ACYCLOVIR tablet

Country: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

ACYCLOVIR (UNII: X4HES1O11F) (ACYCLOVIR - UNII:X4HES1O11F)

থেকে পাওয়া:

PharmPak, Inc.

প্রশাসন রুট:

ORAL

প্রেসক্রিপশন টাইপ:

PRESCRIPTION DRUG

থেরাপিউটিক ইঙ্গিত:

Herpes Zoster Infections: Acyclovir tablets, USP are indicated for the acute treatment of herpes zoster (shingles). Genital Herpes: Acyclovir tablets, USP are indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes. Chickenpox: Acyclovir tablets, USP are indicated for the treatment of chickenpox (varicella). Acyclovir tablets are contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

পণ্য সারাংশ:

Acyclovir tablets USP, 400 mg containing 400 mg of acyclovir USP are pink, shield shaped, flat tablets debossed with 'J' on one side and '49' in triangle on the other. They are supplied as follows: Acyclovir 400mg, 10ct 54348-627-10 Acyclovir 400mg, 15ct 54348-627-15 Acyclovir 400mg, 20ct 54348-627-20 Acyclovir 400mg, 21ct 54348-627-21 Acyclovir 400mg, 25ct 54348-627-25 Acyclovir 400mg, 30ct 54348-627-30 Acyclovir 400mg, 60ct 54348-627-60 Store between 15º and 25ºC. Protect from light and moisture. Manufactured By: HETERO TM                                                                            Hetero Labs Limited, Unit V, Polepally,                 2022708                        Jadcherla, Mahaboob Nagar-509 301, India.                                           Barcode Revised: June 2013

অনুমোদন অবস্থা:

Abbreviated New Drug Application

পণ্য বৈশিষ্ট্য

ACYCLOVIR- ACYCLOVIR TABLET
PHARMPAK, INC.
----------
ACYCLOVIR TABLETS, USP
RX ONLY
DESCRIPTION
Acyclovir is a synthetic nucleoside analogue active against
herpesviruses. Acyclovir
tablets, USP is a formulation for oral administration.
Each Acyclovir Tablet contains 400 mg or 800 mg of acyclovir. In
addition, each tablet
contains the inactive ingredients colloidal silicon dioxide, magnesium
stearate,
microcrystalline cellulose, povidone and sodium starch glycolate. The
400 mg and 800
mg tablet also contains ferric oxide and FD&C blue lake # 2 Indigo
carmine AL,
respectively.
Acyclovir USP is a white to off white crystalline powder, slightly
hygroscopic with the
molecular formula C
H
N
O
and a molecular weight of 225.20. The maximum
solubility in water at 37°C is 2.5 mg/mL. The pka's of acyclovir are
2.27 and 9.25.
The chemical name of acyclovir is 6H-Purin-6-one,
2-amino-1,9-dihydro-9-[(2-
hydroxyethoxy)methyl]-. It has the following structural formula:
VIROLOGY
MECHANISM OF ANTIVIRAL ACTION: Acyclovir is a synthetic purine
nucleoside analogue
with _in vitro_ and _in vivo_ inhibitory activity against herpes
simplex virus types 1 (HSV-1), 2
(HSV-2), and varicella-zoster virus (VZV).
The inhibitory activity of acyclovir is highly selective due to its
affinity for the enzyme
thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme
converts acyclovir
into acyclovir monophosphate, a nucleotide analogue. The monophosphate
is further
converted into diphosphate by cellular guanylate kinase and into
triphosphate by a
number of cellular enzymes. _In vitro_, acyclovir triphosphate stops
replication of herpes
viral DNA. This is accomplished in 3 ways: 1) competitive inhibition
of viral DNA
polymerase, 2) incorporation into and termination of the growing viral
DNA chain, and 3)
inactivation of the viral DNA polymerase. The greater antiviral
activity of acyclovir against
HSV compared with VZV is due to its more efficient phosphorylation by
the viral TK.
ANTIVIRAL ACTIVITIES: The quantitative relationship between the _