gastrointestinalen Störungen wie Ulzerationen oder

Hämorrhagien.

Nicht anwenden bei Funktionsstörungen von Leber, Herz oder Nieren. Weitere

Gegenanzeigen sind Blutgerinnungsstörungen.

Nicht anwenden bei bekannter Überempfindlichkeit gegenüber dem Wirkstoff oder einem

der sonstigen Bestandteile.

Nicht anwenden bei Pferden, die jünger als 6 Wochen sind.

Vorsichtsmassnahmen

Falls Nebenwirkungen auftreten, sollte die Behandlung abgebrochen und der Rat eines

Tierarztes eingeholt werden.

Nicht anwenden bei dehydrierten, hypovolämischen oder hypotonischen Tieren, da hier

ein potentielles Risiko einer Nierentoxizität besteht.

Laborstudien am Rind haben keinen Hinweis auf teratogene, foetotoxische oder

maternotoxische Wirkungen geliefert. Es wurden jedoch keine Daten für das Pferd

erhoben. Deshalb wird die Anwendung bei dieser Spezies während Trächtigkeit und

Säugezeit / Laktation nicht empfohlen.

Unerwünschte Wirkungen

VetVigilance: Pharmacovigilance-Meldung erstatten

In Einzelfällen wurden während der klinischen Studien die für NSAIDs typischen

Nebenwirkungen (leichte Urtikaria, Diarrhoe) beobachtet. Die Symptome waren nach

Absetzen der Therapie reversibel.

In sehr seltenen Fällen wurde über Appetitverlust, Lethargie, abdominalen Schmerz und

Colitis berichtet.

In sehr seltenen Fällen kann es zu anaphylaktoiden Reaktionen kommen, die

schwerwiegend sein können (auch lebensbedrohend). Diese sollten symptomatisch

behandelt werden.

Essbare Gewebe: 3 Tage

Nicht bei Stuten anwenden, deren Milch für den menschlichen Verzehr vorgesehen ist.

Wechselwirkungen

Nicht zusammen mit Glukokortikoiden, anderen nichtsteroidalen Antiphlogistika oder

Antikoagulantien verabreichen.

Sonstige Hinweise

Lagerungshinweise

Bei Raumtemperatur (15 - 25°C) aufbewahren. Nach Verabreichen des Medikamentes die

Flasche mit dem Deckel wieder verschliessen und die Dosierspritze mit warmem Wasser

ausspülen und trocknen lassen. Medikament ausser Reichweite von Kindern

aufbewahren. Das Präparat darf nur bis zu dem auf der Packung mit "EXP." bezeichneten

Datum verwendet werden. Aufbrauchfrist nach 1. Entnahme: 3 Monate

Anwenderhinweise

Personen mit bekannter Überempfindlichkeit gegenüber NSAIDs sollten den direkten

Kontakt mit dem Tierarzneimittel vermeiden. Bei versehentlicher Einnahme ist

unverzüglich ein Arzt aufzusuchen (Packungsbeilage mitnehmen!).

Packungen

Flaschen zu 100 ml und 250 ml mit Dosierspritze

Abgabekategorie: B

Swissmedic Nr. 65'142

Informationsstand: 02/2014

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November is #DiabetesAwarenessMonth  #DYK using a glucose meter to check and monitor blood sugar is a daily part of life for millions of Americans with diabetes? Check out the @US_FDA's tips on how to safely use glucose meters and test strips for diabetes

November is #DiabetesAwarenessMonth #DYK using a glucose meter to check and monitor blood sugar is a daily part of life for millions of Americans with diabetes? Check out the @US_FDA's tips on how to safely use glucose meters and test strips for diabetes

November is #DiabetesAwarenessMonth #DYK using a glucose meter to check and monitor blood sugar is a daily part of life for millions of Americans with diabetes? Check out the @US_FDA's tips on how to safely use glucose meters and test strips for diabetes: https://go.usa.gov/xPdK4 

