Country: ইস্রায়েল
ভাষা: ইংরেজি
সূত্র: Ministry of Health
AMINOPHYLLINE
TEVA PHARMACEUTICAL INDUSTRIES LTD, ISRAEL
R03DA05
SOLUTION FOR INJECTION
AMINOPHYLLINE 250 MG / 10 ML
I.V
Required
TEVA PHARMACEUTICAL WORKS PRIVATE LIMITED COMPANY, HUNGARY
AMINOPHYLLINE
AMINOPHYLLINE
For symptomatic relief or prevention of bronchial asthma and for treatment of reversible bronchospasm associated with chronic bronchitis and emphysema.
2014-05-31
העדוה העדוה לע לע הרמחה הרמחה ( ( עדימ עדימ ןולעב )תוחיטב ןולעב )תוחיטב ל ל אפור אפור ןכדועמ( ןכדועמ( 05.2013 05.2013 ) ) ךיראת ___________ MARCH 27, 2014 ______ םש רישכת תילגנאב רפסמו םושירה ____________ AMINOPHYLLINE INJECTION: 063 85 22594 21 _ םש לעב םושירה _ עבט תוישעת תויטבצמרפ .ד.ת ,מ"עב 3190 ת"פ , _ _ ספוט הז דעוימ טורפל תורמחהה דבלב ! תורמחהה תושקובמה קרפ ןולעב טסקט יחכונ טסקט שדח INDICATION CONTRAINDICATIONS POSOLOGY, DOSAGE & ADMINISTRATION SPECIAL WARNINGS AND SPECIAL PRECAUTIONS FOR USE _Children_ Children have a marked sensitivity to the CNS stimulant action of theophylline. This should be taken into consideration for proper dosage adjustment and monitoring. Rapid intravenous injection is not recommended in children. _Use in the Elderly_ Elderly patients are at significantly greater risk of experiencing serious toxicity from theophylline than younger patients due to pharmacokinetic and pharmacodynamic changes associated with aging. Caution should be exercised when aminophylline is administered to patients older than 60 years of age. Theophylline clearance in healthy adults older than 60 years of age is 30% lower than healthy younger adults. These patients may require adjustment in dosage or dosing interval To reduce the undesirable stimulating effects of aminophylline on the central nervous and cardiovascular systems, intravenous administration of the drug should be slow and should not exceed a rate of 25 mg/min. Aminophylline has a narrow therapeutic index and serum levels should be monitored regularly, particularly during initiation of therapy. Aminophylline injection should be administered cautiously to patients over 55 years of age. Elderly patients or those with cardiac or hepatic disease should be monitored carefully for signs of theophylline toxicity. Care should be taken in patients unde সম্পূর্ণ নথি পড়ুন
AMINOPHYLLINE 4. 5. 2014, RH " ע עבקנ הז ןולע טמרופ " רשואו קדבנ ונכותו תואירבה דרשמ י ." רשואמ ןולע : יאמ 2014 “This leaflet form at has been determined by the Ministry of Health and the content thereof has been checked and approved.” Date of approval: May 2014. AMINOPHYLLINE INJECTION COMPOSITION Each ampoule of 10 ml contains: _Active Ingredient _ Aminophylline dihydrate 250 mg _Other Ingredient _ Water for injection. MECHANISM OF ACTION Aminophylline is a soluble compound of theophylline with ethylenediamine. The main action of theophylline is a direct relaxation of the smooth muscles of the bronchial airways and pulmonary blood vessels, thus acting as a bronchodilator. It has also been demonstrated that aminophylline has a potent effect on diaphragmatic contractility in normal persons and may then be capable of reducing fatigability and therapy improve contractility in patients with chronic obstructive airway disease. The exact mode of action remains unsettled. Although theophylline does cause inhibition of phosphodiesterase with a resultant increase in intracellular cyclic AMP, other agents similarly inhibit the enzyme producing a rise of cyclic AMP but are unassociated with any demonstrable bronchodilation. Other mechanisms proposed include an effect on translocation of intracellular calcium, prostaglandin antagonism, stimulation of catecholamines endogenously, inhibition of cyclic guanosine monophosphate metabolism and adenosine receptor antagonisms. None of these mechanisms has been proved. _In vitro_, theophylline has been shown to act synergistically with beta agonists and there is now available data which demonstrates an additive effect _ in vivo_ with combined use. Theophylline also manifests other actions typical of the xanthine derivatives such as coronary vasodilation and diuresis. INDICATIONS For symptomatic relief or prevention of bronchial asthma and for treatment of reversible bronchospasm associated with chronic bronchitis and emphyse সম্পূর্ণ নথি পড়ুন