PALLADONE 10 MGML

País: Israel

Idioma: anglès

Font: Ministry of Health

ingredients actius:

HYDROMORPHONE HYDROCHLORIDE

Disponible des:

RAFA LABORATORIES LTD

Codi ATC:

N02AA03

formulario farmacéutico:

SOLUTION FOR INJECTION

Composición:

HYDROMORPHONE HYDROCHLORIDE 20 MG / 2 ML

Vía de administración:

I.M, I.V, S.C

tipo de receta:

Required

Fabricat per:

RAFA LABORATORIES LTD, JERUSALEM

Grupo terapéutico:

HYDROMORPHONE

Área terapéutica:

HYDROMORPHONE

indicaciones terapéuticas:

Relief of moderate to severe pain such as that due to surgery or cancer.

Data d'autorització:

2012-04-30

Fitxa tècnica

1
Doctor Leaflet
HIGHLY CONCENTRATED
PALLADONE INJECTION 10 MG/ML
(Preservative Free)
Solution for injection
IM, SC, IV
Narcotic prescription required
COMPOSITION
Each 2 ml ampoule contains: Hydromorphone HCl 20 mg (10mg/ml).
Palladone Injection also contains citric acid 2 mg/ml and tri-sodium
citrate dihydrate 2.28 mg/ml
Palladone Injection contains no preservatives.
The solution is clear and colorless.
ACTION
Hydromorphone is a semisynthetic opioid agonist analgesic that acts
primarily at the mu opiate
receptor. Opiate receptors in the central nervous system mediate
analgesic activity. Opioid
agonists occupy the same receptors as endogenous opioid peptides
(enkephalins or endorphins),
and both may alter the central release of neurotransmitters from
afferent nerves sensitive to
noxious stimuli. Opioid antagonists block the opiate receptor, inhibit
the pharmacological
activity of the agonist and will precipitate withdrawal in dependent
patients.
Hydromorphone has similar pharmacological and pharmacokinetic
properties to morphine to
which it is chemically related. Hydromorphone is recognized by the
World Health Organization
as an alternative opioid to morphine for severe pain. This is
important since one of the
cornerstones of severe pain management is opioid rotation. Opioid
rotation consists of
switching a patient from one opioid to another in order to achieve
adequate analgesia with few
side effects. In particular, hydromorphone may have a better side
effect profile than morphine
in some individuals, producing less severe constipation and vomiting.
In the post-operative
setting as well, hydromorphone is a suitable alternative to morphine,
especially in patients with
a history of an unsatisfactory response to morphine e.g. excessive
vomiting.
There are several administration techniques for parenteral delivery of
hydromorphone,
including a single or double injection (e.g. post-operative), multiple
intermittent bolus injections
(e.g. in the cancer patient), or continuous infusion with or without
bolus as-needed in