Endex 19

Hauptinformation

  • Handelsname:
  • Endex® 19,5% ad us. vet., orale Suspension
  • Darreichungsform:
  • 5% ad us. vet., orale Suspension
  • Verwenden für:
  • Tiere
  • Art der Medizin:
  • allopathic Droge

Dokumenten

  • Information für medizinisches Fachpersonal:
  • Das Informationsblatt für dieses Produkt ist derzeit nicht verfügbar, können Sie eine Anfrage an unseren Kundendienst zu senden und wir werden Sie benachrichtigen, sobald wir in der Lage, um es zu erhalten.


    Fordern Sie die Packungsbeilage für medizinisches Fachpersonal.

Lokalisierung

  • Erhältlich in:
  • Endex® 19,5% ad us. vet., orale Suspension
    Schweiz
  • Sprache:
  • Deutsch

Therapeutische Informationen

  • Therapiegruppe:
  • Oral anwendbares Breitband-Anthelminthikum gegen Nematoden und Leberegelbefall bei Rindern

Weitere Informationen

Status

  • Quelle:
  • Institut für Veterinärpharmakologie
  • Zulassungsnummer:
  • 51377
  • Letzte Änderung:
  • 03-11-2018

Packungsbeilage

Endex

19,5% ad us. vet., orale Suspension

Elanco Tiergesundheit AG

Oral anwendbares Breitband-Anthelminthikum gegen Nematoden und

Leberegelbefall bei Rindern

ATCvet: QP52AE51

Zusammensetzung

1 ml Suspension enthält:

Wirkstoff: Triclabendazol 120 mg, Levamisolhydrochlorid 75 mg. Konservierungsmittel:

E 210, E 216, E 218. Antioxidantien: E 223. Excipiens ad suspensionem

Fachinformationen Wirkstoffe (CliniPharm)

Levamisol - Triclabendazol

Eigenschaften / Wirkungen

Levamisol wirkt gegen Nematoden und Triclabendazol gegen Leberegel. Der

Wirkmechanismus von Levamisol beruht auf der cholinergen Aktivität, die zu spastischen

Lähmungen der Nematoden führt. Ausserdem hemmt Levamisol die Fumarat-Reduktase.

Pharmakokinetik

Levamisol und Triclabendazol werden nach oraler Verabreichung rasch resorbiert. Das

resorbierte Triclabendazol wird sehr schnell zu Sulfoxiden und Sulfonen oxidiert. Maximale

Plasmakonzentrationen von Levamisol werden bereits nach 0,5 - 1 Stunde und für

Triclabendazol 24 - 36 Stunden nach der Verabreichung erreicht. Die Ausscheidung von

Levamisol erfolgt über den Urin und Kot und diejenige von Triclabendazol hauptsächlich

über den Kot.

Indikationen

Endex 19.5% eignet sich zur gleichzeitigen Behandlung reifer und sich entwickelnder

unreifer Stadien von Magenwürmern (Haemonchus, Ostertagia, T. axei), Darmwürmern

(Trichostrongylus, Cooperia, Nematodirus, Bunostomum, Oesophagostomum) und

Lungenwürmern (Dictyocaulus) sowie allen Formen der Infektion durch den grossen

Leberegel (frühe unreife, unreife und geschlechtsreife Stadien von Fasciola hepatica und

F. gigantica) bei Rindern.

Endex 19,5% wird oral mit Hilfe der üblichen Eingabegeräte oder einer Plastikspritze

verabreicht.

Empfohlene Dosis

12,0 mg Triclabendazol / kg Körpergewicht

7,5 mg Levamisolhydrochlorid / kg Körpergewicht

Praktische Dosierungsanleitung

1 ml/10 kg Körpergewicht.

Körpergewicht

Dosierung

50 kg

5,0 ml

100 kg

10,0 ml

150 kg

15,0 ml

200 kg

20,0 ml

250 kg

25,0 ml

300 kg

30,0 ml

für jeweils 50 kg mehr5,0 ml

Behandlungsprogramm

Endex 19.5% wird bei gleichzeitigem Befall mit Nematoden und grossem Leberegel

verabreicht.

Die Behandlung vor Beginn der Weidesaison beseitigt Würmer, die im Tier überwintert

haben und verhindert eine Verseuchung der Weide.

Die Behandlung während der Weidezeit eliminiert inzwischen erworbene Infektionen und

verringert die Kontamination der Weide mit Wurmeiern, die später zu Infektionen und

Erkrankungen führen würden.

Die Behandlung nach der Weideperiode wird empfohlen, um inzwischen neu erworbene

Infektionen zu eliminieren.

-Alle zugekauften Tiere sollten behandelt werden, bevor sie zur Herde stossen.

Anwendungseinschränkungen

Kontraindikationen

Das Produkt ist gegen geschlechtsreife Ostertagia-Stadien und sich entwickelnde Larven

wirksam. Es ist aber nicht zur Bekämpfung inhibierter Larven indiziert.