FDA - U.S. Food and Drug Administration

2-11-2018

.@US_FDA  issues a class I recall: Roche Diagnostics recalls CoaguChek  XS PT Test  Strips due to inaccurate INR test results. Find out more:  https://go.usa.gov/xPVER  #FDA #MedicalDevicepic.twitter.com/EYmVZHrUZc

.@US_FDA issues a class I recall: Roche Diagnostics recalls CoaguChek XS PT Test Strips due to inaccurate INR test results. Find out more: https://go.usa.gov/xPVER  #FDA #MedicalDevicepic.twitter.com/EYmVZHrUZc

. @US_FDA issues a class I recall: Roche Diagnostics recalls CoaguChek XS PT Test Strips due to inaccurate INR test results. Find out more: https://go.usa.gov/xPVER  #FDA #MedicalDevice pic.twitter.com/EYmVZHrUZc

FDA - U.S. Food and Drug Administration

2-11-2018

Check out @US_FDA's information on Direct-to-Consumer Tests:  https://go.usa.gov/xPVPu  #MedicalDevice #FDA

Check out @US_FDA's information on Direct-to-Consumer Tests: https://go.usa.gov/xPVPu  #MedicalDevice #FDA

Check out @US_FDA's information on Direct-to-Consumer Tests: https://go.usa.gov/xPVPu  #MedicalDevice #FDA

FDA - U.S. Food and Drug Administration

2-11-2018

#DYK the @US_FDA recently authorized the first direct-to-consumer test   for detecting genetic variants that may be associated with medication   metabolism? Learn more about the authorization:  https://go.usa.gov/xPVUt  #MedicalDevice #FDA

#DYK the @US_FDA recently authorized the first direct-to-consumer test for detecting genetic variants that may be associated with medication metabolism? Learn more about the authorization: https://go.usa.gov/xPVUt  #MedicalDevice #FDA

#DYK the @US_FDA recently authorized the first direct-to-consumer test for detecting genetic variants that may be associated with medication metabolism? Learn more about the authorization: https://go.usa.gov/xPVUt  #MedicalDevice #FDA

FDA - U.S. Food and Drug Administration

1-11-2018

The @US_FDA issues a letter to health care providers regarding possible battery failure in Getinge's Maquet/Datascope intra-aortic balloon pumps. Read the letter here:  https://go.usa.gov/xPyHT  #MedicalDevice

The @US_FDA issues a letter to health care providers regarding possible battery failure in Getinge's Maquet/Datascope intra-aortic balloon pumps. Read the letter here: https://go.usa.gov/xPyHT  #MedicalDevice

The @US_FDA issues a letter to health care providers regarding possible battery failure in Getinge's Maquet/Datascope intra-aortic balloon pumps. Read the letter here: https://go.usa.gov/xPyHT  #MedicalDevice

FDA - U.S. Food and Drug Administration

1-11-2018

The @US_FDA warns patients & health care providers should not change drug treatment based on results from certain genetic tests w/ unapproved claims to predict a patient’s response to specific medications. Read the Safety Communication here:  https://go.u

The @US_FDA warns patients & health care providers should not change drug treatment based on results from certain genetic tests w/ unapproved claims to predict a patient’s response to specific medications. Read the Safety Communication here: https://go.u

The @US_FDA warns patients & health care providers should not change drug treatment based on results from certain genetic tests w/ unapproved claims to predict a patient’s response to specific medications. Read the Safety Communication here: https://go.usa.gov/xPysF  #MedicalDevice

FDA - U.S. Food and Drug Administration

31-10-2018

Imraldi (Samsung Bioepis NL B.V.)

Imraldi (Samsung Bioepis NL B.V.)

