STIEVA-A 0.1% 1mg/g cream tube

Country: অস্ট্রেলিয়া

ভাষা: ইংরেজি

সূত্র: Department of Health (Therapeutic Goods Administration)

সক্রিয় উপাদান:

Tretinoin

থেকে পাওয়া:

GlaxoSmithKline Australia Pty Ltd

INN (International Name):

Tretinoin

তথ্য লিফলেট

STIEVA-A
® CREAM
_[Tretinoin 0.025% w/w, 0.05% w/w,0.1% w/w]_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET?
Please read this leaflet carefully
before you use Stieva-A Cream.
This leaflet answers some common
questions about Stieva-A. It does not
contain all of the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the expected benefits of you using
Stieva-A Cream against the risks this
medicine could have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT IS STIEVA-A
CREAM USED FOR?
Stieva-A Cream is used to treat acne
(spots).
Stieva-A belongs to a group of
medicines called retinoids.
Stieva-A Cream helps to:
•
Make your skin less oily
•
Loosen blackheads and
whiteheads so that they come out
more easily
•
Stop new blackheads, whiteheads
and spots from forming
•
Lowers the number of red,
inflamed acne spots.
Stieva-A Cream is for use by adults
and adolescents with acne.
IT IS NOT FOR USE BY CHILDREN.
Your doctor may have prescribed
Stieva-A Cream for another reason.
Stieva-A Cream is not addictive.
BEFORE YOU USE STIEVA-
A CREAM
_DO NOT USE IF:_
You must not use Stieva-A Cream if:
•
you have ever had an allergic
reaction to tretinoin or any of the
ingredients listed toward the end
of this leaflet. (See "Ingredients")
•
IF YOU OR ANY OF YOUR CLOSE
FAMILY HAVE HAD SKIN CANCER
•
IF YOU ARE PREGNANT OR TRYING TO
BECOME PREGNANT
•
IF YOU ARE BREAST-FEEDING
•
THE EXPIRY DATE (EXP) PRINTED
ON THE PACK HAS PASSED
•
THE PACKAGING IS TORN OR SHOWS
SIGNS OF TAMPERING
_TELL YOUR DOCTOR IF:_
You must tell your doctor if:
•
YOU ARE ALLERGIC TO FOODS, DYES,
PRESERVATIVES OR ANY OTHER
MEDICINES.
•
YOU ARE USING ANY OTHER
MEDICINES FOR ACNE.
You may need to use the two
products at different times of the
day (eg. one in the morning and
the other at bedtime).
•
YOU ARE TAKING ANY OTHE

পণ্য বৈশিষ্ট্য

1
PRODUCT INFORMATION
STIEVA-A
® CREAMS 0.025% W/W, 0.05% W/W AND 0.1% W/W
NAME OF THE MEDICINE
tretinoin_ _
_Chemical names_: 3,
7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-non-tetraenoic
acid; all-_trans_-retinoic acid; tretinoin
Chemical structure
Molecular formula: C
20
H
28
O
2
. Molecular weight: 300.4.
CAS Number: 302-79-4
DESCRIPTION
Stieva-A Creams 0.025%, 0.05% and 0.1% contain the active ingredient
Tretinoin USP at a
concentration of 0.25 mg/g, 0.5 mg/g and 1.0 mg/g respectively in a
vanishing cream base.
Stieva-A Cream also includes the following excipients: butylated
hydroxytoluene, butylated
hydroxyanisole, disodium edetate, isopropyl palmitate, methyl
hydroxybenzoate, propyl
hydroxybenzoate, PEG-40 stearate, propylene glycol, stearic acid,
stearyl alcohol, soft, white
paraffin, purified water, titanium dioxide*.
*Please note titanium dioxide is present in Stieva-A 0.1% cream
formulation only.
PHARMACOLOGY
Tretinoin is a known metabolite of vitamin A, which regulates
epithelial cell growth and
differentiation. It is thought that topically applied tretinoin in
acne acts by:

stimulating mitosis in the epidermis

reducing intercelluar cohesion in the stratum corneum

contesting the hyperkeratosis characteristic of acne vulgaris

aiding desquamation, preventing the formation of lesions

mediating an increased production of less cohesive epidermal sebaceous
cells, which
appears to promote the initial expulsion of comedones and their
subsequent prevention.
2
Tretinoin shows weak inhibition of leukotriene-B4-induced migration of
polymorphonuclear
leukocytes which may contribute to its topical anti-inflammatory
activity. More marked
inhibition of polymorphonuclear leukocyte migration is seen with
isotretinoin. The weaker effect
of tretinoin compared to isotretinoin may account for the greater
rebound effect seen with topical
tretinoin when compared with topical isotretinoin.
PHARMACODYNAMIC EFFECTS
The pharmacological action of tretinoin remains to be fully
elucidated. It has