Vorsichtsmassnahmen

Keine.

Unerwünschte Wirkungen

VetVigilance: Pharmacovigilance-Meldung erstatten

Überdosierung kann zu vorübergehenden Nebenwirkungen führen (Muskelzittern,

Speichelfluss).

Essbare Gewebe: 28 Tage. Milch: 12 Tage, Behandlungen während der Trächtigkeit

sollten spätestens 7 Tage vor dem Abkalben erfolgen.

Wechselwirkungen

Keine bekannt.

Sonstige Hinweise

Nur für Tiere. Für Kinder unzugänglich aufbewahren. Nach Gebrauch Hände waschen.

Jegliche Verunreinigung mit dem Produkt oder dem leeren Behälter von stehenden und

fliessenden Gewässern sowie Wasserläufen vermeiden. Entleerte Behälter unschädlich

beseitigen. Bei Raumtemperatur (15 - 25°C) aufbewahren. Vor Feuchtigkeit, Frost und

Hitze schützen. Vor Gebrauch gut schütteln. Verabreichungsspritze vor und nach

Gebrauch gut reinigen.

Packungen

Flasche zu 800 ml.

Abgabekategorie: B

Swissmedic Nr. 51'377

Informationsstand: 03/2006

Dieser Text ist behördlich genehmigt.

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19-9-2018

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19-9-2018

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19-9-2018

Memantine Mylan (Mylan S.A.S.)

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19-9-2018

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Europe -DG Health and Food Safety

11-9-2018

 Risk assessment guideline focus group meeting, European Medicines Agency, London, UK, From: 19-Sep-2018, To: 19-Sep-2018

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28-8-2018

ACCM meeting statement, Meeting 19, 22 March 2018

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Advisory Committee on Complementary Medicines Meeting 19 meeting statement

Therapeutic Goods Administration - Australia

17-8-2018

 Minutes of the COMP meeting of 19-21 June 2018

Minutes of the COMP meeting of 19-21 June 2018

Europe - EMA - European Medicines Agency

7-8-2018

Onsior (Elanco Europe Ltd)

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Onsior (Active substance: Robenacoxib) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)5416 of Tue, 07 Aug 2018 European Medicines Agency (EMA) procedure number: EMEA/V/C/127/T/19

Europe -DG Health and Food Safety

23-7-2018

 Minutes of the CVMP meeting of 19-21 June 2018

Minutes of the CVMP meeting of 19-21 June 2018

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19-7-2018

EU/3/12/1083 (Global Regulatory Limited)

EU/3/12/1083 (Global Regulatory Limited)

EU/3/12/1083 (Active substance: Humanised single chain monoclonal antibody against CD37) - Transfer of orphan designation - Commission Decision (2018)4839 of Thu, 19 Jul 2018 European Medicines Agency (EMA) procedure number: EMA/OD/128/12/T/02

Europe -DG Health and Food Safety

19-7-2018

EU/3/16/1783 (Reglntel Ltd)

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EU/3/16/1783 (Active substance: N-(5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide) - Transfer of orphan designation - Commission Decision (2018)4810 of Thu, 19 Jul 2018 European Medicines Agency (EMA) procedure number: EMA/OD/138/16/T/02

Europe -DG Health and Food Safety

19-7-2018

HES (hydroxyethyl starch)

HES (hydroxyethyl starch)

HES (hydroxyethyl starch) (Active substance: hydroxyethyl starch (HES), solutions for infusion) - Community Referrals - Art 107i - Commission Decision (2018)4832 of Thu, 19 Jul 2018 European Medicines Agency (EMA) procedure number: EMEA/H/A-107i/1457

Europe -DG Health and Food Safety

19-7-2018

Aplidin (Pharma Mar S.A.)

Aplidin (Pharma Mar S.A.)

Aplidin (Active substance: plitidepsin) - Refusal of authorisation - Commission Decision (2018)4831 of Thu, 19 Jul 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/4354

Europe -DG Health and Food Safety

19-7-2018

Regulatory and procedural guideline:  Post-orphan medicinal product designation procedures: guidance for sponsors to submit an application via the current existing submission process until 19 Sept 2018

Regulatory and procedural guideline: Post-orphan medicinal product designation procedures: guidance for sponsors to submit an application via the current existing submission process until 19 Sept 2018

The opinions on orphan designation are adopted by the Committee for Orphan Medicinal Products (COMP) at their monthly meetings at the European Medicines Agency (EMA).

Europe - EMA - European Medicines Agency

18-7-2018

Agenda:  Agenda - CVMP agenda of the 17-19 July 2018 meeting

Agenda: Agenda - CVMP agenda of the 17-19 July 2018 meeting

Committee for Medicinal Products for Veterinary Use - Draft agenda of July 2018 meeting

Europe - EMA - European Medicines Agency

17-7-2018

Agenda:  Agenda - COMP agenda of the 17-19 July 2018 meeting

Agenda: Agenda - COMP agenda of the 17-19 July 2018 meeting

Draft agenda for the meeting on 17-19 July 2018

Europe - EMA - European Medicines Agency

28-6-2018

 Minutes of the COMP meeting of 17-19 April 2018

Minutes of the COMP meeting of 17-19 April 2018

Europe - EMA - European Medicines Agency

19-6-2018

Zerbaxa (Merck Sharp and Dohme B.V.)

