País: Nova Zelanda
Idioma: anglès
Font: Medsafe (Medicines Safety Authority)
Alanylglutamine 200 mg/mL; ;
Fresenius Kabi New Zealand Limited
Alanylglutamine 200 mg/mL
200 mg/mL
Concentrate for infusion
Active: Alanylglutamine 200 mg/mL Excipient: Nitrogen Water for injection
Bottle, glass, 50 mL
General sale
General sale
Ajinomoto North America Inc
Dipeptiven® is indicated as part of a clinical nutrition regimen in patients in hypercatabolic and/or hypermetabolic states. It should be given together with parenteral or enteral nutrition or a combination of both.
Package - Contents - Shelf Life: Bottle, glass, - 50 mL - 24 months from date of manufacture stored at or below 25°C - Bottle, glass, - 100 mL - 24 months from date of manufacture stored at or below 25°C - Bottle, glass, - 250 mL - 24 months from date of manufacture stored at or below 25°C
2004-07-19
March, 2012 CMI FOR DIPEPTIVEN Filename: DipCMI10312-clean Page 1 of 2 Changes: indication DIPEPTIVEN ® Alanylglutamine CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common question about Dipeptiven. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you being given Dipeptiven against the benefits this medicine is expected to have for you. If you have any concerns about this medicine, ask your doctor or pharmacist. Keep this leaflet. You may need to read it again. WHAT IS DIPEPTIVEN USED FOR AND HOW DOES IT WORK Dipeptiven is an amino acid/dipeptide infusion solution, which is given as part of parenteral and/or enteral nutritional therapy. When the intake of nutrients or food into the mouth or directly into the gut is not possible or it is not enough to supply the body’s needs then nutrients or foods can be given intravenously or through the gastrointestinal tract or a combination of both. This is especially important for people whose bodies are under physical stress from illness or recent surgery. During illness or after surgery the body requires nutrition or food. Amino acids are the building blocks used by the body to make proteins. Dipeptiven is usually given as a supplement to amino acid solutions or an amino acid containing infusion regimen as part of complete nutritional support. Your doctor may have prescribed Dipeptiven for another reason. Ask your doctor if you have any questions about why Dipeptiven has been prescribed for you. BEFORE YOU ARE GIVEN DIPEPTIVEN When should you NOT be given Dipeptiven ? _You _ _should _ _NOT _ _be _ _given _ _Dipeptiven if: _ You have an allergy to Dipeptiven or any of the ingredients listed at the end of this leaflet. You have severe liver failure. You have severe kidney failure (if dialysis facilities are not available). You have too much acid in your blood, also called metabo Llegiu el document complet
Filename: DipDS0312-clean Page 1 of 5 DATA SHEET NAME OF MEDICINE DIPEPTIVEN ® (N(2)-l-alanyl-l-glutamine 200 mg/mL) Concentrate for Solution for Infusion PRESENTATION Dipeptiven is a clear, colourless concentrate for solution for infusion. Content 100 mL contains: 20 g N(2)-L-alanyl-L-glutamine (= 8.20 g L-alanine, 13.46 g L-glutamine) Water for Injections Theoretical osmolarity 921 mosmol/L Titration acidity 90 – 105 mmol NaOH/L pH value 5.4 - 6.0 USES ACTIONS The dipeptide N(2)-L-alanyl-L-glutamine is endogenously split into the amino acids glutamine and alanine hereby supplying glutamine with infusion solutions for parenteral nutrition. The released amino acids flow as nutrients into their respective body pools and are metabolised according to the needs of the organism. Many disease conditions, in which parenteral nutrition is indicated, are accompanied by a glutamine depletion, which glutamine containing infusion regimens counteract. PHARMACOKINETICS N(2)-L-alanyl-L-glutamine is rapidly split into alanine and glutamine after infusion. In man, half-lives of between 2.4 and 3.8 (in terminal renal insufficiency 4.2 min) and a plasma clearance of between 1.6 and 2.7 L/min were determined. The disappearance of the dipeptide was accompanied by an equimolar increase of the corresponding free amino acids. Hydrolysis probably takes place exclusively in the extracellular space. Renal elimination of N(2)-L-alanyl-glutamine under constant infusion is below 5 % and thus the same as that of infused amino acids. INDICATIONS Dipeptiven is indicated as part of a clinical nutritio Llegiu el document complet