Imraldi (Active substance: adalimumab) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)7344 of Wed, 31 Oct 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/4279/T/15

Europe -DG Health and Food Safety

30-10-2018

#DYK: Mammograms are still the best tool for breast cancer screening.  Check out @US_FDA’s information on the importance of choosing a certified mammography facility:  https://go.usa.gov/xPPpT  #MedicalDevice #BreastCancerAwarenessMonthpic.twitter.com/YaG

#DYK: Mammograms are still the best tool for breast cancer screening. Check out @US_FDA’s information on the importance of choosing a certified mammography facility: https://go.usa.gov/xPPpT  #MedicalDevice #BreastCancerAwarenessMonthpic.twitter.com/YaG

#DYK: Mammograms are still the best tool for breast cancer screening. Check out @US_FDA’s information on the importance of choosing a certified mammography facility: https://go.usa.gov/xPPpT  #MedicalDevice #BreastCancerAwarenessMonth pic.twitter.com/YaGqeGgrTH

FDA - U.S. Food and Drug Administration

26-10-2018

Men can also be diagnosed with breast cancer. Check out the @US_FDA’s information regarding breast cancer in men, available treatments and counseling options:  https://go.usa.gov/xPPpx  ) #MedicalDevice #BreastCancerAwarenessMonthpic.twitter.com/aZBjgCGsB

Men can also be diagnosed with breast cancer. Check out the @US_FDA’s information regarding breast cancer in men, available treatments and counseling options: https://go.usa.gov/xPPpx  ) #MedicalDevice #BreastCancerAwarenessMonthpic.twitter.com/aZBjgCGsB

Men can also be diagnosed with breast cancer. Check out the @US_FDA’s information regarding breast cancer in men, available treatments and counseling options: https://go.usa.gov/xPPpx  ) #MedicalDevice #BreastCancerAwarenessMonth pic.twitter.com/aZBjgCGsB1

FDA - U.S. Food and Drug Administration

24-10-2018

It’s #BreastCancerAwarenessMonth and the @US_FDA is reminding patients and caregivers that thermography is not a substitute for mammograms.pic.twitter.com/XGJFHvut4x

It’s #BreastCancerAwarenessMonth and the @US_FDA is reminding patients and caregivers that thermography is not a substitute for mammograms.pic.twitter.com/XGJFHvut4x

It’s #BreastCancerAwarenessMonth and the @US_FDA is reminding patients and caregivers that thermography is not a substitute for mammograms. pic.twitter.com/XGJFHvut4x

FDA - U.S. Food and Drug Administration

22-10-2018

EU/3/16/1640 (Celgene Europe B.V.)

EU/3/16/1640 (Celgene Europe B.V.)

EU/3/16/1640 (Active substance: 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol methanesulfonate) - Transfer of orphan designation - Commission Decision (2018)6989 of Mon, 22 Oct 2018 European Medicines Agency (EMA) procedure number: EMA/OD/253/15/T/01

Europe -DG Health and Food Safety

22-10-2018

EU/3/15/1495 (Ultragenyx Netherlands B.V.)

EU/3/15/1495 (Ultragenyx Netherlands B.V.)

EU/3/15/1495 (Active substance: Triheptanoin) - Transfer of orphan designation - Commission Decision (2018)6992 of Mon, 22 Oct 2018 European Medicines Agency (EMA) procedure number: EMA/OD/007/15/T/02

Europe -DG Health and Food Safety

22-10-2018

EU/3/15/1532 (Sirius Regulatory Consulting EU Limited)

EU/3/15/1532 (Sirius Regulatory Consulting EU Limited)

EU/3/15/1532 (Active substance: Insulin human) - Transfer of orphan designation - Commission Decision (2018)6985 of Mon, 22 Oct 2018

Europe -DG Health and Food Safety

21-10-2018

Whether it’s funding scientific research, examining policy approaches to vexing safety issues, or launching public education campaigns, you can be assured that this is a top commitment for us, and #FDA is fully engaged in promoting and protecting the heal

Whether it’s funding scientific research, examining policy approaches to vexing safety issues, or launching public education campaigns, you can be assured that this is a top commitment for us, and #FDA is fully engaged in promoting and protecting the heal