Zerbaxa (Merck Sharp and Dohme B.V.)

Zerbaxa (Active substance: ceftolozane / tazobactam) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)3914 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/3772/T/17

Europe -DG Health and Food Safety

19-6-2018

SOLYMBIC (Amgen Europe B.V.)

SOLYMBIC (Amgen Europe B.V.)

SOLYMBIC (Active substance: adalimumab) - Centralised - Withdrawal - Commission Decision (2018)3913 of Tue, 19 Jun 2018

Europe -DG Health and Food Safety

19-6-2018

Zepatier (Merck Sharp and Dohme B.V.)

Zepatier (Merck Sharp and Dohme B.V.)

Zepatier (Active substance: elbasvir / grazoprevir) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)3917 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/4126/T/15

Europe -DG Health and Food Safety

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Maviret (AbbVie Deutschland GmbH and Co. KG)

Maviret (AbbVie Deutschland GmbH and Co. KG)

Maviret (Active substance: glecaprevir / pibrentasvir) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)3916 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/4430/T/11

Europe -DG Health and Food Safety

19-6-2018

Insuman (Sanofi-Aventis Deutschland GmbH)

Insuman (Sanofi-Aventis Deutschland GmbH)

Insuman (Active substance: human insulin) - Centralised - Yearly update - Commission Decision (2018)3889 of Tue, 19 Jun 2018

Europe -DG Health and Food Safety

19-6-2018

Aftovaxpur Doe (Merial)

Aftovaxpur Doe (Merial)

Aftovaxpur Doe (Active substance: purified, inactivated foot-and-mouth disease virus strains O1 Manisa, O1 BFS, O Taiwan 3/97, A22 Iraq, A24 Cruzeiro, A Turkey 14/98, Asia 1 Shamir, SAT2 Saudi Arabia) - Centralised - Renewal - Commission Decision (2018)3891 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/V/C/2292/R/8

Europe -DG Health and Food Safety

19-6-2018

Dany's BienenWohl (Dany Bienenwohl GmbH)

Dany's BienenWohl (Dany Bienenwohl GmbH)

Dany's BienenWohl (Active substance: oxalic acid dihydrate) - Centralised - Authorisation - Commission Decision (2018)3892 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/V/C/4667

Europe -DG Health and Food Safety

19-6-2018

Iscover (Sanofi-Aventis groupe)

Iscover (Sanofi-Aventis groupe)

Iscover (Active substance: Clopidogrel) - Centralised - Yearly update - Commission Decision (2018)3888 of Tue, 19 Jun 2018

Europe -DG Health and Food Safety

19-6-2018

Lusduna (Merck Sharp and Dohme B.V.)

Lusduna (Merck Sharp and Dohme B.V.)

Lusduna (Active substance: insulin glargine) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)3918 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/4101/T/6

Europe -DG Health and Food Safety

19-6-2018

ZINPLAVA (Merck Sharp and Dohme B.V.)

ZINPLAVA (Merck Sharp and Dohme B.V.)

ZINPLAVA (Active substance: bezlotoxumab) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)3915 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/4136/T/11

Europe -DG Health and Food Safety

19-6-2018

Aerinaze (Merck Sharp and Dohme Limited)

Aerinaze (Merck Sharp and Dohme Limited)

Aerinaze (Active substance: desloratadine; pseudoephedrine sulphate) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)3930 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/772/T/37

Europe -DG Health and Food Safety

19-6-2018

Neoclarityn (Merck Sharp and Dohme Limited)

Neoclarityn (Merck Sharp and Dohme Limited)

Neoclarityn (Active substance: desloratadine) - Centralised - Transfer Marketing Authorisation Holder - Commission Decision (2018)3931 of Tue, 19 Jun 2018 European Medicines Agency (EMA) procedure number: EMEA/H/C/314/T/88

Europe -DG Health and Food Safety

19-6-2018

Onbrez Breezhaler (Novartis Europharm Limited)

Onbrez Breezhaler (Novartis Europharm Limited)

Onbrez Breezhaler (Active substance: indacaterol) - Corrigendum - Commission Decision (2018)2573 of Tue, 19 Jun 2018

Europe -DG Health and Food Safety

19-6-2018

Orgalutran (Merck Sharp and Dohme Limited)

Orgalutran (Merck Sharp and Dohme Limited)

Orgalutran (Active substance: ganirelix) - Corrigendum - Commission Decision (2017)2520 of Tue, 19 Jun 2018

Europe -DG Health and Food Safety