Diabetmin 1000mg Film-Coated Tablet

Země: Malajsie

Jazyk: angličtina

Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivní složka:

METFORMIN HYDROCHLORIDE

Dostupné s:

HOVID BERHAD

INN (Mezinárodní Name):

METFORMIN HYDROCHLORIDE

Jednotky v balení:

100tablet Tablets

Výrobce:

HOVID BERHAD

Charakteristika produktu

DIABETMIN TABLET
VIDIA17-var4 (MY)
595
DESCRIPTION
DIABETMIN 500MG TABLET:
Round,
white
film-coated
tablet,
bevel-edged
and
shallow convex faces with deep score line on one side.
DIABETMIN RETARD TABLET:
Round, white uncoated tablet with convex faces.
DIABETMIN 850MG TABLET:
Round, white film-coated tablet with deep convex faces
and 'hovid' embossed on one face.
DIABETMIN 1000MG TABLET:
Oblong, white film-coated tablet, deep convex faces,
deep scored and "HD" embossed on one face and
scored on the other face.
COMPOSITION
DIABETMIN 500MG TABLET:
Metformin Hydrochloride 500mg per tablet.
DIABETMIN RETARD TABLET:
Metformin Hydrochloride 850mg per tablet (Extended-release).
DIABETMIN 850MG TABLET:
Metformin Hydrochloride 850mg per tablet.
DIABETMIN 1000MG TABLET:
Metformin Hydrochloride 1000mg per tablet.
ACTIONS AND PHARMACOLOGY
Metformin is an oral biguanide antidiabetic agent. Its
mode of action is thought to be multifactorial and includes
delayed uptake of glucose from the gastro-intestinal tract;
increased
peripheral
glucose
utilization
mediated
by
increased insulin sensitivity; and inhibition of increased
hepatic and renal gluconeogenesis.
PHARMACOKINETICS
Metformin Hydrochloride is slowly and incompletely
absorbed from the gastrointestinal tract. The absolute
bioavailability of a single 500mg dose is reported to be
about 50 to 60%, although this is reduced somewhat if
taken with food. Plasma protein binding is negligible. It
is
excreted
unchanged
in
the
urine.
The
plasma
elimination half-life is reported to range from about 2 to
6 hours after oral administration.
INDICATIONS
Metformin
is
used
in
the
treatment
of
non-insulin-dependent diabetes mellitus (type 2) in adults,
not
responding
to
exercise
and
dietary
modification.
Diabetmin may be used as monotherapy or in combination
with other oral antidiabetic agents, or with insulin.
CONTRAINDICATIONS
This medication is contraindicated in patients with the
following medical problems:
•
Hypersensitivity to metformin.
•
Any condition needing close blood glucose