Whether it’s funding scientific research, examining policy approaches to vexing safety issues, or launching public education campaigns, you can be assured that this is a top commitment for us, and #FDA is fully engaged in promoting and protecting the health of the nation’s women pic.twitter.com/euQki9iqsL

FDA - U.S. Food and Drug Administration

19-10-2018

New Safety Communication. @US_FDA   is sharing Updated Information To Reduce Potential Cardiac Surgery   Infection Risks Associated With the LivaNova 3T Heater-Cooler Systems. Read More:  https://go.usa.gov/xPnNW  #FDA #MedicalDevice

New Safety Communication. @US_FDA is sharing Updated Information To Reduce Potential Cardiac Surgery Infection Risks Associated With the LivaNova 3T Heater-Cooler Systems. Read More: https://go.usa.gov/xPnNW  #FDA #MedicalDevice

New Safety Communication. @US_FDA is sharing Updated Information To Reduce Potential Cardiac Surgery Infection Risks Associated With the LivaNova 3T Heater-Cooler Systems. Read More: https://go.usa.gov/xPnNW  #FDA #MedicalDevice

FDA - U.S. Food and Drug Administration

17-10-2018

Interact with experts from CDER, CBER & CDRH to learn what’s important when conducting clinical trials & preparing submissions for FDA review.

Register for FDA #CDERSBIA Clinical Investigator Training Course – November 13-15 in Silver Spring, MD.  https:

Interact with experts from CDER, CBER & CDRH to learn what’s important when conducting clinical trials & preparing submissions for FDA review. Register for FDA #CDERSBIA Clinical Investigator Training Course – November 13-15 in Silver Spring, MD. https:

Interact with experts from CDER, CBER & CDRH to learn what’s important when conducting clinical trials & preparing submissions for FDA review. Register for FDA #CDERSBIA Clinical Investigator Training Course – November 13-15 in Silver Spring, MD. https://go.usa.gov/xPqku  pic.twitter.com/EYNZANlgr9

FDA - U.S. Food and Drug Administration

17-10-2018

Save the date & Join the @US_FDA’s  Patient Engagement Advisory Committee on Nov 15th to discuss  patient-generated health data from sources like social media, activity  trackers, and patient-driven registries. Learn more:  https://go.usa.gov/xPRau  #Digi

Save the date & Join the @US_FDA’s Patient Engagement Advisory Committee on Nov 15th to discuss patient-generated health data from sources like social media, activity trackers, and patient-driven registries. Learn more: https://go.usa.gov/xPRau  #Digi

Save the date & Join the @US_FDA’s Patient Engagement Advisory Committee on Nov 15th to discuss patient-generated health data from sources like social media, activity trackers, and patient-driven registries. Learn more: https://go.usa.gov/xPRau  #DigitalHealth #PEAC2018 pic.twitter.com/NU61Snpxxw

FDA - U.S. Food and Drug Administration

15-10-2018

We have created a rumor control page for Hurricane #Michael that will be updated regularly. Help us share this info and remember to always check with official sources like @FLSERT, @GeorgiaEMA and @femaregion4.

 http://fema.gov/hurricane-michael-rumor-co

We have created a rumor control page for Hurricane #Michael that will be updated regularly. Help us share this info and remember to always check with official sources like @FLSERT, @GeorgiaEMA and @femaregion4. http://fema.gov/hurricane-michael-rumor-co

We have created a rumor control page for Hurricane #Michael that will be updated regularly. Help us share this info and remember to always check with official sources like @FLSERT, @GeorgiaEMA and @femaregion4. http://fema.gov/hurricane-michael-rumor-control … pic.twitter.com/T3h7ZiFUrZ

FDA - U.S. Food and Drug Administration

15-10-2018

Riximyo (Sandoz GmbH)

Riximyo (Sandoz GmbH)

Riximyo (Active substance: rituximab) - Centralised - Yearly update - Commission Decision (2018)6811 of Mon, 15 Oct 2018

Europe -DG Health and Food Safety